Cholinoreceptor autoantibodies in Sjögren syndrome

Previous studies have demonstrated that antibodies against cholinoreceptors of exocrine glands correlate with dry mouth in persons with primary Sjögren syndrome (pSS). The aim of the present investigation was to establish if serum IgG antibodies (pSS IgG) were able to interact with cholinoreceptors...

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Autores:
Tipo de recurso:
Fecha de publicación:
2007
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/27362
Acceso en línea:
https://doi.org/10.1177/154405910708600905
https://repository.urosario.edu.co/handle/10336/27362
Palabra clave:
PGE2
Submandibular gland
Sjögren syndrome
Autoantibodies
Cholinoceptor antibodies
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License
Restringido (Acceso a grupos específicos)
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oai_identifier_str oai:repository.urosario.edu.co:10336/27362
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling c27574f8-8d1b-482e-8e12-3c43b28d47c992d36571-a009-4870-9620-92f3d34dee77194747786004cba5369-58e0-4898-a7dc-92b405b649f99fc8eaeb-239d-46c2-ac6a-81a96aba4a202020-08-19T14:41:53Z2020-08-19T14:41:53Z2007-09-01Previous studies have demonstrated that antibodies against cholinoreceptors of exocrine glands correlate with dry mouth in persons with primary Sjögren syndrome (pSS). The aim of the present investigation was to establish if serum IgG antibodies (pSS IgG) were able to interact with cholinoreceptors in rat submandibular gland-dependent stimulation of cyclooxygenase 2 (COX-2) mRNA expression and PGE2 production. Our findings indicated that pSS IgG-stimulating M3, M4, and M1 cholinoreceptors exerted an increase in COX-2 mRNA without affecting COX-1 mRNA expression and increased PGE2 production. Inhibitors of phospholipase A2, COX- s, L-type calcium channel currents, and Ca2+-ATPase from sarcoplasmic reticulum prevented the pSS IgG effect on PGE2 production. An ionophore of calcium mimicked pSS IgG action, suggesting a crucial role of calcium homeostasis in the cholinoreceptor-stimulated increase in PGE2 production. Moreover, the amounts of PGE2 in saliva and in sera from persons with pSS were significantly higher than in pre- or post-menopausal women. These findings illustrate the importance of autoantibodies to cholinoreceptors in the generation of chronic inflammation of target tissues in SS.application/pdfhttps://doi.org/10.1177/154405910708600905ISSN: 0022-0345EISSN: 1544-0591https://repository.urosario.edu.co/handle/10336/27362engInternational & American Associations for Dental Research836No. 9832Journal of Dental ResearchVol. 86Journal of Dental Research, ISSN: 0022-0345;EISSN: 1544-0591, Vol.86, No.9 (2007); pp. 832-836https://journals.sagepub.com/doi/abs/10.1177/154405910708600905Restringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecJournal of Dental Researchinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURPGE2Submandibular glandSjögren syndromeAutoantibodiesCholinoceptor antibodiesCholinoreceptor autoantibodies in Sjögren syndromeAutoanticuerpos colinorreceptores en el síndrome de SjögrenarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Reina, S.Orman, B.Anaya, Juan-ManuelSterin-Borda, L.Borda, E.10336/27362oai:repository.urosario.edu.co:10336/273622021-08-10 21:27:50.721https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Cholinoreceptor autoantibodies in Sjögren syndrome
dc.title.TranslatedTitle.spa.fl_str_mv Autoanticuerpos colinorreceptores en el síndrome de Sjögren
title Cholinoreceptor autoantibodies in Sjögren syndrome
spellingShingle Cholinoreceptor autoantibodies in Sjögren syndrome
PGE2
Submandibular gland
Sjögren syndrome
Autoantibodies
Cholinoceptor antibodies
title_short Cholinoreceptor autoantibodies in Sjögren syndrome
title_full Cholinoreceptor autoantibodies in Sjögren syndrome
title_fullStr Cholinoreceptor autoantibodies in Sjögren syndrome
title_full_unstemmed Cholinoreceptor autoantibodies in Sjögren syndrome
title_sort Cholinoreceptor autoantibodies in Sjögren syndrome
dc.subject.keyword.spa.fl_str_mv PGE2
Submandibular gland
Sjögren syndrome
Autoantibodies
Cholinoceptor antibodies
topic PGE2
Submandibular gland
Sjögren syndrome
Autoantibodies
Cholinoceptor antibodies
description Previous studies have demonstrated that antibodies against cholinoreceptors of exocrine glands correlate with dry mouth in persons with primary Sjögren syndrome (pSS). The aim of the present investigation was to establish if serum IgG antibodies (pSS IgG) were able to interact with cholinoreceptors in rat submandibular gland-dependent stimulation of cyclooxygenase 2 (COX-2) mRNA expression and PGE2 production. Our findings indicated that pSS IgG-stimulating M3, M4, and M1 cholinoreceptors exerted an increase in COX-2 mRNA without affecting COX-1 mRNA expression and increased PGE2 production. Inhibitors of phospholipase A2, COX- s, L-type calcium channel currents, and Ca2+-ATPase from sarcoplasmic reticulum prevented the pSS IgG effect on PGE2 production. An ionophore of calcium mimicked pSS IgG action, suggesting a crucial role of calcium homeostasis in the cholinoreceptor-stimulated increase in PGE2 production. Moreover, the amounts of PGE2 in saliva and in sera from persons with pSS were significantly higher than in pre- or post-menopausal women. These findings illustrate the importance of autoantibodies to cholinoreceptors in the generation of chronic inflammation of target tissues in SS.
publishDate 2007
dc.date.created.spa.fl_str_mv 2007-09-01
dc.date.accessioned.none.fl_str_mv 2020-08-19T14:41:53Z
dc.date.available.none.fl_str_mv 2020-08-19T14:41:53Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1177/154405910708600905
dc.identifier.issn.none.fl_str_mv ISSN: 0022-0345
EISSN: 1544-0591
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/27362
url https://doi.org/10.1177/154405910708600905
https://repository.urosario.edu.co/handle/10336/27362
identifier_str_mv ISSN: 0022-0345
EISSN: 1544-0591
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 836
dc.relation.citationIssue.none.fl_str_mv No. 9
dc.relation.citationStartPage.none.fl_str_mv 832
dc.relation.citationTitle.none.fl_str_mv Journal of Dental Research
dc.relation.citationVolume.none.fl_str_mv Vol. 86
dc.relation.ispartof.spa.fl_str_mv Journal of Dental Research, ISSN: 0022-0345;EISSN: 1544-0591, Vol.86, No.9 (2007); pp. 832-836
dc.relation.uri.spa.fl_str_mv https://journals.sagepub.com/doi/abs/10.1177/154405910708600905
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_16ec
dc.rights.acceso.spa.fl_str_mv Restringido (Acceso a grupos específicos)
rights_invalid_str_mv Restringido (Acceso a grupos específicos)
http://purl.org/coar/access_right/c_16ec
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv International & American Associations for Dental Research
dc.source.spa.fl_str_mv Journal of Dental Research
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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