Evaluación pronóstica del receptor hormonal de progesterona en pacientes con cáncer de mama luminal tratadas con quimioterapia neoadyuvante

Introducción: el cáncer de mama, es una enfermedad heterogénea, con diferentes grados de agresividad, que dependen de su expresión fenotípica, destacándose el comportamiento de los receptores hormonales y Her2, que contribuyen finalmente a la respuesta al tratamiento y pronóstico de la enfermedad. M...

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Fecha de publicación:
2023
Institución:
Universidad del Rosario
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Repositorio EdocUR - U. Rosario
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spa
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oai:repository.urosario.edu.co:10336/41492
Acceso en línea:
https://repository.urosario.edu.co/handle/10336/41492
Palabra clave:
Cáncer de mama
Receptor de progesterona
Quimioterapia neoadyuvante
Breast Neoplasms
Progesterone receptor
Neoadjuvant chemotherapy
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id EDOCUR2_b5379c8112a6a9bfdd30559c85044740
oai_identifier_str oai:repository.urosario.edu.co:10336/41492
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.none.fl_str_mv Evaluación pronóstica del receptor hormonal de progesterona en pacientes con cáncer de mama luminal tratadas con quimioterapia neoadyuvante
dc.title.TranslatedTitle.none.fl_str_mv Prognostic evaluation of the progesterone hormone receptor in patients with luminal breast cancer treated with neoadjuvant chemotherapy
title Evaluación pronóstica del receptor hormonal de progesterona en pacientes con cáncer de mama luminal tratadas con quimioterapia neoadyuvante
spellingShingle Evaluación pronóstica del receptor hormonal de progesterona en pacientes con cáncer de mama luminal tratadas con quimioterapia neoadyuvante
Cáncer de mama
Receptor de progesterona
Quimioterapia neoadyuvante
Breast Neoplasms
Progesterone receptor
Neoadjuvant chemotherapy
title_short Evaluación pronóstica del receptor hormonal de progesterona en pacientes con cáncer de mama luminal tratadas con quimioterapia neoadyuvante
title_full Evaluación pronóstica del receptor hormonal de progesterona en pacientes con cáncer de mama luminal tratadas con quimioterapia neoadyuvante
title_fullStr Evaluación pronóstica del receptor hormonal de progesterona en pacientes con cáncer de mama luminal tratadas con quimioterapia neoadyuvante
title_full_unstemmed Evaluación pronóstica del receptor hormonal de progesterona en pacientes con cáncer de mama luminal tratadas con quimioterapia neoadyuvante
title_sort Evaluación pronóstica del receptor hormonal de progesterona en pacientes con cáncer de mama luminal tratadas con quimioterapia neoadyuvante
dc.contributor.advisor.none.fl_str_mv Cuello López, Javier Mauricio
dc.subject.none.fl_str_mv Cáncer de mama
Receptor de progesterona
Quimioterapia neoadyuvante
topic Cáncer de mama
Receptor de progesterona
Quimioterapia neoadyuvante
Breast Neoplasms
Progesterone receptor
Neoadjuvant chemotherapy
dc.subject.keyword.none.fl_str_mv Breast Neoplasms
Progesterone receptor
Neoadjuvant chemotherapy
description Introducción: el cáncer de mama, es una enfermedad heterogénea, con diferentes grados de agresividad, que dependen de su expresión fenotípica, destacándose el comportamiento de los receptores hormonales y Her2, que contribuyen finalmente a la respuesta al tratamiento y pronóstico de la enfermedad. Métodos: el objetivo principal de este estudio analítico, retrospectivo de cohorte histórica fue evaluar el valor pronostico del receptor progesterona en pacientes diagnosticadas con cáncer de mama luminal manejadas con quimioterapia neoadyuvante. Resultados: en un tiempo de seguimiento de 7,5 años, se estudiaron 178 pacientes, en su mayoría con fenotipo ER+/PR- (79,2%), sin embargo, no se observaron diferencias estadísticamente significativas en estos grupos a excepción del índice de enfermedad residual RDBN en el análisis multivariado para la evaluación pronostica del receptor de progesterona. Conclusión: En pacientes con cáncer de mama subtipo luminal tratadas con quimioterapia neoadyuvante, el estado del receptor de progesterona no se asoció como factor pronóstico de supervivencia.
