Effect of disodium monofluorphosphate on plasma and blood viscosity in the rat
Alpha macroglobulins (AM) are plasma proteins whose main function is to inactivate proteinases, protecting the tissues from the action of these enzymes. AM have influence on plasma viscosity (PV) and binds monofluorophosphate (MFP), which disturbs its homeostasis. The aim of this work was to evaluat...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2008
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/23682
- Acceso en línea:
- https://doi.org/10.3233/CH-2008-1135
https://repository.urosario.edu.co/handle/10336/23682
- Palabra clave:
- Alpha 2 macroglobulin
Fluorophosphate
Sodium chloride
Animal cell
Animal experiment
Article
Blood viscosity
Controlled study
Erythrocyte
Male
Nonhuman
Plasma
Rat
Alpha-macroglobulins
Animals
Blood viscosity
Bone density conservation agents
Erythrocyte deformability
Fluorides
Male
Phosphates
Rats
Blood
Macroglobulin
Monofluorophosphate
Viscosity
oral
Administration
- Rights
- License
- Abierto (Texto Completo)
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df41dea3-1780-40c3-bd2f-dee6f7898c27-1a775e106-dc90-41b7-8cc5-6768208a8ed9-14635083b-2aec-4217-a2b1-25e753f2dd98-1ee90f2f1-8962-412f-a6c5-9857eaf3f67a-12020-05-26T00:04:23Z2020-05-26T00:04:23Z2008Alpha macroglobulins (AM) are plasma proteins whose main function is to inactivate proteinases, protecting the tissues from the action of these enzymes. AM have influence on plasma viscosity (PV) and binds monofluorophosphate (MFP), which disturbs its homeostasis. The aim of this work was to evaluate whether the administration with MFP could modify blood viscosity. AM levels (?mol/l), PV (mPa·s), viscosity of red blood cells suspensions in NaCl 9 g/l (VES) and in autologue plasma (VEP) were measured in fifty-day old rats after a single dose of 80 ?mol MFP or after 30 days of treatment with 80 ?mol of MFP. Relative viscosity (RV) was calculated as the ratio VEP/PV. AM and PV increased significantly after 30 min of an oral dose of MFP. Controls (n=6), AM: 19.65±0.85, PV: 1.39±0.01, treated (n=6), AM: 22.88±0.75 (p less than 0.05), PV: 1.76±0.14 (p less than 0.05). After 30 days of treatment with MFP, AM and PV increased significantly. Controls (n=6), AM: 10.76±1.33, PV: 1.19±0.04, treated (n=6), AM: 17.66±1.27 (p less than 0.05), PV: 1.38±0.03 (p less than 0.05). The treatment with MFP modifies neither the VEP nor the RV. These results would indicate that AM and/or MFP did not interact with erythrocyte membrane and did not modify erythrocyte deformability. © 2008 - IOS Press and the authors. All rights reserved.application/pdfhttps://doi.org/10.3233/CH-2008-113513860291https://repository.urosario.edu.co/handle/10336/23682eng265No. 4259Clinical Hemorheology and MicrocirculationVol. 40Clinical Hemorheology and Microcirculation, ISSN:13860291, Vol.40, No.4 (2008); pp. 259-265https://www.scopus.com/inward/record.uri?eid=2-s2.0-58149381917&doi=10.3233%2fCH-2008-1135&partnerID=40&md5=ef5077fbf467c10637ea646434b9d0afAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURAlpha 2 macroglobulinFluorophosphateSodium chlorideAnimal cellAnimal experimentArticleBlood viscosityControlled studyErythrocyteMaleNonhumanPlasmaRatAlpha-macroglobulinsAnimalsBlood viscosityBone density conservation agentsErythrocyte deformabilityFluoridesMalePhosphatesRatsBloodMacroglobulinMonofluorophosphateViscosityoralAdministrationEffect of disodium monofluorphosphate on plasma and blood viscosity in the ratarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Di Loreto V.Rigalli A.Cinara L.Hernández G.10336/23682oai:repository.urosario.edu.co:10336/236822022-05-02 07:37:21.19877https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Effect of disodium monofluorphosphate on plasma and blood viscosity in the rat |
title |
Effect of disodium monofluorphosphate on plasma and blood viscosity in the rat |
spellingShingle |
Effect of disodium monofluorphosphate on plasma and blood viscosity in the rat Alpha 2 macroglobulin Fluorophosphate Sodium chloride Animal cell Animal experiment Article Blood viscosity Controlled study Erythrocyte Male Nonhuman Plasma Rat Alpha-macroglobulins Animals Blood viscosity Bone density conservation agents Erythrocyte deformability Fluorides Male Phosphates Rats Blood Macroglobulin Monofluorophosphate Viscosity oral Administration |
