Índice del perfil del donante renal (KDPI) como factor pronóstico del trasplante

La enfermedad renal crónica ha aumentado a nivel mundial y nacional, mientras que el número de donantes viene en descenso, y los pacientes en lista de espera aumentan. Los donantes cadavéricos son una opción para estos pacientes, y han sido utilizados en últimos años para aumentar los órganos dispon...

Full description

Autores:
Tipo de recurso:
Fecha de publicación:
2016
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
spa
OAI Identifier:
oai:repository.urosario.edu.co:10336/12210
Acceso en línea:
https://doi.org/10.48713/10336_12210
http://repository.urosario.edu.co/handle/10336/12210
Palabra clave:
KDPI
supervivencia del injerto
donante cadavérico
Trasplante Renal
Incidencia & prevención de la enfermedad
Epidemiología
Obtención de tejidos y órganos
Enfermedades renales
Epidemiología
Kidney donor profile index
KDPI
Graft survival
Cadaveric donor
Kidney transplantation
Epidemiología
Rights
License
Abierto (Texto completo)
id EDOCUR2_9fb0a1ac41a6b4b55dc7cf1c13f77c41
oai_identifier_str oai:repository.urosario.edu.co:10336/12210
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.spa.fl_str_mv Índice del perfil del donante renal (KDPI) como factor pronóstico del trasplante
title Índice del perfil del donante renal (KDPI) como factor pronóstico del trasplante
spellingShingle Índice del perfil del donante renal (KDPI) como factor pronóstico del trasplante
KDPI
supervivencia del injerto
donante cadavérico
Trasplante Renal
Incidencia & prevención de la enfermedad
Epidemiología
Obtención de tejidos y órganos
Enfermedades renales
Epidemiología
Kidney donor profile index
KDPI
Graft survival
Cadaveric donor
Kidney transplantation
Epidemiología
title_short Índice del perfil del donante renal (KDPI) como factor pronóstico del trasplante
title_full Índice del perfil del donante renal (KDPI) como factor pronóstico del trasplante
title_fullStr Índice del perfil del donante renal (KDPI) como factor pronóstico del trasplante
title_full_unstemmed Índice del perfil del donante renal (KDPI) como factor pronóstico del trasplante
title_sort Índice del perfil del donante renal (KDPI) como factor pronóstico del trasplante
dc.contributor.advisor.none.fl_str_mv Sanabria Rangel, José Mauricio
dc.subject.spa.fl_str_mv KDPI
supervivencia del injerto
donante cadavérico
Trasplante Renal
topic KDPI
supervivencia del injerto
donante cadavérico
Trasplante Renal
Incidencia & prevención de la enfermedad
Epidemiología
Obtención de tejidos y órganos
Enfermedades renales
Epidemiología
Kidney donor profile index
KDPI
Graft survival
Cadaveric donor
Kidney transplantation
Epidemiología
dc.subject.ddc.none.fl_str_mv Incidencia & prevención de la enfermedad
dc.subject.decs.spa.fl_str_mv Epidemiología
Obtención de tejidos y órganos
Enfermedades renales
Epidemiología
dc.subject.keyword.eng.fl_str_mv Kidney donor profile index
KDPI
Graft survival
Cadaveric donor
Kidney transplantation
dc.subject.lemb.spa.fl_str_mv Epidemiología
description La enfermedad renal crónica ha aumentado a nivel mundial y nacional, mientras que el número de donantes viene en descenso, y los pacientes en lista de espera aumentan. Los donantes cadavéricos son una opción para estos pacientes, y han sido utilizados en últimos años para aumentar los órganos disponibles. La evaluación de la calidad de estos es importante para optimizar su uso. Estudio analítico tipo cohorte retrospectiva, cálculo de KDPI en donantes cadavéricos, seguimiento función renal creatinina sérica 1 mes, 3 meses, 6 meses y un año. Correlación supervivencia del injerto, función renal, KDPI y EPTS. Análisis de supervivencia y regresión logística con variables del donante, receptor y acto quirúrgico.
