The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents

This study reports six HR-HPV types' infection prevalence discriminated by species and multiple infection in unvaccinated Colombian female adolescents, as well as some factors modulating the risk of infection. HPV DNA for six high-risk viral types was identified in cervical samples taken from 2...

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Autores:
Tipo de recurso:
Fecha de publicación:
2016
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/21982
Acceso en línea:
https://doi.org/10.1371/journal.pone.0166502
https://repository.urosario.edu.co/handle/10336/21982
Palabra clave:
Enfermedades
Adult
Article
Child
Controlled study
Female
Prevalence
Virus DNA
Concurrent sexual partnership
Sexually transmitted disease
Squamous intraepithelial lesion of the cervi
Rights
License
Abierto (Texto Completo)
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oai_identifier_str oai:repository.urosario.edu.co:10336/21982
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.spa.fl_str_mv The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents
title The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents
spellingShingle The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents
Enfermedades
Adult
Article
Child
Controlled study
Female
Prevalence
Virus DNA
Concurrent sexual partnership
Sexually transmitted disease
Squamous intraepithelial lesion of the cervi
title_short The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents
title_full The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents
title_fullStr The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents
title_full_unstemmed The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents
title_sort The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents
dc.subject.ddc.spa.fl_str_mv Enfermedades
topic Enfermedades
Adult
Article
Child
Controlled study
Female
Prevalence
Virus DNA
Concurrent sexual partnership
Sexually transmitted disease
Squamous intraepithelial lesion of the cervi
dc.subject.keyword.spa.fl_str_mv Adult
Article
Child
Controlled study
Female
Prevalence
Virus DNA
Concurrent sexual partnership
Sexually transmitted disease
Squamous intraepithelial lesion of the cervi
description This study reports six HR-HPV types' infection prevalence discriminated by species and multiple infection in unvaccinated Colombian female adolescents, as well as some factors modulating the risk of infection. HPV DNA for six high-risk viral types was identified in cervical samples taken from 2,134 12-19 year-old females using conventional generic and typespecific PCR. Binomial logistical regression analysis was used for modelling HR-HPV infection and multiple infection risk. The interaction between variables in a stepwise model was also included in such analysis. Viral DNA was detected in 48.97% of the females; 28.52% of them had multiple infections, HPV-16 being the most frequently occurring type (37.44%). Cytological abnormality prevalence was 15.61%. Being over 16 years-old (1.66: 1.01-2.71 95%CI), white ethnicity (4.40: 1.16-16.73 95%CI), having had 3 or more sexual partners (1.77: 1.11-2.81 95%CI) and prior sexually-transmitted infections (STI) (1.65: 1.17-2.32 95%CI) were associated with a greater risk of HPV infection. Having given birth was related to a higher risk of infection by A7 species and antecedent of abortion to less risk of coinfection. Where the females in this study came from also influenced the risk of infection by A7 species as female adolescents from the Andean region had a lower risk of infection (0.42: 0.18-0.99 95%CI). The presence of factors related to risky sexual behaviour in the study population indicated that public health services should pay special attention to female adolescents to modify the risk of infection by high-risk HPV types and decrease their impact on this age group. © 2016 Del Río-Ospina et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
publishDate 2016
dc.date.created.none.fl_str_mv 2016
dc.date.issued.none.fl_str_mv 2016
dc.date.accessioned.none.fl_str_mv 2020-05-12T12:25:46Z
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dc.type.eng.fl_str_mv article
