HLA class II polymorphism in Latin American patients with multiple sclerosis
Objective: To identify HLA-DRB1 alleles contributing to susceptibility to multiple sclerosis (MS) in a Colombian population and to estimate the common effect size of HLA class II on MS susceptibility in Latin American populations through a meta-analysis. Methods: A total of 65 Colombian patients wit...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2010
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/23400
- Acceso en línea:
- https://doi.org/10.1016/j.autrev.2009.11.001
https://repository.urosario.edu.co/handle/10336/23400
- Palabra clave:
- HLA antigen class 2
HLA DR antigen
Myelin basic protein
Adult
Allele
Antigen binding
Case control study
Colombia
Controlled study
Disease predisposition
DNA extraction
DNA polymorphism
Female
Gene identification
Genetic risk
Human
Major clinical study
Male
Multiple sclerosis
Nucleotide sequence
Oligonucleotide probe
Review
Risk
Autoantigens
Case-Control Studies
Colombia
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Histocompatibility Testing
HLA-DQ Antigens
HLA-DR Antigens
Humans
Male
Multiple Sclerosis
Myelin Basic Proteins
Peptide Fragments
Protein Binding
Risk Factors
HLA antigens
Latin America
Meta-analysis
Multiple sclerosis
Myelin basic protein
Genetic
Polymorphism
- Rights
- License
- Abierto (Texto Completo)
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|
dc.title.spa.fl_str_mv |
HLA class II polymorphism in Latin American patients with multiple sclerosis |
title |
HLA class II polymorphism in Latin American patients with multiple sclerosis |
spellingShingle |
HLA class II polymorphism in Latin American patients with multiple sclerosis HLA antigen class 2 HLA DR antigen Myelin basic protein Adult Allele Antigen binding Case control study Colombia Controlled study Disease predisposition DNA extraction DNA polymorphism Female Gene identification Genetic risk Human Major clinical study Male Multiple sclerosis Nucleotide sequence Oligonucleotide probe Review Risk Autoantigens Case-Control Studies Colombia Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Histocompatibility Testing HLA-DQ Antigens HLA-DR Antigens Humans Male Multiple Sclerosis Myelin Basic Proteins Peptide Fragments Protein Binding Risk Factors HLA antigens Latin America Meta-analysis Multiple sclerosis Myelin basic protein Genetic Polymorphism |
title_short |
HLA class II polymorphism in Latin American patients with multiple sclerosis |
title_full |
HLA class II polymorphism in Latin American patients with multiple sclerosis |
title_fullStr |
HLA class II polymorphism in Latin American patients with multiple sclerosis |
title_full_unstemmed |
HLA class II polymorphism in Latin American patients with multiple sclerosis |
title_sort |
HLA class II polymorphism in Latin American patients with multiple sclerosis |
dc.subject.keyword.spa.fl_str_mv |
HLA antigen class 2 HLA DR antigen Myelin basic protein Adult Allele Antigen binding Case control study Colombia Controlled study Disease predisposition DNA extraction DNA polymorphism Female Gene identification Genetic risk Human Major clinical study Male Multiple sclerosis Nucleotide sequence Oligonucleotide probe Review Risk Autoantigens Case-Control Studies Colombia Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Histocompatibility Testing HLA-DQ Antigens HLA-DR Antigens Humans Male Multiple Sclerosis Myelin Basic Proteins Peptide Fragments Protein Binding Risk Factors HLA antigens Latin America Meta-analysis Multiple sclerosis Myelin basic protein |
topic |