publishDate 2016
dc.date.accessioned.none.fl_str_mv 2016-07-05T19:49:02Z
dc.date.available.none.fl_str_mv 2016-07-05T19:49:02Z
dc.date.created.none.fl_str_mv 2016-05-05
dc.date.issued.none.fl_str_mv 2016
dc.type.eng.fl_str_mv bachelorThesis
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.spa.spa.fl_str_mv Trabajo de grado
dc.identifier.doi.none.fl_str_mv https://doi.org/10.48713/10336_12210
dc.identifier.uri.none.fl_str_mv http://repository.urosario.edu.co/handle/10336/12210
url https://doi.org/10.48713/10336_12210
http://repository.urosario.edu.co/handle/10336/12210
dc.language.iso.none.fl_str_mv spa
language spa
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto completo)
dc.rights.cc.spa.fl_str_mv Atribución-SinDerivadas 2.5 Colombia
dc.rights.uri.none.fl_str_mv http://creativecommons.org/licenses/by-nd/2.5/co/
rights_invalid_str_mv Abierto (Texto completo)
Atribución-SinDerivadas 2.5 Colombia
http://creativecommons.org/licenses/by-nd/2.5/co/
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Universidad del Rosario
dc.publisher.department.spa.fl_str_mv Facultad de medicina
institution Universidad del Rosario
dc.source.bibliographicCitation.none.fl_str_mv 1. Niño Murcia M. Informe Trasplantes Colombia 2014. 2014.
2. Tedla FM, Friedman E a. The Trend Toward Geriatric Nephrology. Prim Care - Clin Off Pract. 2008;35(3):515–30.
3. Rao PS, Schaubel DE, Guidinger MK, Andreoni K a, Wolfe R a, Merion RM, et al. A comprehensive risk quantification score for deceased donor kidneys: the kidney donor risk index. Transplantation. 2009;88(2):231–6.
4. OPTN, SRTR, UNOS. A Guide to Calculating and Interpreting the Kidney Donor Profile Index ( KDPI ). 2012;1–12.
5. Niño Murcia M. Informe Trasplantes en Colombia 2013. 2013.
6. Instituto Nacional de Salud. Informe anual red donación y trasplantes. 2013;3:127.
7. Alberu J. Comercio de órganos en Latinoamérica.
8. Acuña L, Sanchez P, Soler L, Barrera A, Torres L, Casas L, et al. Situación ERC Colombia 2014 [Internet]. Bogotá, Colombia; 2015. Available from: http://www.cuentadealtocosto.org/byblos/Docs/SITUACION ECR COLOMBIA 2014.swf
9. Wolfe R, Ashby VB, Milford EL, Akinlolu O O, Ettenger RE, Agodoa LY, et al. Mortality in patients on dialysis and transplant recipients: comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first transplant. N Engl J Med. 1999;341(Number 23):1725–30.
10. Cameron JI, Whiteside C, Katz J, Devins GM. Differences in quality of life across renal replacement therapies: a meta-analytic comparison. Am J Kidney Dis. 2000;35(4):629–37.
11. Gill JS, Tonelli M, Johnson N, Kiberd B, Landsberg D, Pereira BJG. The impact of waiting time and comorbid conditions on the survival benefit of kidney transplantation. Kidney Int. 2005;68(5):2345–51.
12. Hernandez RA, Malek SK, Milford EL, Finlayson SRG, Tullius SG. The Combined Risk of Donor Quality and Recipient Age. Transplantation. 2014;98(10):1069–76
13. Merion RM, Ashby VB, Wolfe R a, Distant D a, Hulbert-Shearon TE, Metzger R a, et al. Deceased-donor characteristics and the survival benefit of kidney transplantation. JAMA. 2005;294(21):2726–33.
14. Matas AJ, Smith JM, Skeans MA, Thompson B, Gustafson SK, Stewart DE, et al. OPTN/SRTR 2013 Annual Data Report: 2013;
15. Matesanz Rafael. International Figures on Newsletter Transplant. 2013;
16. Salinas M. Informe anual Red de Donación y Trasplante. 2011.
17. Gandolfini I, Buzio C, Zanelli P, Palmisano A, Cremaschi E, Vaglio A, et al. The Kidney Donor Profile Index (KDPI) of Marginal Donors Allocated by Standardized Pretransplant Donor Biopsy Assessment: Distribution and Association With Graft Outcomes. Am J Transplant. 2014;14(11):2515–25.
18. Gupta A, Chen G, Kaplan B. KDPI and Donor Selection. Am J Transplant. 2014;14(11):2444–5.
19. Lee P.K. A, Abramowicz D. Is the Kidney Donor Risk Index a step forward in the assessment of deceased donor kidney quality? Nephrol Dial Transplant. 2014;1–6.
20. Mohamed N, Cornell LD. Donor Kidney Evaluation. Surg Pathol Clin. Elsevier Inc; 2014;7(3):357–65.
21. Massie a. B, Luo X, Chow EKH, Alejo JL, Desai NM, Segev DL. Survival Benefit of Primary Deceased Donor Transplantation With High-KDPI Kidneys. Am J Transplant. 2014;14(10):2310–6.
