Eficacia del diagnóstico prenatal no invasivo por células fetales libres en sangre materna 1990-2014. Revisión sistemática
ANTECEDENTES: El aislamiento de células fetales libres o ADN fetal en sangre materna abre una ventana de posibilidades diagnósticas no invasivas para patologías monogénicas y cromosómicas, además de permitir la identificación del sexo y del RH fetal. Actualmente existen múltiples estudios que evalúa...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2015
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- spa
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/10537
- Acceso en línea:
- https://doi.org/10.48713/10336_10537
http://repository.urosario.edu.co/handle/10336/10537
- Palabra clave:
- Diagnóstico prenatal
Método no invasivo
células fetales libres
revision sistemática
Ginecología & otras especialidades médicas
Epidemiología
Obstetricia
Embarazo
Prenatal diagnosis
fetal cells
non invasive
systematic review
- Rights
- License
- Abierto (Texto completo)
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EDOCUR2 |
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Repositorio EdocUR - U. Rosario |
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|
| dc.title.spa.fl_str_mv |
Eficacia del diagnóstico prenatal no invasivo por células fetales libres en sangre materna 1990-2014. Revisión sistemática |
| title |
Eficacia del diagnóstico prenatal no invasivo por células fetales libres en sangre materna 1990-2014. Revisión sistemática |
| spellingShingle |
Eficacia del diagnóstico prenatal no invasivo por células fetales libres en sangre materna 1990-2014. Revisión sistemática Diagnóstico prenatal Método no invasivo células fetales libres revision sistemática Ginecología & otras especialidades médicas Epidemiología Obstetricia Embarazo Prenatal diagnosis fetal cells non invasive systematic review |
| title_short |
Eficacia del diagnóstico prenatal no invasivo por células fetales libres en sangre materna 1990-2014. Revisión sistemática |
| title_full |
Eficacia del diagnóstico prenatal no invasivo por células fetales libres en sangre materna 1990-2014. Revisión sistemática |
| title_fullStr |
Eficacia del diagnóstico prenatal no invasivo por células fetales libres en sangre materna 1990-2014. Revisión sistemática |
| title_full_unstemmed |
Eficacia del diagnóstico prenatal no invasivo por células fetales libres en sangre materna 1990-2014. Revisión sistemática |
| title_sort |
Eficacia del diagnóstico prenatal no invasivo por células fetales libres en sangre materna 1990-2014. Revisión sistemática |
| dc.contributor.advisor.none.fl_str_mv |
Amaya-Amaya, Jenny |
| dc.subject.spa.fl_str_mv |
Diagnóstico prenatal Método no invasivo células fetales libres revision sistemática |
| topic |
Diagnóstico prenatal Método no invasivo células fetales libres revision sistemática Ginecología & otras especialidades médicas Epidemiología Obstetricia Embarazo Prenatal diagnosis fetal cells non invasive systematic review |
| dc.subject.ddc.none.fl_str_mv |
Ginecología & otras especialidades médicas |
| dc.subject.decs.spa.fl_str_mv |
Epidemiología Obstetricia Embarazo |
| dc.subject.keyword.eng.fl_str_mv |
Prenatal diagnosis fetal cells non invasive systematic review |
| description |
ANTECEDENTES: El aislamiento de células fetales libres o ADN fetal en sangre materna abre una ventana de posibilidades diagnósticas no invasivas para patologías monogénicas y cromosómicas, además de permitir la identificación del sexo y del RH fetal. Actualmente existen múltiples estudios que evalúan la eficacia de estos métodos, mostrando resultados costo-efectivos y de menor riesgo que el estándar de oro. Este trabajo describe la evidencia encontrada acerca del diagnóstico prenatal no invasivo luego de realizar una revisión sistemática de la literatura. OBJETIVOS: El objetivo de este estudio fue reunir la evidencia que cumpla con los criterios de búsqueda, en el tema del diagnóstico fetal no invasivo por células fetales libres en sangre materna para determinar su utilidad diagnóstica. MÉTODOS: Se realizó una revisión sistemática de la literatura con el fin de determinar si el diagnóstico prenatal no invasivo por células fetales libres en sangre materna es efectivo como método de diagnóstico. RESULTADOS: Se encontraron 5,893 artículos que cumplían con los criterios de búsqueda; 67 cumplieron los criterios de inclusión: 49.3% (33/67) correspondieron a estudios de corte transversal, 38,8% (26/67) a estudios de cohortes y el 11.9% (8/67) a estudios casos y controles. Se obtuvieron resultados de sensibilidad, especificidad y tipo de prueba. CONCLUSIÓN: En la presente revisión sistemática, se evidencia como el diagnóstico prenatal no invasivo es una técnica feasible, reproducible y sensible para el diagnóstico fetal, evitando el riesgo de un diagnóstico invasivo. |
