Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region
Background: We estimated the proportion of cervical intraepithelial neoplasia (CIN) cases attributed to 14 HPV types, including quadrivalent (qHPV) (6/11/16/18) and 9-valent (9vHPV) (6/11/16/18/31/33/45/52/58) vaccine types, by region. Methods: Women ages 15-26 and 24-45 years from 5 regions were en...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2016
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/18903
- Acceso en línea:
- https://doi.org/10.1016/j.pvr.2016.03.002
http://repository.urosario.edu.co/handle/10336/18903
- Palabra clave:
- Human papillomavirus
Cervical cancer
Cervical intraepithelial neoplasia
Adenocarcinoma in situ
Enfermedades
Wart Virus Vaccine
Adenocarcinoma In Situ
Age Distribution
Article
Condyloma Acuminatum
Genotype
Geographic Distribution
Health Program
Human
Human Papillomavirus Type 11
Human Papillomavirus Type 16
Human Papillomavirus Type 18
Human Papillomavirus Type 31
Human Papillomavirus Type 33
Human Papillomavirus Type 45
Human Papillomavirus Type 52
Human Papillomavirus Type 58
Human Papillomavirus Type 6
Immunization
Infection Risk
Mixed Infection
Molecular Epidemiology
Nonhuman
Prevalence
Priority Journal
Systematic Review
Uterine Cervix Carcinoma In Situ
Virus Detection
Wart Virus
Adenocarcinoma
Adolescent
Adult
Asia
Classification
Europe
Female
Genetics
Isolation And Purification
Middle Aged
North America
Papillomaviridae
Randomized Controlled Trial (Topic)
South And Central America
Uterine Cervix Carcinoma In Situ
Virology
Young Adult
Adenocarcinoma
Adolescent
Adult
Asia
Cervical Intraepithelial Neoplasia
Europe
Female
Genotype
Humans
Latin America
Middle Aged
North America
Papillomaviridae
Randomized Controlled Trials As Topic
Young Adult
Papiloma
Neoplasmas
Adenocarcinoma in Situ
- Rights
- License
- Abierto (Texto Completo)
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dc.title.spa.fl_str_mv |
Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region |
title |
Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region |
spellingShingle |
Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region Human papillomavirus Cervical cancer Cervical intraepithelial neoplasia Adenocarcinoma in situ Enfermedades Wart Virus Vaccine Adenocarcinoma In Situ Age Distribution Article Condyloma Acuminatum Genotype Geographic Distribution Health Program Human Human Papillomavirus Type 11 Human Papillomavirus Type 16 Human Papillomavirus Type 18 Human Papillomavirus Type 31 Human Papillomavirus Type 33 Human Papillomavirus Type 45 Human Papillomavirus Type 52 Human Papillomavirus Type 58 Human Papillomavirus Type 6 Immunization Infection Risk Mixed Infection Molecular Epidemiology Nonhuman Prevalence Priority Journal Systematic Review Uterine Cervix Carcinoma In Situ Virus Detection Wart Virus Adenocarcinoma Adolescent Adult Asia Classification Europe Female Genetics Isolation And Purification Middle Aged North America Papillomaviridae Randomized Controlled Trial (Topic) South And Central America Uterine Cervix Carcinoma In Situ Virology Young Adult Adenocarcinoma Adolescent Adult Asia Cervical Intraepithelial Neoplasia Europe Female Genotype Humans Latin America Middle Aged North America Papillomaviridae Randomized Controlled Trials As Topic Young Adult Papiloma Neoplasmas Adenocarcinoma in Situ |
title_short |
Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region |
title_full |
Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region |
title_fullStr |
Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region |
title_full_unstemmed |
Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region |
title_sort |
Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region |
dc.subject.spa.fl_str_mv |
Human papillomavirus Cervical cancer Cervical intraepithelial neoplasia Adenocarcinoma in situ |
topic |
Human papillomavirus Cervical cancer Cervical intraepithelial neoplasia Adenocarcinoma in situ Enfermedades Wart Virus Vaccine Adenocarcinoma In Situ Age Distribution Article Condyloma Acuminatum Genotype Geographic Distribution Health Program Human Human Papillomavirus Type 11 Human Papillomavirus Type 16 Human Papillomavirus Type 18 Human Papillomavirus Type 31 Human Papillomavirus Type 33 Human Papillomavirus Type 45 Human Papillomavirus Type 52 Human Papillomavirus Type 58 Human Papillomavirus Type 6 Immunization Infection Risk Mixed Infection Molecular Epidemiology Nonhuman Prevalence Priority Journal Systematic Review Uterine Cervix Carcinoma In Situ Virus Detection Wart Virus Adenocarcinoma Adolescent Adult Asia Classification Europe Female Genetics Isolation And Purification Middle Aged North America Papillomaviridae Randomized Controlled Trial (Topic) South And Central America Uterine Cervix Carcinoma In Situ Virology Young Adult Adenocarcinoma Adolescent Adult Asia Cervical Intraepithelial Neoplasia Europe Female Genotype Humans Latin America Middle Aged North America Papillomaviridae Randomized Controlled Trials As Topic Young Adult Papiloma Neoplasmas Adenocarcinoma in Situ |
dc.subject.ddc.spa.fl_str_mv |
Enfermedades |
dc.subject.decs.spa.fl_str_mv |
Wart Virus Vaccine Adenocarcinoma In Situ Age Distribution Article Condyloma Acuminatum Genotype Geographic Distribution Health Program Human Human Papillomavirus Type 11 Human Papillomavirus Type 16 Human Papillomavirus Type 18 Human Papillomavirus Type 31 Human Papillomavirus Type 33 Human Papillomavirus Type 45 Human Papillomavirus Type 52 Human Papillomavirus Type 58 Human Papillomavirus Type 6 Immunization Infection Risk Mixed Infection Molecular Epidemiology Nonhuman Prevalence Priority Journal Systematic Review Uterine Cervix Carcinoma In Situ Virus Detection Wart Virus Adenocarcinoma Adolescent Adult Asia Classification Europe Female Genetics Isolation And Purification Middle Aged North America Papillomaviridae Randomized Controlled Trial (Topic) South And Central America Uterine Cervix Carcinoma In Situ Virology Young Adult Adenocarcinoma Adolescent Adult Asia Cervical Intraepithelial Neoplasia Europe Female Genotype Humans Latin America Middle Aged North America Papillomaviridae Randomized Controlled Trials As Topic Young Adult |
dc.subject.lemb.spa.fl_str_mv |
Papiloma Neoplasmas Adenocarcinoma in Situ |
description |
Background: We estimated the proportion of cervical intraepithelial neoplasia (CIN) cases attributed to 14 HPV types, including quadrivalent (qHPV) (6/11/16/18) and 9-valent (9vHPV) (6/11/16/18/31/33/45/52/58) vaccine types, by region. Methods: Women ages 15-26 and 24-45 years from 5 regions were enrolled in qHPV vaccine clinical trials. Among 10,706 women (placebo arms), 1539 CIN1, 945 CIN2/3, and 24 adenocarcinoma in situ (AIS) cases were diagnosed by pathology panel consensus. Results: Predominant HPV types were 16/51/52/56 (anogenital infection), 16/39/51/52/56 (CIN1), and 16/31/52/58 (CIN2/3). In regions with largest sample sizes, minimal regional variation was observed in 9vHPV type prevalence in CIN1 (~50%) and CIN2/3 (81-85%). Types 