Effect of disodium monofluorphosphate on plasma and blood viscosity in the rat

Alpha macroglobulins (AM) are plasma proteins whose main function is to inactivate proteinases, protecting the tissues from the action of these enzymes. AM have influence on plasma viscosity (PV) and binds monofluorophosphate (MFP), which disturbs its homeostasis. The aim of this work was to evaluat...

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Autores:
Tipo de recurso:
Fecha de publicación:
2008
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23682
Acceso en línea:
https://doi.org/10.3233/CH-2008-1135
https://repository.urosario.edu.co/handle/10336/23682
Palabra clave:
Alpha 2 macroglobulin
Fluorophosphate
Sodium chloride
Animal cell
Animal experiment
Article
Blood viscosity
Controlled study
Erythrocyte
Male
Nonhuman
Plasma
Rat
Alpha-macroglobulins
Animals
Blood viscosity
Bone density conservation agents
Erythrocyte deformability
Fluorides
Male
Phosphates
Rats
Blood
Macroglobulin
Monofluorophosphate
Viscosity
oral
Administration
Rights
License
Abierto (Texto Completo)
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oai_identifier_str oai:repository.urosario.edu.co:10336/23682
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling df41dea3-1780-40c3-bd2f-dee6f7898c27-1a775e106-dc90-41b7-8cc5-6768208a8ed9-14635083b-2aec-4217-a2b1-25e753f2dd98-1ee90f2f1-8962-412f-a6c5-9857eaf3f67a-12020-05-26T00:04:23Z2020-05-26T00:04:23Z2008Alpha macroglobulins (AM) are plasma proteins whose main function is to inactivate proteinases, protecting the tissues from the action of these enzymes. AM have influence on plasma viscosity (PV) and binds monofluorophosphate (MFP), which disturbs its homeostasis. The aim of this work was to evaluate whether the administration with MFP could modify blood viscosity. AM levels (?mol/l), PV (mPa·s), viscosity of red blood cells suspensions in NaCl 9 g/l (VES) and in autologue plasma (VEP) were measured in fifty-day old rats after a single dose of 80 ?mol MFP or after 30 days of treatment with 80 ?mol of MFP. Relative viscosity (RV) was calculated as the ratio VEP/PV. AM and PV increased significantly after 30 min of an oral dose of MFP. Controls (n=6), AM: 19.65±0.85, PV: 1.39±0.01, treated (n=6), AM: 22.88±0.75 (p less than 0.05), PV: 1.76±0.14 (p less than 0.05). After 30 days of treatment with MFP, AM and PV increased significantly. Controls (n=6), AM: 10.76±1.33, PV: 1.19±0.04, treated (n=6), AM: 17.66±1.27 (p less than 0.05), PV: 1.38±0.03 (p less than 0.05). The treatment with MFP modifies neither the VEP nor the RV. These results would indicate that AM and/or MFP did not interact with erythrocyte membrane and did not modify erythrocyte deformability. © 2008 - IOS Press and the authors. All rights reserved.application/pdfhttps://doi.org/10.3233/CH-2008-113513860291https://repository.urosario.edu.co/handle/10336/23682eng265No. 4259Clinical Hemorheology and MicrocirculationVol. 40Clinical Hemorheology and Microcirculation, ISSN:13860291, Vol.40, No.4 (2008); pp. 259-265https://www.scopus.com/inward/record.uri?eid=2-s2.0-58149381917&doi=10.3233%2fCH-2008-1135&partnerID=40&md5=ef5077fbf467c10637ea646434b9d0afAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURAlpha 2 macroglobulinFluorophosphateSodium chlorideAnimal cellAnimal experimentArticleBlood viscosityControlled studyErythrocyteMaleNonhumanPlasmaRatAlpha-macroglobulinsAnimalsBlood viscosityBone density conservation agentsErythrocyte deformabilityFluoridesMalePhosphatesRatsBloodMacroglobulinMonofluorophosphateViscosityoralAdministrationEffect of disodium monofluorphosphate on plasma and blood viscosity in the ratarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Di Loreto V.Rigalli A.Cinara L.Hernández G.10336/23682oai:repository.urosario.edu.co:10336/236822022-05-02 07:37:21.19877https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Effect of disodium monofluorphosphate on plasma and blood viscosity in the rat
title Effect of disodium monofluorphosphate on plasma and blood viscosity in the rat
spellingShingle Effect of disodium monofluorphosphate on plasma and blood viscosity in the rat
