Novel risk factors for cardiovascular disease in rheumatoid arthritis

Since cardiovascular disease (CVD) is the most common cause of mortality in patients with rheumatoid arthritis (RA), we aimed to determine factors associated with such a complication in a large series of Colombian patients. This was a cross-sectional analytical study in which 800 consecutive Colombi...

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Autores:
Tipo de recurso:
Fecha de publicación:
2013
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/24277
Acceso en línea:
https://doi.org/10.1007/s12026-013-8398-7
https://repository.urosario.edu.co/handle/10336/24277
Palabra clave:
Abdominal obesity
Adult
Article
Autoimmunity
Body mass
Cardiovascular disease
Carotid artery disease
Colombia
Cross-sectional study
Data extraction
Disease duration
Female
Health practitioner
Human
Hypercholesterolemia
Hypertension
Major clinical study
Male
Medline
Meta analysis (topic)
Non insulin dependent diabetes mellitus
Peripheral occlusive artery disease
Priority journal
Rheumatoid arthritis
Risk factor
Smoking
Systematic review (topic)
Thrombosis
Adult
Animals
Autoimmunity
Cardiovascular diseases
Colombia
Cross-sectional studies
Female
Genetic predisposition to disease
Humans
Hypercholesterolemia
Male
Middle aged
Obesity
Risk factors
Cardiovascular disease
Familial autoimmunity
Non-traditional risk factors
Rheumatoid arthritis
type 2
rheumatoid
Arthritis
Diabetes mellitus
Rights
License
Abierto (Texto Completo)
id EDOCUR2_be5a35f4ddd49616d844ee32d8bf0fe1
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network_name_str Repositorio EdocUR - U. Rosario
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spelling 06d01a9c-7112-4ad7-b82e-5dedc26c7a1f182cf7c8-7899-427d-8bf1-8ba9d4dd58cb80ad7a9c-42eb-4d68-b578-b9670635e932f7fc84f7-ce45-4016-9200-7fc16ae72b6852249701194747786002020-05-26T00:11:02Z2020-05-26T00:11:02Z2013Since cardiovascular disease (CVD) is the most common cause of mortality in patients with rheumatoid arthritis (RA), we aimed to determine factors associated with such a complication in a large series of Colombian patients. This was a cross-sectional analytical study in which 800 consecutive Colombian patients with RA were assessed for variables associated with CVD. Furthermore, a systematic literature review was performed to address the state of the art about non-traditional risk factors for CVD in RA. The preferred reporting items for systematic reviews and meta-analyses guidelines were followed in data extraction, analysis, and reporting of articles selected. Hypercholesterolemia, type 2 diabetes mellitus, abnormal body mass index, abdominal obesity, and current smoking were all traditional risk factors significantly associated with CVD in Colombians. As non-traditional risk factors, familial autoimmunity, more than 10 years of duration of the disease, patients working on household duties, use of systemic steroids, and low education level were associated with CVD in the studied population. Out of a total of 9,812 articles identified in PubMed and Scopus databases, 140 fulfilled the eligibility criteria and were included. Through this systematic review, several factors and outcomes related to CVD were confirmed and identified. These were categorized into genetics, RA-related, and others. Traditional risk factors do not completely explain the high rates of CVD in patients with RA; thus, novel risk factors related to autoimmunity are now recognized predicting the presence of CVD as strong as traditional risk factors. Our results may assist health professionals and policymakers in making decisions about CVD in patients with RA. © 2013 Springer Science+Business Media New York.application/pdfhttps://doi.org/10.1007/s12026-013-8398-70257277Xhttps://repository.urosario.edu.co/handle/10336/24277eng286No. 43892267Immunologic ResearchVol. 56Immunologic Research, ISSN:0257277X, Vol.56, No.43892 (2013); pp. 267-286https://www.scopus.com/inward/record.uri?eid=2-s2.0-84879549613&doi=10.1007%2fs12026-013-8398-7&partnerID=40&md5=e1bd1437ccf00a9cddf8c4796ab53141Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURAbdominal obesityAdultArticleAutoimmunityBody massCardiovascular diseaseCarotid artery diseaseColombiaCross-sectional studyData extractionDisease durationFemaleHealth practitionerHumanHypercholesterolemiaHypertensionMajor clinical studyMaleMedlineMeta analysis (topic)Non insulin dependent diabetes mellitusPeripheral occlusive artery diseasePriority journalRheumatoid arthritisRisk factorSmokingSystematic review (topic)ThrombosisAdultAnimalsAutoimmunityCardiovascular diseasesColombiaCross-sectional studiesFemaleGenetic predisposition to diseaseHumansHypercholesterolemiaMaleMiddle agedObesityRisk factorsCardiovascular diseaseFamilial autoimmunityNon-traditional risk factorsRheumatoid arthritistype 2rheumatoidArthritisDiabetes mellitusNovel risk factors for cardiovascular disease in rheumatoid arthritisarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Amaya-Amaya, JennySarmiento-Monroy, Juan CamiloMantilla, Ruben-DarioPineda-Tamayo, RicardoRojas-Villarraga, AdrianaAnaya, Juan-Manuel10336/24277oai:repository.urosario.edu.co:10336/242772022-05-02 07:37:13.731964https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Novel risk factors for cardiovascular disease in rheumatoid arthritis
title Novel risk factors for cardiovascular disease in rheumatoid arthritis
spellingShingle Novel risk factors for cardiovascular disease in rheumatoid arthritis
Abdominal obesity
Adult
Article
Autoimmunity
Body mass
Cardiovascular disease
Carotid artery disease
Colombia
Cross-sectional study
Data extraction
Disease duration
Female
Health practitioner
Human
Hypercholesterolemia
