Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women: a case-control study
Viruses have been implicated in cancer development in both humans and animals. The role of viruses in cancer is typically to initiate cellular transformation through cellular DNA damage, although specific mechanisms remain unknown. Silent and long-term viral infections need to be present, in order t...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2021
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/35217
- Acceso en línea:
- https://doi.org/10.1371/journal.pone.0257492
https://repository.urosario.edu.co/handle/10336/35217
- Palabra clave:
- Cáncer de mama
Factores de riesgo de cáncer
Cánceres y neoplasias
Tumores malignos
Reacción en cadena de la polimerasa
Virus y cáncer
Leucemia bovina
Polymerase chain reaction
Viruses and cancer
Ciencias médicas, Medicina
Enfermedades
Breast cancer
Cancer risk factors
Cancers and neoplasms
Malignant tumors
Bovine leukaemia
- Rights
- License
- Atribución-NoComercial-CompartirIgual 2.5 Colombia
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| dc.title.es.fl_str_mv |
Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women: a case-control study |
| dc.title.alternative.es.fl_str_mv |
Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women |
| title |
Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women: a case-control study |
| spellingShingle |
Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women: a case-control study Cáncer de mama Factores de riesgo de cáncer Cánceres y neoplasias Tumores malignos Reacción en cadena de la polimerasa Virus y cáncer Leucemia bovina Polymerase chain reaction Viruses and cancer Ciencias médicas, Medicina Enfermedades Breast cancer Cancer risk factors Cancers and neoplasms Malignant tumors Bovine leukaemia |
| title_short |
Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women: a case-control study |
| title_full |
Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women: a case-control study |
| title_fullStr |
Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women: a case-control study |
| title_full_unstemmed |
Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women: a case-control study |
| title_sort |
Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women: a case-control study |
| dc.subject.es.fl_str_mv |
Cáncer de mama Factores de riesgo de cáncer Cánceres y neoplasias Tumores malignos Reacción en cadena de la polimerasa Virus y cáncer Leucemia bovina Polymerase chain reaction Viruses and cancer |
| topic |
Cáncer de mama Factores de riesgo de cáncer Cánceres y neoplasias Tumores malignos Reacción en cadena de la polimerasa Virus y cáncer Leucemia bovina Polymerase chain reaction Viruses and cancer Ciencias médicas, Medicina Enfermedades Breast cancer Cancer risk factors Cancers and neoplasms Malignant tumors Bovine leukaemia |
| dc.subject.ddc.es.fl_str_mv |
Ciencias médicas, Medicina Enfermedades |
| dc.subject.keyword.es.fl_str_mv |
Breast cancer Cancer risk factors Cancers and neoplasms Malignant tumors Bovine leukaemia |
| description |
Viruses have been implicated in cancer development in both humans and animals. The role of viruses in cancer is typically to initiate cellular transformation through cellular DNA damage, although specific mechanisms remain unknown. Silent and long-term viral infections need to be present, in order to initiate cancer disease. In efforts to establish a causative role of viruses, first is needed to demonstrate the strength and consistency of associations in different populations. The aim of this study was to determine the association of bovine leukemia virus (BLV), a causative agent of leukemia in cattle, with breast cancer and its biomarkers used as prognosis of the severity of the disease (Ki67, HER2, hormonal receptors) in Colombian women. An unmatched, observational case–control study was conducted among women undergoing breast surgery between 2016–2018. Malignant samples (n = 75) were considered as cases and benign samples (n = 83) as controls. Nested-liquid PCR, in-situ PCR and immunohistochemistry were used for viral detection in blood and breast tissues. For the risk assessment, only BLV positive samples from breast tissues were included in the analysis. BLV was higher in cases group (61.3%) compared with controls (48.2%), with a statistically significant association between the virus and breast cancer in the unconditional logistic regression (adjusted-OR = 2.450,95%CI:1.088–5.517, p = 0.031). In this study, BLV was found in both blood and breast tissues of participants and an association between breast cancer and the virus was confirmed in Colombia, as an intermediate risk factor. |
