Influence of methotrexate on the frequency of postoperative infectious complications in patients with rheumatoid arthritis

OBJECTIVE: To evaluate the influence of methotrexate (MTX) on the frequency of postoperative complications in patients with rheumatoid arthritis (RA). METHODS: We conducted a randomized unblinded prospective study in 64 patients with RA treated with MTX and who underwent orthopedic surgery. Two grou...

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Fecha de publicación:
1993
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/27868
Acceso en línea:
https://repository.urosario.edu.co/handle/10336/27868
Palabra clave:
Influence of methotrexate (MTX)
Rheumatoid arthritis
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id EDOCUR2_8936de524ab5db882667f09c7d45e643
oai_identifier_str oai:repository.urosario.edu.co:10336/27868
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 19474778600e8938956-af14-46bd-9749-62565a90def12123eb57-c16d-41b8-82c2-691c3393078d363a398e-e9c8-42e8-bf3b-ad30173847260ffaf063-7823-42e6-9c94-b6fe251a08ab1a64a238-9594-45d2-b69e-880e07fa20ef2020-08-19T14:44:20Z2020-08-19T14:44:20Z1993OBJECTIVE: To evaluate the influence of methotrexate (MTX) on the frequency of postoperative complications in patients with rheumatoid arthritis (RA). METHODS: We conducted a randomized unblinded prospective study in 64 patients with RA treated with MTX and who underwent orthopedic surgery. Two groups of patients were constituted: in Group A (32 patients), MTX was interrupted 7 days before the surgery; in Group B (32 patients), MTX was not discontinued. RESULTS: Fifty surgical procedures were performed in Group A and 39 procedures in Group B. No postoperative infection was observed in any group. A prolonged wound healing was noticed in 6 cases in Group A and in 4 cases in Group B (not significant). CONCLUSION: We suggest that the interruption of MTX is not required in patients with RA when an orthopedic surgical treatment is planned. However a large prospective study is needed to make a definitive conclusion.application/pdfISSN: 0315-162XEISSN: 1499-2752https://repository.urosario.edu.co/handle/10336/27868engEurope PMC1132No. 71129Journal of RheumatologyVol. 20Journal of Rheumatology, ISSN: 0315-162X;EISSN: 1499-2752, Vol.20, No.7 (30 June 1993); pp.1129-1132https://europepmc.org/article/med/8371204Bloqueado (Texto referencial)http://purl.org/coar/access_right/c_14cbJournal of Rheumatologyinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURInfluence of methotrexate (MTX)Rheumatoid arthritisInfluence of methotrexate on the frequency of postoperative infectious complications in patients with rheumatoid arthritisInfluencia del metotrexato en la frecuencia de complicaciones infecciosas posoperatorias en pacientes con artritis reumatoidearticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Anaya, Juan-ManuelSany, J.Canovas, F.Combe, BJorgensen, C.Saker, S10336/27868oai:repository.urosario.edu.co:10336/278682022-05-02 07:37:13.443328https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Influence of methotrexate on the frequency of postoperative infectious complications in patients with rheumatoid arthritis
dc.title.TranslatedTitle.spa.fl_str_mv Influencia del metotrexato en la frecuencia de complicaciones infecciosas posoperatorias en pacientes con artritis reumatoide
title Influence of methotrexate on the frequency of postoperative infectious complications in patients with rheumatoid arthritis
spellingShingle Influence of methotrexate on the frequency of postoperative infectious complications in patients with rheumatoid arthritis
Influence of methotrexate (MTX)
Rheumatoid arthritis
title_short Influence of methotrexate on the frequency of postoperative infectious complications in patients with rheumatoid arthritis
title_full Influence of methotrexate on the frequency of postoperative infectious complications in patients with rheumatoid arthritis
title_fullStr Influence of methotrexate on the frequency of postoperative infectious complications in patients with rheumatoid arthritis
title_full_unstemmed Influence of methotrexate on the frequency of postoperative infectious complications in patients with rheumatoid arthritis
title_sort Influence of methotrexate on the frequency of postoperative infectious complications in patients with rheumatoid arthritis
dc.subject.keyword.spa.fl_str_mv Influence of methotrexate (MTX)
Rheumatoid arthritis
topic Influence of methotrexate (MTX)
Rheumatoid arthritis
description OBJECTIVE: To evaluate the influence of methotrexate (MTX) on the frequency of postoperative complications in patients with rheumatoid arthritis (RA). METHODS: We conducted a randomized unblinded prospective study in 64 patients with RA treated with MTX and who underwent orthopedic surgery. Two groups of patients were constituted: in Group A (32 patients), MTX was interrupted 7 days before the surgery; in Group B (32 patients), MTX was not discontinued. RESULTS: Fifty surgical procedures were performed in Group A and 39 procedures in Group B. No postoperative infection was observed in any group. A prolonged wound healing was noticed in 6 cases in Group A and in 4 cases in Group B (not significant). CONCLUSION: We suggest that the interruption of MTX is not required in patients with RA when an orthopedic surgical treatment is planned. However a large prospective study is needed to make a definitive conclusion.
publishDate 1993
dc.date.created.spa.fl_str_mv 1993
dc.date.accessioned.none.fl_str_mv 2020-08-19T14:44:20Z
dc.date.available.none.fl_str_mv 2020-08-19T14:44:20Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.issn.none.fl_str_mv ISSN: 0315-162X
EISSN: 1499-2752
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/27868
identifier_str_mv ISSN: 0315-162X
EISSN: 1499-2752
url https://repository.urosario.edu.co/handle/10336/27868
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 1132
dc.relation.citationIssue.none.fl_str_mv No. 7
dc.relation.citationStartPage.none.fl_str_mv 1129
dc.relation.citationTitle.none.fl_str_mv Journal of Rheumatology
dc.relation.citationVolume.none.fl_str_mv Vol. 20
dc.relation.ispartof.spa.fl_str_mv Journal of Rheumatology, ISSN: 0315-162X;EISSN: 1499-2752, Vol.20, No.7 (30 June 1993); pp.1129-1132
dc.relation.uri.spa.fl_str_mv https://europepmc.org/article/med/8371204
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_14cb
dc.rights.acceso.spa.fl_str_mv Bloqueado (Texto referencial)
rights_invalid_str_mv Bloqueado (Texto referencial)
http://purl.org/coar/access_right/c_14cb
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Europe PMC
dc.source.spa.fl_str_mv Journal of Rheumatology
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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