The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis
Background: Despite the prevalence of obesity and the multiple position stands promoting exercise for the treatment of obesity and hepatic function, a meta-analytic approach has not previously been used to examine the effects in the pediatric population. The aim of the study was to determine the eff...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2017
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/23659
- Acceso en línea:
- https://doi.org/10.1089/chi.2017.0027
https://repository.urosario.edu.co/handle/10336/23659
- Palabra clave:
- Alanine aminotransferase
Aspartate aminotransferase
Gamma glutamyltransferase
Abdominal fat
Adolescent
Blood
Child
Childhood obesity
Diagnostic imaging
Enzymology
Exercise
Female
Human
Liver
Male
Medline
Meta analysis
Nonalcoholic fatty liver
Pathophysiology
Physiology
Subcutaneous fat
Abdominal fat
Adolescent
Alanine transaminase
Aspartate aminotransferases
Child
Exercise
Female
Gamma-glutamyltransferase
Humans
Liver
Male
Medline
Non-alcoholic fatty liver disease
Pediatric obesity
Subcutaneous fat
Ectopic adiposity
Fatty liver
Nonalcoholic steatohepatitis
Physical activity
- Rights
- License
- Abierto (Texto Completo)
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85d3ab3b-4a58-4836-9196-efc1f34afa74-1dd720aeb-5f85-44cd-bc7d-58877ddc8b55-14d347195-d4a2-4a45-9c5a-3b85e9e8a2f5-178ae6cb7-473c-4f4f-a34a-1b6e96da8aac-1a17278e0-e33e-4492-9cea-8d57a509142f-12020-05-26T00:04:07Z2020-05-26T00:04:07Z2017Background: Despite the prevalence of obesity and the multiple position stands promoting exercise for the treatment of obesity and hepatic function, a meta-analytic approach has not previously been used to examine the effects in the pediatric population. The aim of the study was to determine the effectiveness of exercise interventions on abdominal fat, liver enzymes, and intrahepatic fat in overweight and obese youth. Materials and Methods: A computerized search was made using three databases. The analysis was restricted to studies that examined the effect of supervised exercise interventions on abdominal fat (visceral and subcutaneous fat), liver enzymes (alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase), and intrahepatic fat. Fourteen clinical trials (1231 youths) were eligible for inclusion in this systematic review and meta-analysis. Standardized mean difference [SMD] and 95% confidence intervals (CIs) were calculated. Results: Exercise was associated with a significant reduction in visceral (SMD = -0.661; 95% CI, -0.976 to -0.346; p less than 0.001), subcutaneous (SMD = -0.352; 95% CI, -0.517 to -0.186; p less than 0.001) and intrahepatic fat (SMD = -0.802; 95% CI, -1.124 to -0.480; p less than 0.001), as well as gamma-glutamyl transferase (SMD = -0.726; 95% CI, -1.203 to -0.249; p less than 0.001), but did not alter any other liver enzyme. Subgroup analysis recommends exercise programs that involve aerobic exercise longer than three sessions per week. Conclusions: This meta-analysis supports current recommendation for physical exercise, mainly aerobic, as an effective intervention for nonalcoholic fatty liver disease progression by targeting hepatic lipid composition, visceral and subcutaneous adipose tissue. Systematic review registration: PROSPERO CRD42016042163. © Copyright 2017, Mary Ann Liebert, Inc..application/pdfhttps://doi.org/10.1089/chi.2017.00272153217621532168https://repository.urosario.edu.co/handle/10336/23659engMary Ann Liebert Inc.282No. 4272Childhood ObesityVol. 13Childhood Obesity, ISSN:21532176, 21532168, Vol.13, No.4 (2017); pp. 272-282https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025175788&doi=10.1089%2fchi.2017.0027&partnerID=40&md5=b1242ab161731df6fd2bfddcc5c8325fAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURAlanine aminotransferaseAspartate aminotransferaseGamma glutamyltransferaseAbdominal fatAdolescentBloodChildChildhood obesityDiagnostic imagingEnzymologyExerciseFemaleHumanLiverMaleMedlineMeta analysisNonalcoholic fatty liverPathophysiologyPhysiologySubcutaneous fatAbdominal fatAdolescentAlanine transaminaseAspartate aminotransferasesChildExerciseFemaleGamma-glutamyltransferaseHumansLiverMaleMedlineNon-alcoholic fatty liver diseasePediatric obesitySubcutaneous fatEctopic adiposityFatty liverNonalcoholic steatohepatitisPhysical activityThe Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-AnalysisarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501González-Ruiz K.Ramírez-Vélez R.Correa-Bautista J.E.Peterson M.D.García-Hermoso A.10336/23659oai:repository.urosario.edu.co:10336/236592022-05-02 07:37:21.190198https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis |
title |
The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis |
spellingShingle |
The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis Alanine aminotransferase Aspartate aminotransferase Gamma glutamyltransferase Abdominal fat Adolescent Blood Child Childhood obesity Diagnostic imaging Enzymology Exercise Female Human Liver Male Medline Meta analysis Nonalcoholic fatty liver Pathophysiology Physiology Subcutaneous fat Abdominal fat Adolescent Alanine transaminase Aspartate aminotransferases Child Exercise Female Gamma-glutamyltransferase Humans Liver Male Medline Non-alcoholic fatty liver disease Pediatric obesity Subcutaneous fat Ectopic adiposity Fatty liver Nonalcoholic steatohepatitis Physical activity |
title_short |
The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis |
title_full |
The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis |
title_fullStr |
The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis |
title_full_unstemmed |
The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis |
title_sort |
The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis |
dc.subject.keyword.spa.fl_str_mv |
Alanine aminotransferase Aspartate aminotransferase Gamma glutamyltransferase Abdominal fat Adolescent Blood Child Childhood obesity Diagnostic imaging Enzymology Exercise Female Human Liver Male Medline Meta analysis Nonalcoholic fatty liver Pathophysiology Physiology Subcutaneous fat Abdominal fat Adolescent Alanine transaminase Aspartate aminotransferases Child Exercise Female Gamma-glutamyltransferase Humans Liver Male Medline Non-alcoholic fatty liver disease Pediatric obesity Subcutaneous fat Ectopic adiposity Fatty liver Nonalcoholic steatohepatitis Physical activity |
topic |
Alanine aminotransferase Aspartate aminotransferase Gamma glutamyltransferase Abdominal fat Adolescent Blood Child Childhood obesity Diagnostic imaging Enzymology Exercise Female Human Liver Male Medline Meta analysis Nonalcoholic fatty liver Pathophysiology Physiology Subcutaneous fat Abdominal fat Adolescent Alanine transaminase Aspartate aminotransferases Child Exercise Female Gamma-glutamyltransferase Humans Liver Male Medline Non-alcoholic fatty liver disease Pediatric obesity Subcutaneous fat Ectopic adiposity Fatty liver Nonalcoholic steatohepatitis Physical activity |
description |
Background: Despite the prevalence of obesity and the multiple position stands promoting exercise for the treatment of obesity and hepatic function, a meta-analytic approach has not previously been used to examine the effects in the pediatric population. The aim of the study was to determine the effectiveness of exercise interventions on abdominal fat, liver enzymes, and intrahepatic fat in overweight and obese youth. Materials and Methods: A computerized search was made using three databases. The analysis was restricted to studies that examined the effect of supervised exercise interventions on abdominal fat (visceral and subcutaneous fat), liver enzymes (alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase), and intrahepatic fat. Fourteen clinical trials (1231 youths) were eligible for inclusion in this systematic review and meta-analysis. Standardized mean difference [SMD] and 95% confidence intervals (CIs) were calculated. Results: Exercise was associated with a significant reduction in visceral (SMD = -0.661; 95% CI, -0.976 to -0.346; p less than 0.001), subcutaneous (SMD = -0.352; 95% CI, -0.517 to -0.186; p less than 0.001) and intrahepatic fat (SMD = -0.802; 95% CI, -1.124 to -0.480; p less than 0.001), as well as gamma-glutamyl transferase (SMD = -0.726; 95% CI, -1.203 to -0.249; p less than 0.001), but did not alter any other liver enzyme. Subgroup analysis recommends exercise programs that involve aerobic exercise longer than three sessions per week. Conclusions: This meta-analysis supports current recommendation for physical exercise, mainly aerobic, as an effective intervention for nonalcoholic fatty liver disease progression by targeting hepatic lipid composition, visceral and subcutaneous adipose tissue. Systematic review registration: PROSPERO CRD42016042163. © Copyright 2017, Mary Ann Liebert, Inc.. |
publishDate |
2017 |
dc.date.created.spa.fl_str_mv |
2017 |
dc.date.accessioned.none.fl_str_mv |
2020-05-26T00:04:07Z |
dc.date.available.none.fl_str_mv |
2020-05-26T00:04:07Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1089/chi.2017.0027 |
dc.identifier.issn.none.fl_str_mv |
21532176 21532168 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/23659 |
url |
https://doi.org/10.1089/chi.2017.0027 https://repository.urosario.edu.co/handle/10336/23659 |
identifier_str_mv |
21532176 21532168 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
282 |
dc.relation.citationIssue.none.fl_str_mv |
No. 4 |
dc.relation.citationStartPage.none.fl_str_mv |
272 |
dc.relation.citationTitle.none.fl_str_mv |
Childhood Obesity |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 13 |
dc.relation.ispartof.spa.fl_str_mv |
Childhood Obesity, ISSN:21532176, 21532168, Vol.13, No.4 (2017); pp. 272-282 |
dc.relation.uri.spa.fl_str_mv |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025175788&doi=10.1089%2fchi.2017.0027&partnerID=40&md5=b1242ab161731df6fd2bfddcc5c8325f |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Mary Ann Liebert Inc. |
institution |
Universidad del Rosario |
dc.source.instname.spa.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167668205289472 |