22. Metzger R a, Delmonico FL, Feng S, Port FK, Wynn JJ, Merion RM. Expanded criteria donors for kidney transplantation. Am J Transplant. 2003;3 Suppl 4:114–25.
23. Kasiske BL, Stewart DE, Bista BR, Salkowski N, Snyder JJ, Israni AK, et al. The role of procurement biopsies in acceptance decisions for kidneys retrieved for transplant. Clin J Am Soc Nephrol. 2014;9(3):562–71.
24. Hwang JK, Park SC, Kwon KH, Choi BS, Kim JI, Yang CW, et al. Long-term outcomes of kidney transplantation from expanded criteria deceased donors at a single center: Comparison with standard criteria deceased donors. Transplant Proc. Elsevier Inc.; 2014;46(2):431–6.
25. Tso PL. Access to renal transplantation for the elderly in the face of new allocation policy: A review of contemporary perspectives on “older” issues. Transplant Rev. Elsevier Inc.; 2014;28(1):6–14.
26. Kauffman H, Bennet L, McBride M, Ellison M. The Expanded Donor. Transplant Rev. 1997;II(4).
27. Messina M, Fop F, Gallo E, Tamagnone M, Segoloni GP. Analysis of four scoring systems and monocentric experience to optimize criteria for marginal kidney transplantation. Transplant Proc. Elsevier Inc.; 2010;42(6):2209–13.
28. Stratta RJ, Rohr MS, Sundberg AK, Farney AC, Hartmann EL, Moore PS, et al. Intermediate-term outcomes with expanded criteria deceased donors in kidney transplantation: a spectrum or specter of quality? Ann Surg. 2006;243(5):594–601; discussion 601–3.
29. Woodside KJ, Merion RM, Leichtman a. B, De Los Santos R, Arrington CJ, Rao PS, et al. Utilization of kidneys with similar kidney donor risk index values from standard versus expanded criteria donors. Am J Transplant. 2012;12(8):2106–14.
30. OPTN, SRTR, UNOS. A Guide to Calculating and Interpreting the Estimated Post-Transplant Survival ( EPTS ) Score Used in the Kidney Allocation System ( KAS ) A Guide to Calculating and Interpreting the Estimated Post-Transplant Survival ( EPTS ) Score Used in the Kidney All. :1–9.
31. Rao PS, Merion RM, Ashby VB, Port FK, Wolfe R a, Kayler LK. Renal transplantation in elderly patients older than 70 years of age: results from the Scientific Registry of Transplant Recipients. Transplantation. 2007;83(8):1069–74.
32. Huang E, Poommipanit N, Sampaio MS, Kuo H-T, Reddy P, Gritsch HA, et al. Intermediate-term outcomes associated with kidney transplantation in recipients 80 years and older: an analysis of the OPTN/UNOS database. Transplantation. 2010;90(9):974–9.
33. Meier-Kriesche H-U, Kaplan B. Waiting time on dialysis as the strongest modifiable risk factor for renal transplant outcomes: a paired donor kidney analysis. Transplantation. 2002;74(10):1377–81.
34. Baskin-Bey ES, Nyberg SL. Matching graft to recipient by predicted survival: can this be an acceptable strategy to improve utilization of deceased donor kidneys? Transplant Rev. 2008;22(3):167–70.
35. Arnau A, Rodrigo E, Miñambres E, Ruiz JC, Ballesteros MA, Piñera C, et al. Prediction of kidney transplant outcome by donor quality scoring systems: Expanded criteria donor and deceased donor score. Transplant Proc. Elsevier Inc.; 2012;44(9):2555–7.
36. Cecka JM, Cohen B, Rosendale J, Smith M. Could more effective use of kidneys recovered from older deceased donors result in more kidney transplants for older patients? Transplantation. 2006;81(7):966–70.
37. Tso PL, Dar WA, Henry ML. With respect to elderly patients: Finding kidneys in the context of new allocation concepts. Am J Transplant. 2012;12(5):1091–8.
38. Hopfer H, Kemény É. Assessment of donor biopsies. Curr Opin Organ Transplant. 2013;18(3):306–12.
39. Azancot MA, Moreso F, Salcedo M, Cantarell C, Perello M, Torres IB, et al. The reproducibility and predictive value on outcome of renal biopsies from expanded criteria donors. Kidney Int. 2013;1–8.
41. Siedlecki A, Irish W, Brennan DC. Delayed graft function in the kidney transplant. Am J Transplant. 2011;11(11):2279–96.
