Comparación de la gravedad de la infección por adenovirus y virus sincitial respiratorio en niños con insuficiencia respiratoria aguda en cuidados intensivos: un estudio multicéntrico de LARed en América Latina entre 2017 y 2022.
Introducción y objetivos: Las infecciones virales son la causa más frecuente de fallo respiratorio agudo (FRA) y la primera causa de ingreso a cuidados intensivos pediátricos (UCIp) en niños. El tipo de agente viral identificado influye en el curso de la enfermedad. La infección por adenovirus es un...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2023
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- spa
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/40178
- Acceso en línea:
- https://doi.org/10.48713/10336_40178
https://repository.urosario.edu.co/handle/10336/40178
- Palabra clave:
- Niño
Falla respiratoria aguda
Adenovirus
Virus sincitial respiratorio
Child
Acute respiratory failure
Adenovirus
Respiratory syncytial virus
- Rights
- License
- Attribution-ShareAlike 4.0 International
id |
EDOCUR2_7ae9819d6e11dced4a9caacbb85f39b6 |
---|---|
oai_identifier_str |
oai:repository.urosario.edu.co:10336/40178 |
network_acronym_str |
EDOCUR2 |
network_name_str |
Repositorio EdocUR - U. Rosario |
repository_id_str |
|
dc.title.none.fl_str_mv |
Comparación de la gravedad de la infección por adenovirus y virus sincitial respiratorio en niños con insuficiencia respiratoria aguda en cuidados intensivos: un estudio multicéntrico de LARed en América Latina entre 2017 y 2022. |
dc.title.TranslatedTitle.none.fl_str_mv |
Comparison of the severity of adenovirus and respiratory syncytial virus infections in children with acute respiratory failure in intensive care: a multicenter study by LARed in Latin America between 2017 and 2022. |
title |
Comparación de la gravedad de la infección por adenovirus y virus sincitial respiratorio en niños con insuficiencia respiratoria aguda en cuidados intensivos: un estudio multicéntrico de LARed en América Latina entre 2017 y 2022. |
spellingShingle |
Comparación de la gravedad de la infección por adenovirus y virus sincitial respiratorio en niños con insuficiencia respiratoria aguda en cuidados intensivos: un estudio multicéntrico de LARed en América Latina entre 2017 y 2022. Niño Falla respiratoria aguda Adenovirus Virus sincitial respiratorio Child Acute respiratory failure Adenovirus Respiratory syncytial virus |
title_short |
Comparación de la gravedad de la infección por adenovirus y virus sincitial respiratorio en niños con insuficiencia respiratoria aguda en cuidados intensivos: un estudio multicéntrico de LARed en América Latina entre 2017 y 2022. |
title_full |
Comparación de la gravedad de la infección por adenovirus y virus sincitial respiratorio en niños con insuficiencia respiratoria aguda en cuidados intensivos: un estudio multicéntrico de LARed en América Latina entre 2017 y 2022. |
title_fullStr |
Comparación de la gravedad de la infección por adenovirus y virus sincitial respiratorio en niños con insuficiencia respiratoria aguda en cuidados intensivos: un estudio multicéntrico de LARed en América Latina entre 2017 y 2022. |
title_full_unstemmed |
Comparación de la gravedad de la infección por adenovirus y virus sincitial respiratorio en niños con insuficiencia respiratoria aguda en cuidados intensivos: un estudio multicéntrico de LARed en América Latina entre 2017 y 2022. |
title_sort |
Comparación de la gravedad de la infección por adenovirus y virus sincitial respiratorio en niños con insuficiencia respiratoria aguda en cuidados intensivos: un estudio multicéntrico de LARed en América Latina entre 2017 y 2022. |
