Glucose-6-phosphate dehydrogenase (G6PD). Response of the human erythrocyte and another cells to the decrease in their activity

Glucose-6-phosphate dehydrogenase is the first enzyme in the pentose phosphate pathway and the main intracellular source of reduced nicotidamineadenine nucleotidephosphate (NADPH), involved in diverse physiological processes such as antioxidant defense, (for instance in the erythrocyte) endothelial...

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Fecha de publicación:
2007
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23715
Acceso en línea:
https://repository.urosario.edu.co/handle/10336/23715
Palabra clave:
Glucose 6 phosphate dehydrogenase
Pentose phosphate
Reduced nicotinamide adenine dinucleotide phosphate
Antioxidant activity
Article
Cell growth
Clinical feature
Colombia
Disease severity
Endothelium cell
Enzyme activity
Enzyme electrophoresis
Erythrocyte
Erythropoiesis
Glucose 6 phosphate dehydrogenase deficiency
Hemolysis
Hemolytic anemia
Human
Inborn error of metabolism
Phagocytosis
Preeclampsia
Prevalence
Signal transduction
Vascularization
World health organization
X chromosome
Congenital hemolytic anemia
Epidemiology
Erythrocyte
Genetics
Glucose-6-phosphate dehydrogenase deficiency
Physiology
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spelling e62362a4-33c4-436a-8f7b-673b85b48661-1d02b20ed-c710-409a-89c9-7a9200be1365-19bbffd22-35d3-47dd-b21f-b04cf0929501-12020-05-26T00:04:45Z2020-05-26T00:04:45Z2007Glucose-6-phosphate dehydrogenase is the first enzyme in the pentose phosphate pathway and the main intracellular source of reduced nicotidamineadenine nucleotidephosphate (NADPH), involved in diverse physiological processes such as antioxidant defense, (for instance in the erythrocyte) endothelial growth modulation, erithropoyesis, vascularization and phagocitosis, G6PDH deficiency is the most common X-chromosome-linked enzymopathy in human beings. Although it is present in any type cell, its absolute deficiency is incompatible with life. According to WHO, 400 million people are affected by G6PD deficiency in the world but in Colombia, the severe form prevalence is about 3% to 7%. There are no data related to slight and moderate alterations, that also have clinical effects. This paper reviews some G6PD biomolecular aspects, its classification according to activity and electrophoretic mobility, as well as some main clinical aspects related to its activity alteration. © 2007 Corporación Editora Médica del Valle.application/pdf1657953401208322https://repository.urosario.edu.co/handle/10336/23715eng75No. 168Colombia MedicaVol. 38Colombia Medica, ISSN:16579534, 01208322, Vol.38, No.1 (2007); pp. 68-75https://www.scopus.com/inward/record.uri?eid=2-s2.0-34147143062&partnerID=40&md5=bf449b08546848be17625a9bbb1b19b6Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURGlucose 6 phosphate dehydrogenasePentose phosphateReduced nicotinamide adenine dinucleotide phosphateAntioxidant activityArticleCell growthClinical featureColombiaDisease severityEndothelium cellEnzyme activityEnzyme electrophoresisErythrocyteErythropoiesisGlucose 6 phosphate dehydrogenase deficiencyHemolysisHemolytic anemiaHumanInborn error of metabolismPhagocytosisPreeclampsiaPrevalenceSignal transductionVascularizationWorld health organizationX chromosomeCongenital hemolytic anemiaEpidemiologyErythrocyteGeneticsGlucose-6-phosphate dehydrogenase deficiencyPhysiologyGlucose-6-phosphate dehydrogenase (G6PD). Response of the human erythrocyte and another cells to the decrease in their activityarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Bonilla J.F.Sánchez M.C.Chuaire L.ORIGINAL477-Manuscript-1435-1-10-20091123.pdfapplication/pdf50552https://repository.urosario.edu.co/bitstreams/61861e71-88b9-4aaa-a100-9a3aaa9e0a24/download9ac2329a7b40d5e2ce36841f134c54caMD51TEXT477-Manuscript-1435-1-10-20091123.pdf.txt477-Manuscript-1435-1-10-20091123.pdf.txtExtracted texttext/plain38376https://repository.urosario.edu.co/bitstreams/265a6968-6e8d-4eab-840c-31b081485b5d/downloadda86a77974c07517cc533a3886ec013bMD52THUMBNAIL477-Manuscript-1435-1-10-20091123.pdf.jpg477-Manuscript-1435-1-10-20091123.pdf.jpgGenerated Thumbnailimage/jpeg4342https://repository.urosario.edu.co/bitstreams/45e13ca1-0ead-4225-8b43-12038e8c422c/downloadbc0ebb8f018ceeddecb202e217cd4153MD5310336/23715oai:repository.urosario.edu.co:10336/237152022-05-02 07:37:14.77192https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Glucose-6-phosphate dehydrogenase (G6PD). Response of the human erythrocyte and another cells to the decrease in their activity
title Glucose-6-phosphate dehydrogenase (G6PD). Response of the human erythrocyte and another cells to the decrease in their activity