Hypertension
Major clinical study
Male
Medline
Meta analysis (topic)
Non insulin dependent diabetes mellitus
Peripheral occlusive artery disease
Priority journal
Rheumatoid arthritis
Risk factor
Smoking
Systematic review (topic)
Thrombosis
Adult
Animals
Autoimmunity
Cardiovascular diseases
Colombia
Cross-sectional studies
Female
Genetic predisposition to disease
Humans
Hypercholesterolemia
Male
Middle aged
Obesity
Risk factors
Cardiovascular disease
Familial autoimmunity
Non-traditional risk factors
Rheumatoid arthritis
type 2
rheumatoid
Arthritis
Diabetes mellitus
title_short Novel risk factors for cardiovascular disease in rheumatoid arthritis
title_full Novel risk factors for cardiovascular disease in rheumatoid arthritis
title_fullStr Novel risk factors for cardiovascular disease in rheumatoid arthritis
title_full_unstemmed Novel risk factors for cardiovascular disease in rheumatoid arthritis
title_sort Novel risk factors for cardiovascular disease in rheumatoid arthritis
dc.subject.keyword.spa.fl_str_mv Abdominal obesity
Adult
Article
Autoimmunity
Body mass
Cardiovascular disease
Carotid artery disease
Colombia
Cross-sectional study
Data extraction
Disease duration
Female
Health practitioner
Human
Hypercholesterolemia
Hypertension
Major clinical study
Male
Medline
Meta analysis (topic)
Non insulin dependent diabetes mellitus
Peripheral occlusive artery disease
Priority journal
Rheumatoid arthritis
Risk factor
Smoking
Systematic review (topic)
Thrombosis
Adult
Animals
Autoimmunity
Cardiovascular diseases
Colombia
Cross-sectional studies
Female
Genetic predisposition to disease
Humans
Hypercholesterolemia
Male
Middle aged
Obesity
Risk factors
Cardiovascular disease
Familial autoimmunity
Non-traditional risk factors
Rheumatoid arthritis
topic Abdominal obesity
Adult
Article
Autoimmunity
Body mass
Cardiovascular disease
Carotid artery disease
Colombia
Cross-sectional study
Data extraction
Disease duration
Female
Health practitioner
Human
Hypercholesterolemia
Hypertension
Major clinical study
Male
Medline
Meta analysis (topic)
Non insulin dependent diabetes mellitus
Peripheral occlusive artery disease
Priority journal
Rheumatoid arthritis
Risk factor
Smoking
Systematic review (topic)
Thrombosis
Adult
Animals
Autoimmunity
Cardiovascular diseases
Colombia
Cross-sectional studies
Female
Genetic predisposition to disease
Humans
Hypercholesterolemia
Male
Middle aged
Obesity
Risk factors
Cardiovascular disease
Familial autoimmunity
Non-traditional risk factors
Rheumatoid arthritis
type 2
rheumatoid
Arthritis
Diabetes mellitus
dc.subject.keyword.eng.fl_str_mv type 2
rheumatoid
Arthritis
Diabetes mellitus
description Since cardiovascular disease (CVD) is the most common cause of mortality in patients with rheumatoid arthritis (RA), we aimed to determine factors associated with such a complication in a large series of Colombian patients. This was a cross-sectional analytical study in which 800 consecutive Colombian patients with RA were assessed for variables associated with CVD. Furthermore, a systematic literature review was performed to address the state of the art about non-traditional risk factors for CVD in RA. The preferred reporting items for systematic reviews and meta-analyses guidelines were followed in data extraction, analysis, and reporting of articles selected. Hypercholesterolemia, type 2 diabetes mellitus, abnormal body mass index, abdominal obesity, and current smoking were all traditional risk factors significantly associated with CVD in Colombians. As non-traditional risk factors, familial autoimmunity, more than 10 years of duration of the disease, patients working on household duties, use of systemic steroids, and low education level were associated with CVD in the studied population. Out of a total of 9,812 articles identified in PubMed and Scopus databases, 140 fulfilled the eligibility criteria and were included. Through this systematic review, several factors and outcomes related to CVD were confirmed and identified. These were categorized into genetics, RA-related, and others. Traditional risk factors do not completely explain the high rates of CVD in patients with RA; thus, novel risk factors related to autoimmunity are now recognized predicting the presence of CVD as strong as traditional risk factors. Our results may assist health professionals and policymakers in making decisions about CVD in patients with RA. © 2013 Springer Science+Business Media New York.
publishDate 2013
dc.date.created.spa.fl_str_mv 2013
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:11:02Z
dc.date.available.none.fl_str_mv 2020-05-26T00:11:02Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1007/s12026-013-8398-7
dc.identifier.issn.none.fl_str_mv 0257277X
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/24277
url https://doi.org/10.1007/s12026-013-8398-7
https://repository.urosario.edu.co/handle/10336/24277
identifier_str_mv 0257277X
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 286
dc.relation.citationIssue.none.fl_str_mv No. 43892
dc.relation.citationStartPage.none.fl_str_mv 267
dc.relation.citationTitle.none.fl_str_mv Immunologic Research
dc.relation.citationVolume.none.fl_str_mv Vol. 56
dc.relation.ispartof.spa.fl_str_mv Immunologic Research, ISSN:0257277X, Vol.56, No.43892 (2013); pp. 267-286
dc.relation.uri.spa.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-84879549613&doi=10.1007%2fs12026-013-8398-7&partnerID=40&md5=e1bd1437ccf00a9cddf8c4796ab53141
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
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dc.format.mimetype.none.fl_str_mv application/pdf
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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