42. Remuzzi G, Grinyò J, Ruggenenti P, Beatini M, Cole EH, Milford EL, et al. Early experience with dual kidney transplantation in adults using expanded donor criteria. Double Kidney Transplant Group (DKG). J Am Soc Nephrol. 1999;10(12):2591–8.
43. Munivenkatappa RB, Schweitzer EJ, Papadimitriou JC, Drachenberg CB, Thom K a., Perencevich EN, et al. The Maryland Aggregate Pathology Index: A deceased donor kidney biopsy scoring system for predicting graft failure. Am J Transplant. 2008;8(11):2316–24.
44. Asociación Medica Mundial. Declaración de Helsinki- Principios éticos para las investigaciones médicas en seres humanos. ONU 2008.
45. DHHS. Reglamento DHHS 45 CFR 46. 2005.
46. Cubillos Gutiérrez J, Sandoval Riveros CL, Andrade Cerquera E, Hermida Gutiérrez NH. Causas que contribuyen a la pérdida del trasplante renal de donante cadavérico en la Fundación Surcolombiana de Trasplantes. Febrero 2007 a noviembre de 2012, Neiva, Colombia. Rev Colomb Anestesiol. 2014;2(2):83–9.
47. Poggio ED, Hila S, Stephany B, Goldfarb D, Herts B, Dennis VW, et al. Donor Kidney Volume and Outcomes Following Live Donor Kidney Transplantation. 2006;(August 2005):616–24.
48. Giral M, Nguyen JM, Karam G, Kessler M, Ligny BH De, Buchler M, et al. Impact of Graft Mass on the Clinical Outcome of Kidney Transplants. :261–8.
49. Kasiske BL, Snyder JONJ, Gilbertson D. Inadequate Donor Size in Cadaver Kidney Transplantation. 2002;2152–9.
50. Moreso F, Seron D, Anunciada A, Hueso M, Ramon JM, Fundallosa, Xavier, Gil-Vernet S, et al. Recipient body surface area as a predictor of posttransplant renal allograft evolution. Clin Transplant. 65(5):671–6.
51. Zhang X, Huang H, Han S, Fu S, Wang L. Alemtuzumab induction in renal transplantation: A meta-analysis and systemic review. Transpl Immunol. Elsevier B.V.; 2012;27(2-3):63–8.
52. Morgan R, O’Callaghan J, Knight S. Alemtuzumab Induction Therapy in Kidney Transplantation: A Systematic Review and Meta-Analysis. Transplantation. 2012;93(12):1179–88.
53. Instituto Nacional de Salud. Informe anual red donación y trasplantes. INS. 2014;1–138.
54. Ponticelli CE. The impact of cold ischemia time on renal transplant outcome. Kidney Int. Nature Publishing Group; 2015;87(2):272–5.
55. Carrier M, Lizé JF. Impact of expanded criteria donors on outcomes of recipients after kidney transplantation. Transplant Proc. Elsevier Inc.; 2012;44(7):2227–30.
56. Messina M, Fop F, Gallo E, Tamagnone M, Segoloni GP. Analysis of four scoring systems and monocentric experience to optimize criteria for marginal kidney transplantation. Transplant Proc [Internet]. Elsevier Inc.; 2010;42(6):2209–13. Available from: http://dx.doi.org/10.1016/j.transproceed.2010.05.038
57. Gobierno Colombia, Ministerio Protección Social. Decreto Número 2493 de 2004. 2005;2005(Diciembre 26):1–31.
58. Schaier M, Seissler N, Becker LE, Schaefer SM, Schmitt E, Meuer S, et al. The extent of HLA-DR expression on HLA-DR+ Tregs allows the identification of patients with clinically relevant borderline rejection. Transpl Int. 2013;26(3):290–9.
59. Willicombe M, Brookes P, Sergeant R, Santos-Nunez E, Steggar C, Galliford J, et al. De Novo DQ Donor-Specific Antibodies Are Associated With a Significant Risk of Antibody-Mediated Rejection and Transplant Glomerulopathy. Transplant J. 2012;94(2):172–7.
60. Cassuto J, Reese P, Sonnad S, Bloom R, Levine M, Olthoff K, et al. Wait List Death and Survival Benefit of Kidney Transplantation among Nonrenal Trasplant Recipients. Am J Transplant. 2010;(10):2502–11.
