Is narcolepsy a classical autoimmune disease?

Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness. It is caused by the loss of orexin producing neurons in the lateral hypothalamus. Current evidences suggest an autoimmune mediated process causing the specific loss of orexin neurons. The high association of the disease with the HLA DQB1?06:02, as well as the link with environmental factors and are important clues supporting this theory. Recently, the association between the occurrence of the disease and vaccination campaign after the 2009 H1N1 pandemic highlighted the importance to increase the knowledge in the Pandora box of the vaccines. This review discusses the last finding regarding the pathogenesis of the disease and its relationship with the H1N1 vaccines. © 2014 Elsevier Ltd. All rights reserved.

• Fecha de publicación: 2015
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/22798
• Acceso en línea: https://doi.org/10.1016/j.phrs.2014.10.005; https://repository.urosario.edu.co/handle/10336/22798
• Palabra clave: Alpha tocopherol; As03 vaccine; Autoantibody; Autoantigen; Cathepsin g; Dna methyltransferase 1; Hla dqa1 antigen; Hla dqb1 antigen; Influenza vaccine; Interleukin 4; Trib2 antibody; Tumor necrosis factor alpha; Unclassified drug; Virus vaccine; Autoantibody; Autoantigen; Influenza vaccine; Autoimmune disease; Autoimmunity; Cd4+ t lymphocyte; Dna polymorphism; Environmental factor; High risk patient; Human; Immune response; Immunopathogenesis; Influenza; Narcolepsy; Nonhuman; Priority journal; Review; Streptococcus infection; T lymphocyte; Th1 cell; Th2 cell; Vaccination; Animal; Autoimmune diseases; Genetics; Immunology; Influenza a virus (h1n1); Narcolepsy; Animals; Autoantibodies; Autoantigens; Autoimmune diseases; Humans; Influenza vaccines; Narcolepsy; Adjuvant; Asia syndrome; Autoimmune diseases; H1n1; Infections; Narcolepsy; human; h1n1 subtype; Influenza a virus; Influenza
• License: Abierto (Texto Completo)