Phospholipid supplementation can attenuate vaccine-induced depressive-like behavior in mice

Human papillomavirus vaccine (HPVv) is used worldwide for prevention of infection. However several reports link this vaccine, with immune-mediated reactions, especially with neurological manifestations. Our previous results showed that HPVv-Gardasil and aluminum-immunized mice developed behavioral impairments. Studies have shown a positive effect of phospholipid supplementation on depression and cognitive functions in mice. Therefore, our goal was to evaluate the effect of a dietary supplement on vaccine-induced depression. Sixty C57BL/6 female mice were immunized with HPVv-Gardasil, aluminum or the vehicle (n = 20 each group), and half of each group were fed 5 times per week with 0.2 ml of a dietary supplement enriched with phosphatidylcholine. The mice were evaluated for depression at 3 months of age, by the forced swimming test. Both the Gardasil and the aluminum-treated mice developed depressive-like behavior when compared to the control group. The HPVv-Gardasil-immunized mice supplemented with phosphatidylcholine significantly reduced their depressive symptoms. This study confirms our previous studies demonstrating depressive-like behavior in mice vaccinated with HPVv-Gardasil. In addition, it demonstrates the ability of phosphatidylcholine-enriched diet to attenuate depressive-like behavior in the HPVv-Gardasil-vaccinated mice. We suggest that phosphatidylcholine supplementation may serve as a treatment for patients suffering vaccine-related neurological manifestations. © 2016, Springer Science+Business Media New York.

• Fecha de publicación: 2017
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/24282
• Acceso en línea: https://doi.org/10.1007/s12026-016-8818-6; https://repository.urosario.edu.co/handle/10336/24282
• Palabra clave: Aluminum hydroxide; Phospholipid; Wart virus vaccine; Aluminum hydroxide; Immunological adjuvant; Pharmaceutical vehicles and additives; Phospholipid; Wart virus vaccine; Animal experiment; Article; Body weight; Concentration (parameters); Controlled study; Depression; Diet supplementation; Female; Forced swim test; Immunization; Motor performance; Mouse; Nonhuman; Phospholipid; Priority journal; Rotarod test; Single drug dose; Animal; Animal behavior; C57bl mouse; Depression; Dietary supplement; Drug effects; Motor activity; Swimming; Vaccination; Aluminum hydroxide; Animals; Depression; Dietary supplements; Female; Human papillomavirus recombinant vaccine quadrivalent, types 6, 11, 16, 18; Mice; Motor activity; Phospholipids; Swimming; Vaccination; Aluminum; Autoimmunity; Behavior; Depression; Gardasil; immunologic; inbred c57bl; animal; pharmaceutic; Adjuvants; Adjuvants; Behavior; Mice
• License: Abierto (Texto Completo)