Fase inicial de una revisión sistemática de literatura sobre el uso de puntos de carbono en radioterapia

Las propiedades que sólo exhiben los materiales con dimensiones manométricas son el fundamento para el desarrollo o mejoría de diferentes aplicaciones biomédicas, como la radioterapia. Los nanomateriales ofrecen la posibilidad de hacer más eficiente esta forma de tratamiento, incrementando la radios...

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Tipo de recurso:
Fecha de publicación:
2020
Institución:
Universidad del Rosario
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Repositorio EdocUR - U. Rosario
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spa
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oai:repository.urosario.edu.co:10336/30705
Acceso en línea:
https://doi.org/10.48713/10336_30705
https://repository.urosario.edu.co/handle/10336/30705
Palabra clave:
Fototerapia
Radioterapia
Revisión de literatura
Aplicación medica de Nanomateriales
Nanotecnología en la medicina
Puntos de Carbono en terapia de radiación
Medicina experimental
Phototherapy
Radiotherapy
Literature Review
Nanomaterials medical application
Nanotechnology in medicine
Carbon points in radiation therapy
Rights
License
Atribución-SinDerivadas 2.5 Colombia
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oai_identifier_str oai:repository.urosario.edu.co:10336/30705
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.spa.fl_str_mv Fase inicial de una revisión sistemática de literatura sobre el uso de puntos de carbono en radioterapia
dc.title.TranslatedTitle.eng.fl_str_mv Initial phase of a systematic literature review on the use of carbon dots in radiotherapy
title Fase inicial de una revisión sistemática de literatura sobre el uso de puntos de carbono en radioterapia
spellingShingle Fase inicial de una revisión sistemática de literatura sobre el uso de puntos de carbono en radioterapia
Fototerapia
Radioterapia
Revisión de literatura
Aplicación medica de Nanomateriales
Nanotecnología en la medicina
Puntos de Carbono en terapia de radiación
Medicina experimental
Phototherapy
Radiotherapy
Literature Review
Nanomaterials medical application
Nanotechnology in medicine
Carbon points in radiation therapy
title_short Fase inicial de una revisión sistemática de literatura sobre el uso de puntos de carbono en radioterapia
title_full Fase inicial de una revisión sistemática de literatura sobre el uso de puntos de carbono en radioterapia
title_fullStr Fase inicial de una revisión sistemática de literatura sobre el uso de puntos de carbono en radioterapia
title_full_unstemmed Fase inicial de una revisión sistemática de literatura sobre el uso de puntos de carbono en radioterapia
title_sort Fase inicial de una revisión sistemática de literatura sobre el uso de puntos de carbono en radioterapia
dc.contributor.advisor.none.fl_str_mv Rodríguez Burbano, Diana Consuelo
Ondo Méndez, Alejandro Oyono
dc.subject.spa.fl_str_mv Fototerapia
Radioterapia
Revisión de literatura
Aplicación medica de Nanomateriales
Nanotecnología en la medicina
Puntos de Carbono en terapia de radiación
topic Fototerapia
Radioterapia
Revisión de literatura
Aplicación medica de Nanomateriales
Nanotecnología en la medicina
Puntos de Carbono en terapia de radiación
Medicina experimental
Phototherapy
Radiotherapy
Literature Review
Nanomaterials medical application
Nanotechnology in medicine
Carbon points in radiation therapy
dc.subject.ddc.spa.fl_str_mv Medicina experimental
dc.subject.keyword.spa.fl_str_mv Phototherapy
Radiotherapy
Literature Review
Nanomaterials medical application
Nanotechnology in medicine
Carbon points in radiation therapy
description Las propiedades que sólo exhiben los materiales con dimensiones manométricas son el fundamento para el desarrollo o mejoría de diferentes aplicaciones biomédicas, como la radioterapia. Los nanomateriales ofrecen la posibilidad de hacer más eficiente esta forma de tratamiento, incrementando la radiosensibilización. Los puntos de carbono son nanopartículas que poseen propiedades físicas, ópticas y químicas que las hacen atractivas para ser implementadas en radioterapia. Sin embargo, al ser un nanomaterial recientemente descubierto, existen muchos campos de la investigación biomédica, como la radioterapia, en los que su potencial uso debe ser estudiado. Este documento de práctica de investigación consta de la realización de la fase inicial de una revisión sistemática de literatura sobre el uso de estas nanopartículas basadas en carbono en radioterapia. Se describe la metodología seguida para identificar la bibliografía más relevante relacionada con el tema, se clasifican de acuerdo a las características principales de la síntesis del nanomaterial y se describe la tendencia actual de las publicaciones relacionadas con el tema objetivo. Es importante mencionar que, al ser la fase inicial de un proyecto de investigación, no se ha terminado y aún se sigue trabajando en éste.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-12-11T22:22:24Z
dc.date.available.none.fl_str_mv 2020-12-11T22:22:24Z
dc.date.created.none.fl_str_mv 2020-12-07
dc.type.eng.fl_str_mv bachelorThesis
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.document.spa.fl_str_mv Revisión de la literatura
dc.type.spa.spa.fl_str_mv Trabajo de grado
dc.identifier.doi.none.fl_str_mv https://doi.org/10.48713/10336_30705
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/30705
url https://doi.org/10.48713/10336_30705
https://repository.urosario.edu.co/handle/10336/30705
dc.language.iso.spa.fl_str_mv spa
language spa
dc.rights.spa.fl_str_mv Atribución-SinDerivadas 2.5 Colombia
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
dc.rights.uri.none.fl_str_mv http://creativecommons.org/licenses/by-nd/2.5/co/
rights_invalid_str_mv Atribución-SinDerivadas 2.5 Colombia
Abierto (Texto Completo)
http://creativecommons.org/licenses/by-nd/2.5/co/
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Universidad del Rosario
dc.publisher.department.spa.fl_str_mv Escuela de Medicina y Ciencias de la Salud
dc.publisher.program.spa.fl_str_mv Ingeniería Biomédica
institution Universidad del Rosario
dc.source.bibliographicCitation.spa.fl_str_mv P. Zhang, A. Darmon, N. Mohamed and S. Paris, "Radiotherapy-Activated Hafnium OxideNanoparticles Produce Abscopal Effect in a MouseColorectal Cancer Model", International Journal of Nanomedicine, vol. 15, pp. 3843-3850, 2020
R. Baskar, K. Lee, R. Yeo and K. Yeoh, "Cancer and Radiation Therapy: Current Advances and Future Directions", International Journal of Medical Sciences, vol. 9, no. 3, pp. 193-199, 2012
K. Haume et al., "Gold nanoparticles for cancer radiotherapy: a review", Cancer Nanotechnology, vol. 7, no. 1, 2016.
Radiotherapy Risk Profile. World Health Organization, 2008.
D. Kwatra, A. Venugopa and S. Anant, "Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer", Translational Cancer Research, vol. 2, no. 4, 2013.
B. Zhivotovsky, B. Joseph and S. Orrenius, "Tumor Radiosensitivity and Apoptosis", Experimental Cell Research, vol. 248, no. 1, pp. 10-17, 1999.
W. Garcia, "Radiosensibilidad y factores genéticos de riesgo en el cáncer de tiroides", Doctorado, Universidad Autónoma de Barcelona, 2012.
K. Cepeda Forero et al., "Radioresistencia en glioblastoma: papel de la hipoxia en la genotoxicidad inducida por radiaciones ionizantes", Ciencia e Investigación Medico Estudiantil Latinoamericana, vol. 23, no. 1, 2018.
J. Xie, L. Gong, S. Zhu, Y. Yong, Z. Gu and Y. Zhao, "Emerging Strategies of Nanomaterial‐Mediated Tumor Radiosensitization", Advanced Materials, vol. 31, no. 3, p. 1802244, 2018
S. Lim, W. Shen and Z. Gao, "Carbon quantum dots and their applications", Chemical Society Reviews, vol. 44, no. 1, pp. 362-381, 2015.
N. Kumar and S. Kumbhat, Essentials in nanoscience and nanotechnology. New Jersey, Canada: John Wiley & Sons, Inc., 2016.
M. Molaei, "Carbon quantum dots and their biomedical and therapeutic applications: a review", RSC Advances, vol. 9, no. 12, pp. 6460-6481, 2019.
M. Tuerhong, Y. XU and X. YIN, "Review on Carbon Dots and Their Applications", Chinese Journal of Analytical Chemistry, vol. 45, no. 1, pp. 139-150, 2017.
M. Abeloff, J. Niederhuber, J. Armitage and J. Tepper, Abeloff's Clinical oncology, 5 ed. Saunders, 2014, pp. 393-422.
M. Granados García, A. Martín and J. Hinojosa Gómez, Tratamiento del cáncer. Distrito Federal: Editorial El Manual Moderno, 2016.
M. Beyzadeoglu, G. Ozyigit and C. Ebruli, Basic Radiation Oncology, 1 ed. Springer-Verlag Berlin Heidelberg, 2010.
Horst Frank, Jailbird, Espectro electromagnético. 2016.
W. Potzel et al., "Interference Effects of Radiation Emitted from Nuclear Excitons", Hyperfine Interactions, vol. 151, pp. 263-281, 2003.
