Is there a common genetic basis for autoimmune diseases?

Autoimmune diseases (ADs) represent a diverse collection of diseases in terms of their demographic profile and primary clinical manifestations. The commonality between them however, is the damage to tissues and organs that arises from the response to self-antigens. The presence of shared pathophysio...

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Tipo de recurso:
Fecha de publicación:
2006
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/8767
Acceso en línea:
https://doi.org/10.1080/17402520600876762
http://repository.urosario.edu.co/handle/10336/8767
Palabra clave:
Enfermedades
Genética
Inmunología
Enfermedades autoinmunes
genetics
inheritance patterns
Sjögren's syndrome
Type 1 diabetes mellitus
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License
Abierto (Texto completo)
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dc.title.spa.fl_str_mv Is there a common genetic basis for autoimmune diseases?
title Is there a common genetic basis for autoimmune diseases?
spellingShingle Is there a common genetic basis for autoimmune diseases?
Enfermedades
Genética
Inmunología
Enfermedades autoinmunes
genetics
inheritance patterns
Sjögren's syndrome
Type 1 diabetes mellitus
title_short Is there a common genetic basis for autoimmune diseases?
title_full Is there a common genetic basis for autoimmune diseases?
title_fullStr Is there a common genetic basis for autoimmune diseases?
title_full_unstemmed Is there a common genetic basis for autoimmune diseases?
title_sort Is there a common genetic basis for autoimmune diseases?
dc.subject.ddc.none.fl_str_mv Enfermedades
topic Enfermedades
Genética
Inmunología
Enfermedades autoinmunes
genetics
inheritance patterns
Sjögren's syndrome
Type 1 diabetes mellitus
dc.subject.decs.spa.fl_str_mv Genética
Inmunología
Enfermedades autoinmunes
dc.subject.keyword.eng.fl_str_mv genetics
inheritance patterns
Sjögren's syndrome
Type 1 diabetes mellitus
description Autoimmune diseases (ADs) represent a diverse collection of diseases in terms of their demographic profile and primary clinical manifestations. The commonality between them however, is the damage to tissues and organs that arises from the response to self-antigens. The presence of shared pathophysiological mechanisms within ADs has stimulated searches for common genetic roots to these diseases. Two approaches have been undertaken to sustain the “common genetic origin” theory of ADs. Firstly, a clinical genetic analysis showed that autoimmunity aggregates within families of probands diagnosed with primary Sjögren's (pSS) syndrome or type 1 diabetes mellitus (T1D). A literature review supported the establishment of a familiar cluster of ADs depending upon the proband's disease phenotype. Secondly, in a same and well-defined population, a large genetic association study indicated that a number of polymorphic genes (i.e. HLA-DRB1, TNF and PTPN22) influence the susceptibility for acquiring different ADs. Likewise, association and linkage studies in different populations have revealed that several susceptibility loci overlap in ADs, and clinical studies have shown that frequent clustering of several ADs occurs. Thus, the genetic factors for ADs consist of two types: those which are common to many ADs (acting in epistatic pleitropy) and those that are specific to a given disorder. Their identification and functional characterization will allow us to predict their effect as well as to indicate potential new therapeutic interventions. Both autoimmunity family history and the co-occurrence of ADs in affected probands should be considered when performing genetic association and linkage studies.