dc.contributor.advisor.none.fl_str_mv |
Vasquez Hoyos, Pablo |
dc.subject.none.fl_str_mv |
Niño Falla respiratoria aguda Adenovirus Virus sincitial respiratorio |
topic |
Niño Falla respiratoria aguda Adenovirus Virus sincitial respiratorio Child Acute respiratory failure Adenovirus Respiratory syncytial virus |
dc.subject.keyword.none.fl_str_mv |
Child Acute respiratory failure Adenovirus Respiratory syncytial virus |
description |
Introducción y objetivos: Las infecciones virales son la causa más frecuente de fallo respiratorio agudo (FRA) y la primera causa de ingreso a cuidados intensivos pediátricos (UCIp) en niños. El tipo de agente viral identificado influye en el curso de la enfermedad. La infección por adenovirus es una de las infecciones más agresivas, aunque no es la más prevalente. Este estudio tiene como objetivo comparar el curso clínico de la infección por adenovirus en relación con la infección por virus sincitial respiratorio (VSR), que es el agente más frecuente implicado en el fallo respiratorio en niños. Métodos: Se llevó a cabo un análisis secundario del registro concurrente de fallo respiratorio agudo de LARed en pacientes pediátricos ingresados en UCIP por FRA secundario a infección respiratoria por adenovirus o VSR entre abril de 2017 y diciembre de 2022. El desenlace primario de gravedad se definió como la estancia hospitalaria, mientras que los desenlaces secundarios incluyeron mortalidad y nueva morbilidad. Se compararon los grupos virales y la estancia mediante análisis de supervivencia ajustada por mortalidad y factores de confusión mediante un modelo de riesgos competitivos. Para los desenlaces secundarios de mortalidad y nueva morbilidad se evaluó como un desenlace compuesto mediante regresión logística multivariada. Resultados: En total, se incluyeron 3,014 pacientes en el estudio, de los cuales 182 presentaban infección por AdV y 2,832 por VSR. La mediana de edad fue de 3.9 meses [RIC 1.8-86], el 62% eran hombres y el 38% mujeres. Previa al ingreso hospitalario, el 32% de los pacientes presentaba comorbilidades, siendo la prematuridad la más frecuente. En comparación con el grupo de pacientes con VSR, los pacientes con infección por AdV presentaron con mayor frecuencia ingreso por neumonía (29% Vs 17%, p<0.01), mayor mediana de edad (8,2 meses Vs 3,7 meses, p<0,01) y mayor frecuencia de comorbilidades (42,7% Vs 32,2, p<0,01). La infección por AdV se asoció con un aumento en la estancia hospitalaria (HR 0,74, IC 95% 0,61-0,89), y mortalidad y morbilidad (ORa 6,15, IC 95% 2,78-13,57). Otros factores que se asociaron con mayor gravedad de la infección fueron: edad, antecedente displasia broncopulmonar, antecedente de daño pulmonar crónico y diagnóstico de neumonía. |
publishDate |
2023 |
dc.date.accessioned.none.fl_str_mv |
2023-07-17T16:09:13Z |
dc.date.available.none.fl_str_mv |
2023-07-17T16:09:13Z |
dc.date.created.none.fl_str_mv |
2023-07-07 |
dc.date.embargoEnd.none.fl_str_mv |
info:eu-repo/date/embargoEnd/2025-07-19 |
dc.type.none.fl_str_mv |
bachelorThesis |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_7a1f |
dc.type.document.none.fl_str_mv |
Trabajo de grado |
dc.type.spa.none.fl_str_mv |
Trabajo de grado |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.48713/10336_40178 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/40178 |
url |
https://doi.org/10.48713/10336_40178 https://repository.urosario.edu.co/handle/10336/40178 |
dc.language.iso.none.fl_str_mv |
spa |
language |
spa |
dc.rights.*.fl_str_mv |