S. Bushong, Manual de radiología para técnicos, 11 ed. Barcelona: Elsevier, 2018, pp. 146-162.
M. Joiner and A. Kogel, Basic clinical radiobiology, 4 ed. Boca Raton: CRC Press/Taylor & Francis Group, 2009.
J. Verdú Rotellar, M. Algara López, P. Foro Arnalot, M. Domínguez Tarragona and A. Blanch Mon, "Atención a los efectos secundarios de la radioterapia", Medifam, vol. 12, no. 7, pp. 426-435, 2002.
P. Devi, S. Saini and K. Kim, "The advanced role of carbon quantum dots in nanomedical applications", Biosensors and Bioelectronics, vol. 141, pp. 1-17, 2019.
K. Ghosal and A. Ghosh, "Carbon dots: The next generation platform for biomedical applications", Materials Science and Engineering: C, vol. 96, pp. 887-903, 2019.
P. Chandra and R. Prakash (Eds.), Nanobiomaterial Engineering. Singapore: Springer Singapore, 2020, pp. 49-70.
S. Dufort et al., "Nebulized Gadolinium-Based Nanoparticles: A Theranostic Approach for Lung Tumor Imaging and Radiosensitization", Small, vol. 11, no. 2, pp. 215-221, 2014.
F. Ferriols Lisart and J. Pitarch Molina, "Principios de la fototerapia y su aplicación en el paciente oncológico", Farmacias Hospitalarias (Madrid), vol. 28, no. 3, pp. 75-83, 2004.
Biblioteca Nicolás Salmerón, La Ecuación de Búsqueda, Almería: Universidad de Almería.
L. Codina, "Ecuaciones de búsqueda: qué son y cómo se utilizan en bases de datos académicas · 1 - Operadores booleanos", Lluís Codina, 2017. [Online]. Available: https://www.lluiscodina.com/ecuaciones-de-busqueda-bases-datos-operadores-booleanos/. [Aceso: 06- Nov- 2020].
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Universidad Politécnica de Valencia, Guía general para búsquedas en bases de datos. Biblioteca y documentación científica, 2017
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F. Jiang et al., "Biocompatible CuO-decorated carbon nanoplatforms for multiplexed imaging and enhanced antitumor efficacy via combined photothermal therapy/chemodynamic therapy/chemotherapy", Science China Materials, vol. 63, no. 9, pp. 1818-1830, 2020.
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N. Irmania, K. Dehvari, G. Gedda, P. Tseng and J. Chang, "Manganese‐doped green tea‐derived carbon quantum dots as a targeted dual imaging and photodynamic therapy platform", Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 108, no. 4, pp. 1616-1625, 2020.
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M. Chowdhury, S. Sarkar and P. Das, "Photosensitizer Tailored Surface Functionalized Carbon Dots for Visible Light Induced Targeted Cancer Therapy", ACS Applied Bio Materials, vol. 2, no. 11, pp. 4953-4965, 2019.
Y. Zhao et al., "Facile Preparation of Double Rare Earth-Doped Carbon Dots for MRI/CT/FI Multimodal Imaging", ACS Applied Nano Materials, vol. 1, no. 6, pp. 2544-2551, 2018.
Z. Ji et al., "Manganese-Doped Carbon Dots for Magnetic Resonance/Optical Dual-Modal Imaging of Tiny Brain Glioma", ACS Biomaterials Science & Engineering, vol. 4, no. 6, pp. 2089-2094, 2018.
