Autoimmune thyroid disease in euthyroid subjects

OBJECTIVE: To determine the prevalence of thyroid autoantibodies and the associated factors in euthyroid subjects. METHODS: In this study, 300 euthyroid subjects chosen by stratified sampling from an inception cohort of 1335 individuals were included. None of the subjects was under treatment. Thyroi...

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Tipo de recurso:
Fecha de publicación:
2018
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
spa
OAI Identifier:
oai:repository.urosario.edu.co:10336/18449
Acceso en línea:
https://doi.org/10.48713/10336_18449
http://repository.urosario.edu.co/handle/10336/18449
Palabra clave:
Euthyroidism
Anti-peroxidase autoantibodies
Anti-thyroglobulin autoantibodies
Autoimmune thyroid disease
Anatomía humana, citología, histología
Tiroides
Tiroglobulina
Autoanticuerpos
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License
Atribución-NoComercial-SinDerivadas 2.5 Colombia
id EDOCUR2_87b37bdbcb2ee679715fe8a47d1a9e64
oai_identifier_str oai:repository.urosario.edu.co:10336/18449
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.spa.fl_str_mv Autoimmune thyroid disease in euthyroid subjects
title Autoimmune thyroid disease in euthyroid subjects
spellingShingle Autoimmune thyroid disease in euthyroid subjects
Euthyroidism
Anti-peroxidase autoantibodies
Anti-thyroglobulin autoantibodies
Autoimmune thyroid disease
Anatomía humana, citología, histología
Tiroides
Tiroglobulina
Autoanticuerpos
title_short Autoimmune thyroid disease in euthyroid subjects
title_full Autoimmune thyroid disease in euthyroid subjects
title_fullStr Autoimmune thyroid disease in euthyroid subjects
title_full_unstemmed Autoimmune thyroid disease in euthyroid subjects
title_sort Autoimmune thyroid disease in euthyroid subjects
dc.contributor.advisor.none.fl_str_mv Ramírez Santana, Heily Carolina
Molano González, Nicolás
dc.contributor.none.fl_str_mv Anaya, Juan-Manuel
Rojas, Manuel
Monsalve, Diana M.
Acosta-Ampudia, Yeny
Pacheco, Yovana
Rodríguez Jiménez, Mónica
dc.subject.spa.fl_str_mv Euthyroidism
Anti-peroxidase autoantibodies
Anti-thyroglobulin autoantibodies
Autoimmune thyroid disease
topic Euthyroidism
Anti-peroxidase autoantibodies
Anti-thyroglobulin autoantibodies
Autoimmune thyroid disease
Anatomía humana, citología, histología
Tiroides
Tiroglobulina
Autoanticuerpos
dc.subject.ddc.spa.fl_str_mv Anatomía humana, citología, histología
dc.subject.lemb.spa.fl_str_mv Tiroides
Tiroglobulina
Autoanticuerpos
description OBJECTIVE: To determine the prevalence of thyroid autoantibodies and the associated factors in euthyroid subjects. METHODS: In this study, 300 euthyroid subjects chosen by stratified sampling from an inception cohort of 1335 individuals were included. None of the subjects was under treatment. Thyroid function was evaluated by measuring serum levels of TSH (0.3-4.5 μIU / ml) and FT4 (5.2-12.7μg / dl). In addition, anti-peroxidase (TPOAbs), anti-thyroglobulin (TgAbs), and anti-TSH receptor (TrAbs) autoantibodies were evaluated together with other 23 autoantibodies and vitamin D levels. The analysis included sociodemographic, clinical, and environmental characteristics. Data were analyzed by chi-square (χ2), Kruskal-Wallis, Mann-Whitney and logistical regression tests. RESULTS: Thyroid autoimmunity was observed in 15.3% of the subjects (TPOAbs in 11.3% and TgAbs in 2%). In six individuals, both autoantibodies were positive. TrAbs were not detected in any individual. Familial thyroid disease (P = 0.021,  = 3.4 CI: 1.2 – 9.5), low libido (P = 0.013,  = 3.8 CI: 1.3 – 10.6), the presence of other ADs (P = 0.014,  = 10.8 CI: 1.6 – 72.9) were associated with thyroid autoantibodies. In addition, VitD insufficiency (P= 0.03), never smoke (P = 0.010,  = 6.9 CI: 1.6 – 30.4), drinking more than 4 cups of coffee (P = 0.036,  = 3.8 CI: 1.1 – 13.1), and higher number of years exposed to wood smoke (P = 0.04), were associated with thyroid autoantibodies. Similar the last analysis, the presence of TPOAbs was associated with familial thyroid disease (P = 0.003,  = 4.9 CI: 1.7 - 14.0), never smoke (P = 0.002,  = 5.7 CI: 1.4 - 21.0), drinking > 4 cups of coffee (P = 0.047,  = 3.6 CI: 1.1 - 13.1), low libido (P = 0.001,  = 5.7 CI: 2.0 - 16.3). In addition, the presence of SS-A / Ro52 (P = 0.009,  = 36.7 CI: 2.5 - 549.9), and Ku (P = 0.046,  = 10.2 CI: 1.1 - 100.7), also was related to these autoantibodies. Regarding TgAbs, the presence of African ancestry (P = 0.01,  = 10.5 CI: 1.7 – 63.2), SS-A / Ro52 (P = 0.03,  = 15.8 CI: 1.2 – 198.6), and CENP-B (P = 0.02,  = 31.2 CI: 1.8 – 565.9) was associated with TgAbs. CONCLUSIONS: Subclinical thyroid autoimmunity is not rare. Environmental, genetic, and immunological factors as well as ancestry are associated risk factors. These results will facilitate the implementation of screening strategies in order to provide timely diagnosis and treatment.