Attribution-ShareAlike 4.0 International |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_f1cf |
dc.rights.acceso.none.fl_str_mv |
Restringido (Temporalmente bloqueado) |
dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-sa/4.0/ |
rights_invalid_str_mv |
Attribution-ShareAlike 4.0 International Restringido (Temporalmente bloqueado) http://creativecommons.org/licenses/by-sa/4.0/ http://purl.org/coar/access_right/c_f1cf |
dc.format.extent.none.fl_str_mv |
59 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Universidad del Rosario |
dc.publisher.department.spa.fl_str_mv |
Escuela de Medicina y Ciencias de la Salud |
dc.publisher.program.spa.fl_str_mv |
Maestría en Epidemiología |
institution |
Universidad del Rosario |
dc.source.bibliographicCitation.none.fl_str_mv |
Wu, Zhan; Zhang, Rong; Liu, Dongdong; Liu, Xuesong; Zhang, Jierong; Zhang, Zhihui; Chen, Sibei; He, Weiqun; Li, Yimin; Xu, Yonghao; Liu, Xiaoqing (2022) Acute Respiratory Distress Syndrome Caused by Human Adenovirus in Adults: A Prospective Observational Study in Guangdong, China. En: Frontiers in Medicine. Vol. 8; Frontiers Media S.A.; Disponible en: https://www.frontiersin.org/articles/10.3389/fmed.2021.791163/full. Disponible en: 10.3389/fmed.2021.791163. Hammer, J; Numa, A; Newth, C J L (1997) Acute Respiratory Distress Syndrome Caused by Respiratory Syncytial Virus. En: Pediatr. Pulmonol. Vol. 23; pp. 176 - 183; Disponible en: https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291099-0496%28199703%2923%3A3%3C176%3A%3AAID-PPUL2%3E3.0.CO%3B2-M?sid=nlm%3Apubmed. Schneider, James; Sweberg, Todd (2013) Acute Respiratory Failure. En: Critical Care Clinics. Vol. 29; No. 2; pp. 167 - 183; Disponible en: https://journals.lww.com/ccnq/Abstract/2022/07000/Acute_Respiratory_Failure.5.aspx. Disponible en: 10.1016/j.ccc.2012.12.004. Friedman, Matthew L.; Nitu, Mara E. (2018) Acute respiratory failure in children. En: Pediatric Annals. Vol. 47; No. 7; pp. e268 - e273; Disponible en: 10.3928/19382359-20180625-01. Trollfors, B. (1994) Acute respiratory infections in children. En: Current Opinion in Infectious Diseases. Vol. 7; No. 2; pp. 157 - 161; Disponible en: 10.1097/00001432-199404000-00002. Disponible en: 10.1097/00001432-199404000-00002. Ghazaly, Marwa M H; Faddan, Nagla H Abu; Raafat, Duaa M; Mohammed, Nagwa A; Nadel, Simon (2021) Acute viral bronchiolitis as a cause of pediatric acute respiratory distress syndrome. En: European Journal of Pediatrics. Vol. 180; pp. 1229 - 1234; Disponible en: https://doi.org/10.1007/s00431-020-; https://link.springer.com/article/10.1007/s00431-020-03852-9. Disponible en: 10.1007/s00431-020. Koirala, Bibek; Wang, Jennifer P. (2013) Adenovirus. En: Viruses and the Lung: Infections and Non-Infectious Viral-Linked Lung Disorders. pp. 35 - 41; 9783642406058; Disponible en: https://link.springer.com/chapter/10.1007/978-3-642-40605-8_4. Disponible en: 10.1007/978-3-642-40605-8_4. Qi, Lifeng; Wang, Yajuan; Wang, Heping; Deng, Jikui (2020) Adenovirus 7 Induces Interlukin-6 Expression in Human Airway Epithelial Cells via p38/NF-κB Signaling Pathway. En: Frontiers in Immunology. Vol. 11; Frontiers Media S.A.; Disponible en: https://www.frontiersin.org/articles/10.3389/fimmu.2020.551413/full. Disponible en: 10.3389/fimmu.2020.551413. Greber, Urs F; Flatt, Justin W (2019) Adenovirus Entry : From Infection to Immunity. pp. 177 - 200; Disponible en: https://www.annualreviews.org/doi/10.1146/annurev-virology-092818-015550?