61. Forbes JM, Cooper ME. Mechanisms of Diabetic Complications. Physiol Rev. 2013;93(1):137–88
62. Wood KJ, Goto R. Mechanisms of Rejection: Current Perspectives. Transplantation. 2012;93(1):1–10.
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
bitstream.url.fl_str_mv https://repository.urosario.edu.co/bitstreams/8cedce6e-cac2-4fb4-a28e-4b98e93ff12a/download
https://repository.urosario.edu.co/bitstreams/8d3a5e40-467b-4e6e-83ab-a7337093a118/download
https://repository.urosario.edu.co/bitstreams/6615c194-048f-4989-afcd-dbb65eee5af5/download
https://repository.urosario.edu.co/bitstreams/1d5cb43f-550d-4aba-aa8d-2f8a1f8d5575/download
https://repository.urosario.edu.co/bitstreams/fc8d6dad-fdcd-41d1-9a6e-1c5a92a72c74/download
bitstream.checksum.fl_str_mv 440a7d69ed36952fe8ea69cf111da7a6
d6348b5a51d2fe37b2eb9f01d3ca43be
615d6cab244462ea2f78491db676870a
c6258f78afb1c3ec3a36d70d36a9624e
1db4bf58e0222443933a4f09199f28c5
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
_version_ 1808391041619853312
spelling Sanabria Rangel, José Mauricio80018291600Giron Luque, FernandoNiño Murcia, AlejandroNiño Torres, LauraSanabria Rangel, José MauricioEspecialista en Epidemiología (en Convenio con el CES)c3efcf97-9884-421c-881c-3bf4e8a4d4a92072d772-7891-48a8-b627-5a831b46a695eb9ce2b4-f3e6-4bac-9c76-8d0817a55587800182916002016-07-05T19:49:02Z2016-07-05T19:49:02Z2016-05-052016La enfermedad renal crónica ha aumentado a nivel mundial y nacional, mientras que el número de donantes viene en descenso, y los pacientes en lista de espera aumentan. Los donantes cadavéricos son una opción para estos pacientes, y han sido utilizados en últimos años para aumentar los órganos disponibles. La evaluación de la calidad de estos es importante para optimizar su uso. Estudio analítico tipo cohorte retrospectiva, cálculo de KDPI en donantes cadavéricos, seguimiento función renal creatinina sérica 1 mes, 3 meses, 6 meses y un año. Correlación supervivencia del injerto, función renal, KDPI y EPTS. Análisis de supervivencia y regresión logística con variables del donante, receptor y acto quirúrgico.End stage chronic kidney disease has been rising its numbers worldwide and nationally, meanwhile the number of organ donors has been showing a decrease in its numbers, and the wait-listed number of patients are growing every day. Cadaveric organ donors are a good option for these patients, and are used in order to increase the number of organs available for transplantation. The evaluation of the quality of these organs for transplantation is critical in order to optimize its use. This is a retrospective cohort study in which we calculated de Kidney Donor Profile Index (KDPI) in cadaveric organ donors, with creatinine follow up at 1 month, 3 months, 6 months and a year. We then analyzed graft survival, renal function, KDPI and EPTS. Finally, we analyzed graft and patient survival and a logistic regression using variables from de donor, recipient and surgical procedure.application/pdfhttps://doi.org/10.48713/10336_12210 http://repository.urosario.edu.co/handle/10336/12210spaUniversidad del RosarioFacultad de medicinaAbierto (Texto completo)Atribución-SinDerivadas 2.5 ColombiaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.http://creativecommons.org/licenses/by-nd/2.5/co/http://purl.org/coar/access_right/c_abf21. Niño Murcia M. Informe Trasplantes Colombia 2014. 2014.2. Tedla FM, Friedman E a. The Trend Toward Geriatric Nephrology. Prim Care - Clin Off Pract. 2008;35(3):515–30.3. Rao PS, Schaubel DE, Guidinger MK, Andreoni K a, Wolfe R a, Merion RM, et al. A comprehensive risk quantification score for deceased donor kidneys: the kidney donor risk index. Transplantation. 2009;88(2):231–6.4. OPTN, SRTR, UNOS. A Guide to Calculating and Interpreting the Kidney Donor Profile Index ( KDPI ). 2012;1–12.5. Niño Murcia M. Informe Trasplantes en Colombia 2013. 2013.6. Instituto Nacional de Salud. Informe anual red donación y trasplantes. 