Gastrointestinal-associated autoantibodies in different autoimmune diseases
Background: Gastrointestinal (GI)-related autoantibodies (Abs) are rarely evaluated in autoimmune diseases (AID) other than inflammatory bowel disease, autoimmune hepatitis and celiac disease. Our aim was to determine the prevalence of these antibodies in a wide spectrum of AID. Methods: We examined...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2012
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/27765
- Acceso en línea:
- https://repository.urosario.edu.co/handle/10336/27765
- Palabra clave:
- Gliadin (AGA)
Tissue-transglutaminase (tTG)
Saccharomyces cerevisiae (ASCA)
Autoantibodies
Inflammatory bowel diseases.
- Rights
- License
- Abierto (Texto Completo)
id |
EDOCUR2_be4e64df54621051d3ba7aab0bc58394 |
---|---|
oai_identifier_str |
oai:repository.urosario.edu.co:10336/27765 |
network_acronym_str |
EDOCUR2 |
network_name_str |
Repositorio EdocUR - U. Rosario |
repository_id_str |
|
spelling |
19474778600e081695e-fe59-4bb5-b489-178c1ae74074-1065e67d8-427b-4811-bcf3-8b588bb5e4de-1983cd9aa-c4c1-4c16-bb3c-8bc108612c5b-13f6be68f-f5fe-4446-9dee-8fb64e075ca3-181a96fdd-8518-4107-a9f7-d694722ae72a-12020-08-19T14:43:45Z2020-08-19T14:43:45Z2012-05-25Background: Gastrointestinal (GI)-related autoantibodies (Abs) are rarely evaluated in autoimmune diseases (AID) other than inflammatory bowel disease, autoimmune hepatitis and celiac disease. Our aim was to determine the prevalence of these antibodies in a wide spectrum of AID. Methods: We examined 923 serum samples representing 18 AID and compared them with 338 samples from healthy subjects. We used the BioPlex 2200-immunoassay (Bio-Rad, USA) to test samples for the presence of IgA and IgG directed at gliadin (AGA), tissue-transglutaminase (tTG), and Saccharomyces cerevisiae (ASCA). Results: Prevalence of IgA AGA was significantly higher in antiphospholipid syndrome (APS) (7.1 %, P=0.012) and in pemphigus vulgaris (25%, P =0.008) patients, as compared with healthy controls. Presence of IgG-AGA was more common among Crohn’s disease (20.5%, P = 0.023) and rheumatoid arthritis (6.5%, P=0.027) patients. IgG anti tTG were frequently observed in APS (6.1%, P=0.012), in giant cell arteritis (11.5%, P=0.013) and in ulcerative colitis (11.1%, P=0.018) patients, and as expected, higher prevalence of ASCA (IgA 19.3% and IgG 27.7%) was found in Crohn’s disease. IgG ASCA were also found in systemic lupus erythematosus (SLE) (4.5%, P=0.01), in Graves’ disease (5.7%, P=0.018), in cryoglobulinemia (7.1%, P=0.006), and in patients with vasculitides (6.5%, P=0.002). In contrast, lower prevalence of IgG type AGA was found in SLE (P=0.034), cryoglobulinemia (P=0.019) and vasculitides (P=0.013) patients. Conclusions: Our findings suggest an association between GI-related- Abs and a wide spectrum of AID. The clinical implication of these findings is yet to be determined.application/pdfEISSN: 2164-7712https://repository.urosario.edu.co/handle/10336/27765engNational Library of Medicine55No. 149American Journal of Clinical and Experimental ImmunologyVol. 1American Journal of Clinical and Experimental Immunology, EISSN: 2164-7712, Vol.1, No.1 (2012); pp. 49–55.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714189/Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2American Journal of Clinical and Experimental Immunologyinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURGliadin (AGA)Tissue-transglutaminase (tTG)Saccharomyces cerevisiae (ASCA)AutoantibodiesInflammatory bowel diseases.Gastrointestinal-associated autoantibodies in different autoimmune diseasesAutoanticuerpos asociados al tubo digestivo en diferentes enfermedades autoinmunesarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Anaya, Juan-ManuelBizzaro, NicolasTincani, AngelaEspinosa, GerardVillalta, DaniloCervera, Ricard10336/27765oai:repository.urosario.edu.co:10336/277652021-06-03 00:50:18.873https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Gastrointestinal-associated autoantibodies in different autoimmune diseases |
dc.title.TranslatedTitle.spa.fl_str_mv |