title_short |
Effect of disodium monofluorphosphate on plasma and blood viscosity in the rat |
title_full |
Effect of disodium monofluorphosphate on plasma and blood viscosity in the rat |
title_fullStr |
Effect of disodium monofluorphosphate on plasma and blood viscosity in the rat |
title_full_unstemmed |
Effect of disodium monofluorphosphate on plasma and blood viscosity in the rat |
title_sort |
Effect of disodium monofluorphosphate on plasma and blood viscosity in the rat |
dc.subject.keyword.spa.fl_str_mv |
Alpha 2 macroglobulin Fluorophosphate Sodium chloride Animal cell Animal experiment Article Blood viscosity Controlled study Erythrocyte Male Nonhuman Plasma Rat Alpha-macroglobulins Animals Blood viscosity Bone density conservation agents Erythrocyte deformability Fluorides Male Phosphates Rats Blood Macroglobulin Monofluorophosphate Viscosity |
topic |
Alpha 2 macroglobulin Fluorophosphate Sodium chloride Animal cell Animal experiment Article Blood viscosity Controlled study Erythrocyte Male Nonhuman Plasma Rat Alpha-macroglobulins Animals Blood viscosity Bone density conservation agents Erythrocyte deformability Fluorides Male Phosphates Rats Blood Macroglobulin Monofluorophosphate Viscosity oral Administration |
dc.subject.keyword.eng.fl_str_mv |
oral Administration |
description |
Alpha macroglobulins (AM) are plasma proteins whose main function is to inactivate proteinases, protecting the tissues from the action of these enzymes. AM have influence on plasma viscosity (PV) and binds monofluorophosphate (MFP), which disturbs its homeostasis. The aim of this work was to evaluate whether the administration with MFP could modify blood viscosity. AM levels (?mol/l), PV (mPa·s), viscosity of red blood cells suspensions in NaCl 9 g/l (VES) and in autologue plasma (VEP) were measured in fifty-day old rats after a single dose of 80 ?mol MFP or after 30 days of treatment with 80 ?mol of MFP. Relative viscosity (RV) was calculated as the ratio VEP/PV. AM and PV increased significantly after 30 min of an oral dose of MFP. Controls (n=6), AM: 19.65±0.85, PV: 1.39±0.01, treated (n=6), AM: 22.88±0.75 (p less than 0.05), PV: 1.76±0.14 (p less than 0.05). After 30 days of treatment with MFP, AM and PV increased significantly. Controls (n=6), AM: 10.76±1.33, PV: 1.19±0.04, treated (n=6), AM: 17.66±1.27 (p less than 0.05), PV: 1.38±0.03 (p less than 0.05). The treatment with MFP modifies neither the VEP nor the RV. These results would indicate that AM and/or MFP did not interact with erythrocyte membrane and did not modify erythrocyte deformability. © 2008 - IOS Press and the authors. All rights reserved. |
publishDate |
2008 |
dc.date.created.spa.fl_str_mv |
2008 |
dc.date.accessioned.none.fl_str_mv |
2020-05-26T00:04:23Z |
dc.date.available.none.fl_str_mv |
2020-05-26T00:04:23Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.3233/CH-2008-1135 |
dc.identifier.issn.none.fl_str_mv |
13860291 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/23682 |
url |
https://doi.org/10.3233/CH-2008-1135 https://repository.urosario.edu.co/handle/10336/23682 |
identifier_str_mv |
13860291 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
265 |
dc.relation.citationIssue.none.fl_str_mv |
No. 4 |
dc.relation.citationStartPage.none.fl_str_mv |
259 |
dc.relation.citationTitle.none.fl_str_mv |
Clinical Hemorheology and Microcirculation |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 40 |
dc.relation.ispartof.spa.fl_str_mv |
Clinical Hemorheology and Microcirculation, ISSN:13860291, Vol.40, No.4 (2008); pp. 259-265 |
dc.relation.uri.spa.fl_str_mv |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-58149381917&doi=10.3233%2fCH-2008-1135&partnerID=40&md5=ef5077fbf467c10637ea646434b9d0af |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
institution |
Universidad del Rosario |
dc.source.instname.spa.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167429337579520 |