Immune protection-inducing protein structures (IMPIPS) against malaria : The weapons needed for beating Odysseus

The review covers the functional and structural approach followed by our group for more than 34 years in the search for a methodology that allows the rational design of chemically synthesised vaccines. An analogy between Odysseus, the cunning hero of the epic poem Odyssey by Homer, and the elusive Plasmodium parasite has been made, to review our research group's main considerations when developing a rational methodology for designing second generation, modified peptide-based, minimal subunit, multi-antigen, multi-stage, chemically synthesised vaccines against Plasmodium falciparum malaria. © 2015 Elsevier Ltd.

• Fecha de publicación: 2015
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/19014
• Acceso en línea: http://repository.urosario.edu.co/handle/10336/19014
• Palabra clave: Impips; Malaria Vaccine; Modified Peptides; Synthetic Peptides; Enfermedades; Hla Dr1 Antigen; Malaria Vaccine; T Lymphocyte Receptor; Malaria Vaccine; Peptide; Protozoal Protein; Recombinant Vaccine; Alpha Helix; Amino Acid Sequence; Antibody Response; Antibody Titer; Aotus; Article; Beta Sheet; Conformational Transition; Erythrocyte; Genetic Trait; Genetic Variability; Human; Humoral Immunity; Hydrogen Bond; Immune Protection Inducing Protein Structure; Immune Response; Immunogenetics; Immunogenicity; Immunological Silence; Malaria Falciparum; Nonhuman; Plasmodium Falciparum; Priority Journal; Protein Conformation; Protein Structure; Chemistry; Immunology; Life Cycle Stage; Malaria, Falciparum; Metabolism; Physiology; Amino Acid Sequence; Humans; Life Cycle Stages; Malaria Vaccines; Malaria, Falciparum; Peptides; Plasmodium Falciparum; Protein Conformation; Protozoan Proteins; Vaccines, Synthetic; Malaria; Vacuna; Plasmodium
• License: Abierto (Texto Completo)