HLA antigen class 2 HLA DR antigen Myelin basic protein Adult Allele Antigen binding Case control study Colombia Controlled study Disease predisposition DNA extraction DNA polymorphism Female Gene identification Genetic risk Human Major clinical study Male Multiple sclerosis Nucleotide sequence Oligonucleotide probe Review Risk Autoantigens Case-Control Studies Colombia Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Histocompatibility Testing HLA-DQ Antigens HLA-DR Antigens Humans Male Multiple Sclerosis Myelin Basic Proteins Peptide Fragments Protein Binding Risk Factors HLA antigens Latin America Meta-analysis Multiple sclerosis Myelin basic protein Genetic Polymorphism |
dc.subject.keyword.eng.fl_str_mv |
Genetic Polymorphism |
description |
Objective: To identify HLA-DRB1 alleles contributing to susceptibility to multiple sclerosis (MS) in a Colombian population and to estimate the common effect size of HLA class II on MS susceptibility in Latin American populations through a meta-analysis. Methods: A total of 65 Colombian patients with MS and 184 matched controls were included. HLA-DRB1 typing was done using the sequence-specific oligonucleotide probe method. A bivariate and a multivariate logistic regression analyses were done. Case-control studies performed in Latin America were searched up to January 2009 through a systematic review of the literature. Effect summary odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by means of the random effect model. Results: A total of 464 cases and 2581 controls from 7 studies and the results of the present study in Colombians were analyzed. HLA-DRB1*15 (OR: 2.3; 95% CI: 1.68-3.07; p and lt; 0.001) and HLA-DQB1*06 (OR: 2.2; 95% CI: 1.54-3.07; p and lt; 0.001) groups as well as DRB1*1501 (OR: 2.6; 95% CI: 1.67-4.02; p and lt; 0.001), DRB1*1503 (OR: 2.2; 95% CI: 1.39-3.62; p = 0.001) and DQB1*0602 (OR: 2.5; 95% CI: 1.66-3.71; p and lt; 0.001) alleles were found to be risk factors for MS. The myelin basic protein immunodominant sequence 221VHFFKNIVT229 was predicted to strongly and simultaneously bind to HLA-DRB1*1501 and *1503. Conclusion: The current study highlights the effect size of HLA class II in MS in Latin America and confirms similar allelic risk factors across diverse populations. Receptor-ligand interactions in the HLA-antigenic peptide complex could have potential predictive and therapeutical implications. © 2009 Elsevier B.V. All rights reserved. |
publishDate |
2010 |
dc.date.created.spa.fl_str_mv |
2010 |
dc.date.accessioned.none.fl_str_mv |
2020-05-26T00:01:44Z |
dc.date.available.none.fl_str_mv |
2020-05-26T00:01:44Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.autrev.2009.11.001 |
dc.identifier.issn.none.fl_str_mv |
15689972 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/23400 |
url |
https://doi.org/10.1016/j.autrev.2009.11.001 https://repository.urosario.edu.co/handle/10336/23400 |
identifier_str_mv |
15689972 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
413 |
dc.relation.citationIssue.none.fl_str_mv |
No. 6 |
dc.relation.citationStartPage.none.fl_str_mv |
407 |
dc.relation.citationTitle.none.fl_str_mv |
Autoimmunity Reviews |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 9 |
dc.relation.ispartof.spa.fl_str_mv |
Autoimmunity Reviews, ISSN:15689972, Vol.9, No.6 (2010); pp. 407-413 |
dc.relation.uri.spa.fl_str_mv |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-77949917895&doi=10.1016%2fj.autrev.2009.11.001&partnerID=40&md5=1b61091f56af782a8350393170a2f2f4 |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
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application/pdf |
institution |
Universidad del Rosario |
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instname:Universidad del Rosario |
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reponame:Repositorio Institucional EdocUR |