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spelling Rodríguez Burbano, Diana Consuelo52994699600Ondo Méndez, Alejandro Oyono79831981600Borja Vega, Alvaro JoseIngeniero BiomédicoFull time441d4bb3-5168-4ffa-877f-68f7d25f815c6002020-12-11T22:22:24Z2020-12-11T22:22:24Z2020-12-07Las propiedades que sólo exhiben los materiales con dimensiones manométricas son el fundamento para el desarrollo o mejoría de diferentes aplicaciones biomédicas, como la radioterapia. Los nanomateriales ofrecen la posibilidad de hacer más eficiente esta forma de tratamiento, incrementando la radiosensibilización. Los puntos de carbono son nanopartículas que poseen propiedades físicas, ópticas y químicas que las hacen atractivas para ser implementadas en radioterapia. Sin embargo, al ser un nanomaterial recientemente descubierto, existen muchos campos de la investigación biomédica, como la radioterapia, en los que su potencial uso debe ser estudiado. Este documento de práctica de investigación consta de la realización de la fase inicial de una revisión sistemática de literatura sobre el uso de estas nanopartículas basadas en carbono en radioterapia. Se describe la metodología seguida para identificar la bibliografía más relevante relacionada con el tema, se clasifican de acuerdo a las características principales de la síntesis del nanomaterial y se describe la tendencia actual de las publicaciones relacionadas con el tema objetivo. Es importante mencionar que, al ser la fase inicial de un proyecto de investigación, no se ha terminado y aún se sigue trabajando en éste.The properties that only materials with manometric dimensions exhibit are the basis for the development or improvement of different biomedical applications, such as radiotherapy. Nanomaterials offer the possibility of making this form of treatment more efficient by increasing radiosensitivity. Carbon dots are nanoparticles that possess physical, optical and chemical properties that make them attractive to be implemented in radiotherapy. However, as a newly discovered nanomaterial, there are many fields of biomedical research, such as radiotherapy, in which its potential use should be studied. This research practice document consists of the initial phase of a systematic literature review on the use of these carbon-based nanoparticles in radiotherapy. The methodology followed to identify the most relevant literature related to the topic is described, classified according to the main characteristics of the nanomaterial synthesis and the current trend of publications related to the target topic is detailed. It is important to mention that, as this is the initial phase of a research project, it has not been completed and work is still ongoing.application/pdfhttps://doi.org/10.48713/10336_30705 https://repository.urosario.edu.co/handle/10336/30705spaUniversidad del RosarioEscuela de Medicina y Ciencias de la SaludIngeniería BiomédicaAtribución-SinDerivadas 2.5 ColombiaAbierto (Texto Completo)EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.http://creativecommons.org/licenses/by-nd/2.5/co/http://purl.org/coar/access_right/c_abf2P. Zhang, A. Darmon, N. Mohamed and S. Paris, "Radiotherapy-Activated Hafnium OxideNanoparticles Produce Abscopal Effect in a MouseColorectal Cancer Model", International Journal of Nanomedicine, vol. 15, pp. 3843-3850, 2020R. Baskar, K. Lee, R. Yeo and K. Yeoh, "Cancer and Radiation Therapy: Current Advances and Future Directions", International Journal of Medical Sciences, vol. 9, no. 3, pp. 193-199, 2012K. Haume et al., "Gold nanoparticles for cancer radiotherapy: a review", Cancer Nanotechnology, vol. 7, no. 1, 2016.Radiotherapy Risk Profile. World Health Organization, 2008.D. Kwatra, A. Venugopa and S. Anant, "Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer", Translational Cancer Research, vol. 2, no. 4, 2013.B. Zhivotovsky, B. Joseph and S. Orrenius, "Tumor Radiosensitivity and Apoptosis", Experimental Cell Research, vol. 248, no. 1, pp. 10-17, 1999.W. Garcia, "Radiosensibilidad y factores genéticos de riesgo en el cáncer de tiroides", Doctorado, Universidad Autónoma de Barcelona, 2012.K. Cepeda Forero et al., "Radioresistencia en glioblastoma: papel de la hipoxia en la genotoxicidad inducida por radiaciones ionizantes", Ciencia e Investigación Medico Estudiantil Latinoamericana, vol. 23, no. 1, 2018.J. Xie, L. Gong, S. Zhu, Y. Yong, Z. Gu and Y. Zhao, "Emerging Strategies of Nanomaterial‐Mediated Tumor Radiosensitization", Advanced Materials, vol. 31, no. 3, p. 1802244, 2018S. Lim, W. Shen and Z. Gao, "Carbon quantum dots and their applications", Chemical Society Reviews, vol. 44, no. 1, pp. 362-381, 