Is there a common genetic basis for autoimmune diseases?
Autoimmune diseases (ADs) represent a diverse collection of diseases in terms of their demographic profile and primary clinical manifestations. The commonality between them however, is the damage to tissues and organs that arises from the response to self-antigens. The presence of shared pathophysio...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2006
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/8767
- Acceso en línea:
- https://doi.org/10.1080/17402520600876762
http://repository.urosario.edu.co/handle/10336/8767
- Palabra clave:
- Enfermedades
Genética
Inmunología
Enfermedades autoinmunes
genetics
inheritance patterns
Sjögren's syndrome
Type 1 diabetes mellitus
- Rights
- License
- Abierto (Texto completo)
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dc.title.spa.fl_str_mv |
Is there a common genetic basis for autoimmune diseases? |
title |
Is there a common genetic basis for autoimmune diseases? |
spellingShingle |
Is there a common genetic basis for autoimmune diseases? Enfermedades Genética Inmunología Enfermedades autoinmunes genetics inheritance patterns Sjögren's syndrome Type 1 diabetes mellitus |
title_short |
Is there a common genetic basis for autoimmune diseases? |
title_full |
Is there a common genetic basis for autoimmune diseases? |
title_fullStr |
Is there a common genetic basis for autoimmune diseases? |
title_full_unstemmed |
Is there a common genetic basis for autoimmune diseases? |
title_sort |
Is there a common genetic basis for autoimmune diseases? |
dc.subject.ddc.none.fl_str_mv |
Enfermedades |
topic |
Enfermedades Genética Inmunología Enfermedades autoinmunes genetics inheritance patterns Sjögren's syndrome Type 1 diabetes mellitus |
dc.subject.decs.spa.fl_str_mv |
Genética Inmunología Enfermedades autoinmunes |
dc.subject.keyword.eng.fl_str_mv |
genetics inheritance patterns Sjögren's syndrome Type 1 diabetes mellitus |
description |
Autoimmune diseases (ADs) represent a diverse collection of diseases in terms of their demographic profile and primary clinical manifestations. The commonality between them however, is the damage to tissues and organs that arises from the response to self-antigens. The presence of shared pathophysiological mechanisms within ADs has stimulated searches for common genetic roots to these diseases. Two approaches have been undertaken to sustain the “common genetic origin” theory of ADs. Firstly, a clinical genetic analysis showed that autoimmunity aggregates within families of probands diagnosed with primary Sjögren's (pSS) syndrome or type 1 diabetes mellitus (T1D). A literature review supported the establishment of a familiar cluster of ADs depending upon the proband's disease phenotype. Secondly, in a same and well-defined population, a large genetic association study indicated that a number of polymorphic genes (i.e. HLA-DRB1, TNF and PTPN22) influence the susceptibility for acquiring different ADs. Likewise, association and linkage studies in different populations have revealed that several susceptibility loci overlap in ADs, and clinical studies have shown that frequent clustering of several ADs occurs. Thus, the genetic factors for ADs consist of two types: those which are common to many ADs (acting in epistatic pleitropy) and those that are specific to a given disorder. Their identification and functional characterization will allow us to predict their effect as well as to indicate potential new therapeutic interventions. Both autoimmunity family history and the co-occurrence of ADs in affected probands should be considered when performing genetic association and linkage studies. |
publishDate |
2006 |
dc.date.created.none.fl_str_mv |
2006-06 |
dc.date.issued.none.fl_str_mv |
2006 |
dc.date.accessioned.none.fl_str_mv |
2014-08-11T15:47:24Z |
dc.date.available.none.fl_str_mv |
2014-08-11T15:47:24Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1080/17402520600876762 |
dc.identifier.issn.none.fl_str_mv |
ISSN:1740-2522 |
dc.identifier.uri.none.fl_str_mv |
http://repository.urosario.edu.co/handle/10336/8767 |
url |
https://doi.org/10.1080/17402520600876762 http://repository.urosario.edu.co/handle/10336/8767 |
identifier_str_mv |
ISSN:1740-2522 |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.relation.citationIssue.none.fl_str_mv |
No. 2 |
