HLA-DRB1 the notorious gene in the mosaic of autoimmunity

The major histocompatibility complex system is the most polymorphic gene cluster of the mammal genome. In humans, this is a genomic locus known as the human leukocyte antigen (HLA) system. The HLA encodes mostly immune-associated proteins whose main effect is the presentation of antigens to the immu...

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Autores:
Tipo de recurso:
Fecha de publicación:
2017
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/24281
Acceso en línea:
https://doi.org/10.1007/s12026-016-8817-7
https://repository.urosario.edu.co/handle/10336/24281
Palabra clave:
Hepatitis B surface antigen
Hepatitis B vaccine
HLA DRB1 antigen
Influenza vaccine
Measles vaccine
Mumps vaccine
Tumor necrosis factor
HLA DRB1 antigen
Vaccine
Ankylosing spondylitis
Article
Autoimmune disease
Autoimmune thyroiditis
Autoimmunity
Cytomegalovirus infection
Epstein Barr virus infection
Ethnicity
Gene
Genetic polymorphism
Genetic risk
Graves disease
Guillain Barre syndrome
Hashimoto disease
Hepatitis B
Hepatitis C
HLA DRB1 gene
Human
Immune response
Infection
Insulin dependent diabetes mellitus
Major histocompatibility complex
Multiple sclerosis
Myositis
Nonhuman
Priority journal
Psoriatic arthritis
Rheumatoid arthritis
Sjoegren syndrome
Spondylarthritis
Systemic lupus erythematosus
Vaccination
Animal
Autoimmunity
Genetics
Animals
Autoimmune Diseases
Autoimmunity
HLA-DRB1 Chains
Humans
Vaccines
Autoimmunity
DRB1
Gene
Genetic
HLA system
Infections
Locus
Vaccines
Genetic
Polymorphism
Rights
License
Abierto (Texto Completo)
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repository_id_str
spelling 232ce352-6420-4ab4-ac33-901ea6e15362-149a78028-3f62-45e8-9399-8c484b6dad3e-1e0647900-20ef-41d2-a11d-fd3a007b02a0-13d22bb2f-30de-41c7-b326-7387fae034ad-11f90d29a-666a-495f-b20f-6c6809c63f8d-150b91925-1d69-4f99-aacf-872f66730347-16b286b69-16c0-4eae-a12c-57f7a4b4c759-12020-05-26T00:11:06Z2020-05-26T00:11:06Z2017The major histocompatibility complex system is the most polymorphic gene cluster of the mammal genome. In humans, this is a genomic locus known as the human leukocyte antigen (HLA) system. The HLA encodes mostly immune-associated proteins whose main effect is the presentation of antigens to the immune cells. Thus, it is clear that it is essential for to the proper function of the immune response against pathogens and strongly implicated in the development of autoimmune diseases. Nonetheless, there are hundreds of polymorphisms of HLA-DRB1 which have been associated with different autoimmune disorders as well as with immune response to infection and vaccines. It is possible that the interaction of specific HLA with pathogenic antigens is one of the keys favoring (or protecting) toward the development of an autoimmune disease. In the era of personalized medicine, it would be of great help to build a map of the genomic risk of each individual to evaluate the risk of developing an autoimmune condition. © 2016, Springer Science+Business Media New York.application/pdfhttps://doi.org/10.1007/s12026-016-8817-70257277Xhttps://repository.urosario.edu.co/handle/10336/24281engHumana Press Inc.98No. 182Immunologic ResearchVol. 65Immunologic Research, ISSN:0257277X, Vol.65, No.1 (2017); pp. 82-98https://www.scopus.com/inward/record.uri?eid=2-s2.0-84978763593&doi=10.1007%2fs12026-016-8817-7&partnerID=40&md5=d95e7ed96b3c119df05a268d2abcee27Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURHepatitis B surface antigenHepatitis B vaccineHLA DRB1 antigenInfluenza vaccineMeasles vaccineMumps vaccineTumor necrosis factorHLA DRB1 antigenVaccineAnkylosing spondylitisArticleAutoimmune diseaseAutoimmune thyroiditisAutoimmunityCytomegalovirus infectionEpstein Barr virus infectionEthnicityGeneGenetic polymorphismGenetic riskGraves diseaseGuillain Barre syndromeHashimoto diseaseHepatitis BHepatitis CHLA DRB1 geneHumanImmune responseInfectionInsulin dependent diabetes mellitusMajor histocompatibility complexMultiple sclerosisMyositisNonhumanPriority journalPsoriatic arthritisRheumatoid arthritisSjoegren syndromeSpondylarthritisSystemic lupus erythematosusVaccinationAnimalAutoimmunityGeneticsAnimalsAutoimmune DiseasesAutoimmunityHLA-DRB1 ChainsHumansVaccinesAutoimmunityDRB1GeneGeneticHLA systemInfectionsLocusVaccinesGeneticPolymorphismHLA-DRB1 the notorious gene in the mosaic of autoimmunityarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Arango M.-T.Perricone C.Kivity S.Cipriano E.Ceccarelli F.Valesini G.Shoenfeld Y.10336/24281oai:repository.urosario.edu.co:10336/242812022-05-02 07:37:18.190723https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv HLA-DRB1 the notorious gene in the mosaic of autoimmunity
title HLA-DRB1 the notorious gene in the mosaic of autoimmunity
spellingShingle HLA-DRB1 the notorious gene in the mosaic of autoimmunity
Hepatitis B surface antigen
Hepatitis B vaccine
HLA DRB1 antigen
Influenza vaccine
Measles vaccine
Mumps vaccine
Tumor necrosis factor
HLA DRB1 antigen
Vaccine
Ankylosing spondylitis
Article
Autoimmune disease
Autoimmune thyroiditis
Autoimmunity
Cytomegalovirus infection
Epstein Barr virus infection
Ethnicity
Gene
Genetic polymorphism
Genetic risk
Graves disease
Guillain Barre syndrome
Hashimoto disease
Hepatitis B
Hepatitis C
HLA DRB1 gene
Human
Immune response
Infection
Insulin dependent diabetes mellitus
Major histocompatibility complex
Multiple sclerosis
Myositis
Nonhuman
Priority journal
Psoriatic arthritis
Rheumatoid arthritis
Sjoegren syndrome
Spondylarthritis
Systemic lupus erythematosus
Vaccination
Animal
Autoimmunity
Genetics
Animals
Autoimmune Diseases
Autoimmunity
HLA-DRB1 Chains
Humans
Vaccines
Autoimmunity
DRB1
Gene
Genetic
HLA system
Infections
Locus
Vaccines
Genetic
Polymorphism
title_short HLA-DRB1 the notorious gene in the mosaic of autoimmunity
title_full HLA-DRB1 the notorious gene in the mosaic of autoimmunity
title_fullStr HLA-DRB1 the notorious gene in the mosaic of autoimmunity
title_full_unstemmed HLA-DRB1 the notorious gene in the mosaic of autoimmunity
title_sort HLA-DRB1 the notorious gene in the mosaic of autoimmunity
dc.subject.keyword.spa.fl_str_mv Hepatitis B surface antigen
Hepatitis B vaccine
HLA DRB1 antigen
Influenza vaccine
Measles vaccine
Mumps vaccine
Tumor necrosis factor
HLA DRB1 antigen
Vaccine
Ankylosing spondylitis
Article
Autoimmune disease
Autoimmune thyroiditis
Autoimmunity
Cytomegalovirus infection
Epstein Barr virus infection
Ethnicity
Gene
Genetic polymorphism
Genetic risk
Graves disease
Guillain Barre syndrome
Hashimoto disease
Hepatitis B
Hepatitis C
HLA DRB1 gene
Human
Immune response
Infection
Insulin dependent diabetes mellitus
Major histocompatibility complex
Multiple sclerosis
Myositis
Nonhuman
Priority journal
Psoriatic arthritis
Rheumatoid arthritis
Sjoegren syndrome
Spondylarthritis