| publishDate |
2015 |
| dc.date.accessioned.none.fl_str_mv |
2015-06-09T18:54:08Z |
| dc.date.available.none.fl_str_mv |
2015-06-09T18:54:08Z |
| dc.date.created.none.fl_str_mv |
2015-05-27 |
| dc.date.issued.none.fl_str_mv |
2015 |
| dc.type.eng.fl_str_mv |
bachelorThesis |
| dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_7a1f |
| dc.type.spa.spa.fl_str_mv |
Trabajo de grado |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.48713/10336_10537 |
| dc.identifier.uri.none.fl_str_mv |
http://repository.urosario.edu.co/handle/10336/10537 |
| url |
https://doi.org/10.48713/10336_10537 http://repository.urosario.edu.co/handle/10336/10537 |
| dc.language.iso.none.fl_str_mv |
spa |
| language |
spa |
| dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto completo) |
| dc.rights.cc.spa.fl_str_mv |
Atribución-NoComercial-SinDerivadas 2.5 Colombia Atribución-NoComercial-SinDerivadas 2.5 Colombia |
| dc.rights.uri.none.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/2.5/co/ |
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Abierto (Texto completo) Atribución-NoComercial-SinDerivadas 2.5 Colombia http://creativecommons.org/licenses/by-nc-nd/2.5/co/ http://purl.org/coar/access_right/c_abf2 |
| dc.format.mimetype.none.fl_str_mv |
application/pdf |
| dc.publisher.spa.fl_str_mv |
Universidad del Rosario |
| dc.publisher.department.spa.fl_str_mv |
Facultad de medicina |
| institution |
Universidad del Rosario |
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De los Ángeles Mori, M., Mansilla, E., García-Santiago, F., Vallespín, E., Palomares, M., Martín, R., ...& Nevado, J. (2012). Diagnóstico prenatal y array-hibridación genómica comparada (CGH)(I). Gestaciones de elevado riesgo. Diagnóstico Prenatal, 23(2), 34-48. Sparks AB, Struble CA, Wang ET, et al. Noninvasive prenatal detection and selective analysis of cell-free DNA obtained from maternal blood: evaluation for trisomy 21 and trisomy 18. Am J Obstet Gynecol 2012;206:319.e1–9. Lo, Y. M., Lo, E. S., Watson, N., Noakes, L., Sargent, I. L., Thilaganathan, B., & Wainscoat, J. S. (1996). Two-way cell traffic between mother and fetus: biologic and clinical implications. Blood, 88(11), 4390-4395. Bianchi, D. W., Flint, A. F., Pizzimenti, M. F., Knoll, J. H., & Latt, S. A. (1990). Isolation of fetal DNA from nucleated erythrocytes in maternal blood. Proceedings of the National Academy of Sciences, 87(9), 3279-3283. Simpson, J. L., & Elias, S. (1993). 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The Lancet, 350(9076), 485-487. Lo, Y. D., Tein, M. S., Lau, T. K., Haines, C. J., Leung, T. N., Poon, P. M., ... & Hjelm, N. M. (1998). Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis. The American Journal of Human Genetics, 62(4), 768-775. Smid, M., Lagona, F., de Benassuti, L., Ferrari, A., Ferrari, M., & Cremonesi, L. (1999). Evaluation of different approaches for fetal DNA analysis from maternal plasma and nucleated blood cells. Clinical chemistry, 45(9), 1570-1572. Lau, T. K., Chen, F., Pan, X., Pooh, R. K., Jiang, F., Li, Y., ... & Zhang, X. (2012). Noninvasive prenatal diagnosis of common fetal chromosomal aneuploidies by maternal plasma DNA sequencing. Journal of Maternal-Fetal and Neonatal Medicine, 25(8), 1370-1374. Faas, B. H. W., Beuling, E. A., Christiaens, G. M., & von dem Borne, A. K. (1998). Detection of fetal RHD-specific sequences in maternal plasma. The lancet, 352(9135), 1196. Bischoff, F. 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The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC medical research methodology, 3(1), 25. Resolución, N. 008430 Del 4 De Octubre De 1993. Ministerio de salud. Driscoll, D. A., & Gross, S. (2009). Prenatal screening for aneuploidy. New England Journal of Medicine, 360(24), 2556-2562. American College of Obstetricians and Gynecologists. (2012). Committee opinion no. 545: Noninvasive prenatal testing for fetal aneuploidy. Obstet Gynecol, 120(6), 1532-1534. Greene, N., Greenland, S., Olsen, J., & Nohr, E. A. (2011). Estimating bias from loss to follow-up in the Danish National Birth Cohort. Epidemiology, 22(6), 815-822. Langer, A., Díaz-Olavarrieta, C., Berdichevsky, K., & Villar, J. (2004). Why is research from developing countries underrepresented in international health literature, and what can be done about it?. Bulletin of the World Health Organization, 82(10), 802-803. Loane, M., Morris, J. K., Addor, M. C., Arriola, L., Budd, J., Doray, B., ... & Dolk, H. (2013). Twenty-year trends in the prevalence of Down syndrome and other trisomies in Europe: impact of maternal age and prenatal screening. European Journal of Human Genetics, 21(1), 27-33. Norwitz, E. R., & Levy, B. (2013). Noninvasive prenatal testing: the future is now. Reviews in obstetrics and gynecology, 6(2), 48. Song, K., Musci, T. J., & Caughey, A. B. (2013). Clinical utility and cost of non-invasive prenatal testing with cfDNA analysis in high-risk women based on a US population. The Journal of Maternal-Fetal & Neonatal Medicine, 26(12), 1180-1185. Wright, C. F., & Burton, H. (2009). The use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis. Human reproduction update, 15(1), 139-151. |
