The effect of exercise training on mediators of inflammation in breast cancer survivors: A systematic review with meta-analysis

Several sources of evidence indicate that exercise during and after breast cancer could positively modulate the tumor microenvironment. This meta-analysis aimed to determine the effects of exercise training on mediators of inflammation in breast cancer survivors. We searched for randomized controlled trials published from January 1990 to March 2014. An inverse variance method of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity. Eight high-quality trials (n = 478) were included. Exercise improved the serum concentrations of IL6 [weighted mean difference (WMD) = -0.55 pg/mL; 95% confidence interval (CI), -1.02 to -0.09], TNF? (WMD = -0.64 pg/mL; 95%CI, -1.21 to -0.06), IL8(MD= -0.49 pg/mL; 95% CI, -0.89 to -0.09), and IL2 (WMD = 1.03 pg/mL; 95% CI, 0.40 to 1.67). No significant differences were found in the serum concentrations of C-reactive protein (WMD = -0.15; 95% CI, -0.56 to 0.25) or IL10 (WMD = 0.41; 95% CI, -0.18 to 1.02). Exercise training positively modulates chronic low-grade inflammation in women with breast cancer, which may impact upon carcinogenic mechanisms and the tumor microenvironment. These findings align with the other positive effects of exercise for breast cancer survivors, reinforcing the appropriateness of exercise prescription in this population. © 2016 American Association for Cancer Research.

• Fecha de publicación: 2016
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/23634
• Acceso en línea: https://doi.org/10.1158/1055-9965.EPI-15-1061; https://repository.urosario.edu.co/handle/10336/23634
• Palabra clave: C reactive protein; Interleukin 10; Interleukin 2; Interleukin 6; Interleukin 8; Tumor necrosis factor alpha; Autacoid; C reactive protein; Interleukin 10; Interleukin 6; Aerobic exercise; Breast cancer; Breast carcinogenesis; Cancer survivor; Chronic inflammation; Evidence based practice; Exercise; Human; Inflammation; Mediator release; Meta analysis; Priority journal; Protein blood level; Randomized controlled trial (topic); Resistance training; Review; Systematic review; Tai Chi; Tumor microenvironment; Yoga; Blood; Breast tumor; Cancer survivor; Enzyme linked immunosorbent assay; Exercise; Female; Kinesiotherapy; Middle aged; Mortality; Physiology; Procedures; Regression analysis; Breast Neoplasms; C-Reactive Protein; Cancer Survivors; Enzyme-Linked Immunosorbent Assay; Exercise; Exercise Therapy; Female; Humans; Inflammation Mediators; Interleukin-10; Interleukin-6; Middle Aged; Randomized Controlled Trials as Topic; Regression Analysis; Human; human; human; IL10 protein; IL6 protein; Physical Conditioning
• License: Abierto (Texto Completo)