Psychiatric Disorders Secondary to Neurometabolic Disorders
Some diseases secondary to inborn errors of metabolism are associated with psychiatric disorders or minor neurological symptoms. The existence of some cases with exclusively psychiatric symptoms represents a diagnostic and therapeutic challenge. The aim of this article is to describe seven treatable...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2018
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/23059
- Acceso en línea:
- https://doi.org/10.1016/j.rcp.2017.05.004
https://repository.urosario.edu.co/handle/10336/23059
- Palabra clave:
- Homocysteine
Neuroleptic agent
Neuroleptic agent
Acute intermittent porphyria
Amino acid metabolism
Balance disorder
Behavior disorder
Cerebrotendinous xanthomatosis
Cognitive defect
Consciousness
Dysautonomia
Locomotion
Mental disease
Metabolic disorder
Neurologic disease
Niemann pick disease
Short survey
Urea cycle disorder
Visual hallucination
Wilson disease
Adolescent
Child
Complication
Drug resistance
Human
Inborn error of metabolism
Mental disease
Metabolic encephalopathy
Pathophysiology
Psychology
Adolescent
Antipsychotic agents
Child
Drug resistance
Humans
Mental disorders
psychiatry
inborn errors
metabolic
inborn
autism
adhd
psychosis
neurodevelopment
Brain diseases
Metabolism
Neurometabolic disorders
- Rights
- License
- Abierto (Texto Completo)
Summary: | Some diseases secondary to inborn errors of metabolism are associated with psychiatric disorders or minor neurological symptoms. The existence of some cases with exclusively psychiatric symptoms represents a diagnostic and therapeutic challenge. The aim of this article is to describe seven treatable neurometabolic disorders that should be taken into account in the psychiatric consultation as they manifest with psychiatric symptoms that mask the organic origin of the disorder. Homocysteine metabolism and urea cycle disorders, Wilson's disease, Niemann-Pick disease Type C, acute porphyria and cerebrotendinous xanthomatosis are described. Following an analysis of the literature, a list of psychiatric symptoms associated with these disorders are proposed, ranging from insidious changes in affective state and thought to atypical symptoms such as visual hallucinations, as well as paradoxical effects of antipsychotics or behavioural disorders in children and adolescents associated with loss of autonomy. The most frequently associated neurological signs, such as alterations in the state of consciousness, motor behaviour and balance disorders, catatonia or progressive cognitive deficit are also listed. Emphasis is placed on the importance of considering resistance to antipsychotic treatment as a warning sign to suspect organicity, as well as the significant improvement in psychiatric impairment when effective and early treatment is established. © 2017 Asociación Colombiana de Psiquiatría |
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