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Amaya-Amaya, Jenny06d01a9c-7112-4ad7-b82e-5dedc26c7a1f-1Perez Zauner, Ana MariaForero Isaza, Maria del RosarioValderrama Beltran, NicoleEspecialista en Epidemiología (en Convenio con el CES)52299045-b1b7-4b03-a2b4-34e8c63c1b6a-1352ffccf-494b-4aa1-8777-41507cd078c1-1dbdc19a1-ac0d-459a-aae8-3423923cf0d7-12015-06-09T18:54:08Z2015-06-09T18:54:08Z2015-05-272015ANTECEDENTES: El aislamiento de células fetales libres o ADN fetal en sangre materna abre una ventana de posibilidades diagnósticas no invasivas para patologías monogénicas y cromosómicas, además de permitir la identificación del sexo y del RH fetal. Actualmente existen múltiples estudios que evalúan la eficacia de estos métodos, mostrando resultados costo-efectivos y de menor riesgo que el estándar de oro. Este trabajo describe la evidencia encontrada acerca del diagnóstico prenatal no invasivo luego de realizar una revisión sistemática de la literatura. OBJETIVOS: El objetivo de este estudio fue reunir la evidencia que cumpla con los criterios de búsqueda, en el tema del diagnóstico fetal no invasivo por células fetales libres en sangre materna para determinar su utilidad diagnóstica. MÉTODOS: Se realizó una revisión sistemática de la literatura con el fin de determinar si el diagnóstico prenatal no invasivo por células fetales libres en sangre materna es efectivo como método de diagnóstico. RESULTADOS: Se encontraron 5,893 artículos que cumplían con los criterios de búsqueda; 67 cumplieron los criterios de inclusión: 49.3% (33/67) correspondieron a estudios de corte transversal, 38,8% (26/67) a estudios de cohortes y el 11.9% (8/67) a estudios casos y controles. Se obtuvieron resultados de sensibilidad, especificidad y tipo de prueba. CONCLUSIÓN: En la presente revisión sistemática, se evidencia como el diagnóstico prenatal no invasivo es una técnica feasible, reproducible y sensible para el diagnóstico fetal, evitando el riesgo de un diagnóstico invasivo.BACKGROUND: Isolation of free fetal cells or fetal DNA in maternal blood opens a window of possibilities for the noninvasive diagnosisof monogenic and chromosomal disorders, andin addition it allows the identification of fetal sex and RH. Currently, there are many studies that evaluate the effectiveness of these methods, showing cost-effective and less risky results than the gold standard. This paper describes the evidence found for noninvasive prenatal diagnosis after conducting a systematic review of the literature. OBJECTIVES: The aim of this study was to collect evidence that meets the search criteria on the matter of noninvasive fetal diagnosis through free fetal cells in maternal blood, to determine its diagnostic utility. METHODS: A systematic literature review was conducted to determine whether noninvasive prenatal diagnosis of fetal cells in maternal free blood is effective as a diagnostic method. RESULTS: 5,893 articles that met the search criteria were found; 67 met the inclusion criteria: 49.3% (33/67) were of cross-sectional studies, 38.8% (26/67) for cohort and 11.9% (8/67) case-control studies. Overall sensitivity, specificity and type of test were obtained. CONCLUSION: In this systematic review, evidence was foundthat noninvasive prenatal diagnosis is a feasible, reproducible and sensitive technique for fetal diagnosis, avoiding the risk of an invasive diagnosis.Ningunoapplication/pdfhttps://doi.org/10.48713/10336_10537 http://repository.urosario.edu.co/handle/10336/10537spaUniversidad del RosarioFacultad de medicinaAbierto (Texto completo)Atribución-NoComercial-SinDerivadas 2.5 ColombiaAtribución-NoComercial-SinDerivadas 2.5 ColombiaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. 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The Journal of Maternal-Fetal & Neonatal Medicine, 26(12), 1180-1185.Wright, C. F., & Burton, H. (2009). The use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis. Human reproduction update, 15(1), 139-151.instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURDiagnóstico prenatalMétodo no invasivocélulas fetales libresrevision sistemáticaGinecología & otras especialidades médicas618600EpidemiologíaObstetriciaEmbarazoPrenatal diagnosisfetal cellsnon invasivesystematic reviewEficacia del diagnóstico prenatal no invasivo por células fetales libres en sangre materna 1990-2014. 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