2013;3:127.7. Alberu J. Comercio de órganos en Latinoamérica.8. Acuña L, Sanchez P, Soler L, Barrera A, Torres L, Casas L, et al. Situación ERC Colombia 2014 [Internet]. Bogotá, Colombia; 2015. Available from: http://www.cuentadealtocosto.org/byblos/Docs/SITUACION ECR COLOMBIA 2014.swf9. Wolfe R, Ashby VB, Milford EL, Akinlolu O O, Ettenger RE, Agodoa LY, et al. Mortality in patients on dialysis and transplant recipients: comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first transplant. N Engl J Med. 1999;341(Number 23):1725–30.10. Cameron JI, Whiteside C, Katz J, Devins GM. Differences in quality of life across renal replacement therapies: a meta-analytic comparison. Am J Kidney Dis. 2000;35(4):629–37.11. Gill JS, Tonelli M, Johnson N, Kiberd B, Landsberg D, Pereira BJG. The impact of waiting time and comorbid conditions on the survival benefit of kidney transplantation. Kidney Int. 2005;68(5):2345–51.12. Hernandez RA, Malek SK, Milford EL, Finlayson SRG, Tullius SG. The Combined Risk of Donor Quality and Recipient Age. Transplantation. 2014;98(10):1069–7613. Merion RM, Ashby VB, Wolfe R a, Distant D a, Hulbert-Shearon TE, Metzger R a, et al. Deceased-donor characteristics and the survival benefit of kidney transplantation. JAMA. 2005;294(21):2726–33.14. Matas AJ, Smith JM, Skeans MA, Thompson B, Gustafson SK, Stewart DE, et al. OPTN/SRTR 2013 Annual Data Report: 2013;15. Matesanz Rafael. International Figures on Newsletter Transplant. 2013;16. Salinas M. Informe anual Red de Donación y Trasplante. 2011.17. Gandolfini I, Buzio C, Zanelli P, Palmisano A, Cremaschi E, Vaglio A, et al. The Kidney Donor Profile Index (KDPI) of Marginal Donors Allocated by Standardized Pretransplant Donor Biopsy Assessment: Distribution and Association With Graft Outcomes. Am J Transplant. 2014;14(11):2515–25.18. Gupta A, Chen G, Kaplan B. KDPI and Donor Selection. Am J Transplant. 2014;14(11):2444–5.19. Lee P.K. A, Abramowicz D. Is the Kidney Donor Risk Index a step forward in the assessment of deceased donor kidney quality? Nephrol Dial Transplant. 2014;1–6.20. Mohamed N, Cornell LD. Donor Kidney Evaluation. Surg Pathol Clin. Elsevier Inc; 2014;7(3):357–65.21. Massie a. B, Luo X, Chow EKH, Alejo JL, Desai NM, Segev DL. Survival Benefit of Primary Deceased Donor Transplantation With High-KDPI Kidneys. Am J Transplant. 2014;14(10):2310–6.22. Metzger R a, Delmonico FL, Feng S, Port FK, Wynn JJ, Merion RM. Expanded criteria donors for kidney transplantation. Am J Transplant. 2003;3 Suppl 4:114–25.23. Kasiske BL, Stewart DE, Bista BR, Salkowski N, Snyder JJ, Israni AK, et al. The role of procurement biopsies in acceptance decisions for kidneys retrieved for transplant. Clin J Am Soc Nephrol. 2014;9(3):562–71.24. Hwang JK, Park SC, Kwon KH, Choi BS, Kim JI, Yang CW, et al. Long-term outcomes of kidney transplantation from expanded criteria deceased donors at a single center: Comparison with standard criteria deceased donors. Transplant Proc. Elsevier Inc.; 2014;46(2):431–6.25. Tso PL. Access to renal transplantation for the elderly in the face of new allocation policy: A review of contemporary perspectives on “older” issues. Transplant Rev. Elsevier Inc.; 2014;28(1):6–14.26. Kauffman H, Bennet L, McBride M, Ellison M. The Expanded Donor. Transplant Rev. 1997;II(4).27. Messina M, Fop F, Gallo E, Tamagnone M, Segoloni GP. Analysis of four scoring systems and monocentric experience to optimize criteria for marginal kidney transplantation. Transplant Proc. Elsevier Inc.; 2010;42(6):2209–13.28. Stratta RJ, Rohr MS, Sundberg AK, Farney AC, Hartmann EL, Moore PS, et al. Intermediate-term outcomes with expanded criteria deceased donors in kidney transplantation: a spectrum or specter of quality? Ann Surg. 2006;243(5):594–601; discussion 601–3.29. Woodside KJ, Merion RM, Leichtman a. B, De Los Santos R, Arrington CJ, Rao PS, et al. Utilization of kidneys with similar kidney donor risk index values from standard versus expanded criteria donors. Am J Transplant. 