Alpha 2 macroglobulin
Fluorophosphate
Sodium chloride
Animal cell
Animal experiment
Article
Blood viscosity
Controlled study
Erythrocyte
Male
Nonhuman
Plasma
Rat
Alpha-macroglobulins
Animals
Blood viscosity
Bone density conservation agents
Erythrocyte deformability
Fluorides
Male
Phosphates
Rats
Blood
Macroglobulin
Monofluorophosphate
Viscosity
oral
Administration
title_short Effect of disodium monofluorphosphate on plasma and blood viscosity in the rat
title_full Effect of disodium monofluorphosphate on plasma and blood viscosity in the rat
title_fullStr Effect of disodium monofluorphosphate on plasma and blood viscosity in the rat
title_full_unstemmed Effect of disodium monofluorphosphate on plasma and blood viscosity in the rat
title_sort Effect of disodium monofluorphosphate on plasma and blood viscosity in the rat
dc.subject.keyword.spa.fl_str_mv Alpha 2 macroglobulin
Fluorophosphate
Sodium chloride
Animal cell
Animal experiment
Article
Blood viscosity
Controlled study
Erythrocyte
Male
Nonhuman
Plasma
Rat
Alpha-macroglobulins
Animals
Blood viscosity
Bone density conservation agents
Erythrocyte deformability
Fluorides
Male
Phosphates
Rats
Blood
Macroglobulin
Monofluorophosphate
Viscosity
topic Alpha 2 macroglobulin
Fluorophosphate
Sodium chloride
Animal cell
Animal experiment
Article
Blood viscosity
Controlled study
Erythrocyte
Male
Nonhuman
Plasma
Rat
Alpha-macroglobulins
Animals
Blood viscosity
Bone density conservation agents
Erythrocyte deformability
Fluorides
Male
Phosphates
Rats
Blood
Macroglobulin
Monofluorophosphate
Viscosity
oral
Administration
dc.subject.keyword.eng.fl_str_mv oral
Administration
description Alpha macroglobulins (AM) are plasma proteins whose main function is to inactivate proteinases, protecting the tissues from the action of these enzymes. AM have influence on plasma viscosity (PV) and binds monofluorophosphate (MFP), which disturbs its homeostasis. The aim of this work was to evaluate whether the administration with MFP could modify blood viscosity. AM levels (?mol/l), PV (mPa·s), viscosity of red blood cells suspensions in NaCl 9 g/l (VES) and in autologue plasma (VEP) were measured in fifty-day old rats after a single dose of 80 ?mol MFP or after 30 days of treatment with 80 ?mol of MFP. Relative viscosity (RV) was calculated as the ratio VEP/PV. AM and PV increased significantly after 30 min of an oral dose of MFP. Controls (n=6), AM: 19.65±0.85, PV: 1.39±0.01, treated (n=6), AM: 22.88±0.75 (p less than 0.05), PV: 1.76±0.14 (p less than 0.05). After 30 days of treatment with MFP, AM and PV increased significantly. Controls (n=6), AM: 10.76±1.33, PV: 1.19±0.04, treated (n=6), AM: 17.66±1.27 (p less than 0.05), PV: 1.38±0.03 (p less than 0.05). The treatment with MFP modifies neither the VEP nor the RV. These results would indicate that AM and/or MFP did not interact with erythrocyte membrane and did not modify erythrocyte deformability. © 2008 - IOS Press and the authors. All rights reserved.
publishDate 2008
dc.date.created.spa.fl_str_mv 2008
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:04:23Z
dc.date.available.none.fl_str_mv 2020-05-26T00:04:23Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.3233/CH-2008-1135
dc.identifier.issn.none.fl_str_mv 13860291
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/23682
url https://doi.org/10.3233/CH-2008-1135
https://repository.urosario.edu.co/handle/10336/23682
identifier_str_mv 13860291
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 265
dc.relation.citationIssue.none.fl_str_mv No. 4
dc.relation.citationStartPage.none.fl_str_mv 259
dc.relation.citationTitle.none.fl_str_mv Clinical Hemorheology and Microcirculation
dc.relation.citationVolume.none.fl_str_mv Vol. 40
dc.relation.ispartof.spa.fl_str_mv Clinical Hemorheology and Microcirculation, ISSN:13860291, Vol.40, No.4 (2008); pp. 259-265
dc.relation.uri.spa.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-58149381917&doi=10.3233%2fCH-2008-1135&partnerID=40&md5=ef5077fbf467c10637ea646434b9d0af
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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