Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1 ∗ PBRs in Fully-Protective Malaria Vaccine Components

The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the po...

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Autores:
Tipo de recurso:
Fecha de publicación:
2018
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/20372
Acceso en línea:
https://repository.urosario.edu.co/handle/10336/20372
Palabra clave:
Vacuna contra la malaria
Enfermedades
β-turns
Structure-function
IMPIPS
LLPI
PPIIL
Malaria vaccine
Malaria
Plasmodium
Rights
License
Abierto (Texto Completo)
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dc.title.spa.fl_str_mv Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1 ∗ PBRs in Fully-Protective Malaria Vaccine Components
title Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1 ∗ PBRs in Fully-Protective Malaria Vaccine Components
spellingShingle Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1 ∗ PBRs in Fully-Protective Malaria Vaccine Components
Vacuna contra la malaria
Enfermedades
β-turns
Structure-function
IMPIPS
LLPI
PPIIL
Malaria vaccine
Malaria
Plasmodium
title_short Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1 ∗ PBRs in Fully-Protective Malaria Vaccine Components
title_full Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1 ∗ PBRs in Fully-Protective Malaria Vaccine Components
title_fullStr Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1 ∗ PBRs in Fully-Protective Malaria Vaccine Components
title_full_unstemmed Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1 ∗ PBRs in Fully-Protective Malaria Vaccine Components
title_sort Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1 ∗ PBRs in Fully-Protective Malaria Vaccine Components
dc.subject.spa.fl_str_mv Vacuna contra la malaria
topic Vacuna contra la malaria
Enfermedades
β-turns
Structure-function
IMPIPS
LLPI
PPIIL
Malaria vaccine
Malaria
Plasmodium
dc.subject.ddc.spa.fl_str_mv Enfermedades
dc.subject.keyword.spa.fl_str_mv β-turns
Structure-function
IMPIPS
LLPI
PPIIL
Malaria vaccine
dc.subject.lemb.spa.fl_str_mv Malaria
Plasmodium
description The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ* allele family) and modified immune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity. © 2018 Bermudez, Alba, Vanegas, Patarroyo and Patarroyo.
publishDate 2018
dc.date.created.none.fl_str_mv 2018
dc.date.issued.none.fl_str_mv 2018
dc.date.accessioned.none.fl_str_mv 2019-10-01T13:58:59Z
dc.date.available.none.fl_str_mv 2019-10-01T13:58:59Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv 10.3389/fchem.2018.00106
dc.identifier.issn.none.fl_str_mv 2296-2646
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/20372
identifier_str_mv 10.3389/fchem.2018.00106
2296-2646
url https://repository.urosario.edu.co/handle/10336/20372
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationTitle.none.fl_str_mv Frontiers in Chemistry
dc.relation.citationVolume.none.fl_str_mv Vol. 6
dc.relation.ispartof.spa.fl_str_mv Frontiers in Chemistry, ISSN:2296-2646, Vol. 6 (2018)
dc.relation.uri.spa.fl_str_mv https://www.frontiersin.org/articles/10.3389/fchem.2018.00106/full
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
institution Universidad del Rosario
dc.source.bibliographicCitation.spa.fl_str_mv Adzhubei, A.A., Sternberg, M.J., Makarov, A.A., Polyproline-II helix in proteins: structure and function (2013) J. Mol. Biol, 425, pp. 2100-2132
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
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