Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region

Background: We estimated the proportion of cervical intraepithelial neoplasia (CIN) cases attributed to 14 HPV types, including quadrivalent (qHPV) (6/11/16/18) and 9-valent (9vHPV) (6/11/16/18/31/33/45/52/58) vaccine types, by region. Methods: Women ages 15-26 and 24-45 years from 5 regions were en...

Full description

Autores:
Tipo de recurso:
Fecha de publicación:
2016
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/18903
Acceso en línea:
https://doi.org/10.1016/j.pvr.2016.03.002
http://repository.urosario.edu.co/handle/10336/18903
Palabra clave:
Human papillomavirus
Cervical cancer
Cervical intraepithelial neoplasia
Adenocarcinoma in situ
Enfermedades
Wart Virus Vaccine
Adenocarcinoma In Situ
Age Distribution
Article
Condyloma Acuminatum
Genotype
Geographic Distribution
Health Program
Human
Human Papillomavirus Type 11
Human Papillomavirus Type 16
Human Papillomavirus Type 18
Human Papillomavirus Type 31
Human Papillomavirus Type 33
Human Papillomavirus Type 45
Human Papillomavirus Type 52
Human Papillomavirus Type 58
Human Papillomavirus Type 6
Immunization
Infection Risk
Mixed Infection
Molecular Epidemiology
Nonhuman
Prevalence
Priority Journal
Systematic Review
Uterine Cervix Carcinoma In Situ
Virus Detection
Wart Virus
Adenocarcinoma
Adolescent
Adult
Asia
Classification
Europe
Female
Genetics
Isolation And Purification
Middle Aged
North America
Papillomaviridae
Randomized Controlled Trial (Topic)
South And Central America
Uterine Cervix Carcinoma In Situ
Virology
Young Adult
Adenocarcinoma
Adolescent
Adult
Asia
Cervical Intraepithelial Neoplasia
Europe
Female
Genotype
Humans
Latin America
Middle Aged
North America
Papillomaviridae
Randomized Controlled Trials As Topic
Young Adult
Papiloma
Neoplasmas
Adenocarcinoma in Situ
Rights
License
Abierto (Texto Completo)
id EDOCUR2_939c2a29074b61b7d16a907b76083227
oai_identifier_str oai:repository.urosario.edu.co:10336/18903
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.spa.fl_str_mv Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region
title Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region
spellingShingle Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region
Human papillomavirus
Cervical cancer
Cervical intraepithelial neoplasia
Adenocarcinoma in situ
Enfermedades
Wart Virus Vaccine
Adenocarcinoma In Situ
Age Distribution
Article
Condyloma Acuminatum
Genotype
Geographic Distribution
Health Program
Human
Human Papillomavirus Type 11
Human Papillomavirus Type 16
Human Papillomavirus Type 18
Human Papillomavirus Type 31
Human Papillomavirus Type 33
Human Papillomavirus Type 45
Human Papillomavirus Type 52
Human Papillomavirus Type 58
Human Papillomavirus Type 6
Immunization
Infection Risk
Mixed Infection
Molecular Epidemiology
Nonhuman
Prevalence
Priority Journal
Systematic Review
Uterine Cervix Carcinoma In Situ
Virus Detection
Wart Virus
Adenocarcinoma
Adolescent
Adult
Asia
Classification
Europe
Female
Genetics
Isolation And Purification
Middle Aged
North America
Papillomaviridae
Randomized Controlled Trial (Topic)
South And Central America
Uterine Cervix Carcinoma In Situ
Virology
Young Adult
Adenocarcinoma
Adolescent
Adult
Asia
Cervical Intraepithelial Neoplasia
Europe
Female
Genotype
Humans
Latin America
Middle Aged
North America
Papillomaviridae
Randomized Controlled Trials As Topic
Young Adult
Papiloma
Neoplasmas
Adenocarcinoma in Situ
title_short Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region
title_full Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region
title_fullStr Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region
title_full_unstemmed Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region
title_sort Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region
dc.subject.spa.fl_str_mv Human papillomavirus
Cervical cancer
