Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis
Genetic determinants of human susceptibility to tuberculosis (TB) have not been completely elucidated. Interleukin-1 beta (IL-1?) and the inhibitor of kB-like (IkBL) are important molecules that participate in the inflammatory response required for the immunological control of a broad spectrum of in...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2006
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/23385
- Acceso en línea:
- https://doi.org/10.1111/j.1399-0039.2006.00566.x
https://repository.urosario.edu.co/handle/10336/23385
- Palabra clave:
- I kappa B
Immunoglobulin enhancer binding protein
Interleukin 1beta
Transporter associated with antigen processing 1
Transporter associated with antigen processing 2
Unclassified drug
Article
Case control study
Controlled study
Disease predisposition
Genetic polymorphism
Genotype
Host pathogen interaction
Human
Major clinical study
Mycobacterium tuberculosis
Nucleotide sequence
Polymerase chain reaction
Priority journal
Single nucleotide polymorphism
Tuberculosis
Adult
ATP-Binding Cassette Transporters
Case-Control Studies
Disease Susceptibility
Genetic Predisposition to Disease
Genotype
Haplotypes
Histocompatibility Antigens Class II
Humans
Interleukin-1
Middle Aged
Mycobacterium tuberculosis
Human immunodeficiency virus
Mycobacterium tuberculosis
Genetics
Host-guest interaction
IKBL
IL1B
TAP
Tuberculosis
Pulmonary
Single Nucleotide
Polymorphism
Tuberculosis
- Rights
- License
- Abierto (Texto Completo)
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941360cf-121f-472f-a80b-323c2541b991e038806a-b13c-46c8-a3df-a975e89a1de02aa1f736-e919-4a89-bd9d-f56f9a9d1f1fc51d333f-a030-432c-b64f-dd2432bd8a7f5754e970-9231-4ac4-9447-ff7707f7eed2194747786002020-05-26T00:01:35Z2020-05-26T00:01:35Z2006Genetic determinants of human susceptibility to tuberculosis (TB) have not been completely elucidated. Interleukin-1 beta (IL-1?) and the inhibitor of kB-like (IkBL) are important molecules that participate in the inflammatory response required for the immunological control of a broad spectrum of infectious agents. The transporter associated with antigen processing (TAP) is involved in the antigen processing via major histocompatibility complex class I molecules and in turn might regulate the T-cell response against Mycobacterium tuberculosis. To better characterize the host genetic factors determining the susceptibility to TB, we evaluated the influence of functional polymorphisms in IL1B, TAP and IKBL genes on the risk of developing pulmonary TB in a Northwestern Colombian population, an endemic area of M. tuberculosis infection. A total of 122 TB patients and 166 healthy controls (N = 166) negative for human immunodeficiency virus infection were examined for IL1B-511 and +3953, TAP1 and TAP2 and IKBL+738 polymorphisms. Univariate analysis disclosed significant differences between patients and controls for IL1B+3953 polymorphism. After unconditional logistic regression analysis, a strong protection conferred by IL1B+3953 T-allele-carrying genotypes was observed. A trend between TAP2*0201 allele and disease was observed. Association between IL1B-511, TAP1 or IKBL polymorphisms and TB disease was not found. These results indicate that a functional polymorphism in the IL1B gene influences the susceptibility to TB and suggest a role for IL-1? in the pathogenesis of mycobacterial infection. © 2006 Blackwell Munksgaard.application/pdfhttps://doi.org/10.1111/j.1399-0039.2006.00566.xhttps://repository.urosario.edu.co/handle/10336/23385eng296No. 4290Tissue AntigensVol. 67Tissue Antigens, Vol.67, No.4 (2006); pp. 290-296https://www.scopus.com/inward/record.uri?eid=2-s2.0-33646079376&doi=10.1111%2fj.1399-0039.2006.00566.x&partnerID=40&md5=ac1cb65c0c62df77d8f840262ee90df4Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURI kappa BImmunoglobulin enhancer binding proteinInterleukin 1betaTransporter associated with antigen processing 1Transporter associated with antigen processing 2Unclassified drugArticleCase control studyControlled studyDisease predispositionGenetic polymorphismGenotypeHost pathogen interactionHumanMajor clinical studyMycobacterium tuberculosisNucleotide sequencePolymerase chain reactionPriority journalSingle nucleotide polymorphismTuberculosisAdultATP-Binding Cassette TransportersCase-Control StudiesDisease SusceptibilityGenetic Predisposition to DiseaseGenotypeHaplotypesHistocompatibility Antigens Class IIHumansInterleukin-1Middle AgedMycobacterium tuberculosisHuman immunodeficiency virusMycobacterium tuberculosisGeneticsHost-guest interactionIKBLIL1BTAPTuberculosisPulmonarySingle NucleotidePolymorphismTuberculosisAnalysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosisarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Gomez L.M.Camargo J.F.Castiblanco J.Ruiz-Narváez E.A.Cadena J.Anaya, Juan-Manuel10336/23385oai:repository.urosario.edu.co:10336/233852022-05-02 07:37:13.137567https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis |
title |
Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis |
spellingShingle |
Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis I kappa B Immunoglobulin enhancer binding protein Interleukin 1beta Transporter associated with antigen processing 1 Transporter associated with antigen processing 2 Unclassified drug Article Case control study Controlled study Disease predisposition Genetic polymorphism Genotype Host pathogen interaction Human Major clinical study Mycobacterium tuberculosis Nucleotide sequence Polymerase chain reaction Priority journal Single nucleotide polymorphism Tuberculosis Adult ATP-Binding Cassette Transporters Case-Control Studies Disease Susceptibility Genetic Predisposition to Disease Genotype Haplotypes Histocompatibility Antigens Class II Humans Interleukin-1 Middle Aged Mycobacterium tuberculosis Human immunodeficiency virus Mycobacterium tuberculosis Genetics Host-guest interaction IKBL IL1B TAP Tuberculosis Pulmonary Single Nucleotide Polymorphism Tuberculosis |
title_short |
Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis |
title_full |
Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis |
title_fullStr |
Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis |
title_full_unstemmed |
Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis |
title_sort |
Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis |
dc.subject.keyword.spa.fl_str_mv |
I kappa B Immunoglobulin enhancer binding protein Interleukin 1beta Transporter associated with antigen processing 1 Transporter associated with antigen processing 2 Unclassified drug Article Case control study Controlled study Disease predisposition Genetic polymorphism Genotype Host pathogen interaction Human Major clinical study Mycobacterium tuberculosis Nucleotide sequence Polymerase chain reaction Priority journal Single nucleotide polymorphism Tuberculosis Adult ATP-Binding Cassette Transporters Case-Control Studies Disease Susceptibility Genetic Predisposition to Disease Genotype Haplotypes Histocompatibility Antigens Class II Humans Interleukin-1 Middle Aged Mycobacterium tuberculosis Human immunodeficiency virus Mycobacterium tuberculosis Genetics Host-guest interaction IKBL IL1B TAP Tuberculosis |
topic |
I kappa B Immunoglobulin enhancer binding protein Interleukin 1beta Transporter associated with antigen processing 1 Transporter associated with antigen processing 2 Unclassified drug Article Case control study Controlled study Disease predisposition Genetic polymorphism Genotype Host pathogen interaction Human Major clinical study Mycobacterium tuberculosis Nucleotide sequence Polymerase chain reaction Priority journal Single nucleotide polymorphism Tuberculosis Adult ATP-Binding Cassette Transporters Case-Control Studies Disease Susceptibility Genetic Predisposition to Disease Genotype Haplotypes Histocompatibility Antigens Class II Humans Interleukin-1 Middle Aged Mycobacterium tuberculosis Human immunodeficiency virus Mycobacterium tuberculosis Genetics Host-guest interaction IKBL IL1B TAP Tuberculosis Pulmonary Single Nucleotide Polymorphism Tuberculosis |
dc.subject.keyword.eng.fl_str_mv |
Pulmonary Single Nucleotide Polymorphism Tuberculosis |
description |
Genetic determinants of human susceptibility to tuberculosis (TB) have not been completely elucidated. Interleukin-1 beta (IL-1?) and the inhibitor of kB-like (IkBL) are important molecules that participate in the inflammatory response required for the immunological control of a broad spectrum of infectious agents. The transporter associated with antigen processing (TAP) is involved in the antigen processing via major histocompatibility complex class I molecules and in turn might regulate the T-cell response against Mycobacterium tuberculosis. To better characterize the host genetic factors determining the susceptibility to TB, we evaluated the influence of functional polymorphisms in IL1B, TAP and IKBL genes on the risk of developing pulmonary TB in a Northwestern Colombian population, an endemic area of M. tuberculosis infection. A total of 122 TB patients and 166 healthy controls (N = 166) negative for human immunodeficiency virus infection were examined for IL1B-511 and +3953, TAP1 and TAP2 and IKBL+738 polymorphisms. Univariate analysis disclosed significant differences between patients and controls for IL1B+3953 polymorphism. After unconditional logistic regression analysis, a strong protection conferred by IL1B+3953 T-allele-carrying genotypes was observed. A trend between TAP2*0201 allele and disease was observed. Association between IL1B-511, TAP1 or IKBL polymorphisms and TB disease was not found. These results indicate that a functional polymorphism in the IL1B gene influences the susceptibility to TB and suggest a role for IL-1? in the pathogenesis of mycobacterial infection. © 2006 Blackwell Munksgaard. |
publishDate |
2006 |
dc.date.created.spa.fl_str_mv |
2006 |
dc.date.accessioned.none.fl_str_mv |
2020-05-26T00:01:35Z |
dc.date.available.none.fl_str_mv |
2020-05-26T00:01:35Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1111/j.1399-0039.2006.00566.x |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/23385 |
url |
https://doi.org/10.1111/j.1399-0039.2006.00566.x https://repository.urosario.edu.co/handle/10336/23385 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
296 |
dc.relation.citationIssue.none.fl_str_mv |
No. 4 |
dc.relation.citationStartPage.none.fl_str_mv |
290 |
dc.relation.citationTitle.none.fl_str_mv |
Tissue Antigens |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 67 |
dc.relation.ispartof.spa.fl_str_mv |
Tissue Antigens, Vol.67, No.4 (2006); pp. 290-296 |
dc.relation.uri.spa.fl_str_mv |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33646079376&doi=10.1111%2fj.1399-0039.2006.00566.x&partnerID=40&md5=ac1cb65c0c62df77d8f840262ee90df4 |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
institution |
Universidad del Rosario |
dc.source.instname.spa.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167452971433984 |