| publishDate |
2021 |
| dc.date.created.none.fl_str_mv |
2021-09-21 |
| dc.date.issued.none.fl_str_mv |
2021-09-21 |
| dc.date.accessioned.none.fl_str_mv |
2022-09-02T15:59:58Z |
| dc.date.available.none.fl_str_mv |
2022-09-02T15:59:58Z |
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article |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_6501 |
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Artículo |
| dc.identifier.doi.es.fl_str_mv |
https://doi.org/10.1371/journal.pone.0257492 |
| dc.identifier.issn.es.fl_str_mv |
1932-6203 |
| dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/35217 |
| url |
https://doi.org/10.1371/journal.pone.0257492 https://repository.urosario.edu.co/handle/10336/35217 |
| identifier_str_mv |
1932-6203 |
| dc.language.iso.es.fl_str_mv |
eng |
| language |
eng |
| dc.relation.uri.es.fl_str_mv |
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0257492 |
| dc.rights.*.fl_str_mv |
Atribución-NoComercial-CompartirIgual 2.5 Colombia |
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http://purl.org/coar/access_right/c_abf2 |
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Abierto (Texto Completo) |
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http://creativecommons.org/licenses/by-nc-sa/2.5/co/ |
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18 pp |
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Universidad del Rosario |
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a36ff56a-0a2b-4c5f-86cb-eeb76e12d44a60070cbd6c8-99fc-4ad1-9a33-c74bda24e570600d96dedee-6c1d-49dd-8dc7-a2776b34ceec60079457397600117f8f04-d94b-44a3-a98c-c0690c4bf0bc60057ec6e01-37db-4ed6-b052-7f543b2991636001bd67a36-30ba-4f81-918d-5b4a1c926490600d28c2ce6-7108-4ab5-9b98-0190948665a0600642f44a2-14c1-4dee-978d-9447e872b6886007965306560039cd18a8-5df8-463d-b612-20d9f886a09a6001f16fa35-3181-43c8-a1da-4f43ac6304166002022-09-02T15:59:58Z2022-09-02T15:59:58Z2021-09-212021-09-21Viruses have been implicated in cancer development in both humans and animals. The role of viruses in cancer is typically to initiate cellular transformation through cellular DNA damage, although specific mechanisms remain unknown. Silent and long-term viral infections need to be present, in order to initiate cancer disease. In efforts to establish a causative role of viruses, first is needed to demonstrate the strength and consistency of associations in different populations. The aim of this study was to determine the association of bovine leukemia virus (BLV), a causative agent of leukemia in cattle, with breast cancer and its biomarkers used as prognosis of the severity of the disease (Ki67, HER2, hormonal receptors) in Colombian women. An unmatched, observational case–control study was conducted among women undergoing breast surgery between 2016–2018. Malignant samples (n = 75) were considered as cases and benign samples (n = 83) as controls. Nested-liquid PCR, in-situ PCR and immunohistochemistry were used for viral detection in blood and breast tissues. For the risk assessment, only BLV positive samples from breast tissues were included in the analysis. BLV was higher in cases group (61.3%) compared with controls (48.2%), with a statistically significant association between the virus and breast cancer in the unconditional logistic regression (adjusted-OR = 2.450,95%CI:1.088–5.517, p = 0.031). In this study, BLV was found in both blood and breast tissues of participants and an association between breast cancer and the virus was confirmed in Colombia, as an intermediate risk factor.Los virus se han implicado en el desarrollo del cáncer tanto en humanos como en animales. El papel de los virus en el cáncer suele ser iniciar la transformación celular