Epithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapy

The epithelial-mesenchymal transition (EMT) is a biological phenomenon responsible for the formation of different tissues and organs during normal metazoan development. Because of the connection of the EMT with the pathogenesis of certain diseases, such as cancer, the attention of the scientific com...

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Tipo de recurso:
Fecha de publicación:
2013
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/22184
Acceso en línea:
https://repository.urosario.edu.co/handle/10336/22184
Palabra clave:
Beta catenin
Fibroblast growth factor
Matrilysin
Microrna 200
Nerve cell adhesion molecule
Osteogenic protein 1
Protein p120
Transcription factor pax2
Transcription factor snail
Transforming growth factor beta
Uvomorulin
Wt1 protein
Apoptosis
Article
Cancer therapy
Carcinogenesis
Cell adhesion
Cell polarity
Cell proliferation
Embryo development
Epithelial mesenchymal transition
Fibrosis
Human
Metastasis
Protein expression
Signal transduction
Stem cell
Tumor growth
Tumor microenvironment
Animals
Antineoplastic agents
Cell adhesion
Cell adhesion molecules
Cell differentiation
Cell movement
Cell polarity
Disease progression
Embryonic development
Epithelial-mesenchymal transition
Fibrosis
Humans
Intracellular signaling peptides and proteins
Micrornas
Molecular targeted therapy
Neoplasm proteins
Neoplasms
Neoplastic stem cells
Signal transduction
Cadherins
Cancer
Cancer stem cells
Cell polarity
Differentiation
Microrna
neoplastic
neoplasm
Cell transformation
Rna
Rights
License
Abierto (Texto Completo)
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spelling a068bac1-88eb-4506-80ce-8e5548bcac2a-1ab3f4669-900f-4031-9a57-351b2c8cd042-12a23e975-7586-4a47-84da-b12513fc36ef-12020-05-25T23:55:42Z2020-05-25T23:55:42Z2013The epithelial-mesenchymal transition (EMT) is a biological phenomenon responsible for the formation of different tissues and organs during normal metazoan development. Because of the connection of the EMT with the pathogenesis of certain diseases, such as cancer, the attention of the scientific community has been directed towards the search for and identification of effective therapeutic targets. These targets include signal transduction in cancerous stem cells and the use of microRNAs, which would inhibit EMT-associated phenotypic changes and tumoral progression. In an attempt to compile relevant and current information, this work addresses concepts that define the EMT and the advances in this field. The wealth of knowledge gained from areas such as the loss of cell polarity and intracellular adhesion complexes, the signaling pathways implicated, microRNA participation in this process, and stemness acquisition in embryonic and cancerous cells, all of which allow for the visualization of promising perspectives, particularly, methods for targeting advanced malignancies, are presented herein.application/pdfhttps://repository.urosario.edu.co/handle/10336/22184eng205No. 2186Investigacion Clinica (Venezuela)Vol. 54Investigacion Clinica (Venezuela), Vol.54, No.2 (2013); pp. 186-205https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878919672&partnerID=40&md5=81ae0438e450a786e159603077c8e347Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURBeta cateninFibroblast growth factorMatrilysinMicrorna 200Nerve cell adhesion moleculeOsteogenic protein 1Protein p120Transcription factor pax2Transcription factor snailTransforming growth factor betaUvomorulinWt1 proteinApoptosisArticleCancer therapyCarcinogenesisCell adhesionCell polarityCell proliferationEmbryo developmentEpithelial mesenchymal transitionFibrosisHumanMetastasisProtein expressionSignal transductionStem cellTumor growthTumor microenvironmentAnimalsAntineoplastic agentsCell adhesionCell adhesion moleculesCell differentiationCell movementCell polarityDisease progressionEmbryonic developmentEpithelial-mesenchymal transitionFibrosisHumansIntracellular signaling peptides and proteinsMicrornasMolecular targeted therapyNeoplasm proteinsNeoplasmsNeoplastic stem cellsSignal transductionCadherinsCancerCancer stem cellsCell polarityDifferentiationMicrornaneoplasticneoplasmCell transformationRnaEpithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapyTransición epitelio-mesenquimática (TEM): Principios e impacto clínico en la terapia contra el cáncerarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Franco-Chuaire M.L.Sánchez-Corredor M.C.Chuaire-Noack L.ORIGINAL372937692008.pdfapplication/pdf761890https://repository.urosario.edu.co/bitstreams/a5b77c6b-12f7-43eb-a00e-6772deca85fd/download6e2c62d9ea9c73e42609ebb97e58da11MD51TEXT372937692008.pdf.txt372937692008.pdf.txtExtracted texttext/plain67162https://repository.urosario.edu.co/bitstreams/6cf65e26-6804-4416-8b6c-5e889519efc0/downloadd3b3bbb9424f81024ce63d809c5e480fMD52THUMBNAIL372937692008.pdf.jpg372937692008.pdf.jpgGenerated Thumbnailimage/jpeg2363https://repository.urosario.edu.co/bitstreams/6e3c3417-9b22-4ab2-a056-1ec8ea66e26b/downloadf4c410263cefe1a14326d46bab801ad6MD5310336/22184oai:repository.urosario.edu.co:10336/221842022-05-02 07:37:20.273634https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Epithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapy
dc.title.TranslatedTitle.spa.fl_str_mv Transición epitelio-mesenquimática (TEM): Principios e impacto clínico en la terapia contra el cáncer
title Epithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapy
