MHC class I genes in the owl monkey: Mosaic organisation, convergence and loci diversity

The MHC class I molecule plays an important role in immune response, pathogen recognition and response against vaccines and self- versus non-self-recognition. Studying MHC class I characteristics thus became a priority when dealing with Aotus to ensure its use as an animal model for biomedical resea...

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Tipo de recurso:
Fecha de publicación:
2005
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/26280
Acceso en línea:
https://doi.org/10.1007/s00251-004-0751-5
https://repository.urosario.edu.co/handle/10336/26280
Palabra clave:
Aotus
MHC class I molecules
Gene conversion
Evolution
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License
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dc.title.spa.fl_str_mv MHC class I genes in the owl monkey: Mosaic organisation, convergence and loci diversity
dc.title.TranslatedTitle.spa.fl_str_mv Genes MHC de clase I en el mono búho: organización mosaica, convergencia y diversidad de loci
title MHC class I genes in the owl monkey: Mosaic organisation, convergence and loci diversity
spellingShingle MHC class I genes in the owl monkey: Mosaic organisation, convergence and loci diversity
Aotus
MHC class I molecules
Gene conversion
Evolution
title_short MHC class I genes in the owl monkey: Mosaic organisation, convergence and loci diversity
title_full MHC class I genes in the owl monkey: Mosaic organisation, convergence and loci diversity
title_fullStr MHC class I genes in the owl monkey: Mosaic organisation, convergence and loci diversity
title_full_unstemmed MHC class I genes in the owl monkey: Mosaic organisation, convergence and loci diversity
title_sort MHC class I genes in the owl monkey: Mosaic organisation, convergence and loci diversity
dc.subject.keyword.spa.fl_str_mv Aotus
MHC class I molecules
Gene conversion
Evolution
topic Aotus
MHC class I molecules
Gene conversion
Evolution
description The MHC class I molecule plays an important role in immune response, pathogen recognition and response against vaccines and self- versus non-self-recognition. Studying MHC class I characteristics thus became a priority when dealing with Aotus to ensure its use as an animal model for biomedical research. Isolation, cloning and sequencing of exons 1–8 from 27 MHC class I alleles obtained from 13 individuals classified as belonging to three owl monkey species (A. nancymaae, A. nigriceps and A. vociferans) were carried out to establish similarities between Aotus MHC class I genes and those expressed by other New and Old World primates. Six Aotus MHC class I sequence groups (Ao-g1, Ao-g2, Ao-g3, Ao-g4, Ao-g5 and Ao-g6) weakly related to non-classical Catarrhini MHC were identified. An allelic lineage was also identified in one A. nancymaae and two A. vociferans monkeys, exhibiting a high degree of conservation, negative selection along the molecule and premature termination of the open reading frame at exon 5 (Ao-g5). These sequences’ high conservation suggests that they more likely correspond to a soluble form of Aotus MHC class I molecules than to a new group of processed pseudogenes. Another group, named Ao-g6, exhibited a strong relationship with Catarrhini’s classical MHC-B-C loci. Sequence evolution and variability analysis indicated that Aotus MHC class I molecules experience inter-locus gene conversion phenomena, contributing towards their high variability
publishDate 2005
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dc.identifier.issn.none.fl_str_mv ISSN: 0093-7711
EISSN: 1432-1211
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https://repository.urosario.edu.co/handle/10336/26280
identifier_str_mv ISSN: 0093-7711
EISSN: 1432-1211
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dc.relation.citationTitle.none.fl_str_mv Immunogenetics
dc.relation.citationVolume.none.fl_str_mv Vol. 56
dc.relation.ispartof.spa.fl_str_mv Immunogenetics, ISSN:0093-7711;EISSN:1432-1211, Vol.56, (January, 2005); pp.818-832
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dc.source.spa.fl_str_mv Immunogenetics
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