Meta-analysis of HLA-DRB1 polymorphism in Latin American patients with rheumatoid arthritis

Objectives: To estimate the common effect size of HLA-DRB1 alleles on rheumatoid arthritis (RA) susceptibility across Latin America populations through a meta-analysis combining the results of published data. Methods: Case-control studies on HLA-DRB1 association with RA in Latin America were searched up to October 2006. Genotype frequencies were extracted according to both shared epitope (SE) and HLA-DR4 positive or negative alleles. The effect summary odds ratio (OR) and 95% confidence intervals was obtained. Heterogeneity and publication bias were assessed. Results: Eight studies containing 684 cases and 1015 controls were included. Under the random effects model, the common OR was 3.28 (1.93, 5.60) (p and lt; 0.0001) and 3.54 (2.47, 5.05) (p = 4.22 × 10- 12) for HLA-DR4 and SE, respectively. There was no evidence of publication bias according to Funnel plot and Egger's regression test (p = 0,445 for DR4 and p = 0,464 for SE meta-analysis). Significant heterogeneity was observed for HLA-DR4 (I2 = 81.06%, Q = 36.96, p = 0.000005) but not for the SE meta-analysis. Conclusions: HLA-DR4 and SE positive HLA-DRB1 alleles (mainly HLA-DRB1*0404) are associated with RA in Latin Americans. Heterogeneity is expected owing to the diverse degree of admixture between the examined populations. Our findings support the HLA as a major susceptibility locus for RA and validate the SE hypothesis in Latin America. © 2007 Elsevier B.V. All rights reserved.

• Fecha de publicación: 2007
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/23333
• Acceso en línea: https://doi.org/10.1016/j.autrev.2006.11.004; https://repository.urosario.edu.co/handle/10336/23333
• Palabra clave: Epitope; Hla dr4 antigen; Allele; Confidence interval; Epitope mapping; Genetic heterogeneity; Genetic polymorphism; Genotype; Hla system; Human; Information processing; Molecular phylogeny; Regression analysis; Review; Rheumatoid arthritis; South and central america; Statistical analysis; Alleles; Case-control studies; Genetic predisposition to disease; Genotype; Hla-dr antigens; Humans; Latin america; Regression analysis; Autoimmune diseases; Hla antigens; Latin america; Major histocompatibility complex; Meta-analysis; Rheumatoid arthritis; mhc class ii; rheumatoid; genetic; Arthritis; Genes; Polymorphism
• License: Abierto (Texto Completo)