Cervical intraepithelial neoplasia
Adenocarcinoma in situ
topic Human papillomavirus
Cervical cancer
Cervical intraepithelial neoplasia
Adenocarcinoma in situ
Enfermedades
Wart Virus Vaccine
Adenocarcinoma In Situ
Age Distribution
Article
Condyloma Acuminatum
Genotype
Geographic Distribution
Health Program
Human
Human Papillomavirus Type 11
Human Papillomavirus Type 16
Human Papillomavirus Type 18
Human Papillomavirus Type 31
Human Papillomavirus Type 33
Human Papillomavirus Type 45
Human Papillomavirus Type 52
Human Papillomavirus Type 58
Human Papillomavirus Type 6
Immunization
Infection Risk
Mixed Infection
Molecular Epidemiology
Nonhuman
Prevalence
Priority Journal
Systematic Review
Uterine Cervix Carcinoma In Situ
Virus Detection
Wart Virus
Adenocarcinoma
Adolescent
Adult
Asia
Classification
Europe
Female
Genetics
Isolation And Purification
Middle Aged
North America
Papillomaviridae
Randomized Controlled Trial (Topic)
South And Central America
Uterine Cervix Carcinoma In Situ
Virology
Young Adult
Adenocarcinoma
Adolescent
Adult
Asia
Cervical Intraepithelial Neoplasia
Europe
Female
Genotype
Humans
Latin America
Middle Aged
North America
Papillomaviridae
Randomized Controlled Trials As Topic
Young Adult
Papiloma
Neoplasmas
Adenocarcinoma in Situ
dc.subject.ddc.spa.fl_str_mv Enfermedades
dc.subject.decs.spa.fl_str_mv Wart Virus Vaccine
Adenocarcinoma In Situ
Age Distribution
Article
Condyloma Acuminatum
Genotype
Geographic Distribution
Health Program
Human
Human Papillomavirus Type 11
Human Papillomavirus Type 16
Human Papillomavirus Type 18
Human Papillomavirus Type 31
Human Papillomavirus Type 33
Human Papillomavirus Type 45
Human Papillomavirus Type 52
Human Papillomavirus Type 58
Human Papillomavirus Type 6
Immunization
Infection Risk
Mixed Infection
Molecular Epidemiology
Nonhuman
Prevalence
Priority Journal
Systematic Review
Uterine Cervix Carcinoma In Situ
Virus Detection
Wart Virus
Adenocarcinoma
Adolescent
Adult
Asia
Classification
Europe
Female
Genetics
Isolation And Purification
Middle Aged
North America
Papillomaviridae
Randomized Controlled Trial (Topic)
South And Central America
Uterine Cervix Carcinoma In Situ
Virology
Young Adult
Adenocarcinoma
Adolescent
Adult
Asia
Cervical Intraepithelial Neoplasia
Europe
Female
Genotype
Humans
Latin America
Middle Aged
North America
Papillomaviridae
Randomized Controlled Trials As Topic
Young Adult
dc.subject.lemb.spa.fl_str_mv Papiloma
Neoplasmas
Adenocarcinoma in Situ
description Background: We estimated the proportion of cervical intraepithelial neoplasia (CIN) cases attributed to 14 HPV types, including quadrivalent (qHPV) (6/11/16/18) and 9-valent (9vHPV) (6/11/16/18/31/33/45/52/58) vaccine types, by region. Methods: Women ages 15-26 and 24-45 years from 5 regions were enrolled in qHPV vaccine clinical trials. Among 10,706 women (placebo arms), 1539 CIN1, 945 CIN2/3, and 24 adenocarcinoma in situ (AIS) cases were diagnosed by pathology panel consensus. Results: Predominant HPV types were 16/51/52/56 (anogenital infection), 16/39/51/52/56 (CIN1), and 16/31/52/58 (CIN2/3). In regions with largest sample sizes, minimal regional variation was observed in 9vHPV type prevalence in CIN1 (~50%) and CIN2/3 (81-85%). Types 31/33/45/52/58 accounted for 25-30% of CIN1 in Latin America and Europe, but 14-18% in North America and Asia. Types 31/33/45/52/58 accounted for 33-38% of CIN2/3 in Latin America (younger women), Europe, and Asia, but 17-18% of CIN2/3 in Latin America (older women) and North America. Non-vaccine HPV types 35/39/51/56/59 had similar or higher prevalence than qHPV types in CIN1 and were attributed to 2-11% of CIN2/3. Conclusions: The 9vHPV vaccine could potentially prevent the majority of CIN1-3, irrespective of geographic region. Notwithstanding, non-vaccine types 35/39/51/56/59 may still be responsible for some CIN1, and to a lesser extent CIN2/3. © 2016 The Authors.
publishDate 2016
dc.date.created.none.fl_str_mv 2016
dc.date.issued.none.fl_str_mv 2016
dc.date.accessioned.none.fl_str_mv 2019-01-22T16:23:31Z
dc.date.available.none.fl_str_mv 2019-01-22T16:23:31Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.pvr.2016.03.002
dc.identifier.issn.none.fl_str_mv ISSN 2405-8521
dc.identifier.uri.none.fl_str_mv http://repository.urosario.edu.co/handle/10336/18903
url https://doi.org/10.1016/j.pvr.2016.03.002
http://repository.urosario.edu.co/handle/10336/18903
identifier_str_mv ISSN 2405-8521
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 69
dc.relation.citationStartPage.none.fl_str_mv 61
dc.relation.citationTitle.none.fl_str_mv Papillomavirus Research
dc.relation.citationVolume.none.fl_str_mv Vol. 2
dc.relation.ispartof.spa.fl_str_mv Papillomavirus Research, ISSN: 2405-8521, Vol. 2 (2016) pp. 61-69
dc.relation.uri.spa.fl_str_mv https://www.sciencedirect.com/science/article/pii/S2405852116000045
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
dc.rights.cc.spa.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv Abierto (Texto Completo)
https://creativecommons.org/licenses/by-nc-nd/4.0/
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
institution Universidad del Rosario
dc.source.bibliographicCitation.spa.fl_str_mv Joura, E.A., Giuliano, A.R., Iversen, O.E., Bouchard, C., Mao, C., Mehlsen, J., A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women (2015) N. Engl. J. Med., 372, pp. 711-723
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
bitstream.url.fl_str_mv https://repository.urosario.edu.co/bitstreams/b744c9a3-e861-40b1-a4fe-0c19c09490f3/download
https://repository.urosario.edu.co/bitstreams/f1da3829-c214-44ac-a0f0-15589e0db525/download
https://repository.urosario.edu.co/bitstreams/c28a0d39-0c84-4219-b559-fcdcd8b99758/download
bitstream.checksum.fl_str_mv 79ebfcb5db32e3ed599352136240f348
cda9b74b6e2e8e7e0b2752275ed7da1e
ea22fc069e4a97f4ebb621958a25328a
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
_version_ 1814167519036964864
spelling bf1c15c8-6263-4708-ae72-b52171b571ca600c59fe302-1d33-46e7-9505-6ccce05f4e7d6004bf7b430-6f34-4105-9798-d04d542084ff600e335a25b-23ce-417e-b21a-71ec40b7e56a60001884558-97a8-4fb9-b45b-9373746dc43660058e46619-3a93-4b53-b4be-ac14b26bd165600a75a5428-1aaa-4075-a93f-98e319385bad6007f622cbd-6336-4a57-86d9-2da5efa572926009173eaed-2b0d-47a3-b9b2-e2cb936eb12960091d013f4-fece-4425-9068-a40f15ef934e60063c5c00e-e9ef-4a13-b070-d25377868d03600a016ed9a-4c40-4d3d-a538-a083f496ecc3600ecccb0c4-cb95-4925-af5a-1ec964a2d76a60067e51933-1262-4f60-a591-02f2ef6f935460034713837-add6-4423-9852-8567cbc8a29260082d160ec-619b-4e48-881b-b44d9e76fc63600a281a8bc-70fb-47ad-90dd-0e817ea4c7d86003222d7b8-c070-4fc3-ae6c-6669826baf18600859d3314-6755-4778-ae47-b35d50bab08a600aa6c5388-b24f-4952-a934-bb330552c452600ff4cdd74-1351-4260-8377-8e470c9182a66001dfc1d2b-911c-4aca-8dcd-77db5e092a426007b81cc5b-aa8b-4130-9547-480a9f380a35600929722d5-aaa7-4f8e-af8f-8f22ebdb4519600336e5d2c-2912-493d-a9fd-5d88fc6c566b60031b00978-d6b8-47c4-8a44-de2e315d2c8f6001dfc1d2b-911c-4aca-8dcd-77db5e092a42600971258d8-c376-4c90-bfd1-7adccbafcc11600b164c45f-e2a6-4845-aa11-69d7c9b7b9c16006848733b-d0a4-4310-bc1f-5b08845594b560057c44576-20c0-4d98-ac4f-5bc3a174319b6002019-01-22T16:23:31Z2019-01-22T16:23:31Z20162016Background: We estimated the proportion of cervical intraepithelial neoplasia (CIN) cases attributed to 14 HPV types, including quadrivalent (qHPV) (6/11/16/18) and 9-valent (9vHPV) (6/11/16/18/31/33/45/52/58) vaccine types, by region. Methods: Women ages 15-26 and 24-45 years from 5 regions were enrolled in qHPV vaccine clinical trials. Among 10,706 women (placebo arms), 1539 CIN1, 945 CIN2/3, and 24 adenocarcinoma in situ (AIS) cases were diagnosed by pathology panel consensus. Results: Predominant HPV types were 16/51/52/56 (anogenital infection), 16/39/51/52/56 (CIN1), and 16/31/52/58 (CIN2/3). In regions with largest sample sizes, minimal regional variation was observed in 9vHPV type prevalence in CIN1 (~50%) and CIN2/3 (81-85%). Types 31/33/45/52/58 accounted for 25-30% of CIN1 in Latin America and