31/33/45/52/58 accounted for 25-30% of CIN1 in Latin America and Europe, but 14-18% in North America and Asia. Types 31/33/45/52/58 accounted for 33-38% of CIN2/3 in Latin America (younger women), Europe, and Asia, but 17-18% of CIN2/3 in Latin America (older women) and North America. Non-vaccine HPV types 35/39/51/56/59 had similar or higher prevalence than qHPV types in CIN1 and were attributed to 2-11% of CIN2/3. Conclusions: The 9vHPV vaccine could potentially prevent the majority of CIN1-3, irrespective of geographic region. Notwithstanding, non-vaccine types 35/39/51/56/59 may still be responsible for some CIN1, and to a lesser extent CIN2/3. © 2016 The Authors. |
publishDate |
2016 |
dc.date.created.none.fl_str_mv |
2016 |
dc.date.issued.none.fl_str_mv |
2016 |
dc.date.accessioned.none.fl_str_mv |
2019-01-22T16:23:31Z |
dc.date.available.none.fl_str_mv |
2019-01-22T16:23:31Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.pvr.2016.03.002 |
dc.identifier.issn.none.fl_str_mv |
ISSN 2405-8521 |
dc.identifier.uri.none.fl_str_mv |
http://repository.urosario.edu.co/handle/10336/18903 |
url |
https://doi.org/10.1016/j.pvr.2016.03.002 http://repository.urosario.edu.co/handle/10336/18903 |
identifier_str_mv |
ISSN 2405-8521 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
69 |
dc.relation.citationStartPage.none.fl_str_mv |
61 |
dc.relation.citationTitle.none.fl_str_mv |
Papillomavirus Research |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 2 |
dc.relation.ispartof.spa.fl_str_mv |
Papillomavirus Research, ISSN: 2405-8521, Vol. 2 (2016) pp. 61-69 |
dc.relation.uri.spa.fl_str_mv |
https://www.sciencedirect.com/science/article/pii/S2405852116000045 |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
dc.rights.cc.spa.fl_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
rights_invalid_str_mv |
Abierto (Texto Completo) https://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
institution |
Universidad del Rosario |
dc.source.bibliographicCitation.spa.fl_str_mv |
Joura, E.A., Giuliano, A.R., Iversen, O.E., Bouchard, C., Mao, C., Mehlsen, J., A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women (2015) N. Engl. J. Med., 372, pp. 711-723 |
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reponame:Repositorio Institucional EdocUR |
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Methods: Women ages 15-26 and 24-45 years from 5 regions were enrolled in qHPV vaccine clinical trials. Among 10,706 women (placebo arms), 1539 CIN1, 945 CIN2/3, and 24 adenocarcinoma in situ (AIS) cases were diagnosed by pathology panel consensus. Results: Predominant HPV types were 16/51/52/56 (anogenital infection), 16/39/51/52/56 (CIN1), and 16/31/52/58 (CIN2/3). In regions with largest sample sizes, minimal regional variation was observed in 9vHPV type prevalence in CIN1 (~50%) and CIN2/3 (81-85%). Types 31/33/45/52/58 accounted for 25-30% of CIN1 in Latin America and Europe, but 14-18% in North America and Asia. Types 31/33/45/52/58 accounted for 33-38% of CIN2/3 in Latin America (younger women), Europe, and Asia, but 17-18% of CIN2/3 in Latin America (older women) and North America. Non-vaccine HPV types 35/39/51/56/59 had similar or higher prevalence than qHPV types in CIN1 and were attributed to 2-11% of CIN2/3. Conclusions: The 9vHPV vaccine could potentially prevent the majority of CIN1-3, irrespective of geographic region. Notwithstanding, non-vaccine types 35/39/51/56/59 may still be responsible for some CIN1, and to a lesser extent CIN2/3. © 2016 The Authors.application/pdfhttps://doi.org/10.1016/j.pvr.2016.03.002ISSN 2405-8521http://repository.urosario.edu.co/handle/10336/18903eng6961Papillomavirus ResearchVol. 