Phospholipid supplementation can attenuate vaccine-induced depressive-like behavior in mice
Human papillomavirus vaccine (HPVv) is used worldwide for prevention of infection. However several reports link this vaccine, with immune-mediated reactions, especially with neurological manifestations. Our previous results showed that HPVv-Gardasil and aluminum-immunized mice developed behavioral i...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2017
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/24282
- Acceso en línea:
- https://doi.org/10.1007/s12026-016-8818-6
https://repository.urosario.edu.co/handle/10336/24282
- Palabra clave:
- Aluminum hydroxide
Phospholipid
Wart virus vaccine
Aluminum hydroxide
Immunological adjuvant
Pharmaceutical vehicles and additives
Phospholipid
Wart virus vaccine
Animal experiment
Article
Body weight
Concentration (parameters)
Controlled study
Depression
Diet supplementation
Female
Forced swim test
Immunization
Motor performance
Mouse
Nonhuman
Phospholipid
Priority journal
Rotarod test
Single drug dose
Animal
Animal behavior
C57bl mouse
Depression
Dietary supplement
Drug effects
Motor activity
Swimming
Vaccination
Aluminum hydroxide
Animals
Depression
Dietary supplements
Female
Human papillomavirus recombinant vaccine quadrivalent, types 6, 11, 16, 18
Mice
Motor activity
Phospholipids
Swimming
Vaccination
Aluminum
Autoimmunity
Behavior
Depression
Gardasil
immunologic
inbred c57bl
animal
pharmaceutic
Adjuvants
Adjuvants
Behavior
Mice
- Rights
- License
- Abierto (Texto Completo)
Summary: | Human papillomavirus vaccine (HPVv) is used worldwide for prevention of infection. However several reports link this vaccine, with immune-mediated reactions, especially with neurological manifestations. Our previous results showed that HPVv-Gardasil and aluminum-immunized mice developed behavioral impairments. Studies have shown a positive effect of phospholipid supplementation on depression and cognitive functions in mice. Therefore, our goal was to evaluate the effect of a dietary supplement on vaccine-induced depression. Sixty C57BL/6 female mice were immunized with HPVv-Gardasil, aluminum or the vehicle (n = 20 each group), and half of each group were fed 5 times per week with 0.2 ml of a dietary supplement enriched with phosphatidylcholine. The mice were evaluated for depression at 3 months of age, by the forced swimming test. Both the Gardasil and the aluminum-treated mice developed depressive-like behavior when compared to the control group. The HPVv-Gardasil-immunized mice supplemented with phosphatidylcholine significantly reduced their depressive symptoms. This study confirms our previous studies demonstrating depressive-like behavior in mice vaccinated with HPVv-Gardasil. In addition, it demonstrates the ability of phosphatidylcholine-enriched diet to attenuate depressive-like behavior in the HPVv-Gardasil-vaccinated mice. We suggest that phosphatidylcholine supplementation may serve as a treatment for patients suffering vaccine-related neurological manifestations. © 2016, Springer Science+Business Media New York. |
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