publishDate 2023
dc.date.accessioned.none.fl_str_mv 2023-11-08T13:10:13Z
dc.date.available.none.fl_str_mv 2023-11-08T13:10:13Z
dc.date.created.none.fl_str_mv 2023-10-31
dc.type.none.fl_str_mv bachelorThesis
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.document.none.fl_str_mv Trabajo de grado
dc.type.spa.none.fl_str_mv Trabajo de grado
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/41492
url https://repository.urosario.edu.co/handle/10336/41492
dc.language.iso.none.fl_str_mv spa
language spa
dc.rights.*.fl_str_mv Attribution-NonCommercial-ShareAlike 4.0 International
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_14cb
dc.rights.acceso.none.fl_str_mv Bloqueado (Texto referencial)
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
rights_invalid_str_mv Attribution-NonCommercial-ShareAlike 4.0 International
Bloqueado (Texto referencial)
http://creativecommons.org/licenses/by-nc-sa/4.0/
http://purl.org/coar/access_right/c_14cb
dc.format.extent.none.fl_str_mv 61 pp
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad del Rosario
Universidad CES. Facultad de Medicina
Universidad de CES. Facultad de medicina
dc.publisher.department.none.fl_str_mv Escuela de Medicina y Ciencias de la Salud
dc.publisher.program.none.fl_str_mv Especialización en Epidemiología
publisher.none.fl_str_mv Universidad del Rosario
Universidad CES. Facultad de Medicina
Universidad de CES. Facultad de medicina
institution Universidad del Rosario
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spelling Cuello López, Javier Mauricioe8444c6d-2db4-4fae-b789-729d45658e49-1Cuello López, MariluzFidalgo Zapata, AnaLópez Agudelo, LauraCuello López, Javier MauricioEspecialista en Epidemiología (en Convenio con el CES)Especialista en EpidemiologíaEspecializaciónFull timeda211e17-b3ec-408c-9f76-43024074fccc-170f187df-929b-426b-8d83-c66a68d8c36e-142634184-6249-41a9-8f14-2fff0f65e6a0-1ae26f6c2-e6f4-48de-8f7c-5f817db16e47-12023-11-08T13:10:13Z2023-11-08T13:10:13Z2023-10-31Introducción: el cáncer de mama, es una enfermedad heterogénea, con diferentes grados de agresividad, que dependen de su expresión fenotípica, destacándose el comportamiento de los receptores hormonales y Her2, que contribuyen finalmente a la respuesta al tratamiento y pronóstico de la enfermedad. Métodos: el objetivo principal de este estudio analítico, retrospectivo de cohorte histórica fue evaluar el valor pronostico del receptor progesterona en pacientes diagnosticadas con cáncer de mama luminal manejadas con quimioterapia neoadyuvante. Resultados: en un tiempo de seguimiento de 7,5 años, se estudiaron 178 pacientes, en su mayoría con fenotipo ER+/PR- (79,2%), sin embargo, no se observaron diferencias estadísticamente significativas en estos grupos a excepción del índice de enfermedad residual RDBN en el análisis multivariado para la evaluación pronostica del receptor de progesterona. Conclusión: En pacientes con cáncer de mama subtipo luminal tratadas con quimioterapia neoadyuvante, el estado del receptor de progesterona no se asoció como factor pronóstico de supervivencia.Abstract: breast cancer is a heterogeneous disease, with different degrees of aggressiveness, which depends on its phenotypic expression, highlighting the behavior of hormone receptors and Her2, which will ultimately contribute to the response to treatment and prognosis of the disease. Methods: The main objective of this analytical, retrospective historical cohort study was to evaluate the prognostic value of the progesterone receptor in patients diagnosed with luminal breast cancer managed with neoadjuvant chemotherapy. Results: in a follow-up time of 7.5 years, 178 patients were studied, mostly with ER+/PR- phenotype (79.2%), however, no statistically significant differences were observed in these, except for the index of RDBN residual disease in multivariate analysis for progesterone receptor prognostic assessment. Conclusion: In patients with luminal subtype breast cancer treated with neoadjuvant chemotherapy, progesterone receptor status was not associated as a prognostic factor for survival.61 ppapplication/pdfhttps://repository.urosario.edu.co/handle/10336/41492spaUniversidad del RosarioUniversidad CES. Facultad de MedicinaUniversidad de CES. Facultad de medicinaEscuela de Medicina y Ciencias de la SaludEspecialización en EpidemiologíaAttribution-NonCommercial-ShareAlike 4.0 InternationalBloqueado (Texto referencial)EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. 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