Epithelial-mesenchymal transition (EMT): Principles and clinical impact in cancer therapy

The epithelial-mesenchymal transition (EMT) is a biological phenomenon responsible for the formation of different tissues and organs during normal metazoan development. Because of the connection of the EMT with the pathogenesis of certain diseases, such as cancer, the attention of the scientific community has been directed towards the search for and identification of effective therapeutic targets. These targets include signal transduction in cancerous stem cells and the use of microRNAs, which would inhibit EMT-associated phenotypic changes and tumoral progression. In an attempt to compile relevant and current information, this work addresses concepts that define the EMT and the advances in this field. The wealth of knowledge gained from areas such as the loss of cell polarity and intracellular adhesion complexes, the signaling pathways implicated, microRNA participation in this process, and stemness acquisition in embryonic and cancerous cells, all of which allow for the visualization of promising perspectives, particularly, methods for targeting advanced malignancies, are presented herein.

• Fecha de publicación: 2013
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/22184
• Acceso en línea: https://repository.urosario.edu.co/handle/10336/22184
• Palabra clave: Beta catenin; Fibroblast growth factor; Matrilysin; Microrna 200; Nerve cell adhesion molecule; Osteogenic protein 1; Protein p120; Transcription factor pax2; Transcription factor snail; Transforming growth factor beta; Uvomorulin; Wt1 protein; Apoptosis; Article; Cancer therapy; Carcinogenesis; Cell adhesion; Cell polarity; Cell proliferation; Embryo development; Epithelial mesenchymal transition; Fibrosis; Human; Metastasis; Protein expression; Signal transduction; Stem cell; Tumor growth; Tumor microenvironment; Animals; Antineoplastic agents; Cell adhesion; Cell adhesion molecules; Cell differentiation; Cell movement; Cell polarity; Disease progression; Embryonic development; Epithelial-mesenchymal transition; Fibrosis; Humans; Intracellular signaling peptides and proteins; Micrornas; Molecular targeted therapy; Neoplasm proteins; Neoplasms; Neoplastic stem cells; Signal transduction; Cadherins; Cancer; Cancer stem cells; Cell polarity; Differentiation; Microrna; neoplastic; neoplasm; Cell transformation; Rna
• License: Abierto (Texto Completo)