Cholinoreceptor autoantibodies in Sjögren syndrome
Previous studies have demonstrated that antibodies against cholinoreceptors of exocrine glands correlate with dry mouth in persons with primary Sjögren syndrome (pSS). The aim of the present investigation was to establish if serum IgG antibodies (pSS IgG) were able to interact with cholinoreceptors...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2007
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/27362
- Acceso en línea:
- https://doi.org/10.1177/154405910708600905
https://repository.urosario.edu.co/handle/10336/27362
- Palabra clave:
- PGE2
Submandibular gland
Sjögren syndrome
Autoantibodies
Cholinoceptor antibodies
- Rights
- License
- Restringido (Acceso a grupos específicos)
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c27574f8-8d1b-482e-8e12-3c43b28d47c992d36571-a009-4870-9620-92f3d34dee77194747786004cba5369-58e0-4898-a7dc-92b405b649f99fc8eaeb-239d-46c2-ac6a-81a96aba4a202020-08-19T14:41:53Z2020-08-19T14:41:53Z2007-09-01Previous studies have demonstrated that antibodies against cholinoreceptors of exocrine glands correlate with dry mouth in persons with primary Sjögren syndrome (pSS). The aim of the present investigation was to establish if serum IgG antibodies (pSS IgG) were able to interact with cholinoreceptors in rat submandibular gland-dependent stimulation of cyclooxygenase 2 (COX-2) mRNA expression and PGE2 production. Our findings indicated that pSS IgG-stimulating M3, M4, and M1 cholinoreceptors exerted an increase in COX-2 mRNA without affecting COX-1 mRNA expression and increased PGE2 production. Inhibitors of phospholipase A2, COX- s, L-type calcium channel currents, and Ca2+-ATPase from sarcoplasmic reticulum prevented the pSS IgG effect on PGE2 production. An ionophore of calcium mimicked pSS IgG action, suggesting a crucial role of calcium homeostasis in the cholinoreceptor-stimulated increase in PGE2 production. Moreover, the amounts of PGE2 in saliva and in sera from persons with pSS were significantly higher than in pre- or post-menopausal women. These findings illustrate the importance of autoantibodies to cholinoreceptors in the generation of chronic inflammation of target tissues in SS.application/pdfhttps://doi.org/10.1177/154405910708600905ISSN: 0022-0345EISSN: 1544-0591https://repository.urosario.edu.co/handle/10336/27362engInternational & American Associations for Dental Research836No. 9832Journal of Dental ResearchVol. 86Journal of Dental Research, ISSN: 0022-0345;EISSN: 1544-0591, Vol.86, No.9 (2007); pp. 832-836https://journals.sagepub.com/doi/abs/10.1177/154405910708600905Restringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecJournal of Dental Researchinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURPGE2Submandibular glandSjögren syndromeAutoantibodiesCholinoceptor antibodiesCholinoreceptor autoantibodies in Sjögren syndromeAutoanticuerpos colinorreceptores en el síndrome de SjögrenarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Reina, S.Orman, B.Anaya, Juan-ManuelSterin-Borda, L.Borda, E.10336/27362oai:repository.urosario.edu.co:10336/273622021-08-10 21:27:50.721https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Cholinoreceptor autoantibodies in Sjögren syndrome |
dc.title.TranslatedTitle.spa.fl_str_mv |
Autoanticuerpos colinorreceptores en el síndrome de Sjögren |
title |
Cholinoreceptor autoantibodies in Sjögren syndrome |
spellingShingle |
Cholinoreceptor autoantibodies in Sjögren syndrome PGE2 Submandibular gland Sjögren syndrome Autoantibodies Cholinoceptor antibodies |
title_short |
Cholinoreceptor autoantibodies in Sjögren syndrome |
title_full |
Cholinoreceptor autoantibodies in Sjögren syndrome |
title_fullStr |
Cholinoreceptor autoantibodies in Sjögren syndrome |
title_full_unstemmed |
Cholinoreceptor autoantibodies in Sjögren syndrome |
title_sort |
Cholinoreceptor autoantibodies in Sjögren syndrome |
dc.subject.keyword.spa.fl_str_mv |
PGE2 Submandibular gland Sjögren syndrome Autoantibodies Cholinoceptor antibodies |
topic |
PGE2 Submandibular gland Sjögren syndrome Autoantibodies Cholinoceptor antibodies |
description |
Previous studies have demonstrated that antibodies against cholinoreceptors of exocrine glands correlate with dry mouth in persons with primary Sjögren syndrome (pSS). The aim of the present investigation was to establish if serum IgG antibodies (pSS IgG) were able to interact with cholinoreceptors in rat submandibular gland-dependent stimulation of cyclooxygenase 2 (COX-2) mRNA expression and PGE2 production. Our findings indicated that pSS IgG-stimulating M3, M4, and M1 cholinoreceptors exerted an increase in COX-2 mRNA without affecting COX-1 mRNA expression and increased PGE2 production. Inhibitors of phospholipase A2, COX- s, L-type calcium channel currents, and Ca2+-ATPase from sarcoplasmic reticulum prevented the pSS IgG effect on PGE2 production. An ionophore of calcium mimicked pSS IgG action, suggesting a crucial role of calcium homeostasis in the cholinoreceptor-stimulated increase in PGE2 production. Moreover, the amounts of PGE2 in saliva and in sera from persons with pSS were significantly higher than in pre- or post-menopausal women. These findings illustrate the importance of autoantibodies to cholinoreceptors in the generation of chronic inflammation of target tissues in SS. |
publishDate |
2007 |
dc.date.created.spa.fl_str_mv |
2007-09-01 |
dc.date.accessioned.none.fl_str_mv |
2020-08-19T14:41:53Z |
dc.date.available.none.fl_str_mv |
2020-08-19T14:41:53Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1177/154405910708600905 |
dc.identifier.issn.none.fl_str_mv |
ISSN: 0022-0345 EISSN: 1544-0591 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/27362 |
url |
https://doi.org/10.1177/154405910708600905 https://repository.urosario.edu.co/handle/10336/27362 |
identifier_str_mv |
ISSN: 0022-0345 EISSN: 1544-0591 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
836 |
dc.relation.citationIssue.none.fl_str_mv |
No. 9 |
dc.relation.citationStartPage.none.fl_str_mv |
832 |
dc.relation.citationTitle.none.fl_str_mv |
Journal of Dental Research |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 86 |
dc.relation.ispartof.spa.fl_str_mv |
Journal of Dental Research, ISSN: 0022-0345;EISSN: 1544-0591, Vol.86, No.9 (2007); pp. 832-836 |
dc.relation.uri.spa.fl_str_mv |
https://journals.sagepub.com/doi/abs/10.1177/154405910708600905 |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_16ec |
dc.rights.acceso.spa.fl_str_mv |
Restringido (Acceso a grupos específicos) |
rights_invalid_str_mv |
Restringido (Acceso a grupos específicos) http://purl.org/coar/access_right/c_16ec |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
International & American Associations for Dental Research |
dc.source.spa.fl_str_mv |
Journal of Dental Research |
institution |
Universidad del Rosario |
dc.source.instname.none.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.none.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167460695244800 |