Relation of sensory peripheral neuropathy in sjögren syndrome to Anti-Ro/SSA

Background: Sjögren syndrome is a common, chronic autoimmune disease that typically produces inflammation and poor function of the salivary and lacrimal glands. Other organs can be affected, including the nervous system. Sensory peripheral neuropathy is a common manifestation of the disease. Methods: Eight-eight patients attending a dry eyesYdry mouth clinic were diagnosed to have primary Sjögren syndrome and underwent a neurological examination. Anti-Ro (or SSA) and anti-La (or SSB) were determined using immunodiffusion as well as Inno-Lia and BioPlex ANA screen. Serum vitamin B12 levels were determined using an enzyme-linked microtiter plate assay. Results: Twenty-seven (31%) of the 88 patients had peripheral neuropathy as defined by loss of light touch, proprioception, or vibratory sensation. Anti-Ro and anti-La were found by immunodiffusion in 12 patients, and 8 of these 12 had neuropathy (W2 = 8.46, P = 0.0036, odds ratio = 6.0 compared to those without precipitating anti-Ro and anti- La). Of the 27 patients with only anti-Ro by immunodiffusion, 13 (48.1%) had neuropathy (W2 = 5.587, P = 0.018, compared to those without anti-Ro). There was no relationship of the other, more sensitive measures of anti-Ro and anti-La to neuropathy. In addition, we found no association of serum vitamin B12 levels to neuropathy among these patients with Sjögren syndrome. Conclusions: Sensory peripheral neuropathy is common among patients with Sjögren syndrome and is associated with the presence of anti-Ro and anti-La when determined by immunodiffusion. Copyright © 2012 by Lippincott Williams and amp; Wilkins.

• Fecha de publicación: 2012
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/22310
• Acceso en línea: https://doi.org/10.1097/RHU.0b013e3182675e4f; https://repository.urosario.edu.co/handle/10336/22310
• Palabra clave: Cyanocobalamin; La antibody; Ro antibody; Adult; Article; Cyanocobalamin deficiency; Disease association; Enzyme linked microtiter plate assay; Female; Human; Immunodiffusion; Major clinical study; Male; Neurologic examination; Peripheral neuropathy; Priority journal; Proprioception; Sensory neuropathy; Sjoegren syndrome; Vibration; Vitamin blood level; Adult; Aged; Autoantigens; Cohort studies; Female; Humans; Immunodiffusion; Male; Middle aged; Peripheral nervous system diseases; Ribonucleoproteins; Sjogren's syndrome; Vitamin b 12; Autoantibodies; Peripheral neuropathy; Sjögren syndrome; Vitamin b 12; antinuclear; Antibodies
• License: Abierto (Texto Completo)