publishDate 2006
dc.date.created.none.fl_str_mv 2006-06
dc.date.issued.none.fl_str_mv 2006
dc.date.accessioned.none.fl_str_mv 2014-08-11T15:47:24Z
dc.date.available.none.fl_str_mv 2014-08-11T15:47:24Z
dc.type.eng.fl_str_mv article
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1080/17402520600876762
dc.identifier.issn.none.fl_str_mv ISSN:1740-2522
dc.identifier.uri.none.fl_str_mv http://repository.urosario.edu.co/handle/10336/8767
url https://doi.org/10.1080/17402520600876762
http://repository.urosario.edu.co/handle/10336/8767
identifier_str_mv ISSN:1740-2522
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.citationIssue.none.fl_str_mv No. 2
dc.relation.citationTitle.none.fl_str_mv Clinical & Developmental Immunology
dc.relation.citationVolume.none.fl_str_mv Vol. 13
dc.relation.ispartof.spa.fl_str_mv Clinical & Developmental Immunology V. 13 N. 2-4 Jun, 2006
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dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto completo)
rights_invalid_str_mv Abierto (Texto completo)
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dc.format.medium.spa.fl_str_mv Recurso electrónico
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dc.format.tipo.spa.fl_str_mv Documento
dc.publisher.spa.fl_str_mv Universidad del Rosario
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
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spelling Comunidad Rosarista19474778600c5e15d68-2e79-46cc-994c-608ea4c1dc2360051cf37f6-25b0-4152-ae95-bb2b21ce5d7e6002014-08-11T15:47:24Z2014-08-11T15:47:24Z2006-062006Autoimmune diseases (ADs) represent a diverse collection of diseases in terms of their demographic profile and primary clinical manifestations. The commonality between them however, is the damage to tissues and organs that arises from the response to self-antigens. The presence of shared pathophysiological mechanisms within ADs has stimulated searches for common genetic roots to these diseases. Two approaches have been undertaken to sustain the “common genetic origin” theory of ADs. Firstly, a clinical genetic analysis showed that autoimmunity aggregates within families of probands diagnosed with primary Sjögren's (pSS) syndrome or type 1 diabetes mellitus (T1D). A literature review supported the establishment of a familiar cluster of ADs depending upon the proband's disease phenotype. Secondly, in a same and well-defined population, a large genetic association study indicated that a number of polymorphic genes (i.e. HLA-DRB1, TNF and PTPN22) influence the susceptibility for acquiring different ADs. Likewise, association and linkage studies in different populations have revealed that several susceptibility loci overlap in ADs, and clinical studies have shown that frequent clustering of several ADs occurs. Thus, the genetic factors for ADs consist of two types: those which are common to many ADs (acting in epistatic pleitropy) and those that are specific to a given disorder. Their identification and functional characterization will allow us to predict their effect as well as to indicate potential new therapeutic interventions. Both autoimmunity family history and the co-occurrence of ADs in affected probands should be considered when performing genetic association and linkage studies.Recurso electrónicoapplication/pdfDocumentohttps://doi.org/10.1080/17402520600876762ISSN:1740-2522http://repository.urosario.edu.co/handle/10336/8767engUniversidad del RosarioNo. 2Clinical & Developmental ImmunologyVol. 13Clinical & Developmental Immunology V. 13 N. 2-4 Jun, 2006http://web.b.ebscohost.com.ez.urosario.edu.co/ehost/pdfviewer/pdfviewer?sid=9eccd8fc-cb3c-48e8-9b12-2809af93ea82%40sessionmgr115&vid=2&hid=108Abierto (Texto completo)EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocUREnfermedades616600GenéticaInmunologíaEnfermedades autoinmunesgeneticsinheritance patternsSjögren's syndromeType 1 diabetes mellitusIs there a common genetic basis for autoimmune diseases?articleArtículohttp://purl.org/coar/resource_type/c_6501Anaya, Juan-ManuelGómez, Luis MiguelCastiblanco, JohnAnaya, Juan-ManuelGómez, LuisMiguelCastiblanco, JohnORIGINALIs there a common.pdfIs there a common.pdfapplication/pdf236836https://repository.urosario.edu.co/bitstreams/a11aec7b-5279-4b0c-84c8-55aeeaf88ea8/downloadc3d41fa0c0d354da7d8f4642b7586880MD51LICENSElicense.txtlicense.txttext/plain2156https://repository.urosario.edu.co/bitstreams/b4f3f241-dfc4-4285-bc28-155e1a4f991c/downloadb4f8fe66e94b897ab4c355bac005ad16MD52TEXTIs there a common.pdf.txtIs there a common.pdf.txtExtracted texttext/plain46700https://repository.urosario.edu.co/bitstreams/affeb041-bfc8-43bd-b124-76dd5bcaf11e/download0a375219de0a8441a90f36964e906be2MD59THUMBNAILIs there a common.pdf.jpgIs there a common.pdf.jpgGenerated 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