Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life

Previous studies have demonstrated that the intake of a 1% conjugated linoleic acid (CLA) diet in an 80:20 mixture of cis-9,trans-11 and trans-10,cis-12 exerts age-specific effects on the immune system: immunoglobulin enhancement and proliferative down-modulation in neonatal and adult rats, respecti...

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Fecha de publicación:
2011
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/27647
Acceso en línea:
https://doi.org/10.1016/j.jnutbio.2010.04.005
https://repository.urosario.edu.co/handle/10336/27647
Palabra clave:
Conjugated linoleic acid
Early life
Immunoglobulin synthesis
Lymphocyte proliferation
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id EDOCUR2_952e39760ea0c314b85b3ad05c0fd170
oai_identifier_str oai:repository.urosario.edu.co:10336/27647
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 52483526600766aab37-8e0a-4ef7-80a0-30e5a3b3aa181577a2f9-5391-4494-9736-17daded5076df0690d40-51c4-41a7-b90c-8d2e3d4e45db27331a50-730b-4136-9048-9032a7d852ceb1a11603-1780-430d-b877-00ae151ab80137126581-ba07-499a-b785-14b322dfae662020-08-19T14:43:08Z2020-08-19T14:43:08Z2011-05-01Previous studies have demonstrated that the intake of a 1% conjugated linoleic acid (CLA) diet in an 80:20 mixture of cis-9,trans-11 and trans-10,cis-12 exerts age-specific effects on the immune system: immunoglobulin enhancement and proliferative down-modulation in neonatal and adult rats, respectively. The present study evaluates the influence of the same diet on antibody synthesis of early infant Wistar rats during suckling and/or after weaning. Dietary supplementation was performed during suckling and early infancy (4 weeks), only during suckling (3 weeks), or only in early infancy (1 week). CLA content in plasma and serum immunoglobulin (Ig) G, IgM and IgA concentration were determined. Proliferation, cytokines and Ig production were evaluated on isolated splenocytes. Cis-9,trans-11- and trans-10,cis-12-CLA isomers were detected in the plasma of all CLA-supplemented animals, and the highest content was quantified in those rats supplemented over the longest period. These rats also exhibited higher concentrations of serum IgG, IgM and IgA. Moreover, splenocytes from CLA-supplemented rats showed the highest IgM and IgG synthesis and interleukin (IL)-6 production, whereas their proliferative ability was lower. In summary, in infant rats, we observed both the enhance antibody synthesis previously reported in neonates, and the reduced lymphoproliferation previously reported in adults.application/pdfhttps://doi.org/10.1016/j.jnutbio.2010.04.005ISSN: 0955-2863EISSN: 1873-4847https://repository.urosario.edu.co/handle/10336/27647engElsevier501No. 5495Journal of Nutritional BiochemistryVol. 22Journal of Nutritional Biochemistry, ISSN: 0955-2863;EISSN: 1873-4847, Vol.22, No.5 (2011); pp. 495-501https://www.sciencedirect.com/science/article/abs/pii/S0955286310001038?via%3DihubRestringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecJournal of Nutritional Biochemistryinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURConjugated linoleic acidEarly lifeImmunoglobulin synthesisLymphocyte proliferationEnhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early lifeMejora de la síntesis de anticuerpos en ratas mediante la alimentación con ácido linoleico conjugado cis-9, trans-11 durante la vida tempranaarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Ramírez Santana, Heily CarolinaCastellote, CristinaCastella, MargaridaMoltó-Puigmartí, CarolinaRivero, MontserratPérez-Cano, Francisco J.Franch, Àngels10336/27647oai:repository.urosario.edu.co:10336/276472021-10-06 23:02:22.482https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life
dc.title.TranslatedTitle.spa.fl_str_mv Mejora de la síntesis de anticuerpos en ratas mediante la alimentación con ácido linoleico conjugado cis-9, trans-11 durante la vida temprana
title Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life
spellingShingle Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life
Conjugated linoleic acid
Early life
Immunoglobulin synthesis
Lymphocyte proliferation
title_short Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life
title_full Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life
title_fullStr Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life
title_full_unstemmed Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life
title_sort Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life
dc.subject.keyword.spa.fl_str_mv Conjugated linoleic acid
Early life
Immunoglobulin synthesis
Lymphocyte proliferation
topic Conjugated linoleic acid
Early life
Immunoglobulin synthesis
Lymphocyte proliferation
description Previous studies have demonstrated that the intake of a 1% conjugated linoleic acid (CLA) diet in an 80:20 mixture of cis-9,trans-11 and trans-10,cis-12 exerts age-specific effects on the immune system: immunoglobulin enhancement and proliferative down-modulation in neonatal and adult rats, respectively. The present study evaluates the influence of the same diet on antibody synthesis of early infant Wistar rats during suckling and/or after weaning. Dietary supplementation was performed during suckling and early infancy (4 weeks), only during suckling (3 weeks), or only in early infancy (1 week). CLA content in plasma and serum immunoglobulin (Ig) G, IgM and IgA concentration were determined. Proliferation, cytokines and Ig production were evaluated on isolated splenocytes. Cis-9,trans-11- and trans-10,cis-12-CLA isomers were detected in the plasma of all CLA-supplemented animals, and the highest content was quantified in those rats supplemented over the longest period. These rats also exhibited higher concentrations of serum IgG, IgM and IgA. Moreover, splenocytes from CLA-supplemented rats showed the highest IgM and IgG synthesis and interleukin (IL)-6 production, whereas their proliferative ability was lower. In summary, in infant rats, we observed both the enhance antibody synthesis previously reported in neonates, and the reduced lymphoproliferation previously reported in adults.
publishDate 2011
dc.date.created.spa.fl_str_mv 2011-05-01
dc.date.accessioned.none.fl_str_mv 2020-08-19T14:43:08Z
dc.date.available.none.fl_str_mv 2020-08-19T14:43:08Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.jnutbio.2010.04.005
dc.identifier.issn.none.fl_str_mv ISSN: 0955-2863
EISSN: 1873-4847
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/27647
url https://doi.org/10.1016/j.jnutbio.2010.04.005
https://repository.urosario.edu.co/handle/10336/27647
identifier_str_mv ISSN: 0955-2863
EISSN: 1873-4847
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 501
dc.relation.citationIssue.none.fl_str_mv No. 5
dc.relation.citationStartPage.none.fl_str_mv 495
dc.relation.citationTitle.none.fl_str_mv Journal of Nutritional Biochemistry
dc.relation.citationVolume.none.fl_str_mv Vol. 22
dc.relation.ispartof.spa.fl_str_mv Journal of Nutritional Biochemistry, ISSN: 0955-2863;EISSN: 1873-4847, Vol.22, No.5 (2011); pp. 495-501
dc.relation.uri.spa.fl_str_mv https://www.sciencedirect.com/science/article/abs/pii/S0955286310001038?via%3Dihub
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_16ec
dc.rights.acceso.spa.fl_str_mv Restringido (Acceso a grupos específicos)
rights_invalid_str_mv Restringido (Acceso a grupos específicos)
http://purl.org/coar/access_right/c_16ec
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Elsevier
dc.source.spa.fl_str_mv Journal of Nutritional Biochemistry
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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