Characterising a microsatellite for DRB typing in Aotus vociferans and Aotus nancymaae (Platyrrhini)
Non-human primates belonging to the Aotus genus have been shown to be excellent experimental models for evaluating drugs and vaccine candidates against malaria and other human diseases. The immune system of this animal model must be characterised to assess whether the results obtained here can be ex...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2014
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/18702
- Acceso en línea:
- https://doi.org/10.1371/journal.pone.0096973
http://repository.urosario.edu.co/handle/10336/18702
- Palabra clave:
- ADN complementario
Antígeno Hla Dr
Antígeno Hla Drb1
Antígeno Hla Drb3
Antígeno mayor de histocompatibilidad clase 1
Antígeno mayor de histocompatibilidad clase 2
Hla antígeno clase 2
ADN microsatélite
Alelos
Célula animal
Aotus Vociferans
Estudio controlado
Secuencia de ADN
Exón
Análisis genético
Genotipo
Técnica de genotipado
Intrón
Mhc Drb Gen
Mhc Drb1 Gen
Mhc Drb3 Gen
Marcador de microsatélite
Evolución Molecular
Filogenia molecular
Árbol filogenético
Ornitorrinco
Alineación de secuencia
Repetición corta en tándem
Aótidos
Repeticiones de microsatélites
Microsatellite Repeats
Histocompatibility Antigens Class Ii
Aotidae
Short Tandem Repeat
Sequence Alignment
Platyrrhini
Phylogenetic Tree
Molecular Phylogeny
Molecular Evolution
Microsatellite Marker
Mhc Drb3 Gene
Mhc Drb1 Gene
Mhc Drb Gene
Intron
Genotyping Technique
Genotype
Genetic Analysis
Exon
Dna Sequence
Controlled Study
Aotus Nancymaae
Animal Cell
Microsatellite Dna
Allele
Hla Antigen Class 2
Major Histocompatibility Antigen Class 2
Hla Drb3 Antigen
Major Histocompatibility Antigen Class 1
Hla Drb1 Antigen
Hla Dr Antigen
Complementary Dna
Aotus Vociferans
Malaria
Histocompatibilidad
Experimentación con animales
Primates
- Rights
- License
- Abierto (Texto Completo)
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|
dc.title.spa.fl_str_mv |
Characterising a microsatellite for DRB typing in Aotus vociferans and Aotus nancymaae (Platyrrhini) |
title |
Characterising a microsatellite for DRB typing in Aotus vociferans and Aotus nancymaae (Platyrrhini) |
spellingShingle |
Characterising a microsatellite for DRB typing in Aotus vociferans and Aotus nancymaae (Platyrrhini) ADN complementario Antígeno Hla Dr Antígeno Hla Drb1 Antígeno Hla Drb3 Antígeno mayor de histocompatibilidad clase 1 Antígeno mayor de histocompatibilidad clase 2 Hla antígeno clase 2 ADN microsatélite Alelos Célula animal Aotus Vociferans Estudio controlado Secuencia de ADN Exón Análisis genético Genotipo Técnica de genotipado Intrón Mhc Drb Gen Mhc Drb1 Gen Mhc Drb3 Gen Marcador de microsatélite Evolución Molecular Filogenia molecular Árbol filogenético Ornitorrinco Alineación de secuencia Repetición corta en tándem Aótidos Repeticiones de microsatélites Microsatellite Repeats Histocompatibility Antigens Class Ii Aotidae Short Tandem Repeat Sequence Alignment Platyrrhini Phylogenetic Tree Molecular Phylogeny Molecular Evolution Microsatellite Marker Mhc Drb3 Gene Mhc Drb1 Gene Mhc Drb Gene Intron Genotyping Technique Genotype Genetic Analysis Exon Dna Sequence Controlled Study Aotus Nancymaae Animal Cell Microsatellite Dna Allele Hla Antigen Class 2 Major Histocompatibility Antigen Class 2 Hla Drb3 Antigen Major Histocompatibility Antigen Class 1 Hla Drb1 Antigen Hla Dr Antigen Complementary Dna Aotus Vociferans Malaria Histocompatibilidad Experimentación con animales Primates |
title_short |
Characterising a microsatellite for DRB typing in Aotus vociferans and Aotus nancymaae (Platyrrhini) |
title_full |
Characterising a microsatellite for DRB typing in Aotus vociferans and Aotus nancymaae (Platyrrhini) |
title_fullStr |
Characterising a microsatellite for DRB typing in Aotus vociferans and Aotus nancymaae (Platyrrhini) |
title_full_unstemmed |
Characterising a microsatellite for DRB typing in Aotus vociferans and Aotus nancymaae (Platyrrhini) |
title_sort |
Characterising a microsatellite for DRB typing in Aotus vociferans and Aotus nancymaae (Platyrrhini) |
dc.subject.spa.fl_str_mv |
ADN complementario Antígeno Hla Dr Antígeno Hla Drb1 Antígeno Hla Drb3 Antígeno mayor de histocompatibilidad clase 1 Antígeno mayor de histocompatibilidad clase 2 Hla antígeno clase 2 ADN microsatélite Alelos Célula animal Aotus Vociferans Estudio controlado Secuencia de ADN Exón Análisis genético Genotipo Técnica de genotipado Intrón Mhc Drb Gen Mhc Drb1 Gen Mhc Drb3 Gen Marcador de microsatélite Evolución Molecular Filogenia molecular Árbol filogenético Ornitorrinco Alineación de secuencia Repetición corta en tándem Aótidos Repeticiones de microsatélites |
topic |