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47642046-c6fb-417f-b0da-b361c59bdb62522497018e1a98cb-2d78-4910-a36d-9d4982bf6ab6beee723c-cc04-46cb-a251-65b3e2a6556eb7904a1b-b4ad-48b0-a26b-ce0baa5277cbd47463d6-6b94-4fef-9cf9-7e20e59e9423194747786002020-05-26T00:01:44Z2020-05-26T00:01:44Z2010Objective: To identify HLA-DRB1 alleles contributing to susceptibility to multiple sclerosis (MS) in a Colombian population and to estimate the common effect size of HLA class II on MS susceptibility in Latin American populations through a meta-analysis. Methods: A total of 65 Colombian patients with MS and 184 matched controls were included. HLA-DRB1 typing was done using the sequence-specific oligonucleotide probe method. A bivariate and a multivariate logistic regression analyses were done. Case-control studies performed in Latin America were searched up to January 2009 through a systematic review of the literature. Effect summary odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by means of the random effect model. Results: A total of 464 cases and 2581 controls from 7 studies and the results of the present study in Colombians were analyzed. HLA-DRB1*15 (OR: 2.3; 95% CI: 1.68-3.07; p and lt; 0.001) and HLA-DQB1*06 (OR: 2.2; 95% CI: 1.54-3.07; p and lt; 0.001) groups as well as DRB1*1501 (OR: 2.6; 95% CI: 1.67-4.02; p and lt; 0.001), DRB1*1503 (OR: 2.2; 95% CI: 1.39-3.62; p = 0.001) and DQB1*0602 (OR: 2.5; 95% CI: 1.66-3.71; p and lt; 0.001) alleles were found to be risk factors for MS. The myelin basic protein immunodominant sequence 221VHFFKNIVT229 was predicted to strongly and simultaneously bind to HLA-DRB1*1501 and *1503. Conclusion: The current study highlights the effect size of HLA class II in MS in Latin America and confirms similar allelic risk factors across diverse populations. Receptor-ligand interactions in the HLA-antigenic peptide complex could have potential predictive and therapeutical implications. © 2009 Elsevier B.V. All rights reserved.application/pdfhttps://doi.org/10.1016/j.autrev.2009.11.00115689972https://repository.urosario.edu.co/handle/10336/23400eng413No. 6407Autoimmunity ReviewsVol. 9Autoimmunity Reviews, ISSN:15689972, Vol.9, No.6 (2010); pp. 407-413https://www.scopus.com/inward/record.uri?eid=2-s2.0-77949917895&doi=10.1016%2fj.autrev.2009.11.001&partnerID=40&md5=1b61091f56af782a8350393170a2f2f4Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURHLA antigen class 2HLA DR antigenMyelin basic proteinAdultAlleleAntigen bindingCase control studyColombiaControlled studyDisease predispositionDNA extractionDNA polymorphismFemaleGene identificationGenetic riskHumanMajor clinical studyMaleMultiple sclerosisNucleotide sequenceOligonucleotide probeReviewRiskAutoantigensCase-Control StudiesColombiaFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseHistocompatibility TestingHLA-DQ AntigensHLA-DR AntigensHumansMaleMultiple SclerosisMyelin Basic ProteinsPeptide FragmentsProtein BindingRisk FactorsHLA antigensLatin AmericaMeta-analysisMultiple sclerosisMyelin basic proteinGeneticPolymorphismHLA class II polymorphism in Latin American patients with multiple sclerosisarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Rojas, Olga-LucíaRojas-Villarraga, AdrianaCruz-Tapias, PaolaSánchez, Jorge LuisSuárez-Escudero, Juan-CamiloPatarroyo, Manuel-AlfonsoAnaya, Juan-ManuelORIGINALHLA_class_II_polymorphism_in_Latin_Ameri.pdfapplication/pdf3155298https://repository.urosario.edu.co/bitstreams/bdebd9f2-fd8a-4a6c-b067-646793353b05/download867bdc24aac6aac5f16d9211bdbec0edMD51TEXTHLA_class_II_polymorphism_in_Latin_Ameri.pdf.txtHLA_class_II_polymorphism_in_Latin_Ameri.pdf.txtExtracted texttext/plain41106https://repository.urosario.edu.co/bitstreams/075034bc-3637-43ab-a8ae-446f9921c1d7/download68bf9cf7c798425b75d686fb6ccac1d5MD52THUMBNAILHLA_class_II_polymorphism_in_Latin_Ameri.pdf.jpgHLA_class_II_polymorphism_in_Latin_Ameri.pdf.jpgGenerated Thumbnailimage/jpeg3814https://repository.urosario.edu.co/bitstreams/2bedab0b-1160-41b4-b528-04b4c2f1499c/downloadd7f296942e23eba4350dd6e90a5f0bf5MD5310336/23400oai:repository.urosario.edu.co:10336/234002022-05-02 07:37:13.605456https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |