The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis

Background: Despite the prevalence of obesity and the multiple position stands promoting exercise for the treatment of obesity and hepatic function, a meta-analytic approach has not previously been used to examine the effects in the pediatric population. The aim of the study was to determine the eff...

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Autores:
Tipo de recurso:
Fecha de publicación:
2017
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23659
Acceso en línea:
https://doi.org/10.1089/chi.2017.0027
https://repository.urosario.edu.co/handle/10336/23659
Palabra clave:
Alanine aminotransferase
Aspartate aminotransferase
Gamma glutamyltransferase
Abdominal fat
Adolescent
Blood
Child
Childhood obesity
Diagnostic imaging
Enzymology
Exercise
Female
Human
Liver
Male
Medline
Meta analysis
Nonalcoholic fatty liver
Pathophysiology
Physiology
Subcutaneous fat
Abdominal fat
Adolescent
Alanine transaminase
Aspartate aminotransferases
Child
Exercise
Female
Gamma-glutamyltransferase
Humans
Liver
Male
Medline
Non-alcoholic fatty liver disease
Pediatric obesity
Subcutaneous fat
Ectopic adiposity
Fatty liver
Nonalcoholic steatohepatitis
Physical activity
Rights
License
Abierto (Texto Completo)
id EDOCUR2_bd28097c198783b9e278c0fe116689d7
oai_identifier_str oai:repository.urosario.edu.co:10336/23659
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 85d3ab3b-4a58-4836-9196-efc1f34afa74-1dd720aeb-5f85-44cd-bc7d-58877ddc8b55-14d347195-d4a2-4a45-9c5a-3b85e9e8a2f5-178ae6cb7-473c-4f4f-a34a-1b6e96da8aac-1a17278e0-e33e-4492-9cea-8d57a509142f-12020-05-26T00:04:07Z2020-05-26T00:04:07Z2017Background: Despite the prevalence of obesity and the multiple position stands promoting exercise for the treatment of obesity and hepatic function, a meta-analytic approach has not previously been used to examine the effects in the pediatric population. The aim of the study was to determine the effectiveness of exercise interventions on abdominal fat, liver enzymes, and intrahepatic fat in overweight and obese youth. Materials and Methods: A computerized search was made using three databases. The analysis was restricted to studies that examined the effect of supervised exercise interventions on abdominal fat (visceral and subcutaneous fat), liver enzymes (alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase), and intrahepatic fat. Fourteen clinical trials (1231 youths) were eligible for inclusion in this systematic review and meta-analysis. Standardized mean difference [SMD] and 95% confidence intervals (CIs) were calculated. Results: Exercise was associated with a significant reduction in visceral (SMD = -0.661; 95% CI, -0.976 to -0.346; p less than 0.001), subcutaneous (SMD = -0.352; 95% CI, -0.517 to -0.186; p less than 0.001) and intrahepatic fat (SMD = -0.802; 95% CI, -1.124 to -0.480; p less than 0.001), as well as gamma-glutamyl transferase (SMD = -0.726; 95% CI, -1.203 to -0.249; p less than 0.001), but did not alter any other liver enzyme. Subgroup analysis recommends exercise programs that involve aerobic exercise longer than three sessions per week. Conclusions: This meta-analysis supports current recommendation for physical exercise, mainly aerobic, as an effective intervention for nonalcoholic fatty liver disease progression by targeting hepatic lipid composition, visceral and subcutaneous adipose tissue. Systematic review registration: PROSPERO CRD42016042163. © Copyright 2017, Mary Ann Liebert, Inc..application/pdfhttps://doi.org/10.1089/chi.2017.00272153217621532168https://repository.urosario.edu.co/handle/10336/23659engMary Ann Liebert Inc.282No. 4272Childhood ObesityVol. 13Childhood Obesity, ISSN:21532176, 21532168, Vol.13, No.4 (2017); pp. 272-282https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025175788&doi=10.1089%2fchi.2017.0027&partnerID=40&md5=b1242ab161731df6fd2bfddcc5c8325fAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURAlanine aminotransferaseAspartate aminotransferaseGamma glutamyltransferaseAbdominal fatAdolescentBloodChildChildhood obesityDiagnostic imagingEnzymologyExerciseFemaleHumanLiverMaleMedlineMeta analysisNonalcoholic fatty liverPathophysiologyPhysiologySubcutaneous fatAbdominal fatAdolescentAlanine transaminaseAspartate aminotransferasesChildExerciseFemaleGamma-glutamyltransferaseHumansLiverMaleMedlineNon-alcoholic fatty liver diseasePediatric obesitySubcutaneous fatEctopic adiposityFatty liverNonalcoholic steatohepatitisPhysical activityThe Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-AnalysisarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501González-Ruiz K.Ramírez-Vélez R.Correa-Bautista J.E.Peterson M.D.García-Hermoso A.10336/23659oai:repository.urosario.edu.co:10336/236592022-05-02 07:37:21.190198https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis
title The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis
spellingShingle The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis
Alanine aminotransferase
Aspartate aminotransferase
Gamma glutamyltransferase
Abdominal fat
Adolescent
