HLA class II polymorphism in Latin American patients with multiple sclerosis

Objective: To identify HLA-DRB1 alleles contributing to susceptibility to multiple sclerosis (MS) in a Colombian population and to estimate the common effect size of HLA class II on MS susceptibility in Latin American populations through a meta-analysis. Methods: A total of 65 Colombian patients wit...

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Autores:
Tipo de recurso:
Fecha de publicación:
2010
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23400
Acceso en línea:
https://doi.org/10.1016/j.autrev.2009.11.001
https://repository.urosario.edu.co/handle/10336/23400
Palabra clave:
HLA antigen class 2
HLA DR antigen
Myelin basic protein
Adult
Allele
Antigen binding
Case control study
Colombia
Controlled study
Disease predisposition
DNA extraction
DNA polymorphism
Female
Gene identification
Genetic risk
Human
Major clinical study
Male
Multiple sclerosis
Nucleotide sequence
Oligonucleotide probe
Review
Risk
Autoantigens
Case-Control Studies
Colombia
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Histocompatibility Testing
HLA-DQ Antigens
HLA-DR Antigens
Humans
Male
Multiple Sclerosis
Myelin Basic Proteins
Peptide Fragments
Protein Binding
Risk Factors
HLA antigens
Latin America
Meta-analysis
Multiple sclerosis
Myelin basic protein
Genetic
Polymorphism
Rights
License
Abierto (Texto Completo)
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network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.spa.fl_str_mv HLA class II polymorphism in Latin American patients with multiple sclerosis
title HLA class II polymorphism in Latin American patients with multiple sclerosis
spellingShingle HLA class II polymorphism in Latin American patients with multiple sclerosis
HLA antigen class 2
HLA DR antigen
Myelin basic protein
Adult
Allele
Antigen binding
Case control study
Colombia
Controlled study
Disease predisposition
DNA extraction
DNA polymorphism
Female
Gene identification
Genetic risk
Human
Major clinical study
Male
Multiple sclerosis
Nucleotide sequence
Oligonucleotide probe
Review
Risk
Autoantigens
Case-Control Studies
Colombia
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Histocompatibility Testing
HLA-DQ Antigens
HLA-DR Antigens
Humans
Male
Multiple Sclerosis
Myelin Basic Proteins
Peptide Fragments
Protein Binding
Risk Factors
HLA antigens
Latin America
Meta-analysis
Multiple sclerosis
Myelin basic protein
Genetic
Polymorphism
title_short HLA class II polymorphism in Latin American patients with multiple sclerosis
title_full HLA class II polymorphism in Latin American patients with multiple sclerosis
title_fullStr HLA class II polymorphism in Latin American patients with multiple sclerosis
title_full_unstemmed HLA class II polymorphism in Latin American patients with multiple sclerosis
title_sort HLA class II polymorphism in Latin American patients with multiple sclerosis
dc.subject.keyword.spa.fl_str_mv HLA antigen class 2
HLA DR antigen
Myelin basic protein
Adult
Allele
Antigen binding
Case control study
Colombia
Controlled study
Disease predisposition
DNA extraction
DNA polymorphism
Female
Gene identification
Genetic risk
Human
Major clinical study
Male
Multiple sclerosis
Nucleotide sequence
Oligonucleotide probe
Review
Risk
Autoantigens
Case-Control Studies
Colombia
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Histocompatibility Testing
HLA-DQ Antigens
HLA-DR Antigens
Humans
Male
Multiple Sclerosis
Myelin Basic Proteins
Peptide Fragments
Protein Binding
Risk Factors
HLA antigens
Latin America
Meta-analysis
Multiple sclerosis
Myelin basic protein
topic HLA antigen class 2
HLA DR antigen
Myelin basic protein
Adult
Allele
Antigen binding
Case control study
Colombia
Controlled study
Disease predisposition
DNA extraction
DNA polymorphism
Female
Gene identification
Genetic risk
Human
Major clinical study
Male
Multiple sclerosis
Nucleotide sequence
Oligonucleotide probe
Review
Risk
Autoantigens
Case-Control Studies
Colombia
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Histocompatibility Testing
HLA-DQ Antigens
HLA-DR Antigens
Humans
Male
Multiple Sclerosis
Myelin Basic Proteins
Peptide Fragments
Protein Binding
Risk Factors
HLA antigens
Latin America
Meta-analysis
Multiple sclerosis
Myelin basic protein
Genetic
Polymorphism
dc.subject.keyword.eng.fl_str_mv Genetic
Polymorphism
description Objective: To identify HLA-DRB1 alleles contributing to susceptibility to multiple sclerosis (MS) in a Colombian population and to estimate the common effect size of HLA class II on MS susceptibility in Latin American populations through a meta-analysis. Methods: A total of 65 Colombian patients with MS and 184 matched controls were included. HLA-DRB1 typing was done using the sequence-specific oligonucleotide probe method. A bivariate and a multivariate logistic regression analyses were done. Case-control studies performed in Latin America were searched up to January 2009 through a systematic review of the literature. Effect summary odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by means of the random effect model. Results: A total of 464 cases and 2581 controls from 7 studies and the results of the present study in Colombians were analyzed. HLA-DRB1*15 (OR: 2.3; 95% CI: 1.68-3.07; p and lt; 0.001) and HLA-DQB1*06 (OR: 2.2; 95% CI: 1.54-3.07; p and lt; 0.001) groups as well as DRB1*1501 (OR: 2.6; 95% CI: 1.67-4.02; p and lt; 0.001), DRB1*1503 (OR: 2.2; 95% CI: 1.39-3.62; p = 0.001) and DQB1*0602 (OR: 2.5; 95% CI: 1.66-3.71; p and lt; 0.001) alleles were found to be risk factors for MS. The myelin basic protein immunodominant sequence 221VHFFKNIVT229 was predicted to strongly and simultaneously bind to HLA-DRB1*1501 and *1503. Conclusion: The current study highlights the effect size of HLA class II in MS in Latin America and confirms similar allelic risk factors across diverse populations. Receptor-ligand interactions in the HLA-antigenic peptide complex could have potential predictive and therapeutical implications. © 2009 Elsevier B.V. All rights reserved.
publishDate 2010
dc.date.created.spa.fl_str_mv 2010
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:01:44Z
dc.date.available.none.fl_str_mv 2020-05-26T00:01:44Z
dc.type.eng.fl_str_mv article
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dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.autrev.2009.11.001
dc.identifier.issn.none.fl_str_mv 15689972
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/23400
url https://doi.org/10.1016/j.autrev.2009.11.001
https://repository.urosario.edu.co/handle/10336/23400
identifier_str_mv 15689972
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 413
dc.relation.citationIssue.none.fl_str_mv No. 6
dc.relation.citationStartPage.none.fl_str_mv 407
dc.relation.citationTitle.none.fl_str_mv Autoimmunity Reviews
dc.relation.citationVolume.none.fl_str_mv Vol. 9
dc.relation.ispartof.spa.fl_str_mv Autoimmunity Reviews, ISSN:15689972, Vol.9, No.6 (2010); pp. 407-413
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institution Universidad del Rosario
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