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed. Zou, Lirong; Yi, Lina; Yu, Jianxiang; Song, Yinchao; Liang, Lijun; Guo, Qianfang; Zhuang, Xue; Zhang, Yunqiang; Kang, Min; Wu, Jie (2021) Adenovirus infection in children hospitalized with pneumonia in Guangzhou, China. En: Influenza and other Respiratory Viruses. Vol. 15; No. 1; pp. 27 - 33; Disponible en: https://onlinelibrary.wiley.com/doi/10.1111/irv.12782. Disponible en: 10.1111/irv.12782. Liu, Chunyan; Xiao, Yan; Zhang, Jing; Ren, Lili; Li, Jianguo; Xie, Zhengde; Xu, Baoping; Yang, Yan; Qian, Suyun; Wang, Jianwei; Shen, Kunling (2015) Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China, 2007 to 2012. En: BMC Infectious Diseases. Vol. 15; No. 1; BioMed Central Ltd.; Disponible en: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-015-1126-2. Disponible en: 10.1186/s12879-015-1126-2. Zhang, Yuanming; Bergelson, Jeffrey M (2005) Adenovirus Receptors. Vol. 79; No. 19; pp. 12125 - 12131; Disponible en: https://journals.asm.org/journal/jvi. Disponible en: 10.1128/JVI.79.19.12125. Gutierrez-Tobar, Ivan F.; Beltran-Arroyave, Claudia; Díaz, Alejandro; Londoño, Juan P.; Jimenez, Karen L.; Zamora, Carmen G.; Camacho-Moreno, German; Alvarez-Olmos, Martha I.; Beltran-Higuera, Sandra J.; Alvarez-Moreno, Carlos A. (2023) Adenovirus Respiratory Infections Post Pandemic in Colombia: An Old Enemy With Increased Severity in Pediatric Population?. En: Pediatric Infectious Disease Journal. Vol. 42; No. 4; pp. E133 - E134; Lippincott Williams and Wilkins; Disponible en: https://journals.lww.com/pidj/Fulltext/2023/04000/Adenovirus_Respiratory_Infections_Post_Pandemic_in.31.aspx. Disponible en: 10.1097/INF.0000000000003827. Lai, Chen Yin; Lee, Chia Jie; Lu, Chun Yi; Lee, Ping Ing; Shao, Pei Lan; Wu, En Ting; Wang, Ching Chia; Tan, Boon Fatt; Chang, Hsin Yu; Hsia, Shao Hsuan; Lin, Jainn Jim; Chang, Luan Yin; Huang, Yhu Chering; Huang, Li Min (2013) Adenovirus Serotype 3 and 7 Infection with Acute Respiratory Failure in Children in Taiwan, 2010-2011. En: PLoS ONE. Vol. 8; No. 1; Disponible en: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053614. Disponible en: 10.1371/journal.pone.0053614. Lynch, Joseph P.; Kajon, Adriana E. (2016) Adenovirus: Epidemiology, Global Spread of Novel Serotypes, and Advances in Treatment and Prevention. En: Seminars in Respiratory and Critical Care Medicine. Vol. 37; No. 4; pp. 586 - 602; Disponible en: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0036-1584923. Disponible en: 10.1055/s-0036-1584923. Costa, Graziela de Araujo; Delgado, Artur F.; Ferraro, Alexandre; Okay, Thelma Suely (2010) Application of the pediatric risk of mortality score (PRISM) score and determination of mortality risk factors in a tertiary pediatric intensive care unit. En: Clinics. Vol. 65; No. 11; pp. 1087 - 1092; Universidade de Sao Paulo; Disponible en: https://www.sciencedirect.com/science/article/pii/S1807593222028897?via%3Dihub. Disponible en: 10.1590/S1807-59322010001100005. Bartholomeusz, A; Locarnini, S (2006) Associated With Antiviral Therapy. En: Antiviral Therapy. Vol. 55; No. November 2005; pp. 52 - 55; Disponible en: 10.1002/jmv. Coutts, Jonathan; Fullarton, John; Morris, Carole; Grubb, Eliza Beth; Buchan, Scot; Rodgers-Gray, Barry; Thwaites, Richard (2020) Association between respiratory syncytial virus hospitalization in infancy and childhood asthma. En: Pediatric Pulmonology. Vol. 55; No. 5; pp. 1104 - 1110; John Wiley and Sons Inc.; Disponible en: https://onlinelibrary.wiley.com/doi/10.1002/ppul.24676. Disponible en: 10.1002/ppul.24676. Insitutio Nacional de Salud (2022) Boletin epidemiologico Colombia. Disponible en: https://www.ins.gov.co/buscador-eventos/Paginas/Vista-Boletin-Epidemilogico.aspx. Davidson, Lauren