Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development

Identifying the principles and rules for developing a logical, rational vaccine methodology against various diseases, is discussed. SPf66, the first multiantigenic, multistage, minimal subunit-based, chemically synthesized anti-P. falciparum malaria vaccine. A robust, sensitive, and specific methodo...

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Autores:
Tipo de recurso:
Fecha de publicación:
2011
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23654
Acceso en línea:
https://doi.org/10.1021/cr100223m
https://repository.urosario.edu.co/handle/10336/23654
Palabra clave:
Class I
Cloning and sequencing
Cytokines
Falciparum malaria
Genes encoding
Hepatic cells
High affinity
Immune systems
Molecular levels
Vaccine development
Biosynthesis
Cloning
Genes
Vaccines
Subunit vaccine
Vaccine
Chemical structure
Human
Immunization
Immunology
Review
Humans
Immunization
Vaccines
Subunit
Molecular
Models
Vaccines
Rights
License
Abierto (Texto Completo)
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network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 76e03223-040d-4e46-864f-3bdecc8d2790-19aa21ff8-49a1-473b-b44a-21551d38c882-19fc64f6d-a903-48f1-ac2e-4e55fd2ed9af-12020-05-26T00:04:04Z2020-05-26T00:04:04Z2011Identifying the principles and rules for developing a logical, rational vaccine methodology against various diseases, is discussed. SPf66, the first multiantigenic, multistage, minimal subunit-based, chemically synthesized anti-P. falciparum malaria vaccine. A robust, sensitive, and specific methodology is developed for defining the intimate molecular interactions mediating merozoite invasion of RBC by synthesizing short merozoite-derived protein peptides binding specifically and with high affinity (HABP) to RBCs. Conserved HABP-mediated sporozoite binding to hepatic cells is identified in EBA-175 for developing a multiantigenic, multistage, fully protective antimalarial vaccine. for developing a logical and rational vaccine methodology at the molecular level, monkeys' immune system molecules is analyzed by cloning and sequencing the Aotus genes encoding immunoglobulins, cytokines, and Class I and II molecules.application/pdfhttps://doi.org/10.1021/cr100223m1520689000092665https://repository.urosario.edu.co/handle/10336/23654eng3507No. 53459Chemical ReviewsVol. 111Chemical Reviews, ISSN:15206890, 00092665, Vol.111, No.5 (2011); pp. 3459-3507https://www.scopus.com/inward/record.uri?eid=2-s2.0-79955897554&doi=10.1021%2fcr100223m&partnerID=40&md5=f90047bb18e44c278ecf94806db0d21bAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURClass ICloning and sequencingCytokinesFalciparum malariaGenes encodingHepatic cellsHigh affinityImmune systemsMolecular levelsVaccine developmentBiosynthesisCloningGenesVaccinesSubunit vaccineVaccineChemical structureHumanImmunizationImmunologyReviewHumansImmunizationVaccinesSubunitMolecularModelsVaccinesStructural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine developmentarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Patarroyo M.E.Bermúdez A.Patarroyo M.A.10336/23654oai:repository.urosario.edu.co:10336/236542022-05-02 07:37:21.187978https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development
title Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development
spellingShingle Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development
Class I
Cloning and sequencing
Cytokines
Falciparum malaria
Genes encoding
Hepatic cells
High affinity
Immune systems
Molecular levels
Vaccine development
Biosynthesis
Cloning
Genes
Vaccines
Subunit vaccine
Vaccine
Chemical structure
Human
Immunization
Immunology
Review
Humans
Immunization
Vaccines
Subunit
Molecular
Models
Vaccines
title_short Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development
title_full Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development
title_fullStr Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development
title_full_unstemmed Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development
title_sort Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development
dc.subject.keyword.spa.fl_str_mv Class I
Cloning and sequencing
Cytokines
Falciparum malaria
Genes encoding
Hepatic cells
High affinity
Immune systems
Molecular levels
Vaccine development
Biosynthesis
Cloning
Genes
Vaccines
Subunit vaccine
Vaccine
Chemical structure
Human
Immunization
Immunology
Review
Humans
Immunization
Vaccines
topic Class I
Cloning and sequencing
Cytokines
Falciparum malaria
Genes encoding
Hepatic cells
High affinity
Immune systems
Molecular levels
Vaccine development
Biosynthesis
Cloning
Genes
Vaccines
Subunit vaccine
Vaccine
Chemical structure
Human
Immunization
Immunology
Review
Humans
Immunization
Vaccines
Subunit
Molecular
Models
Vaccines
dc.subject.keyword.eng.fl_str_mv Subunit
Molecular
Models
Vaccines
description Identifying the principles and rules for developing a logical, rational vaccine methodology against various diseases, is discussed. SPf66, the first multiantigenic, multistage, minimal subunit-based, chemically synthesized anti-P. falciparum malaria vaccine. A robust, sensitive, and specific methodology is developed for defining the intimate molecular interactions mediating merozoite invasion of RBC by synthesizing short merozoite-derived protein peptides binding specifically and with high affinity (HABP) to RBCs. Conserved HABP-mediated sporozoite binding to hepatic cells is identified in EBA-175 for developing a multiantigenic, multistage, fully protective antimalarial vaccine. for developing a logical and rational vaccine methodology at the molecular level, monkeys' immune system molecules is analyzed by cloning and sequencing the Aotus genes encoding immunoglobulins, cytokines, and Class I and II molecules.
publishDate 2011
dc.date.created.spa.fl_str_mv 2011
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:04:04Z
dc.date.available.none.fl_str_mv 2020-05-26T00:04:04Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1021/cr100223m
dc.identifier.issn.none.fl_str_mv 15206890
00092665
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/23654
url https://doi.org/10.1021/cr100223m
https://repository.urosario.edu.co/handle/10336/23654
identifier_str_mv 15206890
00092665
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 3507
dc.relation.citationIssue.none.fl_str_mv No. 5
dc.relation.citationStartPage.none.fl_str_mv 3459
dc.relation.citationTitle.none.fl_str_mv Chemical Reviews
dc.relation.citationVolume.none.fl_str_mv Vol. 111
dc.relation.ispartof.spa.fl_str_mv Chemical Reviews, ISSN:15206890, 00092665, Vol.111, No.5 (2011); pp. 3459-3507
dc.relation.uri.spa.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-79955897554&doi=10.1021%2fcr100223m&partnerID=40&md5=f90047bb18e44c278ecf94806db0d21b
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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