Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region

Background: We estimated the proportion of cervical intraepithelial neoplasia (CIN) cases attributed to 14 HPV types, including quadrivalent (qHPV) (6/11/16/18) and 9-valent (9vHPV) (6/11/16/18/31/33/45/52/58) vaccine types, by region. Methods: Women ages 15-26 and 24-45 years from 5 regions were enrolled in qHPV vaccine clinical trials. Among 10,706 women (placebo arms), 1539 CIN1, 945 CIN2/3, and 24 adenocarcinoma in situ (AIS) cases were diagnosed by pathology panel consensus. Results: Predominant HPV types were 16/51/52/56 (anogenital infection), 16/39/51/52/56 (CIN1), and 16/31/52/58 (CIN2/3). In regions with largest sample sizes, minimal regional variation was observed in 9vHPV type prevalence in CIN1 (~50%) and CIN2/3 (81-85%). Types 31/33/45/52/58 accounted for 25-30% of CIN1 in Latin America and Europe, but 14-18% in North America and Asia. Types 31/33/45/52/58 accounted for 33-38% of CIN2/3 in Latin America (younger women), Europe, and Asia, but 17-18% of CIN2/3 in Latin America (older women) and North America. Non-vaccine HPV types 35/39/51/56/59 had similar or higher prevalence than qHPV types in CIN1 and were attributed to 2-11% of CIN2/3. Conclusions: The 9vHPV vaccine could potentially prevent the majority of CIN1-3, irrespective of geographic region. Notwithstanding, non-vaccine types 35/39/51/56/59 may still be responsible for some CIN1, and to a lesser extent CIN2/3. © 2016 The Authors.

• Fecha de publicación: 2016
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/18903
• Acceso en línea: https://doi.org/10.1016/j.pvr.2016.03.002; http://repository.urosario.edu.co/handle/10336/18903
• Palabra clave: Human papillomavirus; Cervical cancer; Cervical intraepithelial neoplasia; Adenocarcinoma in situ; Enfermedades; Wart Virus Vaccine; Adenocarcinoma In Situ; Age Distribution; Article; Condyloma Acuminatum; Genotype; Geographic Distribution; Health Program; Human; Human Papillomavirus Type 11; Human Papillomavirus Type 16; Human Papillomavirus Type 18; Human Papillomavirus Type 31; Human Papillomavirus Type 33; Human Papillomavirus Type 45; Human Papillomavirus Type 52; Human Papillomavirus Type 58; Human Papillomavirus Type 6; Immunization; Infection Risk; Mixed Infection; Molecular Epidemiology; Nonhuman; Prevalence; Priority Journal; Systematic Review; Uterine Cervix Carcinoma In Situ; Virus Detection; Wart Virus; Adenocarcinoma; Adolescent; Adult; Asia; Classification; Europe; Female; Genetics; Isolation And Purification; Middle Aged; North America; Papillomaviridae; Randomized Controlled Trial (Topic); South And Central America; Uterine Cervix Carcinoma In Situ; Virology; Young Adult; Adenocarcinoma; Adolescent; Adult; Asia; Cervical Intraepithelial Neoplasia; Europe; Female; Genotype; Humans; Latin America; Middle Aged; North America; Papillomaviridae; Randomized Controlled Trials As Topic; Young Adult; Papiloma; Neoplasmas; Adenocarcinoma in Situ
• License: Abierto (Texto Completo)