spellingShingle Glucose-6-phosphate dehydrogenase (G6PD). Response of the human erythrocyte and another cells to the decrease in their activity
Glucose 6 phosphate dehydrogenase
Pentose phosphate
Reduced nicotinamide adenine dinucleotide phosphate
Antioxidant activity
Article
Cell growth
Clinical feature
Colombia
Disease severity
Endothelium cell
Enzyme activity
Enzyme electrophoresis
Erythrocyte
Erythropoiesis
Glucose 6 phosphate dehydrogenase deficiency
Hemolysis
Hemolytic anemia
Human
Inborn error of metabolism
Phagocytosis
Preeclampsia
Prevalence
Signal transduction
Vascularization
World health organization
X chromosome
Congenital hemolytic anemia
Epidemiology
Erythrocyte
Genetics
Glucose-6-phosphate dehydrogenase deficiency
Physiology
title_short Glucose-6-phosphate dehydrogenase (G6PD). Response of the human erythrocyte and another cells to the decrease in their activity
title_full Glucose-6-phosphate dehydrogenase (G6PD). Response of the human erythrocyte and another cells to the decrease in their activity
title_fullStr Glucose-6-phosphate dehydrogenase (G6PD). Response of the human erythrocyte and another cells to the decrease in their activity
title_full_unstemmed Glucose-6-phosphate dehydrogenase (G6PD). Response of the human erythrocyte and another cells to the decrease in their activity
title_sort Glucose-6-phosphate dehydrogenase (G6PD). Response of the human erythrocyte and another cells to the decrease in their activity
dc.subject.keyword.spa.fl_str_mv Glucose 6 phosphate dehydrogenase
Pentose phosphate
Reduced nicotinamide adenine dinucleotide phosphate
Antioxidant activity
Article
Cell growth
Clinical feature
Colombia
Disease severity
Endothelium cell
Enzyme activity
Enzyme electrophoresis
Erythrocyte
Erythropoiesis
Glucose 6 phosphate dehydrogenase deficiency
Hemolysis
Hemolytic anemia
Human
Inborn error of metabolism
Phagocytosis
Preeclampsia
Prevalence
Signal transduction
Vascularization
World health organization
X chromosome
Congenital hemolytic anemia
Epidemiology
Erythrocyte
Genetics
Glucose-6-phosphate dehydrogenase deficiency
Physiology
topic Glucose 6 phosphate dehydrogenase
Pentose phosphate
Reduced nicotinamide adenine dinucleotide phosphate
Antioxidant activity
Article
Cell growth
Clinical feature
Colombia
Disease severity
Endothelium cell
Enzyme activity
Enzyme electrophoresis
Erythrocyte
Erythropoiesis
Glucose 6 phosphate dehydrogenase deficiency
Hemolysis
Hemolytic anemia
Human
Inborn error of metabolism
Phagocytosis
Preeclampsia
Prevalence
Signal transduction
Vascularization
World health organization
X chromosome
Congenital hemolytic anemia
Epidemiology
Erythrocyte
Genetics
Glucose-6-phosphate dehydrogenase deficiency
Physiology
description Glucose-6-phosphate dehydrogenase is the first enzyme in the pentose phosphate pathway and the main intracellular source of reduced nicotidamineadenine nucleotidephosphate (NADPH), involved in diverse physiological processes such as antioxidant defense, (for instance in the erythrocyte) endothelial growth modulation, erithropoyesis, vascularization and phagocitosis, G6PDH deficiency is the most common X-chromosome-linked enzymopathy in human beings. Although it is present in any type cell, its absolute deficiency is incompatible with life. According to WHO, 400 million people are affected by G6PD deficiency in the world but in Colombia, the severe form prevalence is about 3% to 7%. There are no data related to slight and moderate alterations, that also have clinical effects. This paper reviews some G6PD biomolecular aspects, its classification according to activity and electrophoretic mobility, as well as some main clinical aspects related to its activity alteration. © 2007 Corporación Editora Médica del Valle.
publishDate 2007
dc.date.created.spa.fl_str_mv 2007
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:04:45Z
dc.date.available.none.fl_str_mv 2020-05-26T00:04:45Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.issn.none.fl_str_mv 16579534
01208322
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/23715
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dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 75
dc.relation.citationIssue.none.fl_str_mv No. 1
dc.relation.citationStartPage.none.fl_str_mv 68
dc.relation.citationTitle.none.fl_str_mv Colombia Medica
dc.relation.citationVolume.none.fl_str_mv Vol. 38
dc.relation.ispartof.spa.fl_str_mv Colombia Medica, ISSN:16579534, 01208322, Vol.38, No.1 (2007); pp. 68-75
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rights_invalid_str_mv Abierto (Texto Completo)
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dc.format.mimetype.none.fl_str_mv application/pdf
institution Universidad del Rosario
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