2Papillomavirus Research, ISSN: 2405-8521, Vol. 2 (2016) pp. 61-69https://www.sciencedirect.com/science/article/pii/S2405852116000045Abierto (Texto Completo)https://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Joura, E.A., Giuliano, A.R., Iversen, O.E., Bouchard, C., Mao, C., Mehlsen, J., A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women (2015) N. Engl. J. Med., 372, pp. 711-723instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURHuman papillomavirusCervical cancerCervical intraepithelial neoplasiaAdenocarcinoma in situEnfermedades616600Wart Virus VaccineAdenocarcinoma In SituAge DistributionArticleCondyloma AcuminatumGenotypeGeographic DistributionHealth ProgramHumanHuman Papillomavirus Type 11Human Papillomavirus Type 16Human Papillomavirus Type 18Human Papillomavirus Type 31Human Papillomavirus Type 33Human Papillomavirus Type 45Human Papillomavirus Type 52Human Papillomavirus Type 58Human Papillomavirus Type 6ImmunizationInfection RiskMixed InfectionMolecular EpidemiologyNonhumanPrevalencePriority JournalSystematic ReviewUterine Cervix Carcinoma In SituVirus DetectionWart VirusAdenocarcinomaAdolescentAdultAsiaClassificationEuropeFemaleGeneticsIsolation And PurificationMiddle AgedNorth AmericaPapillomaviridaeRandomized Controlled Trial (Topic)South And Central AmericaUterine Cervix Carcinoma In SituVirologyYoung AdultAdenocarcinomaAdolescentAdultAsiaCervical Intraepithelial NeoplasiaEuropeFemaleGenotypeHumansLatin AmericaMiddle AgedNorth AmericaPapillomaviridaeRandomized Controlled Trials As TopicYoung AdultPapilomaNeoplasmasAdenocarcinoma in SituHuman papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by regionarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Castellsagué, XavierAult, Kevin A.Bosch, F. XavierBrown, DarronCuzick, JackFerris, Daron G.Joura, Elmar A.Garland, Suzanne M.Giuliano, Anna RHernandez-Avila, MauricioHuh, WarnerIversen, Ole-ErikKjaer, Susanne K.Luna, JoaquinMonsonego, JosephMuñoz, NubiaMyers, EvanPaavonen, JormaPitisuttihum, PunneeSteben, MarcWheeler, Cosette M.Perez, GonzaloSaah, AlfredPitisuttihum, PunneeSteben, MarcWheeler, Cosette M.Perez, GonzaloSaah, AlfredLuxembourg, AlainSings, Heather LVelicer, ChristineCastellsagué, XavierAult, Kevin A.Bosch, F. XavierBrown, DarronCuzick, JackFerris, Daron G.Joura, Elmar A.Garland, Suzanne M.Giuliano, Anna RHernandez-Avila, MauricioHuh, WarnerIversen, Ole-ErikKjaer, Susanne K.Luna, JoaquinMonsonego, JosephMuñoz, NubiaMyers, EvanPaavonen, JormaPitisuttihum, PunneeSteben, MarcWheeler, Cosette M.Perez, GonzaloSaah, AlfredPitisuttihum, PunneeSteben, MarcWheeler, Cosette M.Perez, GonzaloSaah, AlfredLuxembourg, AlainSings, Heather LVelicer, ChristineORIGINAL53.pdfapplication/pdf1850621https://repository.urosario.edu.co/bitstreams/b744c9a3-e861-40b1-a4fe-0c19c09490f3/download79ebfcb5db32e3ed599352136240f348MD51TEXT53.pdf.txt53.pdf.txtExtracted texttext/plain46169https://repository.urosario.edu.co/bitstreams/f1da3829-c214-44ac-a0f0-15589e0db525/downloadcda9b74b6e2e8e7e0b2752275ed7da1eMD52THUMBNAIL53.pdf.jpg53.pdf.jpgGenerated Thumbnailimage/jpeg4466https://repository.urosario.edu.co/bitstreams/c28a0d39-0c84-4219-b559-fcdcd8b99758/downloadea22fc069e4a97f4ebb621958a25328aMD5310336/18903oai:repository.urosario.edu.co:10336/189032021-03-26 09:24:55.837https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |