Sternal osteomyelitis and scrofuloderma due to BCG vaccination

BCG vaccine has been used for nearly 100 years in the prevention of tuberculosis. The case of a 13 month-old girl vaccinated as a newborn with BCG is described as presenting a sternal mass with associated periostic erosion. The mass was resected, and histopathological examination revealed a chronic inflammatory reaction with caseous granulomas, and extension to bone and skin. PCR amplifications using specific primers for Mycobacterium tuberculosis on paraffin-embedded tissue were negative. BCG vaccination at birth, the histological appearance and the absence of M. tuberculosis DNA in the resected tissue indicated that osteomyelitis and scrofuloderma were a consequence of BCG. Osteomyelitis is a rarely occurring adverse effect of BCG vaccination, more commonly seen in immunosuppressed patients. In the patient described above, no symptoms of immunodeficiency were seen, however.

• Fecha de publicación: 2003
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/23529
• Acceso en línea: https://repository.urosario.edu.co/handle/10336/23529
• Palabra clave: Bacterial DNA; BCG vaccine; Article; Case report; Female; Genetics; Human; Infant; Isolation and purification; Microbiology; Mycobacterium tuberculosis; Osteomyelitis; Pathology; Polymerase chain reaction; Skin tuberculosis; Sternum; Tuberculous arthritis; Vaccination; BCG Vaccine; Female; Humans; Infant; Mycobacterium tuberculosis; Osteomyelitis; Polymerase Chain Reaction; Sternum; Vaccination; Bacterial; Cutaneous; Osteoarticular; DNA; Tuberculosis; Tuberculosis
• License: Abierto (Texto Completo)