M.; Berkelhamer, Sara K. (2017) Bronchopulmonary dysplasia: Chronic lung disease of infancy and long-term pulmonary outcomes. En: Journal of Clinical Medicine. Vol. 6; No. 1; MDPI; Disponible en: https://www.mdpi.com/2077-0383/6/1/4. Disponible en: 10.3390/jcm6010004. Garcia, Constanza Marcela; Suarez, Edgar Prieto (2014) Caracterización epidemiológica de la infección respiratoria aguda grave y circulación viral en Boyacá, Julio de 2012 a Julio de 2013. pp. 85 - 85; Disponible en: https://repositorio.unal.edu.co/handle/unal/49646. Xu, Lili; Liu, Jun; Liu, Chunyan; Duan, Yali; Zhu, Yun; Xu, Baoping; Xie, Zhengde (2018) Case-control study of the epidemiological and clinical features of human adenovirus 55 and human adenovirus 7 infection in children with acute lower respiratory tract infections in Beijing, China, 2008-2013. En: BMC Infectious Diseases. Vol. 18; No. 1; BioMed Central Ltd; Disponible en: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-018-3520-z. Disponible en: 10.1186/s12879-018-3520-z. Bakir, Julia; Juárez, Mariá Del V.; Lución, Mariá F.; Areso, Mariá S.; Viegas, Mariana; Mistchenko, Alicia S.; Gentile, Ángela (2020) Clinical and epidemiological study of acute lower respiratory tract infections caused by adenovirus in hospitalized children. Nineteen years of active epidemiological surveillance. En: Archivos Argentinos de Pediatria. Vol. 118; No. 3; pp. 193 - 201; Sociedad Argentina de Pediatria; Disponible en: https://www.sap.org.ar/docs/publicaciones/archivosarg/2020/v118n3a03e.pdf. Disponible en: 10.5546/aap.2020.eng.193. Muthupandi, V; Dianagrace, R; Narayanan, E; Sathya, J (2022) Comparison of PRISM III and PIM II Score in Predicting Mortality in Paediatric Intensive Care Unit: An Observational Study. En: JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH.: JCDR Research and Publications; Disponible en: https://www.jcdr.net/articles/PDF/15971/51410_CE[Ra1]_F(KR)_PF1(TW_SS)_PFA(TW_KM)_PN(KM).pdf. Disponible en: 10.7860/jcdr/2022/51410.15971. Bratton, Susan L.; Newth, Christopher J.L.; Zuppa, Athena F.; Moler, Frank W.; Meert, Kathleen L.; Berg, Robert A.; Berger, John; Wessel, David; Pollack, Murray; Harrison, Rick; Carcillo, Joseph A.; Shanley, Thomas P.; Liu, Teresa; Holubkov, Richard; Dean, J. Michael; Nicholson, Carol E. (2012) Critical care for pediatric asthma: wide care variability and challenges for study. En: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. Vol. 13; No. 4; pp. 407 - 414; Pediatr Crit Care Med; Disponible en: https://journals.lww.com/pccmjournal/Abstract/2012/07000/Critical_care_for_pediatric_asthma__Wide_care.6.aspx. Disponible en: 10.1097/PCC.0B013E318238B428. Chatterjee, Archana; Mavunda, Kunjana; Krilov, Leonard R. (2021) Current State of Respiratory Syncytial Virus Disease and Management. En: Infectious Diseases and Therapy. Vol. 10; pp. 5 - 16; Adis; Disponible en: https://link.springer.com/article/10.1007/s40121-020-00387-2. Disponible en: 10.1007/s40121-020-00387-2. Mao, Nai Ying; Zhu, Zhen; Zhang, Yan; Xu, Wen Bo (2022) Current status of human adenovirus infection in China. En: World Journal of Pediatrics. Vol. 18; No. 8; pp. 533 - 537; Springer Nature Singapore; 1251902200; Disponible en: https://link.springer.com/article/10.1007/s12519-022-00568-8. Disponible en: 10.1007/s12519-022-00568-8. Jeon, Ga Won; Oh, Minkyung; Chang, Yun Sil (2021) Definitions of bronchopulmonary dysplasia and long-term outcomes of extremely preterm infants in Korean Neonatal Network. En: Scientific Reports. Vol. 11; No. 1; Nature Research; Disponible en: https://www.nature.com/articles/s41598-021-03644-7. Disponible en: 10.1038/s41598-021-03644-7. Driscoll, Amanda J.; Arshad, S. Hasan; Bont, Louis; Brunwasser, Steven M.; Cherian, Thomas; Englund, Janet A.; Fell, Deshayne B.; Hammitt, Laura L.; Hartert, Tina V.; Innis, Bruce L.; Karron, Ruth A.; Langley, Gayle E.; Mulholland, E. Kim; Munywoki, Patrick K.; Nair, Harish; Ortiz, Justin R.; Savitz, David A.; Scheltema, Nienke M.; Simões, Eric A.F.; Smith, Peter G.; Were, Fred; Zar, Heather J.; Feikin, Daniel R. (2020) Does respiratory syncytial virus lower respiratory illness in early life cause recurrent wheeze of early childhood and asthma? Critical review of the evidence and guidance for future studies from a World Health Organization-sponsored meeting. En: Vaccine. Vol. 38; No. 11; pp. 2435 - 2448; Elsevier Ltd; Disponible en: https://www.sciencedirect.com/science/article/pii/S0264410X20300359?via%3Dihub. Disponible en: 10.1016/j.vaccine.2020.01.020. Azzari, Chiara; Baraldi, Eugenio; Bonanni, Paolo; Bozzola, Elena; Coscia, Alessandra; Lanari, Marcello; Manzoni, Paolo; Mazzone, Teresa; Sandri, Fabrizio; Checcucci Lisi, Giovanni; Parisi, Salvatore; Piacentini, Giorgio; Mosca, Fabio (2021) Epidemiology and prevention of respiratory syncytial virus infections in children in Italy. En: Italian Journal of Pediatrics. Vol. 47; No. 1; BioMed Central Ltd; Disponible en: https://ijponline.biomedcentral.com/articles/10.1186/s13052-021-01148-8. Disponible en: 10.1186/s13052-021-01148-8. Nolan, Vikki G.; Arnold, Sandra R.; Bramley, Anna M.; Ampofo, Krow; Williams, Derek J.; Grijalva, Carlos G.; Self, Wesley H.; Anderson, Evan J.; Wunderink, Richard G.; Edwards, Kathryn M.; Pavia, Andrew T.; Jain, Seema; McCullers, Jonathan A. (2018) Etiology and impact of coinfections in children hospitalized with community-acquired pneumonia. En: Journal of Infectious Diseases. Vol. 218; No. 2; pp. 179 - 188; Oxford University Press; Disponible en: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-017-2891-x. Disponible en: 10.1093/infdis/jix641. Fathmawati, Fathmawati; Rauf, Saidah; Indraswari, Braghmandita Widya (2021) Factors related with the incidence of acute respiratory infections in toddlers in Sleman, Yogyakarta, Indonesia: Evidence from the Sleman Health and Demographic Surveillance System. En: PLoS ONE. Vol. 16; No. 9 September; pp. 1 - 13; 1111111111; Disponible en: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0257881. Disponible en: 10.1371/journal.pone.0257881. Henquell, Cécile; Bœuf, Benoît; Mirand, Audrey; Bacher, Catherine; Traore, Ousmane; Déchelotte, Pierre; Labbé, André; Bailly, Jean Luc; Peigue-Lafeuille, Hélène (2009) Fatal adenovirus infection in a neonate and transmission to health-care workers. En: Journal of Clinical Virology. Vol. 45; No. 4; pp. 345 - 348; Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1386653209001826?via%3Dihub. Disponible en: 10.1016/j.jcv.2009.04.019. Pollack, Murray M.; Holubkov, Richard; Glass, Penny; Dean, J. Michael; Meert, Kathleen L.; Zimmerman, Jerry; Anand, Kanwaljeet J.S.; Carcillo, Joseph; Newth, Christopher J.L.; Harrison, Rick; Willson, Douglas F.; Nicholson, Carol; Heidemann, Sabrina; Frey, Maureen; Bell, Michael; Reardon, Jean; Prodhan, Parthak; Hefley, Glenda; Brogan, Thomas; Barker, Ruth; Venkataraman, Shekhar T.; Abraham, Alan; Fajardo, J. Francisco; Donaldson, Amy; Burr, Jeri; Singh, Devinder; Enriquez, Rene; Jenkins, Tammara; Cobb, Linda Ewing; Gilles, Elizabeth; Sholas, Maurice; Matthews, Dennis (2009) Functional status scale: New pediatric outcome measure. En: Pediatrics. Vol. 124; No. 