PROTECTIVE ROLE OF ACTIVATED PROTEIN C AGAINST APOPTOSIS IN NEURONAL AND ENDOTHELIAL MODELS
The neurodegenerative diseases are the result of the interaction of several factors that converge in neuronal death. Neuronalapoptosis is believe to have a mayor physiophatological role in this process which is accompanied by alterations in thevascular brain endothelium, contributing to alterations...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2009
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/28463
- Acceso en línea:
- https://doi.org/10.1111/j.1471-4159.2009.05818.x
https://repository.urosario.edu.co/handle/10336/28463
- Palabra clave:
- Neurodegenerative diseases
Neuronalapoptosis
Alterations in thevascular brain endothelium
Key regulator of neuronal survival/death equilibrium
Pathophysiology of neuronal death
- Rights
- License
- Abierto (Texto Completo)
| Summary: | The neurodegenerative diseases are the result of the interaction of several factors that converge in neuronal death. Neuronalapoptosis is believe to have a mayor physiophatological role in this process which is accompanied by alterations in thevascular brain endothelium, contributing to alterations in the blood-brain barrier, a key regulator of neuronal survival/death equilibrium. Increased levels of the sphingolipid ceramide have been described in diverse neurodegenerative disorders and following several cellular stress insults and is believe to contribute to thepathophysiology of neuronal death. |
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