Autoanticuerpos asociados al tubo digestivo en diferentes enfermedades autoinmunes |
title |
Gastrointestinal-associated autoantibodies in different autoimmune diseases |
spellingShingle |
Gastrointestinal-associated autoantibodies in different autoimmune diseases Gliadin (AGA) Tissue-transglutaminase (tTG) Saccharomyces cerevisiae (ASCA) Autoantibodies Inflammatory bowel diseases. |
title_short |
Gastrointestinal-associated autoantibodies in different autoimmune diseases |
title_full |
Gastrointestinal-associated autoantibodies in different autoimmune diseases |
title_fullStr |
Gastrointestinal-associated autoantibodies in different autoimmune diseases |
title_full_unstemmed |
Gastrointestinal-associated autoantibodies in different autoimmune diseases |
title_sort |
Gastrointestinal-associated autoantibodies in different autoimmune diseases |
dc.subject.keyword.spa.fl_str_mv |
Gliadin (AGA) Tissue-transglutaminase (tTG) Saccharomyces cerevisiae (ASCA) Autoantibodies Inflammatory bowel diseases. |
topic |
Gliadin (AGA) Tissue-transglutaminase (tTG) Saccharomyces cerevisiae (ASCA) Autoantibodies Inflammatory bowel diseases. |
description |
Background: Gastrointestinal (GI)-related autoantibodies (Abs) are rarely evaluated in autoimmune diseases (AID) other than inflammatory bowel disease, autoimmune hepatitis and celiac disease. Our aim was to determine the prevalence of these antibodies in a wide spectrum of AID. Methods: We examined 923 serum samples representing 18 AID and compared them with 338 samples from healthy subjects. We used the BioPlex 2200-immunoassay (Bio-Rad, USA) to test samples for the presence of IgA and IgG directed at gliadin (AGA), tissue-transglutaminase (tTG), and Saccharomyces cerevisiae (ASCA). Results: Prevalence of IgA AGA was significantly higher in antiphospholipid syndrome (APS) (7.1 %, P=0.012) and in pemphigus vulgaris (25%, P =0.008) patients, as compared with healthy controls. Presence of IgG-AGA was more common among Crohn’s disease (20.5%, P = 0.023) and rheumatoid arthritis (6.5%, P=0.027) patients. IgG anti tTG were frequently observed in APS (6.1%, P=0.012), in giant cell arteritis (11.5%, P=0.013) and in ulcerative colitis (11.1%, P=0.018) patients, and as expected, higher prevalence of ASCA (IgA 19.3% and IgG 27.7%) was found in Crohn’s disease. IgG ASCA were also found in systemic lupus erythematosus (SLE) (4.5%, P=0.01), in Graves’ disease (5.7%, P=0.018), in cryoglobulinemia (7.1%, P=0.006), and in patients with vasculitides (6.5%, P=0.002). In contrast, lower prevalence of IgG type AGA was found in SLE (P=0.034), cryoglobulinemia (P=0.019) and vasculitides (P=0.013) patients. Conclusions: Our findings suggest an association between GI-related- Abs and a wide spectrum of AID. The clinical implication of these findings is yet to be determined. |
publishDate |
2012 |
dc.date.created.spa.fl_str_mv |
2012-05-25 |
dc.date.accessioned.none.fl_str_mv |
2020-08-19T14:43:45Z |
dc.date.available.none.fl_str_mv |
2020-08-19T14:43:45Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.issn.none.fl_str_mv |
EISSN: 2164-7712 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/27765 |
identifier_str_mv |
EISSN: 2164-7712 |
url |
https://repository.urosario.edu.co/handle/10336/27765 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
55 |
dc.relation.citationIssue.none.fl_str_mv |
No. 1 |
dc.relation.citationStartPage.none.fl_str_mv |
49 |
dc.relation.citationTitle.none.fl_str_mv |
American Journal of Clinical and Experimental Immunology |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 1 |
dc.relation.ispartof.spa.fl_str_mv |
American Journal of Clinical and Experimental Immunology, EISSN: 2164-7712, Vol.1, No.1 (2012); pp. 49–55. |
dc.relation.uri.spa.fl_str_mv |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714189/ |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
National Library of Medicine |
dc.source.spa.fl_str_mv |
American Journal of Clinical and Experimental Immunology |
institution |
Universidad del Rosario |
dc.source.instname.none.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.none.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1808390947513303040 |