publishDate 2018
dc.date.accessioned.none.fl_str_mv 2018-09-06T16:39:12Z
dc.date.available.none.fl_str_mv 2018-09-06T16:39:12Z
dc.date.created.none.fl_str_mv 2018-09-04
dc.date.issued.none.fl_str_mv 2018
dc.type.eng.fl_str_mv bachelorThesis
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.spa.spa.fl_str_mv Trabajo de grado
dc.identifier.doi.none.fl_str_mv https://doi.org/10.48713/10336_18449
dc.identifier.uri.none.fl_str_mv http://repository.urosario.edu.co/handle/10336/18449
url https://doi.org/10.48713/10336_18449
http://repository.urosario.edu.co/handle/10336/18449
dc.language.iso.none.fl_str_mv spa
language spa
dc.rights.spa.fl_str_mv Atribución-NoComercial-SinDerivadas 2.5 Colombia
Atribución-NoComercial-SinDerivadas 2.5 Colombia
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
dc.rights.uri.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
rights_invalid_str_mv Atribución-NoComercial-SinDerivadas 2.5 Colombia
Abierto (Texto Completo)
http://creativecommons.org/licenses/by-nc-nd/2.5/co/
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Universidad del Rosario
dc.publisher.department.spa.fl_str_mv Facultad de medicina
institution Universidad del Rosario
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spelling Anaya, Juan-ManuelRojas, ManuelMonsalve, Diana M.Acosta-Ampudia, YenyPacheco, YovanaRodríguez Jiménez, MónicaRamírez Santana, Heily Carolina52483526600Molano González, Nicolás80873475600Rodríguez Velandia, Yhojan AlexisEspecialista en Epidemiología (en Convenio con el CES)10229617356002018-09-06T16:39:12Z2018-09-06T16:39:12Z2018-09-042018OBJECTIVE: To determine the prevalence of thyroid autoantibodies and the associated factors in euthyroid subjects. METHODS: In this study, 300 euthyroid subjects chosen by stratified sampling from an inception cohort of 1335 individuals were included. None of the subjects was under treatment. Thyroid function was evaluated by measuring serum levels of TSH (0.3-4.5 μIU / ml) and FT4 (5.2-12.7μg / dl). In addition, anti-peroxidase (TPOAbs), anti-thyroglobulin (TgAbs), and anti-TSH receptor (TrAbs) autoantibodies were evaluated together with other 23 autoantibodies and vitamin D levels. The analysis included sociodemographic, clinical, and environmental characteristics. Data were analyzed by chi-square (χ2), Kruskal-Wallis, Mann-Whitney and logistical regression tests. RESULTS: Thyroid autoimmunity was observed in 15.3% of the subjects (TPOAbs in 11.3% and TgAbs in 2%). In six individuals, both autoantibodies were positive. TrAbs were not detected in any individual. Familial thyroid disease (P = 0.021,  = 3.4 CI: 1.2 – 9.5), low libido (P = 0.013,  = 3.8 CI: 1.3 – 10.6), the presence of other ADs (P = 0.014,  = 10.8 CI: 1.6 – 72.9) were associated with thyroid autoantibodies. In addition, VitD insufficiency (P= 0.03), never smoke (P = 0.010,  = 6.9 CI: 1.6 – 30.4), drinking more than 4 cups of coffee (P = 0.036,  = 3.8 CI: 1.1 – 13.1), and higher number of years exposed to wood smoke (P = 0.04), were associated with thyroid autoantibodies. Similar the last analysis, the presence of TPOAbs was associated with familial thyroid disease (P = 0.003,  = 4.9 CI: 1.7 - 14.0), never smoke (P = 0.002,  = 5.7 CI: 1.4 - 21.0), drinking > 4 cups of coffee (P = 0.047,  = 3.6 CI: 1.1 - 13.1), low libido (P = 0.001,  = 5.7 CI: 2.0 - 16.3). In addition, the presence of SS-A / Ro52 (P = 0.009,  = 36.7 CI: 2.5 - 549.9), and Ku (P = 0.046,  = 10.2 CI: 1.1 - 100.7), also was related to these autoantibodies. Regarding TgAbs, the presence of African ancestry (P = 0.01,  = 10.5 CI: 1.7 – 63.2), SS-A / Ro52 (P = 0.03,  = 15.8 CI: 1.2 – 198.6), and CENP-B (P = 0.02,  = 31.2 CI: 1.8 – 565.9) was associated with TgAbs. CONCLUSIONS: Subclinical thyroid autoimmunity is not rare. Environmental, genetic, and immunological factors as well as ancestry are associated risk factors. These results will facilitate the implementation of screening strategies in order to provide timely diagnosis and treatment.application/pdfhttps://doi.org/10.48713/10336_18449 http://repository.urosario.edu.co/handle/10336/18449spaUniversidad del RosarioFacultad de medicinaAtribución-NoComercial-SinDerivadas 2.5 ColombiaAtribución-NoComercial-SinDerivadas 2.5 ColombiaAbierto (Texto Completo)EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. 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