a través del daño del ADN celular, aunque se desconocen los mecanismos específicos. Las infecciones virales silenciosas ya largo plazo deben estar presentes para iniciar la enfermedad del cáncer. En los esfuerzos por establecer un papel causal de los virus, primero se necesita demostrar la fuerza y consistencia de las asociaciones en diferentes poblaciones. El objetivo de este estudio fue determinar la asociación del virus de la leucemia bovina (BLV), agente causal de la leucemia en bovinos, con el cáncer de mama y sus biomarcadores utilizados como pronóstico de la gravedad de la enfermedad (Ki67, HER2, receptores hormonales) en mujeres colombianas. Se realizó un estudio observacional de casos y controles sin igual entre mujeres que se sometieron a cirugía de mama entre 2016 y 2018. Las muestras malignas (n = 75) se consideraron casos y las muestras benignas (n = 83) como controles. Se utilizaron PCR líquida anidada, PCR in situ e inmunohistoquímica para la detección viral en sangre y tejidos mamarios. Para la evaluación de riesgos, solo se incluyeron en el análisis muestras positivas para BLV de tejidos mamarios. El BLV fue mayor en el grupo de casos (61,3 %) en comparación con los controles (48,2 %), con una asociación estadísticamente significativa entre el virus y el cáncer de mama en la regresión logística incondicional (OR ajustado = 2,450, IC del 95 %: 1,088–5,517, p = 0,031). En este estudio, se encontró BLV tanto en la sangre como en los tejidos mamarios de las participantes y se confirmó una asociación entre el cáncer de mama y el virus en Colombia, como un factor de riesgo intermedio.18 ppapplication/pdfhttps://doi.org/10.1371/journal.pone.02574921932-6203https://repository.urosario.edu.co/handle/10336/35217enghttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0257492Atribución-NoComercial-CompartirIgual 2.5 ColombiaAbierto (Texto Completo)EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.http://creativecommons.org/licenses/by-nc-sa/2.5/co/http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURCáncer de mamaFactores de riesgo de cáncerCánceres y neoplasiasTumores malignosReacción en cadena de la polimerasaVirus y cáncerLeucemia bovinaPolymerase chain reactionViruses and cancerCiencias médicas, Medicina610600Enfermedades616600Breast cancerCancer risk factorsCancers and neoplasmsMalignant tumorsBovine leukaemiaRisk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women: a case-control studyRisk factor for breast cancer development under exposure to bovine leukemia virus in Colombian womenarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Olaya-Galan, Nury-NathaliaSalas Cárdenas, Sandra P.Rodriguez Sarmiento, Jorge L.Ibáñez Pinilla, MilcíadesMonroy, RicardoCorredor Figueroa, Adriana P.Rubiano, WilsonShen, HuaMinBuehring, Gertrude C.Patarroyo, Manuel A.Gutierrez, Maria F.salas cardenas patriciaORIGINALRisk-factor-for-breast-cancer.pdfRisk-factor-for-breast-cancer.pdfapplication/pdf764482https://repository.urosario.edu.co/bitstreams/ce693d7f-2bab-4b85-8948-f0d000f50203/download4541508e6a548a0ca87c508cec47f20aMD51LICENSElicense.txtlicense.txttext/plain1475https://repository.urosario.edu.co/bitstreams/be7b179a-d843-4025-bbde-24c517ec401b/downloadfab9d9ed61d64f6ac005dee3306ae77eMD52CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81037https://repository.urosario.edu.co/bitstreams/3d4b35e7-c3db-4694-af7b-7bd0b858e0d3/download1487462a1490a8fc01f5999ce7b3b9ccMD53TEXTRisk-factor-for-breast-cancer.pdf.txtRisk-factor-for-breast-cancer.pdf.txtExtracted texttext/plain69791https://repository.urosario.edu.co/bitstreams/c5a3a2ec-cf7e-4b2d-a4df-1474df529c53/download0577340cf4e525ccfa77b1f46ee8b379MD54THUMBNAILRisk-factor-for-breast-cancer.pdf.jpgRisk-factor-for-breast-cancer.pdf.jpgGenerated Thumbnailimage/jpeg4373https://repository.urosario.edu.co/bitstreams/131528c0-039a-4b13-a6d7-7ee6e7d8b8ff/download0f42b36456fb4cf9a9de6724bd12da19MD5510336/35217oai:repository.urosario.edu.co:10336/352172022-09-06 03:04:50.612http://creativecommons.org/licenses/by-nc-sa/2.5/co/Atribución-NoComercial-CompartirIgual 2.5 Colombiahttps://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.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 |