2015.N. Kumar and S. Kumbhat, Essentials in nanoscience and nanotechnology. New Jersey, Canada: John Wiley & Sons, Inc., 2016.M. Molaei, "Carbon quantum dots and their biomedical and therapeutic applications: a review", RSC Advances, vol. 9, no. 12, pp. 6460-6481, 2019.M. Tuerhong, Y. XU and X. YIN, "Review on Carbon Dots and Their Applications", Chinese Journal of Analytical Chemistry, vol. 45, no. 1, pp. 139-150, 2017.M. Abeloff, J. Niederhuber, J. Armitage and J. Tepper, Abeloff's Clinical oncology, 5 ed. Saunders, 2014, pp. 393-422.M. Granados García, A. Martín and J. Hinojosa Gómez, Tratamiento del cáncer. Distrito Federal: Editorial El Manual Moderno, 2016.M. Beyzadeoglu, G. Ozyigit and C. Ebruli, Basic Radiation Oncology, 1 ed. Springer-Verlag Berlin Heidelberg, 2010.Horst Frank, Jailbird, Espectro electromagnético. 2016.W. Potzel et al., "Interference Effects of Radiation Emitted from Nuclear Excitons", Hyperfine Interactions, vol. 151, pp. 263-281, 2003.S. Bushong, Manual de radiología para técnicos, 11 ed. Barcelona: Elsevier, 2018, pp. 146-162.M. Joiner and A. Kogel, Basic clinical radiobiology, 4 ed. Boca Raton: CRC Press/Taylor & Francis Group, 2009.J. Verdú Rotellar, M. Algara López, P. Foro Arnalot, M. Domínguez Tarragona and A. Blanch Mon, "Atención a los efectos secundarios de la radioterapia", Medifam, vol. 12, no. 7, pp. 426-435, 2002.P. Devi, S. Saini and K. Kim, "The advanced role of carbon quantum dots in nanomedical applications", Biosensors and Bioelectronics, vol. 141, pp. 1-17, 2019.K. Ghosal and A. Ghosh, "Carbon dots: The next generation platform for biomedical applications", Materials Science and Engineering: C, vol. 96, pp. 887-903, 2019.P. Chandra and R. Prakash (Eds.), Nanobiomaterial Engineering. Singapore: Springer Singapore, 2020, pp. 49-70.S. Dufort et al., "Nebulized Gadolinium-Based Nanoparticles: A Theranostic Approach for Lung Tumor Imaging and Radiosensitization", Small, vol. 11, no. 2, pp. 215-221, 2014.F. Ferriols Lisart and J. Pitarch Molina, "Principios de la fototerapia y su aplicación en el paciente oncológico", Farmacias Hospitalarias (Madrid), vol. 28, no. 3, pp. 75-83, 2004.Biblioteca Nicolás Salmerón, La Ecuación de Búsqueda, Almería: Universidad de Almería.L. Codina, "Ecuaciones de búsqueda: qué son y cómo se utilizan en bases de datos académicas · 1 - Operadores booleanos", Lluís Codina, 2017. [Online]. 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Zou et al., "Biomineralization-Inspired Synthesis of Cerium-Doped Carbonaceous Nanoparticles for Highly Hydroxyl Radical Scavenging Activity", Nanoscale Research Letters, vol. 13, no. 1, 2018.instname:Universidad del Rosarioinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURFototerapiaRadioterapiaRevisión de literaturaAplicación medica de NanomaterialesNanotecnología en la medicinaPuntos de Carbono en terapia de radiaciónMedicina experimental619600PhototherapyRadiotherapyLiterature ReviewNanomaterials medical applicationNanotechnology in medicineCarbon points in radiation therapyFase inicial de una revisión sistemática de literatura sobre el uso de puntos de carbono en radioterapiaInitial phase of a systematic literature review on the use of carbon dots in radiotherapybachelorThesisRevisión de la literaturaTrabajo de gradohttp://purl.org/coar/resource_type/c_7a1fEscuela de Medicina y Ciencias de la SaludORIGINALBorjaVega-AlvaroJose-2020.pdfBorjaVega-AlvaroJose-2020.pdfapplication/pdf1011686https://repository.urosario.edu.co/bitstreams/a568d9f6-ab6b-4bdf-85d9-09d0585929aa/downloadb9036a9d16301b7eaa6f45cef203a7bdMD51LICENSElicense.txtlicense.txttext/plain1475https://repository.urosario.edu.co/bitstreams/054806f1-5ec4-463e-b091-c5d0757a71de/downloadfab9d9ed61d64f6ac005dee3306ae77eMD52CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://repository.urosario.edu.co/bitstreams/34c463ba-44d2-41b0-b5ec-87d7f13fac72/downloaddab767be7a093b539031785b3bf95490MD53TEXTBorjaVega-AlvaroJose-2020.pdf.txtBorjaVega-AlvaroJose-2020.pdf.txtExtracted texttext/plain55942https://repository.urosario.edu.co/bitstreams/08c3b095-40b7-4650-9476-4df36965eb76/download58386daba8233d7fd31717c4170ee293MD54THUMBNAILBorjaVega-AlvaroJose-2020.pdf.jpgBorjaVega-AlvaroJose-2020.pdf.jpgGenerated Thumbnailimage/jpeg2569https://repository.urosario.edu.co/bitstreams/e94fed17-6239-455b-9f08-5953b6b7ab8e/download5f55871130ffa0051a3ba76618b076c3MD5510336/30705oai:repository.urosario.edu.co:10336/307052022-05-02 07:37:22.040074http://creativecommons.org/licenses/by-nd/2.5/co/Atribución-SinDerivadas 2.5 Colombiahttps://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.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