Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development
Identifying the principles and rules for developing a logical, rational vaccine methodology against various diseases, is discussed. SPf66, the first multiantigenic, multistage, minimal subunit-based, chemically synthesized anti-P. falciparum malaria vaccine. A robust, sensitive, and specific methodo...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2011
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/23654
- Acceso en línea:
- https://doi.org/10.1021/cr100223m
https://repository.urosario.edu.co/handle/10336/23654
- Palabra clave:
- Class I
Cloning and sequencing
Cytokines
Falciparum malaria
Genes encoding
Hepatic cells
High affinity
Immune systems
Molecular levels
Vaccine development
Biosynthesis
Cloning
Genes
Vaccines
Subunit vaccine
Vaccine
Chemical structure
Human
Immunization
Immunology
Review
Humans
Immunization
Vaccines
Subunit
Molecular
Models
Vaccines
- Rights
- License
- Abierto (Texto Completo)
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oai:repository.urosario.edu.co:10336/23654 |
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EDOCUR2 |
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Repositorio EdocUR - U. Rosario |
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76e03223-040d-4e46-864f-3bdecc8d2790-19aa21ff8-49a1-473b-b44a-21551d38c882-19fc64f6d-a903-48f1-ac2e-4e55fd2ed9af-12020-05-26T00:04:04Z2020-05-26T00:04:04Z2011Identifying the principles and rules for developing a logical, rational vaccine methodology against various diseases, is discussed. SPf66, the first multiantigenic, multistage, minimal subunit-based, chemically synthesized anti-P. falciparum malaria vaccine. A robust, sensitive, and specific methodology is developed for defining the intimate molecular interactions mediating merozoite invasion of RBC by synthesizing short merozoite-derived protein peptides binding specifically and with high affinity (HABP) to RBCs. Conserved HABP-mediated sporozoite binding to hepatic cells is identified in EBA-175 for developing a multiantigenic, multistage, fully protective antimalarial vaccine. for developing a logical and rational vaccine methodology at the molecular level, monkeys' immune system molecules is analyzed by cloning and sequencing the Aotus genes encoding immunoglobulins, cytokines, and Class I and II molecules.application/pdfhttps://doi.org/10.1021/cr100223m1520689000092665https://repository.urosario.edu.co/handle/10336/23654eng3507No. 53459Chemical ReviewsVol. 111Chemical Reviews, ISSN:15206890, 00092665, Vol.111, No.5 (2011); pp. 3459-3507https://www.scopus.com/inward/record.uri?eid=2-s2.0-79955897554&doi=10.1021%2fcr100223m&partnerID=40&md5=f90047bb18e44c278ecf94806db0d21bAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURClass ICloning and sequencingCytokinesFalciparum malariaGenes encodingHepatic cellsHigh affinityImmune systemsMolecular levelsVaccine developmentBiosynthesisCloningGenesVaccinesSubunit vaccineVaccineChemical structureHumanImmunizationImmunologyReviewHumansImmunizationVaccinesSubunitMolecularModelsVaccinesStructural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine developmentarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Patarroyo M.E.Bermúdez A.Patarroyo M.A.10336/23654oai:repository.urosario.edu.co:10336/236542022-05-02 07:37:21.187978https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development |
title |
Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development |
spellingShingle |
Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development Class I Cloning and sequencing Cytokines Falciparum malaria Genes encoding Hepatic cells High affinity Immune systems Molecular levels Vaccine development Biosynthesis Cloning Genes Vaccines Subunit vaccine Vaccine Chemical structure Human Immunization Immunology Review Humans Immunization Vaccines Subunit Molecular Models Vaccines |
title_short |
Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development |
title_full |
Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development |
title_fullStr |
Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development |
title_full_unstemmed |
Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development |
title_sort |
Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development |
dc.subject.keyword.spa.fl_str_mv |
Class I Cloning and sequencing Cytokines Falciparum malaria Genes encoding Hepatic cells High affinity Immune systems Molecular levels Vaccine development Biosynthesis Cloning Genes Vaccines Subunit vaccine Vaccine Chemical structure Human Immunization Immunology Review Humans Immunization Vaccines |
topic |
Class I Cloning and sequencing Cytokines Falciparum malaria Genes encoding Hepatic cells High affinity Immune systems Molecular levels Vaccine development Biosynthesis Cloning Genes Vaccines Subunit vaccine Vaccine Chemical structure Human Immunization Immunology Review Humans Immunization Vaccines Subunit Molecular Models Vaccines |
dc.subject.keyword.eng.fl_str_mv |
Subunit Molecular Models Vaccines |
description |
Identifying the principles and rules for developing a logical, rational vaccine methodology against various diseases, is discussed. SPf66, the first multiantigenic, multistage, minimal subunit-based, chemically synthesized anti-P. falciparum malaria vaccine. A robust, sensitive, and specific methodology is developed for defining the intimate molecular interactions mediating merozoite invasion of RBC by synthesizing short merozoite-derived protein peptides binding specifically and with high affinity (HABP) to RBCs. Conserved HABP-mediated sporozoite binding to hepatic cells is identified in EBA-175 for developing a multiantigenic, multistage, fully protective antimalarial vaccine. for developing a logical and rational vaccine methodology at the molecular level, monkeys' immune system molecules is analyzed by cloning and sequencing the Aotus genes encoding immunoglobulins, cytokines, and Class I and II molecules. |
publishDate |
2011 |
dc.date.created.spa.fl_str_mv |
2011 |
dc.date.accessioned.none.fl_str_mv |
2020-05-26T00:04:04Z |
dc.date.available.none.fl_str_mv |
2020-05-26T00:04:04Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1021/cr100223m |
dc.identifier.issn.none.fl_str_mv |
15206890 00092665 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/23654 |
url |
https://doi.org/10.1021/cr100223m https://repository.urosario.edu.co/handle/10336/23654 |
identifier_str_mv |
15206890 00092665 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
3507 |
dc.relation.citationIssue.none.fl_str_mv |
No. 5 |
dc.relation.citationStartPage.none.fl_str_mv |
3459 |
dc.relation.citationTitle.none.fl_str_mv |
Chemical Reviews |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 111 |
dc.relation.ispartof.spa.fl_str_mv |
Chemical Reviews, ISSN:15206890, 00092665, Vol.111, No.5 (2011); pp. 3459-3507 |
dc.relation.uri.spa.fl_str_mv |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-79955897554&doi=10.1021%2fcr100223m&partnerID=40&md5=f90047bb18e44c278ecf94806db0d21b |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
institution |
Universidad del Rosario |
dc.source.instname.spa.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167680843776000 |