Glucose-6-phosphate dehydrogenase (G6PD). Response of the human erythrocyte and another cells to the decrease in their activity
Glucose-6-phosphate dehydrogenase is the first enzyme in the pentose phosphate pathway and the main intracellular source of reduced nicotidamineadenine nucleotidephosphate (NADPH), involved in diverse physiological processes such as antioxidant defense, (for instance in the erythrocyte) endothelial...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2007
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/23715
- Acceso en línea:
- https://repository.urosario.edu.co/handle/10336/23715
- Palabra clave:
- Glucose 6 phosphate dehydrogenase
Pentose phosphate
Reduced nicotinamide adenine dinucleotide phosphate
Antioxidant activity
Article
Cell growth
Clinical feature
Colombia
Disease severity
Endothelium cell
Enzyme activity
Enzyme electrophoresis
Erythrocyte
Erythropoiesis
Glucose 6 phosphate dehydrogenase deficiency
Hemolysis
Hemolytic anemia
Human
Inborn error of metabolism
Phagocytosis
Preeclampsia
Prevalence
Signal transduction
Vascularization
World health organization
X chromosome
Congenital hemolytic anemia
Epidemiology
Erythrocyte
Genetics
Glucose-6-phosphate dehydrogenase deficiency
Physiology
- Rights
- License
- Abierto (Texto Completo)
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e62362a4-33c4-436a-8f7b-673b85b48661-1d02b20ed-c710-409a-89c9-7a9200be1365-19bbffd22-35d3-47dd-b21f-b04cf0929501-12020-05-26T00:04:45Z2020-05-26T00:04:45Z2007Glucose-6-phosphate dehydrogenase is the first enzyme in the pentose phosphate pathway and the main intracellular source of reduced nicotidamineadenine nucleotidephosphate (NADPH), involved in diverse physiological processes such as antioxidant defense, (for instance in the erythrocyte) endothelial growth modulation, erithropoyesis, vascularization and phagocitosis, G6PDH deficiency is the most common X-chromosome-linked enzymopathy in human beings. Although it is present in any type cell, its absolute deficiency is incompatible with life. According to WHO, 400 million people are affected by G6PD deficiency in the world but in Colombia, the severe form prevalence is about 3% to 7%. There are no data related to slight and moderate alterations, that also have clinical effects. This paper reviews some G6PD biomolecular aspects, its classification according to activity and electrophoretic mobility, as well as some main clinical aspects related to its activity alteration. © 2007 Corporación Editora Médica del Valle.application/pdf1657953401208322https://repository.urosario.edu.co/handle/10336/23715eng75No. 168Colombia MedicaVol. 38Colombia Medica, ISSN:16579534, 01208322, Vol.38, No.1 (2007); pp. 68-75https://www.scopus.com/inward/record.uri?eid=2-s2.0-34147143062&partnerID=40&md5=bf449b08546848be17625a9bbb1b19b6Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURGlucose 6 phosphate dehydrogenasePentose phosphateReduced nicotinamide adenine dinucleotide phosphateAntioxidant activityArticleCell growthClinical featureColombiaDisease severityEndothelium cellEnzyme activityEnzyme electrophoresisErythrocyteErythropoiesisGlucose 6 phosphate dehydrogenase deficiencyHemolysisHemolytic anemiaHumanInborn error of metabolismPhagocytosisPreeclampsiaPrevalenceSignal transductionVascularizationWorld health organizationX chromosomeCongenital hemolytic anemiaEpidemiologyErythrocyteGeneticsGlucose-6-phosphate dehydrogenase deficiencyPhysiologyGlucose-6-phosphate dehydrogenase (G6PD). Response of the human erythrocyte and another cells to the decrease in their activityarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Bonilla J.F.Sánchez M.C.Chuaire L.ORIGINAL477-Manuscript-1435-1-10-20091123.pdfapplication/pdf50552https://repository.urosario.edu.co/bitstreams/61861e71-88b9-4aaa-a100-9a3aaa9e0a24/download9ac2329a7b40d5e2ce36841f134c54caMD51TEXT477-Manuscript-1435-1-10-20091123.pdf.txt477-Manuscript-1435-1-10-20091123.pdf.txtExtracted texttext/plain38376https://repository.urosario.edu.co/bitstreams/265a6968-6e8d-4eab-840c-31b081485b5d/downloadda86a77974c07517cc533a3886ec013bMD52THUMBNAIL477-Manuscript-1435-1-10-20091123.pdf.jpg477-Manuscript-1435-1-10-20091123.pdf.jpgGenerated Thumbnailimage/jpeg4342https://repository.urosario.edu.co/bitstreams/45e13ca1-0ead-4225-8b43-12038e8c422c/downloadbc0ebb8f018ceeddecb202e217cd4153MD5310336/23715oai:repository.urosario.edu.co:10336/237152022-05-02 07:37:14.77192https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Glucose-6-phosphate dehydrogenase (G6PD). Response of the human erythrocyte and another cells to the decrease in their activity |
title |
Glucose-6-phosphate dehydrogenase (G6PD). Response of the human erythrocyte and another cells to the decrease in their activity |
spellingShingle |
Glucose-6-phosphate dehydrogenase (G6PD). Response of the human erythrocyte and another cells to the decrease in their activity Glucose 6 phosphate dehydrogenase Pentose phosphate Reduced nicotinamide adenine dinucleotide phosphate Antioxidant activity Article Cell growth Clinical feature Colombia Disease severity Endothelium cell Enzyme activity Enzyme electrophoresis Erythrocyte Erythropoiesis Glucose 6 phosphate dehydrogenase deficiency Hemolysis Hemolytic anemia Human Inborn error of metabolism Phagocytosis Preeclampsia Prevalence Signal transduction Vascularization World health organization X chromosome Congenital hemolytic anemia Epidemiology Erythrocyte Genetics Glucose-6-phosphate dehydrogenase deficiency Physiology |
title_short |
Glucose-6-phosphate dehydrogenase (G6PD). Response of the human erythrocyte and another cells to the decrease in their activity |
title_full |
Glucose-6-phosphate dehydrogenase (G6PD). Response of the human erythrocyte and another cells to the decrease in their activity |
title_fullStr |
Glucose-6-phosphate dehydrogenase (G6PD). Response of the human erythrocyte and another cells to the decrease in their activity |
title_full_unstemmed |
Glucose-6-phosphate dehydrogenase (G6PD). Response of the human erythrocyte and another cells to the decrease in their activity |
title_sort |
Glucose-6-phosphate dehydrogenase (G6PD). Response of the human erythrocyte and another cells to the decrease in their activity |
dc.subject.keyword.spa.fl_str_mv |
Glucose 6 phosphate dehydrogenase Pentose phosphate Reduced nicotinamide adenine dinucleotide phosphate Antioxidant activity Article Cell growth Clinical feature Colombia Disease severity Endothelium cell Enzyme activity Enzyme electrophoresis Erythrocyte Erythropoiesis Glucose 6 phosphate dehydrogenase deficiency Hemolysis Hemolytic anemia Human Inborn error of metabolism Phagocytosis Preeclampsia Prevalence Signal transduction Vascularization World health organization X chromosome Congenital hemolytic anemia Epidemiology Erythrocyte Genetics Glucose-6-phosphate dehydrogenase deficiency Physiology |
topic |
Glucose 6 phosphate dehydrogenase Pentose phosphate Reduced nicotinamide adenine dinucleotide phosphate Antioxidant activity Article Cell growth Clinical feature Colombia Disease severity Endothelium cell Enzyme activity Enzyme electrophoresis Erythrocyte Erythropoiesis Glucose 6 phosphate dehydrogenase deficiency Hemolysis Hemolytic anemia Human Inborn error of metabolism Phagocytosis Preeclampsia Prevalence Signal transduction Vascularization World health organization X chromosome Congenital hemolytic anemia Epidemiology Erythrocyte Genetics Glucose-6-phosphate dehydrogenase deficiency Physiology |
description |
Glucose-6-phosphate dehydrogenase is the first enzyme in the pentose phosphate pathway and the main intracellular source of reduced nicotidamineadenine nucleotidephosphate (NADPH), involved in diverse physiological processes such as antioxidant defense, (for instance in the erythrocyte) endothelial growth modulation, erithropoyesis, vascularization and phagocitosis, G6PDH deficiency is the most common X-chromosome-linked enzymopathy in human beings. Although it is present in any type cell, its absolute deficiency is incompatible with life. According to WHO, 400 million people are affected by G6PD deficiency in the world but in Colombia, the severe form prevalence is about 3% to 7%. There are no data related to slight and moderate alterations, that also have clinical effects. This paper reviews some G6PD biomolecular aspects, its classification according to activity and electrophoretic mobility, as well as some main clinical aspects related to its activity alteration. © 2007 Corporación Editora Médica del Valle. |
publishDate |
2007 |
dc.date.created.spa.fl_str_mv |
2007 |
dc.date.accessioned.none.fl_str_mv |
2020-05-26T00:04:45Z |
dc.date.available.none.fl_str_mv |
2020-05-26T00:04:45Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.issn.none.fl_str_mv |
16579534 01208322 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/23715 |
identifier_str_mv |
16579534 01208322 |
url |
https://repository.urosario.edu.co/handle/10336/23715 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
75 |
dc.relation.citationIssue.none.fl_str_mv |
No. 1 |
dc.relation.citationStartPage.none.fl_str_mv |
68 |
dc.relation.citationTitle.none.fl_str_mv |
Colombia Medica |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 38 |
dc.relation.ispartof.spa.fl_str_mv |
Colombia Medica, ISSN:16579534, 01208322, Vol.38, No.1 (2007); pp. 68-75 |
dc.relation.uri.spa.fl_str_mv |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-34147143062&partnerID=40&md5=bf449b08546848be17625a9bbb1b19b6 |
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http://purl.org/coar/access_right/c_abf2 |
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Abierto (Texto Completo) |
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Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
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application/pdf |
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Universidad del Rosario |
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