1; Disponible en: https://publications.aap.org/pediatrics/article-abstract/124/1/e18/71666/Functional-Status-Scale-New-Pediatric-Outcome?redirectedFrom=fulltext. Disponible en: 10.1542/peds.2008-1987. Weiss, Scott L.; Fitzgerald, Julie C.; Pappachan, John; Wheeler, Derek; Jaramillo-Bustamante, Juan C.; Salloo, Asma; Singhi, Sunit C.; Erickson, Simon; Roy, Jason A.; Bush, Jenny L.; Nadkarni, Vinay M.; Thomas, Neal J. (2015) Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study. En: American journal of respiratory and critical care medicine. Vol. 191; No. 10; pp. 1147 - 1157; Am J Respir Crit Care Med; Disponible en: https://www.atsjournals.org/doi/10.1164/rccm.201412-2323OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed. Disponible en: 10.1164/RCCM.201412-2323OC. Shi, Ting; McAllister, David A.; O'Brien, Katherine L.; Simoes, Eric A.F.; Madhi, Shabir A.; Gessner, Bradford D.; Polack, Fernando P.; Balsells, Evelyn; Acacio, Sozinho; Aguayo, Claudia; Alassani, Issifou; Ali, Asad; Antonio, Martin; Awasthi, Shally; Awori, Juliet O.; Azziz-Baumgartner, Eduardo; Baggett, Henry C.; Baillie, Vicky L.; Balmaseda, Angel; Barahona, Alfredo; Basnet, Sudha; Bassat, Quique; Basualdo, Wilma; Bigogo, Godfrey; Bont, Louis; Breiman, Robert F.; Brooks, W. Abdullah; Broor, Shobha; Bruce, Nigel; Bruden, Dana; Buchy, Philippe; Campbell, Stuart; Carosone-Link, Phyllis; Chadha, Mandeep; Chipeta, James; Chou, Monidarin; Clara, Wilfrido; Cohen, Cheryl; de Cuellar, Elizabeth; Dang, Duc Anh; Dash-yandag, Budragchaagiin; Deloria-Knoll, Maria; Dherani, Mukesh; Eap, Tekchheng; Ebruke, Bernard E.; Echavarria, Marcela; de Freitas Lázaro Emediato, Carla Cecília; Fasce, Rodrigo A.; Feikin, Daniel R.; Feng, Luzhao; Gentile, Angela; Gordon, Aubree; Goswami, Doli; Goyet, Sophie; Groome, Michelle; Halasa, Natasha; Hirve, Siddhivinayak; Homaira, Nusrat; Howie, Stephen R.C.; Jara, Jorge; Jroundi, Imane; Kartasasmita, Cissy B.; Khuri-Bulos, Najwa; Kotloff, Karen L.; Krishnan, Anand; Libster, Romina; Lopez, Olga; Lucero, Marilla G.; Lucion, Florencia; Lupisan, Socorro P.; Marcone, Debora N.; McCracken, John P.; Mejia, Mario; Moisi, Jennifer C.; Montgomery, Joel M.; Moore, David P.; Moraleda, Cinta; Moyes, Jocelyn; Munywoki, Patrick; Mutyara, Kuswandewi; Nicol, Mark P.; Nokes, D. James; Nymadawa, Pagbajabyn; da Costa Oliveira, Maria Tereza; Oshitani, Histoshi; Pandey, Nitin; Paranhos-Baccalà, Gláucia; Phillips, Lia N.; Picot, Valentina Sanchez; Rahman, Mustafizur; Rakoto-Andrianarivelo, Mala; Rasmussen, Zeba A.; Rath, Barbara A.; Robinson, Annick; Romero, Candice; Russomando, Graciela; Salimi, Vahid; Sawatwong, Pongpun; Scheltema, Nienke; Schweiger, Brunhilde; Scott, J. Anthony G.; Seidenberg, Phil; Shen, Kunling; Singleton, Rosalyn; Sotomayor, Viviana; Strand, Tor A.; Sutanto, Agustinus; Sylla, Mariam; Tapia, Milagritos D.; Thamthitiwat, Somsak; Thomas, Elizabeth D.; Tokarz, Rafal; Turner, Claudia; Venter, Marietjie; Waicharoen, Sunthareeya; Wang, Jianwei; Watthanaworawit, Wanitda; Yoshida, Lay Myint; Yu, Hongjie; Zar, Heather J.; Campbell, Harry; Nair, Harish (2017) Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study. En: The Lancet. Vol. 390; No. 10098; pp. 946 - 958; Lancet Publishing Group; Disponible en: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)30938-8/fulltext. Disponible en: 10.1016/S0140-6736(17)30938-8. Chen, Yi; Lin, Tao; Wang, Chang Bing; Liang, Wan Li; Lian, Guang Wan; Zanin, Mark; Wong, Sook San; Tian, Xin Gui; Zhong, Jia Yu; Zhang, Ying Ying; Xie, Jia Hui; Zheng, Ling Ling; Chen, Fei Yan; Dang, Run; Zhao, Ming Qi; Yang, Yi Yu; Zhou, Rong; Zhu, