HLA-DRB1 the notorious gene in the mosaic of autoimmunity
The major histocompatibility complex system is the most polymorphic gene cluster of the mammal genome. In humans, this is a genomic locus known as the human leukocyte antigen (HLA) system. The HLA encodes mostly immune-associated proteins whose main effect is the presentation of antigens to the immu...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2017
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/24281
- Acceso en línea:
- https://doi.org/10.1007/s12026-016-8817-7
https://repository.urosario.edu.co/handle/10336/24281
- Palabra clave:
- Hepatitis B surface antigen
Hepatitis B vaccine
HLA DRB1 antigen
Influenza vaccine
Measles vaccine
Mumps vaccine
Tumor necrosis factor
HLA DRB1 antigen
Vaccine
Ankylosing spondylitis
Article
Autoimmune disease
Autoimmune thyroiditis
Autoimmunity
Cytomegalovirus infection
Epstein Barr virus infection
Ethnicity
Gene
Genetic polymorphism
Genetic risk
Graves disease
Guillain Barre syndrome
Hashimoto disease
Hepatitis B
Hepatitis C
HLA DRB1 gene
Human
Immune response
Infection
Insulin dependent diabetes mellitus
Major histocompatibility complex
Multiple sclerosis
Myositis
Nonhuman
Priority journal
Psoriatic arthritis
Rheumatoid arthritis
Sjoegren syndrome
Spondylarthritis
Systemic lupus erythematosus
Vaccination
Animal
Autoimmunity
Genetics
Animals
Autoimmune Diseases
Autoimmunity
HLA-DRB1 Chains
Humans
Vaccines
Autoimmunity
DRB1
Gene
Genetic
HLA system
Infections
Locus
Vaccines
Genetic
Polymorphism
- Rights
- License
- Abierto (Texto Completo)
Summary: | The major histocompatibility complex system is the most polymorphic gene cluster of the mammal genome. In humans, this is a genomic locus known as the human leukocyte antigen (HLA) system. The HLA encodes mostly immune-associated proteins whose main effect is the presentation of antigens to the immune cells. Thus, it is clear that it is essential for to the proper function of the immune response against pathogens and strongly implicated in the development of autoimmune diseases. Nonetheless, there are hundreds of polymorphisms of HLA-DRB1 which have been associated with different autoimmune disorders as well as with immune response to infection and vaccines. It is possible that the interaction of specific HLA with pathogenic antigens is one of the keys favoring (or protecting) toward the development of an autoimmune disease. In the era of personalized medicine, it would be of great help to build a map of the genomic risk of each individual to evaluate the risk of developing an autoimmune condition. © 2016, Springer Science+Business Media New York. |
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