Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis

Genetic determinants of human susceptibility to tuberculosis (TB) have not been completely elucidated. Interleukin-1 beta (IL-1?) and the inhibitor of kB-like (IkBL) are important molecules that participate in the inflammatory response required for the immunological control of a broad spectrum of in...

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Autores:
Tipo de recurso:
Fecha de publicación:
2006
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23385
Acceso en línea:
https://doi.org/10.1111/j.1399-0039.2006.00566.x
https://repository.urosario.edu.co/handle/10336/23385
Palabra clave:
I kappa B
Immunoglobulin enhancer binding protein
Interleukin 1beta
Transporter associated with antigen processing 1
Transporter associated with antigen processing 2
Unclassified drug
Article
Case control study
Controlled study
Disease predisposition
Genetic polymorphism
Genotype
Host pathogen interaction
Human
Major clinical study
Mycobacterium tuberculosis
Nucleotide sequence
Polymerase chain reaction
Priority journal
Single nucleotide polymorphism
Tuberculosis
Adult
ATP-Binding Cassette Transporters
Case-Control Studies
Disease Susceptibility
Genetic Predisposition to Disease
Genotype
Haplotypes
Histocompatibility Antigens Class II
Humans
Interleukin-1
Middle Aged
Mycobacterium tuberculosis
Human immunodeficiency virus
Mycobacterium tuberculosis
Genetics
Host-guest interaction
IKBL
IL1B
TAP
Tuberculosis
Pulmonary
Single Nucleotide
Polymorphism
Tuberculosis
Rights
License
Abierto (Texto Completo)
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oai_identifier_str oai:repository.urosario.edu.co:10336/23385
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 941360cf-121f-472f-a80b-323c2541b991e038806a-b13c-46c8-a3df-a975e89a1de02aa1f736-e919-4a89-bd9d-f56f9a9d1f1fc51d333f-a030-432c-b64f-dd2432bd8a7f5754e970-9231-4ac4-9447-ff7707f7eed2194747786002020-05-26T00:01:35Z2020-05-26T00:01:35Z2006Genetic determinants of human susceptibility to tuberculosis (TB) have not been completely elucidated. Interleukin-1 beta (IL-1?) and the inhibitor of kB-like (IkBL) are important molecules that participate in the inflammatory response required for the immunological control of a broad spectrum of infectious agents. The transporter associated with antigen processing (TAP) is involved in the antigen processing via major histocompatibility complex class I molecules and in turn might regulate the T-cell response against Mycobacterium tuberculosis. To better characterize the host genetic factors determining the susceptibility to TB, we evaluated the influence of functional polymorphisms in IL1B, TAP and IKBL genes on the risk of developing pulmonary TB in a Northwestern Colombian population, an endemic area of M. tuberculosis infection. A total of 122 TB patients and 166 healthy controls (N = 166) negative for human immunodeficiency virus infection were examined for IL1B-511 and +3953, TAP1 and TAP2 and IKBL+738 polymorphisms. Univariate analysis disclosed significant differences between patients and controls for IL1B+3953 polymorphism. After unconditional logistic regression analysis, a strong protection conferred by IL1B+3953 T-allele-carrying genotypes was observed. A trend between TAP2*0201 allele and disease was observed. Association between IL1B-511, TAP1 or IKBL polymorphisms and TB disease was not found. These results indicate that a functional polymorphism in the IL1B gene influences the susceptibility to TB and suggest a role for IL-1? in the pathogenesis of mycobacterial infection. © 2006 Blackwell Munksgaard.application/pdfhttps://doi.org/10.1111/j.1399-0039.2006.00566.xhttps://repository.urosario.edu.co/handle/10336/23385eng296No. 4290Tissue AntigensVol. 67Tissue Antigens, Vol.67, No.4 (2006); pp. 290-296https://www.scopus.com/inward/record.uri?eid=2-s2.0-33646079376&doi=10.1111%2fj.1399-0039.2006.00566.x&partnerID=40&md5=ac1cb65c0c62df77d8f840262ee90df4Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURI kappa BImmunoglobulin enhancer binding proteinInterleukin 1betaTransporter associated with antigen processing 1Transporter associated with antigen processing 2Unclassified drugArticleCase control studyControlled studyDisease predispositionGenetic polymorphismGenotypeHost pathogen interactionHumanMajor clinical studyMycobacterium tuberculosisNucleotide sequencePolymerase chain reactionPriority journalSingle nucleotide polymorphismTuberculosisAdultATP-Binding Cassette TransportersCase-Control StudiesDisease SusceptibilityGenetic Predisposition to DiseaseGenotypeHaplotypesHistocompatibility Antigens Class IIHumansInterleukin-1Middle AgedMycobacterium tuberculosisHuman immunodeficiency virusMycobacterium tuberculosisGeneticsHost-guest interactionIKBLIL1BTAPTuberculosisPulmonarySingle NucleotidePolymorphismTuberculosisAnalysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosisarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Gomez L.M.Camargo J.F.Castiblanco J.Ruiz-Narváez E.A.Cadena J.Anaya, Juan-Manuel10336/23385oai:repository.urosario.edu.co:10336/233852022-05-02 07:37:13.137567https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis
title Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis
spellingShingle Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis
I kappa B
Immunoglobulin enhancer binding protein
Interleukin 1beta
Transporter associated with antigen processing 1
Transporter associated with antigen processing 2
Unclassified drug
Article
Case control study