ADN complementario Antígeno Hla Dr Antígeno Hla Drb1 Antígeno Hla Drb3 Antígeno mayor de histocompatibilidad clase 1 Antígeno mayor de histocompatibilidad clase 2 Hla antígeno clase 2 ADN microsatélite Alelos Célula animal Aotus Vociferans Estudio controlado Secuencia de ADN Exón Análisis genético Genotipo Técnica de genotipado Intrón Mhc Drb Gen Mhc Drb1 Gen Mhc Drb3 Gen Marcador de microsatélite Evolución Molecular Filogenia molecular Árbol filogenético Ornitorrinco Alineación de secuencia Repetición corta en tándem Aótidos Repeticiones de microsatélites Microsatellite Repeats Histocompatibility Antigens Class Ii Aotidae Short Tandem Repeat Sequence Alignment Platyrrhini Phylogenetic Tree Molecular Phylogeny Molecular Evolution Microsatellite Marker Mhc Drb3 Gene Mhc Drb1 Gene Mhc Drb Gene Intron Genotyping Technique Genotype Genetic Analysis Exon Dna Sequence Controlled Study Aotus Nancymaae Animal Cell Microsatellite Dna Allele Hla Antigen Class 2 Major Histocompatibility Antigen Class 2 Hla Drb3 Antigen Major Histocompatibility Antigen Class 1 Hla Drb1 Antigen Hla Dr Antigen Complementary Dna Aotus Vociferans Malaria Histocompatibilidad Experimentación con animales Primates |
dc.subject.keyword.eng.fl_str_mv |
Microsatellite Repeats Histocompatibility Antigens Class Ii Aotidae Short Tandem Repeat Sequence Alignment Platyrrhini Phylogenetic Tree Molecular Phylogeny Molecular Evolution Microsatellite Marker Mhc Drb3 Gene Mhc Drb1 Gene Mhc Drb Gene Intron Genotyping Technique Genotype Genetic Analysis Exon Dna Sequence Controlled Study Aotus Nancymaae Animal Cell Microsatellite Dna Allele Hla Antigen Class 2 Major Histocompatibility Antigen Class 2 Hla Drb3 Antigen Major Histocompatibility Antigen Class 1 Hla Drb1 Antigen Hla Dr Antigen Complementary Dna |
dc.subject.keyword.lat.fl_str_mv |
Aotus Vociferans |
dc.subject.lemb.spa.fl_str_mv |
Malaria Histocompatibilidad Experimentación con animales Primates |
description |
Non-human primates belonging to the Aotus genus have been shown to be excellent experimental models for evaluating drugs and vaccine candidates against malaria and other human diseases. The immune system of this animal model must be characterised to assess whether the results obtained here can be extrapolated to humans. Class I and II major histocompatibility complex (MHC) proteins are amongst the most important molecules involved in response to pathogens; in spite of this, the techniques available for genotyping these molecules are usually expensive and/or time-consuming. Previous studies have reported MHC-DRB class II gene typing by microsatellite in Old World primates and humans, showing that such technique provides a fast, reliable and effective alternative to the commonly used ones. Based on this information, a microsatellite present in MHC-DRB intron 2 and its evolutionary patterns were identified in two Aotus species (A. vociferans and A. nancymaae ), as well as its potential for genotyping class II MHC-DRB in these primates. © 2014 López et al. |
publishDate |
2014 |
dc.date.created.none.fl_str_mv |
2014 |
dc.date.issued.none.fl_str_mv |
2014-03-12 |
dc.date.accessioned.none.fl_str_mv |
2018-11-19T15:46:28Z |
dc.date.available.none.fl_str_mv |
2018-11-19T15:46:28Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1371/journal.pone.0096973 |
dc.identifier.issn.none.fl_str_mv |
1932-6203 |
dc.identifier.uri.none.fl_str_mv |
http://repository.urosario.edu.co/handle/10336/18702 |
url |
https://doi.org/10.1371/journal.pone.0096973 http://repository.urosario.edu.co/handle/10336/18702 |
identifier_str_mv |
1932-6203 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationIssue.none.fl_str_mv |
No. 5 |
dc.relation.citationTitle.none.fl_str_mv |
PLoS ONE |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 9 |
dc.relation.ispartof.spa.fl_str_mv |
PLoS ONE, ISSN: 1932-6203, Vol. 9/No. 5 (2014) |
dc.relation.uri.spa.fl_str_mv |
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096973&type=printable |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
dc.rights.cc.spa.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
rights_invalid_str_mv |
Abierto (Texto Completo) https://creativecommons.org/licenses/by/4.0/ http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
institution |
Universidad del Rosario |
dc.source.bibliographicCitation.spa.fl_str_mv |
Ward, J.M., Vallender, E.J., The resurgence and genetic implications of New World primates in biomedical research (2012) Trends Genet, 28, pp. 586-591 |
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instname:Universidad del Rosario |
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reponame:Repositorio Institucional EdocUR |
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