The impact of glial activation in the aging brain

The past decade or so has witnessed a rekindling of interest in glia requiring a re-evaluation of the early descriptions of astrocytes as merely support cells, and microglia as adopting either a resting state or an activated state in a binary fashion. We now know that both cell types contribute to t...

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Autores:
Tipo de recurso:
Fecha de publicación:
2010
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/29827
Acceso en línea:
https://repository.urosario.edu.co/handle/10336/29827
Palabra clave:
Astrocytes
Microglia
Immune function
T cells
Ageing
CD200
Rights
License
Abierto (Texto Completo)
id EDOCUR2_bceb62849ff30653f66b661560994158
oai_identifier_str oai:repository.urosario.edu.co:10336/29827
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 7994277260090ba5f48-8ccb-4a69-aaa6-fa5370402c75-12b6d690e-14ad-4e07-9f5a-fc277408ac29-1196a1325-8278-4233-b1c4-bd2edb7584ea-1dd86eb5d-6031-469c-beb1-0a70b412657a-12020-09-11T21:05:37Z2020-09-11T21:05:37Z2010The past decade or so has witnessed a rekindling of interest in glia requiring a re-evaluation of the early descriptions of astrocytes as merely support cells, and microglia as adopting either a resting state or an activated state in a binary fashion. We now know that both cell types contribute to the optimal functioning of neurons in the healthy brain, and that altered function of either cell impacts on neuronal function and consequently cognitive function. The evidence indicates that both astrocytic and microglial phenotype change with age and that the shift from the resting state is associated with deterioration in synaptic function. In this review, we consider the rapidly-expanding array of functions attributed to these cells and focus on evaluating the changes in cell activation that accompany ageing.application/pdfISSN: 2152-5250https://repository.urosario.edu.co/handle/10336/29827engNational Center for Biotechnology Information, U.S. National Library of Medicine278. No. 3262Aging and DiseaseVol. 1Aging and Disease, ISSN: 2152-5250,Vol. 1, No.3 (2010); pp.262–278.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295033/Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Aging and Diseaseinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURAstrocytesMicrogliaImmune functionT cellsAgeingCD200The impact of glial activation in the aging brainEl impacto de la activación glial en el cerebro envejecidoarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501González Reyes, Rodrigo EstebanLynch, MarinaLynch, AileenMurphy, KevinCowley, Thelma10336/29827oai:repository.urosario.edu.co:10336/298272021-06-03 00:52:37.514https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv The impact of glial activation in the aging brain
dc.title.TranslatedTitle.spa.fl_str_mv El impacto de la activación glial en el cerebro envejecido
title The impact of glial activation in the aging brain
spellingShingle The impact of glial activation in the aging brain
Astrocytes
Microglia
Immune function
T cells
Ageing
CD200
title_short The impact of glial activation in the aging brain
title_full The impact of glial activation in the aging brain
title_fullStr The impact of glial activation in the aging brain
title_full_unstemmed The impact of glial activation in the aging brain
title_sort The impact of glial activation in the aging brain
dc.subject.keyword.spa.fl_str_mv Astrocytes
Microglia
Immune function
T cells
Ageing
CD200
topic Astrocytes
Microglia
Immune function
T cells
Ageing
CD200
description The past decade or so has witnessed a rekindling of interest in glia requiring a re-evaluation of the early descriptions of astrocytes as merely support cells, and microglia as adopting either a resting state or an activated state in a binary fashion. We now know that both cell types contribute to the optimal functioning of neurons in the healthy brain, and that altered function of either cell impacts on neuronal function and consequently cognitive function. The evidence indicates that both astrocytic and microglial phenotype change with age and that the shift from the resting state is associated with deterioration in synaptic function. In this review, we consider the rapidly-expanding array of functions attributed to these cells and focus on evaluating the changes in cell activation that accompany ageing.
publishDate 2010
dc.date.created.spa.fl_str_mv 2010
dc.date.accessioned.none.fl_str_mv 2020-09-11T21:05:37Z
dc.date.available.none.fl_str_mv 2020-09-11T21:05:37Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.issn.none.fl_str_mv ISSN: 2152-5250
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/29827
identifier_str_mv ISSN: 2152-5250
url https://repository.urosario.edu.co/handle/10336/29827
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 278.
dc.relation.citationIssue.none.fl_str_mv No. 3
dc.relation.citationStartPage.none.fl_str_mv 262
dc.relation.citationTitle.none.fl_str_mv Aging and Disease
dc.relation.citationVolume.none.fl_str_mv Vol. 1
dc.relation.ispartof.spa.fl_str_mv Aging and Disease, ISSN: 2152-5250,Vol. 1, No.3 (2010); pp.262–278.
dc.relation.uri.spa.fl_str_mv https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295033/
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv National Center for Biotechnology Information, U.S. National Library of Medicine
dc.source.spa.fl_str_mv Aging and Disease
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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