Epithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapy
The epithelial-mesenchymal transition (EMT) is a biological phenomenon responsible for the formation of different tissues and organs during normal metazoan development. Because of the connection of the EMT with the pathogenesis of certain diseases, such as cancer, the attention of the scientific com...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2013
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/22184
- Acceso en línea:
- https://repository.urosario.edu.co/handle/10336/22184
- Palabra clave:
- Beta catenin
Fibroblast growth factor
Matrilysin
Microrna 200
Nerve cell adhesion molecule
Osteogenic protein 1
Protein p120
Transcription factor pax2
Transcription factor snail
Transforming growth factor beta
Uvomorulin
Wt1 protein
Apoptosis
Article
Cancer therapy
Carcinogenesis
Cell adhesion
Cell polarity
Cell proliferation
Embryo development
Epithelial mesenchymal transition
Fibrosis
Human
Metastasis
Protein expression
Signal transduction
Stem cell
Tumor growth
Tumor microenvironment
Animals
Antineoplastic agents
Cell adhesion
Cell adhesion molecules
Cell differentiation
Cell movement
Cell polarity
Disease progression
Embryonic development
Epithelial-mesenchymal transition
Fibrosis
Humans
Intracellular signaling peptides and proteins
Micrornas
Molecular targeted therapy
Neoplasm proteins
Neoplasms
Neoplastic stem cells
Signal transduction
Cadherins
Cancer
Cancer stem cells
Cell polarity
Differentiation
Microrna
neoplastic
neoplasm
Cell transformation
Rna
- Rights
- License
- Abierto (Texto Completo)
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a068bac1-88eb-4506-80ce-8e5548bcac2a-1ab3f4669-900f-4031-9a57-351b2c8cd042-12a23e975-7586-4a47-84da-b12513fc36ef-12020-05-25T23:55:42Z2020-05-25T23:55:42Z2013The epithelial-mesenchymal transition (EMT) is a biological phenomenon responsible for the formation of different tissues and organs during normal metazoan development. Because of the connection of the EMT with the pathogenesis of certain diseases, such as cancer, the attention of the scientific community has been directed towards the search for and identification of effective therapeutic targets. These targets include signal transduction in cancerous stem cells and the use of microRNAs, which would inhibit EMT-associated phenotypic changes and tumoral progression. In an attempt to compile relevant and current information, this work addresses concepts that define the EMT and the advances in this field. The wealth of knowledge gained from areas such as the loss of cell polarity and intracellular adhesion complexes, the signaling pathways implicated, microRNA participation in this process, and stemness acquisition in embryonic and cancerous cells, all of which allow for the visualization of promising perspectives, particularly, methods for targeting advanced malignancies, are presented herein.application/pdfhttps://repository.urosario.edu.co/handle/10336/22184eng205No. 2186Investigacion Clinica (Venezuela)Vol. 54Investigacion Clinica (Venezuela), Vol.54, No.2 (2013); pp. 186-205https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878919672&partnerID=40&md5=81ae0438e450a786e159603077c8e347Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURBeta cateninFibroblast growth factorMatrilysinMicrorna 200Nerve cell adhesion moleculeOsteogenic protein 1Protein p120Transcription factor pax2Transcription factor snailTransforming growth factor betaUvomorulinWt1 proteinApoptosisArticleCancer therapyCarcinogenesisCell adhesionCell polarityCell proliferationEmbryo developmentEpithelial mesenchymal transitionFibrosisHumanMetastasisProtein expressionSignal transductionStem cellTumor growthTumor microenvironmentAnimalsAntineoplastic agentsCell adhesionCell adhesion moleculesCell differentiationCell movementCell polarityDisease progressionEmbryonic developmentEpithelial-mesenchymal transitionFibrosisHumansIntracellular signaling peptides and proteinsMicrornasMolecular targeted therapyNeoplasm proteinsNeoplasmsNeoplastic stem cellsSignal transductionCadherinsCancerCancer stem cellsCell polarityDifferentiationMicrornaneoplasticneoplasmCell transformationRnaEpithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapyTransición epitelio-mesenquimática (TEM): Principios e impacto clínico en la terapia contra el cáncerarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Franco-Chuaire M.L.Sánchez-Corredor M.C.Chuaire-Noack L.ORIGINAL372937692008.pdfapplication/pdf761890https://repository.urosario.edu.co/bitstreams/a5b77c6b-12f7-43eb-a00e-6772deca85fd/download6e2c62d9ea9c73e42609ebb97e58da11MD51TEXT372937692008.pdf.txt372937692008.pdf.txtExtracted texttext/plain67162https://repository.urosario.edu.co/bitstreams/6cf65e26-6804-4416-8b6c-5e889519efc0/downloadd3b3bbb9424f81024ce63d809c5e480fMD52THUMBNAIL372937692008.pdf.jpg372937692008.pdf.jpgGenerated Thumbnailimage/jpeg2363https://repository.urosario.edu.co/bitstreams/6e3c3417-9b22-4ab2-a056-1ec8ea66e26b/downloadf4c410263cefe1a14326d46bab801ad6MD5310336/22184oai:repository.urosario.edu.co:10336/221842022-05-02 07:37:20.273634https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Epithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapy |
dc.title.TranslatedTitle.spa.fl_str_mv |
Transición epitelio-mesenquimática (TEM): Principios e impacto clínico en la terapia contra el cáncer |
title |
Epithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapy |
spellingShingle |
Epithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapy Beta catenin Fibroblast growth factor Matrilysin Microrna 200 Nerve cell adhesion molecule Osteogenic protein 1 Protein p120 Transcription factor pax2 Transcription factor snail Transforming growth factor beta Uvomorulin Wt1 protein Apoptosis Article Cancer therapy Carcinogenesis Cell adhesion Cell polarity Cell proliferation Embryo development Epithelial mesenchymal transition Fibrosis Human Metastasis Protein expression Signal transduction Stem cell Tumor growth Tumor microenvironment Animals Antineoplastic agents Cell adhesion Cell adhesion molecules Cell differentiation Cell movement Cell polarity Disease progression Embryonic development Epithelial-mesenchymal transition Fibrosis Humans Intracellular signaling peptides and proteins Micrornas Molecular targeted therapy Neoplasm proteins Neoplasms Neoplastic stem cells Signal transduction Cadherins Cancer Cancer stem cells Cell polarity Differentiation Microrna neoplastic neoplasm Cell transformation Rna |
title_short |
Epithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapy |
title_full |
Epithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapy |
title_fullStr |
Epithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapy |
title_full_unstemmed |
Epithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapy |
title_sort |
Epithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapy |
dc.subject.keyword.spa.fl_str_mv |
Beta catenin Fibroblast growth factor Matrilysin Microrna 200 Nerve cell adhesion molecule Osteogenic protein 1 Protein p120 Transcription factor pax2 Transcription factor snail Transforming growth factor beta Uvomorulin Wt1 protein Apoptosis Article Cancer therapy Carcinogenesis Cell adhesion Cell polarity Cell proliferation Embryo development Epithelial mesenchymal transition Fibrosis Human Metastasis Protein expression Signal transduction Stem cell Tumor growth Tumor microenvironment Animals Antineoplastic agents Cell adhesion Cell adhesion molecules Cell differentiation Cell movement Cell polarity Disease progression Embryonic development Epithelial-mesenchymal transition Fibrosis Humans Intracellular signaling peptides and proteins Micrornas Molecular targeted therapy Neoplasm proteins Neoplasms Neoplastic stem cells Signal transduction Cadherins Cancer Cancer stem cells Cell polarity Differentiation Microrna |
topic |
Beta catenin Fibroblast growth factor Matrilysin Microrna 200 Nerve cell adhesion molecule Osteogenic protein 1 Protein p120 Transcription factor pax2 Transcription factor snail Transforming growth factor beta Uvomorulin Wt1 protein Apoptosis Article Cancer therapy Carcinogenesis Cell adhesion Cell polarity Cell proliferation Embryo development Epithelial mesenchymal transition Fibrosis Human Metastasis Protein expression Signal transduction Stem cell Tumor growth Tumor microenvironment Animals Antineoplastic agents Cell adhesion Cell adhesion molecules Cell differentiation Cell movement Cell polarity Disease progression Embryonic development Epithelial-mesenchymal transition Fibrosis Humans Intracellular signaling peptides and proteins Micrornas Molecular targeted therapy Neoplasm proteins Neoplasms Neoplastic stem cells Signal transduction Cadherins Cancer Cancer stem cells Cell polarity Differentiation Microrna neoplastic neoplasm Cell transformation Rna |
dc.subject.keyword.eng.fl_str_mv |
neoplastic neoplasm Cell transformation Rna |
description |
The epithelial-mesenchymal transition (EMT) is a biological phenomenon responsible for the formation of different tissues and organs during normal metazoan development. Because of the connection of the EMT with the pathogenesis of certain diseases, such as cancer, the attention of the scientific community has been directed towards the search for and identification of effective therapeutic targets. These targets include signal transduction in cancerous stem cells and the use of microRNAs, which would inhibit EMT-associated phenotypic changes and tumoral progression. In an attempt to compile relevant and current information, this work addresses concepts that define the EMT and the advances in this field. The wealth of knowledge gained from areas such as the loss of cell polarity and intracellular adhesion complexes, the signaling pathways implicated, microRNA participation in this process, and stemness acquisition in embryonic and cancerous cells, all of which allow for the visualization of promising perspectives, particularly, methods for targeting advanced malignancies, are presented herein. |
publishDate |
2013 |
dc.date.created.spa.fl_str_mv |
2013 |
dc.date.accessioned.none.fl_str_mv |
2020-05-25T23:55:42Z |
dc.date.available.none.fl_str_mv |
2020-05-25T23:55:42Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/22184 |
url |
https://repository.urosario.edu.co/handle/10336/22184 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
205 |
dc.relation.citationIssue.none.fl_str_mv |
No. 2 |
dc.relation.citationStartPage.none.fl_str_mv |
186 |
dc.relation.citationTitle.none.fl_str_mv |
Investigacion Clinica (Venezuela) |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 54 |
dc.relation.ispartof.spa.fl_str_mv |
Investigacion Clinica (Venezuela), Vol.54, No.2 (2013); pp. 186-205 |
dc.relation.uri.spa.fl_str_mv |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878919672&partnerID=40&md5=81ae0438e450a786e159603077c8e347 |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
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application/pdf |
institution |
Universidad del Rosario |
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