Controlled study
Disease predisposition
Genetic polymorphism
Genotype
Host pathogen interaction
Human
Major clinical study
Mycobacterium tuberculosis
Nucleotide sequence
Polymerase chain reaction
Priority journal
Single nucleotide polymorphism
Tuberculosis
Adult
ATP-Binding Cassette Transporters
Case-Control Studies
Disease Susceptibility
Genetic Predisposition to Disease
Genotype
Haplotypes
Histocompatibility Antigens Class II
Humans
Interleukin-1
Middle Aged
Mycobacterium tuberculosis
Human immunodeficiency virus
Mycobacterium tuberculosis
Genetics
Host-guest interaction
IKBL
IL1B
TAP
Tuberculosis
Pulmonary
Single Nucleotide
Polymorphism
Tuberculosis
title_short Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis
title_full Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis
title_fullStr Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis
title_full_unstemmed Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis
title_sort Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis
dc.subject.keyword.spa.fl_str_mv I kappa B
Immunoglobulin enhancer binding protein
Interleukin 1beta
Transporter associated with antigen processing 1
Transporter associated with antigen processing 2
Unclassified drug
Article
Case control study
Controlled study
Disease predisposition
Genetic polymorphism
Genotype
Host pathogen interaction
Human
Major clinical study
Mycobacterium tuberculosis
Nucleotide sequence
Polymerase chain reaction
Priority journal
Single nucleotide polymorphism
Tuberculosis
Adult
ATP-Binding Cassette Transporters
Case-Control Studies
Disease Susceptibility
Genetic Predisposition to Disease
Genotype
Haplotypes
Histocompatibility Antigens Class II
Humans
Interleukin-1
Middle Aged
Mycobacterium tuberculosis
Human immunodeficiency virus
Mycobacterium tuberculosis
Genetics
Host-guest interaction
IKBL
IL1B
TAP
Tuberculosis
topic I kappa B
Immunoglobulin enhancer binding protein
Interleukin 1beta
Transporter associated with antigen processing 1
Transporter associated with antigen processing 2
Unclassified drug
Article
Case control study
Controlled study
Disease predisposition
Genetic polymorphism
Genotype
Host pathogen interaction
Human
Major clinical study
Mycobacterium tuberculosis
Nucleotide sequence
Polymerase chain reaction
Priority journal
Single nucleotide polymorphism
Tuberculosis
Adult
ATP-Binding Cassette Transporters
Case-Control Studies
Disease Susceptibility
Genetic Predisposition to Disease
Genotype
Haplotypes
Histocompatibility Antigens Class II
Humans
Interleukin-1
Middle Aged
Mycobacterium tuberculosis
Human immunodeficiency virus
Mycobacterium tuberculosis
Genetics
Host-guest interaction
IKBL
IL1B
TAP
Tuberculosis
Pulmonary
Single Nucleotide
Polymorphism
Tuberculosis
dc.subject.keyword.eng.fl_str_mv Pulmonary
Single Nucleotide
Polymorphism
Tuberculosis
description Genetic determinants of human susceptibility to tuberculosis (TB) have not been completely elucidated. Interleukin-1 beta (IL-1?) and the inhibitor of kB-like (IkBL) are important molecules that participate in the inflammatory response required for the immunological control of a broad spectrum of infectious agents. The transporter associated with antigen processing (TAP) is involved in the antigen processing via major histocompatibility complex class I molecules and in turn might regulate the T-cell response against Mycobacterium tuberculosis. To better characterize the host genetic factors determining the susceptibility to TB, we evaluated the influence of functional polymorphisms in IL1B, TAP and IKBL genes on the risk of developing pulmonary TB in a Northwestern Colombian population, an endemic area of M. tuberculosis infection. A total of 122 TB patients and 166 healthy controls (N = 166) negative for human immunodeficiency virus infection were examined for IL1B-511 and +3953, TAP1 and TAP2 and IKBL+738 polymorphisms. Univariate analysis disclosed significant differences between patients and controls for IL1B+3953 polymorphism. After unconditional logistic regression analysis, a strong protection conferred by IL1B+3953 T-allele-carrying genotypes was observed. A trend between TAP2*0201 allele and disease was observed. Association between IL1B-511, TAP1 or IKBL polymorphisms and TB disease was not found. These results indicate that a functional polymorphism in the IL1B gene influences the susceptibility to TB and suggest a role for IL-1? in the pathogenesis of mycobacterial infection. © 2006 Blackwell Munksgaard.
publishDate 2006
dc.date.created.spa.fl_str_mv 2006
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:01:35Z
dc.date.available.none.fl_str_mv 2020-05-26T00:01:35Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1111/j.1399-0039.2006.00566.x
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/23385
url https://doi.org/10.1111/j.1399-0039.2006.00566.x
https://repository.urosario.edu.co/handle/10336/23385
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 296
dc.relation.citationIssue.none.fl_str_mv No. 4
dc.relation.citationStartPage.none.fl_str_mv 290
dc.relation.citationTitle.none.fl_str_mv Tissue Antigens
dc.relation.citationVolume.none.fl_str_mv Vol. 67
dc.relation.ispartof.spa.fl_str_mv Tissue Antigens, Vol.67, No.4 (2006); pp. 290-296
dc.relation.uri.spa.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-33646079376&doi=10.1111%2fj.1399-0039.2006.00566.x&partnerID=40&md5=ac1cb65c0c62df77d8f840262ee90df4
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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