2012;12(8):2106–14.30. OPTN, SRTR, UNOS. A Guide to Calculating and Interpreting the Estimated Post-Transplant Survival ( EPTS ) Score Used in the Kidney Allocation System ( KAS ) A Guide to Calculating and Interpreting the Estimated Post-Transplant Survival ( EPTS ) Score Used in the Kidney All. :1–9.31. Rao PS, Merion RM, Ashby VB, Port FK, Wolfe R a, Kayler LK. Renal transplantation in elderly patients older than 70 years of age: results from the Scientific Registry of Transplant Recipients. Transplantation. 2007;83(8):1069–74.32. Huang E, Poommipanit N, Sampaio MS, Kuo H-T, Reddy P, Gritsch HA, et al. Intermediate-term outcomes associated with kidney transplantation in recipients 80 years and older: an analysis of the OPTN/UNOS database. Transplantation. 2010;90(9):974–9.33. Meier-Kriesche H-U, Kaplan B. Waiting time on dialysis as the strongest modifiable risk factor for renal transplant outcomes: a paired donor kidney analysis. Transplantation. 2002;74(10):1377–81.34. Baskin-Bey ES, Nyberg SL. Matching graft to recipient by predicted survival: can this be an acceptable strategy to improve utilization of deceased donor kidneys? Transplant Rev. 2008;22(3):167–70.35. Arnau A, Rodrigo E, Miñambres E, Ruiz JC, Ballesteros MA, Piñera C, et al. Prediction of kidney transplant outcome by donor quality scoring systems: Expanded criteria donor and deceased donor score. Transplant Proc. Elsevier Inc.; 2012;44(9):2555–7.36. Cecka JM, Cohen B, Rosendale J, Smith M. Could more effective use of kidneys recovered from older deceased donors result in more kidney transplants for older patients? Transplantation. 2006;81(7):966–70.37. Tso PL, Dar WA, Henry ML. With respect to elderly patients: Finding kidneys in the context of new allocation concepts. Am J Transplant. 2012;12(5):1091–8.38. Hopfer H, Kemény É. Assessment of donor biopsies. Curr Opin Organ Transplant. 2013;18(3):306–12.39. Azancot MA, Moreso F, Salcedo M, Cantarell C, Perello M, Torres IB, et al. The reproducibility and predictive value on outcome of renal biopsies from expanded criteria donors. Kidney Int. 2013;1–8.41. Siedlecki A, Irish W, Brennan DC. Delayed graft function in the kidney transplant. Am J Transplant. 2011;11(11):2279–96.42. Remuzzi G, Grinyò J, Ruggenenti P, Beatini M, Cole EH, Milford EL, et al. Early experience with dual kidney transplantation in adults using expanded donor criteria. Double Kidney Transplant Group (DKG). J Am Soc Nephrol. 1999;10(12):2591–8.43. Munivenkatappa RB, Schweitzer EJ, Papadimitriou JC, Drachenberg CB, Thom K a., Perencevich EN, et al. The Maryland Aggregate Pathology Index: A deceased donor kidney biopsy scoring system for predicting graft failure. Am J Transplant. 2008;8(11):2316–24.44. Asociación Medica Mundial. Declaración de Helsinki- Principios éticos para las investigaciones médicas en seres humanos. ONU 2008.45. DHHS. Reglamento DHHS 45 CFR 46. 2005.46. Cubillos Gutiérrez J, Sandoval Riveros CL, Andrade Cerquera E, Hermida Gutiérrez NH. Causas que contribuyen a la pérdida del trasplante renal de donante cadavérico en la Fundación Surcolombiana de Trasplantes. Febrero 2007 a noviembre de 2012, Neiva, Colombia. Rev Colomb Anestesiol. 2014;2(2):83–9.47. Poggio ED, Hila S, Stephany B, Goldfarb D, Herts B, Dennis VW, et al. Donor Kidney Volume and Outcomes Following Live Donor Kidney Transplantation. 2006;(August 2005):616–24.48. Giral M, Nguyen JM, Karam G, Kessler M, Ligny BH De, Buchler M, et al. Impact of Graft Mass on the Clinical Outcome of Kidney Transplants. :261–8.49. Kasiske BL, Snyder JONJ, Gilbertson D. Inadequate Donor Size in Cadaver Kidney Transplantation. 2002;2152–9.50. Moreso F, Seron D, Anunciada A, Hueso M, Ramon JM, Fundallosa, Xavier, Gil-Vernet S, et al. Recipient body surface area as a predictor of posttransplant renal allograft evolution. Clin Transplant. 