spellingShingle Epithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapy
Beta catenin
Fibroblast growth factor
Matrilysin
Microrna 200
Nerve cell adhesion molecule
Osteogenic protein 1
Protein p120
Transcription factor pax2
Transcription factor snail
Transforming growth factor beta
Uvomorulin
Wt1 protein
Apoptosis
Article
Cancer therapy
Carcinogenesis
Cell adhesion
Cell polarity
Cell proliferation
Embryo development
Epithelial mesenchymal transition
Fibrosis
Human
Metastasis
Protein expression
Signal transduction
Stem cell
Tumor growth
Tumor microenvironment
Animals
Antineoplastic agents
Cell adhesion
Cell adhesion molecules
Cell differentiation
Cell movement
Cell polarity
Disease progression
Embryonic development
Epithelial-mesenchymal transition
Fibrosis
Humans
Intracellular signaling peptides and proteins
Micrornas
Molecular targeted therapy
Neoplasm proteins
Neoplasms
Neoplastic stem cells
Signal transduction
Cadherins
Cancer
Cancer stem cells
Cell polarity
Differentiation
Microrna
neoplastic
neoplasm
Cell transformation
Rna
title_short Epithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapy
title_full Epithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapy
title_fullStr Epithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapy
title_full_unstemmed Epithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapy
title_sort Epithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapy
dc.subject.keyword.spa.fl_str_mv Beta catenin
Fibroblast growth factor
Matrilysin
Microrna 200
Nerve cell adhesion molecule
Osteogenic protein 1
Protein p120
Transcription factor pax2
Transcription factor snail
Transforming growth factor beta
Uvomorulin
Wt1 protein
Apoptosis
Article
Cancer therapy
Carcinogenesis
Cell adhesion
Cell polarity
Cell proliferation
Embryo development
Epithelial mesenchymal transition
Fibrosis
Human
Metastasis
Protein expression
Signal transduction
Stem cell
Tumor growth
Tumor microenvironment
Animals
Antineoplastic agents
Cell adhesion
Cell adhesion molecules
Cell differentiation
Cell movement
Cell polarity
Disease progression
Embryonic development
Epithelial-mesenchymal transition
Fibrosis
Humans
Intracellular signaling peptides and proteins
Micrornas
Molecular targeted therapy
Neoplasm proteins
Neoplasms
Neoplastic stem cells
Signal transduction
Cadherins
Cancer
Cancer stem cells
Cell polarity
Differentiation
Microrna
topic Beta catenin
Fibroblast growth factor
Matrilysin
Microrna 200
Nerve cell adhesion molecule
Osteogenic protein 1
Protein p120
Transcription factor pax2
Transcription factor snail
Transforming growth factor beta
Uvomorulin
Wt1 protein
Apoptosis
Article
Cancer therapy
Carcinogenesis
Cell adhesion
Cell polarity
Cell proliferation
Embryo development
Epithelial mesenchymal transition
Fibrosis
Human
Metastasis
Protein expression
Signal transduction
Stem cell
Tumor growth
Tumor microenvironment
Animals
Antineoplastic agents
Cell adhesion
Cell adhesion molecules
Cell differentiation
Cell movement
Cell polarity
Disease progression
Embryonic development
Epithelial-mesenchymal transition
Fibrosis
Humans
Intracellular signaling peptides and proteins
Micrornas
Molecular targeted therapy
Neoplasm proteins
Neoplasms
Neoplastic stem cells
Signal transduction
Cadherins
Cancer
Cancer stem cells
Cell polarity
Differentiation
Microrna
neoplastic
neoplasm
Cell transformation
Rna
dc.subject.keyword.eng.fl_str_mv neoplastic
neoplasm
Cell transformation
Rna
description The epithelial-mesenchymal transition (EMT) is a biological phenomenon responsible for the formation of different tissues and organs during normal metazoan development. Because of the connection of the EMT with the pathogenesis of certain diseases, such as cancer, the attention of the scientific community has been directed towards the search for and identification of effective therapeutic targets. These targets include signal transduction in cancerous stem cells and the use of microRNAs, which would inhibit EMT-associated phenotypic changes and tumoral progression. In an attempt to compile relevant and current information, this work addresses concepts that define the EMT and the advances in this field. The wealth of knowledge gained from areas such as the loss of cell polarity and intracellular adhesion complexes, the signaling pathways implicated, microRNA participation in this process, and stemness acquisition in embryonic and cancerous cells, all of which allow for the visualization of promising perspectives, particularly, methods for targeting advanced malignancies, are presented herein.
publishDate 2013
dc.date.created.spa.fl_str_mv 2013
dc.date.accessioned.none.fl_str_mv 2020-05-25T23:55:42Z
dc.date.available.none.fl_str_mv 2020-05-25T23:55:42Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/22184
url https://repository.urosario.edu.co/handle/10336/22184
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 205
dc.relation.citationIssue.none.fl_str_mv No. 2
dc.relation.citationStartPage.none.fl_str_mv 186
dc.relation.citationTitle.none.fl_str_mv Investigacion Clinica (Venezuela)
dc.relation.citationVolume.none.fl_str_mv Vol. 54
dc.relation.ispartof.spa.fl_str_mv Investigacion Clinica (Venezuela), Vol.54, No.2 (2013); pp. 186-205
dc.relation.uri.spa.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878919672&partnerID=40&md5=81ae0438e450a786e159603077c8e347
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
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