MHC class I genes in the owl monkey: Mosaic organisation, convergence and loci diversity
The MHC class I molecule plays an important role in immune response, pathogen recognition and response against vaccines and self- versus non-self-recognition. Studying MHC class I characteristics thus became a priority when dealing with Aotus to ensure its use as an animal model for biomedical resea...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2005
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/26280
- Acceso en línea:
- https://doi.org/10.1007/s00251-004-0751-5
https://repository.urosario.edu.co/handle/10336/26280
- Palabra clave:
- Aotus
MHC class I molecules
Gene conversion
Evolution
- Rights
- License
- Abierto (Texto Completo)
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b78fc884-88e1-4a6b-bc03-5a6f8f876db2-18fae7db6-7b9b-4538-b476-6f5ae5a41e7a-1e42731e8-7a4b-45a1-996f-edc995cce7f2-110ecd4f9-843f-4ef2-bec0-7d39d3381a13-179653065-12020-08-06T16:21:11Z2020-08-06T16:21:11Z2005-01-15The MHC class I molecule plays an important role in immune response, pathogen recognition and response against vaccines and self- versus non-self-recognition. Studying MHC class I characteristics thus became a priority when dealing with Aotus to ensure its use as an animal model for biomedical research. Isolation, cloning and sequencing of exons 1–8 from 27 MHC class I alleles obtained from 13 individuals classified as belonging to three owl monkey species (A. nancymaae, A. nigriceps and A. vociferans) were carried out to establish similarities between Aotus MHC class I genes and those expressed by other New and Old World primates. Six Aotus MHC class I sequence groups (Ao-g1, Ao-g2, Ao-g3, Ao-g4, Ao-g5 and Ao-g6) weakly related to non-classical Catarrhini MHC were identified. An allelic lineage was also identified in one A. nancymaae and two A. vociferans monkeys, exhibiting a high degree of conservation, negative selection along the molecule and premature termination of the open reading frame at exon 5 (Ao-g5). These sequences’ high conservation suggests that they more likely correspond to a soluble form of Aotus MHC class I molecules than to a new group of processed pseudogenes. Another group, named Ao-g6, exhibited a strong relationship with Catarrhini’s classical MHC-B-C loci. Sequence evolution and variability analysis indicated that Aotus MHC class I molecules experience inter-locus gene conversion phenomena, contributing towards their high variabilityapplication/pdfhttps://doi.org/10.1007/s00251-004-0751-5ISSN: 0093-7711EISSN: 1432-1211https://repository.urosario.edu.co/handle/10336/26280engSpringer Nature832818ImmunogeneticsVol. 56Immunogenetics, ISSN:0093-7711;EISSN:1432-1211, Vol.56, (January, 2005); pp.818-832https://link.springer.com/article/10.1007/s00251-004-0751-5Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Immunogeneticsinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURAotusMHC class I moleculesGene conversionEvolutionMHC class I genes in the owl monkey: Mosaic organisation, convergence and loci diversityGenes MHC de clase I en el mono búho: organización mosaica, convergencia y diversidad de lociarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Cardenas, Paula P.Suarez, Carlos F.Martinez, PilarPatarroyo, Manuel E.Patarroyo, Manuel A.ORIGINALCardenas2005_Article_MHCClassIGenesInTheOwlMonkeyMo.pdfapplication/pdf970306https://repository.urosario.edu.co/bitstreams/ae0c2b3b-b5a7-44b9-b51b-af4d22748442/downloadb710c83335e3e7f9aaed53629d81cd57MD51TEXTCardenas2005_Article_MHCClassIGenesInTheOwlMonkeyMo.pdf.txtCardenas2005_Article_MHCClassIGenesInTheOwlMonkeyMo.pdf.txtExtracted texttext/plain64344https://repository.urosario.edu.co/bitstreams/0cbdd660-6f3b-4aff-9130-214fe50a1ca4/download6df18facb49d1901ca428b1a6435c1d4MD52THUMBNAILCardenas2005_Article_MHCClassIGenesInTheOwlMonkeyMo.pdf.jpgCardenas2005_Article_MHCClassIGenesInTheOwlMonkeyMo.pdf.jpgGenerated Thumbnailimage/jpeg4598https://repository.urosario.edu.co/bitstreams/0eb2e302-ef3c-4d37-b90a-ff9458c7b696/download37bcb3d8423c958ce3014c704be8aa22MD5310336/26280oai:repository.urosario.edu.co:10336/262802021-06-03 00:50:55.136https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