Systemic lupus erythematosus
Vaccination
Animal
Autoimmunity
Genetics
Animals
Autoimmune Diseases
Autoimmunity
HLA-DRB1 Chains
Humans
Vaccines
Autoimmunity
DRB1
Gene
Genetic
HLA system
Infections
Locus
Vaccines
topic Hepatitis B surface antigen
Hepatitis B vaccine
HLA DRB1 antigen
Influenza vaccine
Measles vaccine
Mumps vaccine
Tumor necrosis factor
HLA DRB1 antigen
Vaccine
Ankylosing spondylitis
Article
Autoimmune disease
Autoimmune thyroiditis
Autoimmunity
Cytomegalovirus infection
Epstein Barr virus infection
Ethnicity
Gene
Genetic polymorphism
Genetic risk
Graves disease
Guillain Barre syndrome
Hashimoto disease
Hepatitis B
Hepatitis C
HLA DRB1 gene
Human
Immune response
Infection
Insulin dependent diabetes mellitus
Major histocompatibility complex
Multiple sclerosis
Myositis
Nonhuman
Priority journal
Psoriatic arthritis
Rheumatoid arthritis
Sjoegren syndrome
Spondylarthritis
Systemic lupus erythematosus
Vaccination
Animal
Autoimmunity
Genetics
Animals
Autoimmune Diseases
Autoimmunity
HLA-DRB1 Chains
Humans
Vaccines
Autoimmunity
DRB1
Gene
Genetic
HLA system
Infections
Locus
Vaccines
Genetic
Polymorphism
dc.subject.keyword.eng.fl_str_mv Genetic
Polymorphism
description The major histocompatibility complex system is the most polymorphic gene cluster of the mammal genome. In humans, this is a genomic locus known as the human leukocyte antigen (HLA) system. The HLA encodes mostly immune-associated proteins whose main effect is the presentation of antigens to the immune cells. Thus, it is clear that it is essential for to the proper function of the immune response against pathogens and strongly implicated in the development of autoimmune diseases. Nonetheless, there are hundreds of polymorphisms of HLA-DRB1 which have been associated with different autoimmune disorders as well as with immune response to infection and vaccines. It is possible that the interaction of specific HLA with pathogenic antigens is one of the keys favoring (or protecting) toward the development of an autoimmune disease. In the era of personalized medicine, it would be of great help to build a map of the genomic risk of each individual to evaluate the risk of developing an autoimmune condition. © 2016, Springer Science+Business Media New York.
publishDate 2017
dc.date.created.spa.fl_str_mv 2017
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:11:06Z
dc.date.available.none.fl_str_mv 2020-05-26T00:11:06Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1007/s12026-016-8817-7
dc.identifier.issn.none.fl_str_mv 0257277X
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/24281
url https://doi.org/10.1007/s12026-016-8817-7
https://repository.urosario.edu.co/handle/10336/24281
identifier_str_mv 0257277X
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 98
dc.relation.citationIssue.none.fl_str_mv No. 1
dc.relation.citationStartPage.none.fl_str_mv 82
dc.relation.citationTitle.none.fl_str_mv Immunologic Research
dc.relation.citationVolume.none.fl_str_mv Vol. 65
dc.relation.ispartof.spa.fl_str_mv Immunologic Research, ISSN:0257277X, Vol.65, No.1 (2017); pp. 82-98
dc.relation.uri.spa.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-84978763593&doi=10.1007%2fs12026-016-8817-7&partnerID=40&md5=d95e7ed96b3c119df05a268d2abcee27
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Humana Press Inc.
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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