Paracoccidioidomycosis: Latin America's own fungal disorder

Paracoccidioidomycosis (PCM) is a systemic, endemic fungal disorder restricted to Latin America (Mexico to Argentina); Brazil accounts for the largest number of cases. Imported cases diagnosed in North America, Europe and Asia represent patients who had previously lived in recognized endemic areas....

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Autores:
Tipo de recurso:
Fecha de publicación:
2012
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23805
Acceso en línea:
https://doi.org/10.1007/s12281-012-0114-x
https://repository.urosario.edu.co/handle/10336/23805
Palabra clave:
Amphotericin B
Amphotericin B deoxycholate
Amphotericin B lipid complex
Antifungal agent
Corticosteroid
Cotrimoxazole
Fluconazole
Fungus antigen
Itraconazole
Ketoconazole
Pyrrole derivative
Ribosome RNA
Sulfonamide
Voriconazole
Agriculture
Alcoholism
Antigen recognition
Article
Brazil
Cause of death
Clinical examination
Clinical feature
Complement fixation test
Conidium
Diagnostic test
Differential diagnosis
Disease course
Dot hybridization
Drug efficacy
Drug safety
Drug treatment failure
Environmental temperature
Enzyme linked immunosorbent assay
Fungal gene
Fungus culture
Fungus identification
Histopathology
Human
Immunodiffusion
Incidence
Loop mediated isothermal amplification
Lower respiratory tract infection
Lung fibrosis
Molecular diagnosis
Nonhuman
Nutrition
Occupational exposure
Paracoccidioides brasiliensis
Pneumonia
Quality of life
Race
Real time polymerase chain reaction
Recurrent infection
RNA gene
Sensitivity and specificity
Serodiagnosis
Sex difference
Smoking
South American blastomycosis
Survival
Unspecified side effect
Western blotting
Acute/subacute paracoccidioidomycosis
Chronic
Endemic areas
Laboratory diagnosis
Latency
Management
Paracoccidioides brasiliensis
Paracoccidioidomycosis
South American Blastomycosis
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Abierto (Texto Completo)
Description
Summary:Paracoccidioidomycosis (PCM) is a systemic, endemic fungal disorder restricted to Latin America (Mexico to Argentina); Brazil accounts for the largest number of cases. Imported cases diagnosed in North America, Europe and Asia represent patients who had previously lived in recognized endemic areas. Paracoccidioides brasiliensis, the etiologic agent, is a thermally dimorphic fungus that in patients and cultures at 37 C adopts a yeast form while at lower temperatures it behaves as a mold that bears the infectious conidia. PCM has a peculiar gender distribution with preference for adult males at a ratio of ?11 to 1. PCM afflicts predominantly adult males engaged in agriculture. It is mostly a chronic disease with acute/subacute cases accounting for less than 15 % of all reports. Specific diagnosis is established late and although available therapy is usually successful in controlling the fungal infection, patients who survive usually develop residual fibrotic lesions that heavily impair their quality of life. © 2012 Springer Science+Business Media New York.