MHC class I genes in the owl monkey: Mosaic organisation, convergence and loci diversity |
dc.title.TranslatedTitle.spa.fl_str_mv |
Genes MHC de clase I en el mono búho: organización mosaica, convergencia y diversidad de loci |
title |
MHC class I genes in the owl monkey: Mosaic organisation, convergence and loci diversity |
spellingShingle |
MHC class I genes in the owl monkey: Mosaic organisation, convergence and loci diversity Aotus MHC class I molecules Gene conversion Evolution |
title_short |
MHC class I genes in the owl monkey: Mosaic organisation, convergence and loci diversity |
title_full |
MHC class I genes in the owl monkey: Mosaic organisation, convergence and loci diversity |
title_fullStr |
MHC class I genes in the owl monkey: Mosaic organisation, convergence and loci diversity |
title_full_unstemmed |
MHC class I genes in the owl monkey: Mosaic organisation, convergence and loci diversity |
title_sort |
MHC class I genes in the owl monkey: Mosaic organisation, convergence and loci diversity |
dc.subject.keyword.spa.fl_str_mv |
Aotus MHC class I molecules Gene conversion Evolution |
topic |
Aotus MHC class I molecules Gene conversion Evolution |
description |
The MHC class I molecule plays an important role in immune response, pathogen recognition and response against vaccines and self- versus non-self-recognition. Studying MHC class I characteristics thus became a priority when dealing with Aotus to ensure its use as an animal model for biomedical research. Isolation, cloning and sequencing of exons 1–8 from 27 MHC class I alleles obtained from 13 individuals classified as belonging to three owl monkey species (A. nancymaae, A. nigriceps and A. vociferans) were carried out to establish similarities between Aotus MHC class I genes and those expressed by other New and Old World primates. Six Aotus MHC class I sequence groups (Ao-g1, Ao-g2, Ao-g3, Ao-g4, Ao-g5 and Ao-g6) weakly related to non-classical Catarrhini MHC were identified. An allelic lineage was also identified in one A. nancymaae and two A. vociferans monkeys, exhibiting a high degree of conservation, negative selection along the molecule and premature termination of the open reading frame at exon 5 (Ao-g5). These sequences’ high conservation suggests that they more likely correspond to a soluble form of Aotus MHC class I molecules than to a new group of processed pseudogenes. Another group, named Ao-g6, exhibited a strong relationship with Catarrhini’s classical MHC-B-C loci. Sequence evolution and variability analysis indicated that Aotus MHC class I molecules experience inter-locus gene conversion phenomena, contributing towards their high variability |
publishDate |
2005 |
dc.date.created.spa.fl_str_mv |
2005-01-15 |
dc.date.accessioned.none.fl_str_mv |
2020-08-06T16:21:11Z |
dc.date.available.none.fl_str_mv |
2020-08-06T16:21:11Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1007/s00251-004-0751-5 |
dc.identifier.issn.none.fl_str_mv |
ISSN: 0093-7711 EISSN: 1432-1211 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/26280 |
url |
https://doi.org/10.1007/s00251-004-0751-5 https://repository.urosario.edu.co/handle/10336/26280 |
identifier_str_mv |
ISSN: 0093-7711 EISSN: 1432-1211 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
832 |
dc.relation.citationStartPage.none.fl_str_mv |
818 |
dc.relation.citationTitle.none.fl_str_mv |
Immunogenetics |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 56 |
dc.relation.ispartof.spa.fl_str_mv |
Immunogenetics, ISSN:0093-7711;EISSN:1432-1211, Vol.56, (January, 2005); pp.818-832 |
dc.relation.uri.spa.fl_str_mv |
https://link.springer.com/article/10.1007/s00251-004-0751-5 |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Springer Nature |
dc.source.spa.fl_str_mv |
Immunogenetics |
institution |
Universidad del Rosario |
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