dc.relation.citationTitle.none.fl_str_mv |
Clinical & Developmental Immunology |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 13 |
dc.relation.ispartof.spa.fl_str_mv |
Clinical & Developmental Immunology V. 13 N. 2-4 Jun, 2006 |
dc.relation.uri.none.fl_str_mv |
http://web.b.ebscohost.com.ez.urosario.edu.co/ehost/pdfviewer/pdfviewer?sid=9eccd8fc-cb3c-48e8-9b12-2809af93ea82%40sessionmgr115&vid=2&hid=108 |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto completo) |
rights_invalid_str_mv |
Abierto (Texto completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.medium.spa.fl_str_mv |
Recurso electrónico |
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application/pdf |
dc.format.tipo.spa.fl_str_mv |
Documento |
dc.publisher.spa.fl_str_mv |
Universidad del Rosario |
institution |
Universidad del Rosario |
dc.source.instname.spa.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
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Comunidad Rosarista19474778600c5e15d68-2e79-46cc-994c-608ea4c1dc2360051cf37f6-25b0-4152-ae95-bb2b21ce5d7e6002014-08-11T15:47:24Z2014-08-11T15:47:24Z2006-062006Autoimmune diseases (ADs) represent a diverse collection of diseases in terms of their demographic profile and primary clinical manifestations. The commonality between them however, is the damage to tissues and organs that arises from the response to self-antigens. The presence of shared pathophysiological mechanisms within ADs has stimulated searches for common genetic roots to these diseases. Two approaches have been undertaken to sustain the “common genetic origin” theory of ADs. Firstly, a clinical genetic analysis showed that autoimmunity aggregates within families of probands diagnosed with primary Sjögren's (pSS) syndrome or type 1 diabetes mellitus (T1D). A literature review supported the establishment of a familiar cluster of ADs depending upon the proband's disease phenotype. Secondly, in a same and well-defined population, a large genetic association study indicated that a number of polymorphic genes (i.e. HLA-DRB1, TNF and PTPN22) influence the susceptibility for acquiring different ADs. Likewise, association and linkage studies in different populations have revealed that several susceptibility loci overlap in ADs, and clinical studies have shown that frequent clustering of several ADs occurs. Thus, the genetic factors for ADs consist of two types: those which are common to many ADs (acting in epistatic pleitropy) and those that are specific to a given disorder. Their identification and functional characterization will allow us to predict their effect as well as to indicate potential new therapeutic interventions. Both autoimmunity family history and the co-occurrence of ADs in affected probands should be considered when performing genetic association and linkage studies.Recurso electrónicoapplication/pdfDocumentohttps://doi.org/10.1080/17402520600876762ISSN:1740-2522http://repository.urosario.edu.co/handle/10336/8767engUniversidad del RosarioNo. 2Clinical & Developmental ImmunologyVol. 13Clinical & Developmental Immunology V. 13 N. 2-4 Jun, 2006http://web.b.ebscohost.com.ez.urosario.edu.co/ehost/pdfviewer/pdfviewer?sid=9eccd8fc-cb3c-48e8-9b12-2809af93ea82%40sessionmgr115&vid=2&hid=108Abierto (Texto completo)EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocUREnfermedades616600GenéticaInmunologíaEnfermedades autoinmunesgeneticsinheritance patternsSjögren's syndromeType 1 diabetes mellitusIs there a common genetic basis for autoimmune diseases?articleArtículohttp://purl.org/coar/resource_type/c_6501Anaya, Juan-ManuelGómez, Luis MiguelCastiblanco, JohnAnaya, Juan-ManuelGómez, LuisMiguelCastiblanco, JohnORIGINALIs there a common.pdfIs there a common.pdfapplication/pdf236836https://repository.urosario.edu.co/bitstreams/a11aec7b-5279-4b0c-84c8-55aeeaf88ea8/downloadc3d41fa0c0d354da7d8f4642b7586880MD51LICENSElicense.txtlicense.txttext/plain2156https://repository.urosario.edu.co/bitstreams/b4f3f241-dfc4-4285-bc28-155e1a4f991c/downloadb4f8fe66e94b897ab4c355bac005ad16MD52TEXTIs there a common.pdf.txtIs there a common.pdf.txtExtracted texttext/plain46700https://repository.urosario.edu.co/bitstreams/affeb041-bfc8-43bd-b124-76dd5bcaf11e/download0a375219de0a8441a90f36964e906be2MD59THUMBNAILIs there a common.pdf.jpgIs there a common.pdf.jpgGenerated 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