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spelling ce1ef5aa-ec94-4c59-a0d6-2096243b5fe2600cf76df25-dcad-4c71-bb5f-65bee35aaff0600b6d9f9f6-1df0-4436-9c85-968aed01a39c600aa2fd24c-0eb4-4d73-8a15-c2b3025f602d60079b9306e-4de9-4cc5-8a80-8ffba6eea51760068fba5f8-9c7c-46d0-af9e-465e1bde7f72600796530656002020-05-12T12:25:46Z2020-05-12T12:25:46Z20162016This study reports six HR-HPV types' infection prevalence discriminated by species and multiple infection in unvaccinated Colombian female adolescents, as well as some factors modulating the risk of infection. HPV DNA for six high-risk viral types was identified in cervical samples taken from 2,134 12-19 year-old females using conventional generic and typespecific PCR. Binomial logistical regression analysis was used for modelling HR-HPV infection and multiple infection risk. The interaction between variables in a stepwise model was also included in such analysis. Viral DNA was detected in 48.97% of the females; 28.52% of them had multiple infections, HPV-16 being the most frequently occurring type (37.44%). Cytological abnormality prevalence was 15.61%. Being over 16 years-old (1.66: 1.01-2.71 95%CI), white ethnicity (4.40: 1.16-16.73 95%CI), having had 3 or more sexual partners (1.77: 1.11-2.81 95%CI) and prior sexually-transmitted infections (STI) (1.65: 1.17-2.32 95%CI) were associated with a greater risk of HPV infection. Having given birth was related to a higher risk of infection by A7 species and antecedent of abortion to less risk of coinfection. Where the females in this study came from also influenced the risk of infection by A7 species as female adolescents from the Andean region had a lower risk of infection (0.42: 0.18-0.99 95%CI). The presence of factors related to risky sexual behaviour in the study population indicated that public health services should pay special attention to female adolescents to modify the risk of infection by high-risk HPV types and decrease their impact on this age group. © 2016 Del Río-Ospina et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.application/pdfhttps://doi.org/10.1371/journal.pone.01665021932-6203https://repository.urosario.edu.co/handle/10336/21982engNo. 11PLoS ONEVol. 11PLoS ONE, ISSN: 1932-6203 Vol. 11, No. 11 (2016)https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0166502&type=printableAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocUREnfermedades616600AdultArticleChildControlled studyFemalePrevalenceVirus DNAConcurrent sexual partnershipSexually transmitted diseaseSquamous intraepithelial lesion of the cerviThe prevalence of high-risk HPV types and factors determining infection in female colombian adolescentsarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501del Río-Ospina, LuisaSoto-de León, Sara CeciliaMilena Camargo, MilenaSánchez, RicardoMancilla, Cindy LizethPatarroyo, Manuel-ElkinPatarroyo, Manuel A.del Río-Ospina, LuisaSoto-De León, Sara CeciliaCamargo, MilenaSánchez, RicardoMancilla, Cindy LizethPatarroyo, Manuel ElkinPatarroyo, Manuel AlfonsoORIGINALThe_prevalence_of_high-risk_HPV_types_and_factors_determining_infection_in_female_colombian_adolescents.pdfapplication/pdf1405738https://repository.urosario.edu.co/bitstreams/0a9066b5-52e8-4308-a1fc-89cfedee847c/download99e0037fbc01fc5e604c8be2c133ee52MD51TEXTThe_prevalence_of_high-risk_HPV_types_and_factors_determining_infection_in_female_colombian_adolescents.pdf.txtThe_prevalence_of_high-risk_HPV_types_and_factors_determining_infection_in_female_colombian_adolescents.pdf.txtExtracted texttext/plain49593https://repository.urosario.edu.co/bitstreams/07bd6bb9-661d-4b56-99de-3ad42bf59d60/downloadc24e9e7d05c511e7f44c52ba7c83f4a3MD52THUMBNAILThe_prevalence_of_high-risk_HPV_types_and_factors_determining_infection_in_female_colombian_adolescents.pdf.jpgThe_prevalence_of_high-risk_HPV_types_and_factors_determining_infection_in_female_colombian_adolescents.pdf.jpgGenerated Thumbnailimage/jpeg4314https://repository.urosario.edu.co/bitstreams/b039791f-3962-4023-8fb6-beee06f86c7d/download9edfd332e77c143d6e33b04cfece5a55MD5310336/21982oai:repository.urosario.edu.co:10336/219822020-05-13 14:48:53.692https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co