Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life
Previous studies have demonstrated that the intake of a 1% conjugated linoleic acid (CLA) diet in an 80:20 mixture of cis-9,trans-11 and trans-10,cis-12 exerts age-specific effects on the immune system: immunoglobulin enhancement and proliferative down-modulation in neonatal and adult rats, respecti...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2011
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/27647
- Acceso en línea:
- https://doi.org/10.1016/j.jnutbio.2010.04.005
https://repository.urosario.edu.co/handle/10336/27647
- Palabra clave:
- Conjugated linoleic acid
Early life
Immunoglobulin synthesis
Lymphocyte proliferation
- Rights
- License
- Restringido (Acceso a grupos específicos)
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oai:repository.urosario.edu.co:10336/27647 |
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52483526600766aab37-8e0a-4ef7-80a0-30e5a3b3aa181577a2f9-5391-4494-9736-17daded5076df0690d40-51c4-41a7-b90c-8d2e3d4e45db27331a50-730b-4136-9048-9032a7d852ceb1a11603-1780-430d-b877-00ae151ab80137126581-ba07-499a-b785-14b322dfae662020-08-19T14:43:08Z2020-08-19T14:43:08Z2011-05-01Previous studies have demonstrated that the intake of a 1% conjugated linoleic acid (CLA) diet in an 80:20 mixture of cis-9,trans-11 and trans-10,cis-12 exerts age-specific effects on the immune system: immunoglobulin enhancement and proliferative down-modulation in neonatal and adult rats, respectively. The present study evaluates the influence of the same diet on antibody synthesis of early infant Wistar rats during suckling and/or after weaning. Dietary supplementation was performed during suckling and early infancy (4 weeks), only during suckling (3 weeks), or only in early infancy (1 week). CLA content in plasma and serum immunoglobulin (Ig) G, IgM and IgA concentration were determined. Proliferation, cytokines and Ig production were evaluated on isolated splenocytes. Cis-9,trans-11- and trans-10,cis-12-CLA isomers were detected in the plasma of all CLA-supplemented animals, and the highest content was quantified in those rats supplemented over the longest period. These rats also exhibited higher concentrations of serum IgG, IgM and IgA. Moreover, splenocytes from CLA-supplemented rats showed the highest IgM and IgG synthesis and interleukin (IL)-6 production, whereas their proliferative ability was lower. In summary, in infant rats, we observed both the enhance antibody synthesis previously reported in neonates, and the reduced lymphoproliferation previously reported in adults.application/pdfhttps://doi.org/10.1016/j.jnutbio.2010.04.005ISSN: 0955-2863EISSN: 1873-4847https://repository.urosario.edu.co/handle/10336/27647engElsevier501No. 5495Journal of Nutritional BiochemistryVol. 22Journal of Nutritional Biochemistry, ISSN: 0955-2863;EISSN: 1873-4847, Vol.22, No.5 (2011); pp. 495-501https://www.sciencedirect.com/science/article/abs/pii/S0955286310001038?via%3DihubRestringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecJournal of Nutritional Biochemistryinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURConjugated linoleic acidEarly lifeImmunoglobulin synthesisLymphocyte proliferationEnhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early lifeMejora de la síntesis de anticuerpos en ratas mediante la alimentación con ácido linoleico conjugado cis-9, trans-11 durante la vida tempranaarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Ramírez Santana, Heily CarolinaCastellote, CristinaCastella, MargaridaMoltó-Puigmartí, CarolinaRivero, MontserratPérez-Cano, Francisco J.Franch, Àngels10336/27647oai:repository.urosario.edu.co:10336/276472021-10-06 23:02:22.482https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life |
dc.title.TranslatedTitle.spa.fl_str_mv |
Mejora de la síntesis de anticuerpos en ratas mediante la alimentación con ácido linoleico conjugado cis-9, trans-11 durante la vida temprana |
title |
Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life |
spellingShingle |
Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life Conjugated linoleic acid Early life Immunoglobulin synthesis Lymphocyte proliferation |
title_short |
Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life |
title_full |
Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life |
title_fullStr |
Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life |
title_full_unstemmed |
Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life |
title_sort |
Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life |
dc.subject.keyword.spa.fl_str_mv |
Conjugated linoleic acid Early life Immunoglobulin synthesis Lymphocyte proliferation |
topic |
Conjugated linoleic acid Early life Immunoglobulin synthesis Lymphocyte proliferation |
description |
Previous studies have demonstrated that the intake of a 1% conjugated linoleic acid (CLA) diet in an 80:20 mixture of cis-9,trans-11 and trans-10,cis-12 exerts age-specific effects on the immune system: immunoglobulin enhancement and proliferative down-modulation in neonatal and adult rats, respectively. The present study evaluates the influence of the same diet on antibody synthesis of early infant Wistar rats during suckling and/or after weaning. Dietary supplementation was performed during suckling and early infancy (4 weeks), only during suckling (3 weeks), or only in early infancy (1 week). CLA content in plasma and serum immunoglobulin (Ig) G, IgM and IgA concentration were determined. Proliferation, cytokines and Ig production were evaluated on isolated splenocytes. Cis-9,trans-11- and trans-10,cis-12-CLA isomers were detected in the plasma of all CLA-supplemented animals, and the highest content was quantified in those rats supplemented over the longest period. These rats also exhibited higher concentrations of serum IgG, IgM and IgA. Moreover, splenocytes from CLA-supplemented rats showed the highest IgM and IgG synthesis and interleukin (IL)-6 production, whereas their proliferative ability was lower. In summary, in infant rats, we observed both the enhance antibody synthesis previously reported in neonates, and the reduced lymphoproliferation previously reported in adults. |
publishDate |
2011 |
dc.date.created.spa.fl_str_mv |
2011-05-01 |
dc.date.accessioned.none.fl_str_mv |
2020-08-19T14:43:08Z |
dc.date.available.none.fl_str_mv |
2020-08-19T14:43:08Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.jnutbio.2010.04.005 |
dc.identifier.issn.none.fl_str_mv |
ISSN: 0955-2863 EISSN: 1873-4847 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/27647 |
url |
https://doi.org/10.1016/j.jnutbio.2010.04.005 https://repository.urosario.edu.co/handle/10336/27647 |
identifier_str_mv |
ISSN: 0955-2863 EISSN: 1873-4847 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
501 |
dc.relation.citationIssue.none.fl_str_mv |
No. 5 |
dc.relation.citationStartPage.none.fl_str_mv |
495 |
dc.relation.citationTitle.none.fl_str_mv |
Journal of Nutritional Biochemistry |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 22 |
dc.relation.ispartof.spa.fl_str_mv |
Journal of Nutritional Biochemistry, ISSN: 0955-2863;EISSN: 1873-4847, Vol.22, No.5 (2011); pp. 495-501 |
dc.relation.uri.spa.fl_str_mv |
https://www.sciencedirect.com/science/article/abs/pii/S0955286310001038?via%3Dihub |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_16ec |
dc.rights.acceso.spa.fl_str_mv |
Restringido (Acceso a grupos específicos) |
rights_invalid_str_mv |
Restringido (Acceso a grupos específicos) http://purl.org/coar/access_right/c_16ec |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Elsevier |
dc.source.spa.fl_str_mv |
Journal of Nutritional Biochemistry |
institution |
Universidad del Rosario |
dc.source.instname.none.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.none.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167734103048192 |