65(5):671–6.51. Zhang X, Huang H, Han S, Fu S, Wang L. Alemtuzumab induction in renal transplantation: A meta-analysis and systemic review. Transpl Immunol. Elsevier B.V.; 2012;27(2-3):63–8.52. Morgan R, O’Callaghan J, Knight S. Alemtuzumab Induction Therapy in Kidney Transplantation: A Systematic Review and Meta-Analysis. Transplantation. 2012;93(12):1179–88.53. Instituto Nacional de Salud. Informe anual red donación y trasplantes. INS. 2014;1–138.54. Ponticelli CE. The impact of cold ischemia time on renal transplant outcome. Kidney Int. Nature Publishing Group; 2015;87(2):272–5.55. Carrier M, Lizé JF. Impact of expanded criteria donors on outcomes of recipients after kidney transplantation. Transplant Proc. Elsevier Inc.; 2012;44(7):2227–30.56. Messina M, Fop F, Gallo E, Tamagnone M, Segoloni GP. Analysis of four scoring systems and monocentric experience to optimize criteria for marginal kidney transplantation. Transplant Proc [Internet]. Elsevier Inc.; 2010;42(6):2209–13. Available from: http://dx.doi.org/10.1016/j.transproceed.2010.05.03857. Gobierno Colombia, Ministerio Protección Social. Decreto Número 2493 de 2004. 2005;2005(Diciembre 26):1–31.58. Schaier M, Seissler N, Becker LE, Schaefer SM, Schmitt E, Meuer S, et al. The extent of HLA-DR expression on HLA-DR+ Tregs allows the identification of patients with clinically relevant borderline rejection. Transpl Int. 2013;26(3):290–9.59. Willicombe M, Brookes P, Sergeant R, Santos-Nunez E, Steggar C, Galliford J, et al. De Novo DQ Donor-Specific Antibodies Are Associated With a Significant Risk of Antibody-Mediated Rejection and Transplant Glomerulopathy. Transplant J. 2012;94(2):172–7.60. Cassuto J, Reese P, Sonnad S, Bloom R, Levine M, Olthoff K, et al. Wait List Death and Survival Benefit of Kidney Transplantation among Nonrenal Trasplant Recipients. Am J Transplant. 2010;(10):2502–11.61. Forbes JM, Cooper ME. Mechanisms of Diabetic Complications. Physiol Rev. 2013;93(1):137–8862. Wood KJ, Goto R. Mechanisms of Rejection: Current Perspectives. Transplantation. 2012;93(1):1–10.instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURKDPIsupervivencia del injertodonante cadavéricoTrasplante RenalIncidencia & prevención de la enfermedad614600EpidemiologíaObtención de tejidos y órganosEnfermedades renalesEpidemiologíaKidney donor profile indexKDPIGraft survivalCadaveric donorKidney transplantationEpidemiologíaÍndice del perfil del donante renal (KDPI) como factor pronóstico del trasplantebachelorThesisTrabajo de gradohttp://purl.org/coar/resource_type/c_7a1fORIGINALProyecto-de-grado-KDPI-Laura-Nino.pdfProyecto-de-grado-KDPI-Laura-Nino.pdfapplication/pdf1890390https://repository.urosario.edu.co/bitstreams/8cedce6e-cac2-4fb4-a28e-4b98e93ff12a/download440a7d69ed36952fe8ea69cf111da7a6MD54CC-LICENSElicense_rdflicense_rdfapplication/octet-stream1223https://repository.urosario.edu.co/bitstreams/8d3a5e40-467b-4e6e-83ab-a7337093a118/downloadd6348b5a51d2fe37b2eb9f01d3ca43beMD53LICENSElicense.txtlicense.txttext/plain2113https://repository.urosario.edu.co/bitstreams/6615c194-048f-4989-afcd-dbb65eee5af5/download615d6cab244462ea2f78491db676870aMD55TEXTProyecto-de-grado-KDPI-Laura-Nino.pdf.txtProyecto-de-grado-KDPI-Laura-Nino.pdf.txtExtracted texttext/plain178888https://repository.urosario.edu.co/bitstreams/1d5cb43f-550d-4aba-aa8d-2f8a1f8d5575/downloadc6258f78afb1c3ec3a36d70d36a9624eMD58THUMBNAILProyecto-de-grado-KDPI-Laura-Nino.pdf.jpgProyecto-de-grado-KDPI-Laura-Nino.pdf.jpgGenerated Thumbnailimage/jpeg2175https://repository.urosario.edu.co/bitstreams/fc8d6dad-fdcd-41d1-9a6e-1c5a92a72c74/download1db4bf58e0222443933a4f09199f28c5MD5910336/12210oai:repository.urosario.edu.co:10336/122102021-10-19 17:55:04.195http://creativecommons.org/licenses/by-nd/2.5/co/https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.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

Publicaciones similares