Chagas disease (Trypanosoma cruzi) and HIV co-infection in Colombia

Chagas disease is a complex zoonotic pathology caused by the kinetoplastid Trypanosoma cruzi. This parasite presents remarkable genetic variability and has been grouped into six discrete typing units (DTUs). The association between the DTUs and clinical outcome remains unknown. Chagas disease and co-infection with HIV/AIDS has been reported widely in Brazil and Argentina. Herein, we present the molecular analyses from a Chagas disease patient with HIV/AIDS co-infection in Colombia who presented severe cardiomyopathy, pleural effusion, and central nervous system involvement. A mixed infection by T. cruzi genotypes was detected. We suggest including T. cruzi in the list of opportunistic pathogens for the management of HIV patients in Colombia. The epidemiological implications of this finding are discussed. © 2014 The Authors.

• Fecha de publicación: 2014
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/18717
• Acceso en línea: http://repository.urosario.edu.co/handle/10336/18717
• Palabra clave: Chagas Disease; Co-Infection; Hiv; Tissue Tropism; Beta Actin; Dna 18S; Glucose; Immunoglobulin G; Kinetoplast Dna; Meropenem; Nifurtimox; Parasite Antigen; Protein; Pyrimethamine Plus Sulfadoxine; Recombinant Antigen; Acquired Immune Deficiency Syndrome; Acute Disease; Adult; Antibiotic Therapy; Article; Asthenia; Autopsy; Brain Biopsy; Brain Disease; Brain Edema; Brain Tomography; Case Report; Chagas Disease; Colombia; Drug Withdrawal; Dyspnea; Echocardiography; Electrocardiography; Female; Genotype; Heart Ejection Fraction; Heart Left Ventricle Overload; Heart Muscle Biopsy; Hospitalization; Human; Human Tissue; Immunoaffinity Chromatography; Lumbar Puncture; Lymphocytic Infiltration; Mitral Valve Regurgitation; Mixed Infection; Myocarditis; Neuroimaging; Nuclear Magnetic Resonance Imaging; Pericarditis; Pleura Effusion; Pleura Fluid; Polymerase Chain Reaction; Protein Cerebrospinal Fluid Level; Somnolence; Thoracocentesis; Thorax Pain; Toxoplasmosis; Tricuspid Valve Regurgitation; Trypanosoma Cruzi; Trypomastigote; Weight Reduction; Western Blotting; Chagas Disease; Classification; Complication; Genetics; Human Immunodeficiency Virus Infection; Isolation And Purification; Parasitology; Adult; Chagas Disease; Coinfection; Colombia; Female; Genotype; Hiv Infections; Humans; Trypanosoma Cruzi; Enfermedad de Chagas; Infecciones por VIH; Trypanosomiasis
• License: Abierto (Texto Completo)