Blood
Child
Childhood obesity
Diagnostic imaging
Enzymology
Exercise
Female
Human
Liver
Male
Medline
Meta analysis
Nonalcoholic fatty liver
Pathophysiology
Physiology
Subcutaneous fat
Abdominal fat
Adolescent
Alanine transaminase
Aspartate aminotransferases
Child
Exercise
Female
Gamma-glutamyltransferase
Humans
Liver
Male
Medline
Non-alcoholic fatty liver disease
Pediatric obesity
Subcutaneous fat
Ectopic adiposity
Fatty liver
Nonalcoholic steatohepatitis
Physical activity
title_short The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis
title_full The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis
title_fullStr The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis
title_full_unstemmed The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis
title_sort The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis
dc.subject.keyword.spa.fl_str_mv Alanine aminotransferase
Aspartate aminotransferase
Gamma glutamyltransferase
Abdominal fat
Adolescent
Blood
Child
Childhood obesity
Diagnostic imaging
Enzymology
Exercise
Female
Human
Liver
Male
Medline
Meta analysis
Nonalcoholic fatty liver
Pathophysiology
Physiology
Subcutaneous fat
Abdominal fat
Adolescent
Alanine transaminase
Aspartate aminotransferases
Child
Exercise
Female
Gamma-glutamyltransferase
Humans
Liver
Male
Medline
Non-alcoholic fatty liver disease
Pediatric obesity
Subcutaneous fat
Ectopic adiposity
Fatty liver
Nonalcoholic steatohepatitis
Physical activity
topic Alanine aminotransferase
Aspartate aminotransferase
Gamma glutamyltransferase
Abdominal fat
Adolescent
Blood
Child
Childhood obesity
Diagnostic imaging
Enzymology
Exercise
Female
Human
Liver
Male
Medline
Meta analysis
Nonalcoholic fatty liver
Pathophysiology
Physiology
Subcutaneous fat
Abdominal fat
Adolescent
Alanine transaminase
Aspartate aminotransferases
Child
Exercise
Female
Gamma-glutamyltransferase
Humans
Liver
Male
Medline
Non-alcoholic fatty liver disease
Pediatric obesity
Subcutaneous fat
Ectopic adiposity
Fatty liver
Nonalcoholic steatohepatitis
Physical activity
description Background: Despite the prevalence of obesity and the multiple position stands promoting exercise for the treatment of obesity and hepatic function, a meta-analytic approach has not previously been used to examine the effects in the pediatric population. The aim of the study was to determine the effectiveness of exercise interventions on abdominal fat, liver enzymes, and intrahepatic fat in overweight and obese youth. Materials and Methods: A computerized search was made using three databases. The analysis was restricted to studies that examined the effect of supervised exercise interventions on abdominal fat (visceral and subcutaneous fat), liver enzymes (alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase), and intrahepatic fat. Fourteen clinical trials (1231 youths) were eligible for inclusion in this systematic review and meta-analysis. Standardized mean difference [SMD] and 95% confidence intervals (CIs) were calculated. Results: Exercise was associated with a significant reduction in visceral (SMD = -0.661; 95% CI, -0.976 to -0.346; p less than 0.001), subcutaneous (SMD = -0.352; 95% CI, -0.517 to -0.186; p less than 0.001) and intrahepatic fat (SMD = -0.802; 95% CI, -1.124 to -0.480; p less than 0.001), as well as gamma-glutamyl transferase (SMD = -0.726; 95% CI, -1.203 to -0.249; p less than 0.001), but did not alter any other liver enzyme. Subgroup analysis recommends exercise programs that involve aerobic exercise longer than three sessions per week. Conclusions: This meta-analysis supports current recommendation for physical exercise, mainly aerobic, as an effective intervention for nonalcoholic fatty liver disease progression by targeting hepatic lipid composition, visceral and subcutaneous adipose tissue. Systematic review registration: PROSPERO CRD42016042163. © Copyright 2017, Mary Ann Liebert, Inc..
publishDate 2017
dc.date.created.spa.fl_str_mv 2017
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:04:07Z
dc.date.available.none.fl_str_mv 2020-05-26T00:04:07Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1089/chi.2017.0027
dc.identifier.issn.none.fl_str_mv 21532176
21532168
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/23659
url https://doi.org/10.1089/chi.2017.0027
https://repository.urosario.edu.co/handle/10336/23659
identifier_str_mv 21532176
21532168
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 282
dc.relation.citationIssue.none.fl_str_mv No. 4
dc.relation.citationStartPage.none.fl_str_mv 272
dc.relation.citationTitle.none.fl_str_mv Childhood Obesity
dc.relation.citationVolume.none.fl_str_mv Vol. 13
dc.relation.ispartof.spa.fl_str_mv Childhood Obesity, ISSN:21532176, 21532168, Vol.13, No.4 (2017); pp. 272-282
dc.relation.uri.spa.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025175788&doi=10.1089%2fchi.2017.0027&partnerID=40&md5=b1242ab161731df6fd2bfddcc5c8325f
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Mary Ann Liebert Inc.
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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