Europe, but 14-18% in North America and Asia. Types 31/33/45/52/58 accounted for 33-38% of CIN2/3 in Latin America (younger women), Europe, and Asia, but 17-18% of CIN2/3 in Latin America (older women) and North America. Non-vaccine HPV types 35/39/51/56/59 had similar or higher prevalence than qHPV types in CIN1 and were attributed to 2-11% of CIN2/3. Conclusions: The 9vHPV vaccine could potentially prevent the majority of CIN1-3, irrespective of geographic region. Notwithstanding, non-vaccine types 35/39/51/56/59 may still be responsible for some CIN1, and to a lesser extent CIN2/3. © 2016 The Authors.application/pdfhttps://doi.org/10.1016/j.pvr.2016.03.002ISSN 2405-8521http://repository.urosario.edu.co/handle/10336/18903eng6961Papillomavirus ResearchVol. 2Papillomavirus Research, ISSN: 2405-8521, Vol. 2 (2016) pp. 61-69https://www.sciencedirect.com/science/article/pii/S2405852116000045Abierto (Texto Completo)https://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Joura, E.A., Giuliano, A.R., Iversen, O.E., Bouchard, C., Mao, C., Mehlsen, J., A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women (2015) N. Engl. J. Med., 372, pp. 711-723instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURHuman papillomavirusCervical cancerCervical intraepithelial neoplasiaAdenocarcinoma in situEnfermedades616600Wart Virus VaccineAdenocarcinoma In SituAge DistributionArticleCondyloma AcuminatumGenotypeGeographic DistributionHealth ProgramHumanHuman Papillomavirus Type 11Human Papillomavirus Type 16Human Papillomavirus Type 18Human Papillomavirus Type 31Human Papillomavirus Type 33Human Papillomavirus Type 45Human Papillomavirus Type 52Human Papillomavirus Type 58Human Papillomavirus Type 6ImmunizationInfection RiskMixed InfectionMolecular EpidemiologyNonhumanPrevalencePriority JournalSystematic ReviewUterine Cervix Carcinoma In SituVirus DetectionWart VirusAdenocarcinomaAdolescentAdultAsiaClassificationEuropeFemaleGeneticsIsolation And PurificationMiddle AgedNorth AmericaPapillomaviridaeRandomized Controlled Trial (Topic)South And Central AmericaUterine Cervix Carcinoma In SituVirologyYoung AdultAdenocarcinomaAdolescentAdultAsiaCervical Intraepithelial NeoplasiaEuropeFemaleGenotypeHumansLatin AmericaMiddle AgedNorth AmericaPapillomaviridaeRandomized Controlled Trials As TopicYoung AdultPapilomaNeoplasmasAdenocarcinoma in SituHuman papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by regionarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Castellsagué, XavierAult, Kevin A.Bosch, F. XavierBrown, DarronCuzick, JackFerris, Daron G.Joura, Elmar A.Garland, Suzanne M.Giuliano, Anna RHernandez-Avila, MauricioHuh, WarnerIversen, Ole-ErikKjaer, Susanne K.Luna, JoaquinMonsonego, JosephMuñoz, NubiaMyers, EvanPaavonen, JormaPitisuttihum, PunneeSteben, MarcWheeler, Cosette M.Perez, GonzaloSaah, AlfredPitisuttihum, PunneeSteben, MarcWheeler, Cosette M.Perez, GonzaloSaah, AlfredLuxembourg, AlainSings, Heather LVelicer, ChristineCastellsagué, XavierAult, Kevin A.Bosch, F. XavierBrown, DarronCuzick, JackFerris, Daron G.Joura, Elmar A.Garland, Suzanne M.Giuliano, Anna RHernandez-Avila, MauricioHuh, WarnerIversen, Ole-ErikKjaer, Susanne K.Luna, JoaquinMonsonego, JosephMuñoz, NubiaMyers, EvanPaavonen, JormaPitisuttihum, PunneeSteben, MarcWheeler, Cosette M.Perez, GonzaloSaah, AlfredPitisuttihum, PunneeSteben, MarcWheeler, Cosette M.Perez, GonzaloSaah, AlfredLuxembourg, AlainSings, Heather LVelicer, ChristineORIGINAL53.pdfapplication/pdf1850621https://repository.urosario.edu.co/bitstreams/b744c9a3-e861-40b1-a4fe-0c19c09490f3/download79ebfcb5db32e3ed599352136240f348MD51TEXT53.pdf.txt53.pdf.txtExtracted texttext/plain46169https://repository.urosario.edu.co/bitstreams/f1da3829-c214-44ac-a0f0-15589e0db525/downloadcda9b74b6e2e8e7e0b2752275ed7da1eMD52THUMBNAIL53.pdf.jpg53.pdf.jpgGenerated Thumbnailimage/jpeg4466https://repository.urosario.edu.co/bitstreams/c28a0d39-0c84-4219-b559-fcdcd8b99758/downloadea22fc069e4a97f4ebb621958a25328aMD5310336/18903oai:repository.urosario.edu.co:10336/189032021-03-26 09:24:55.837https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co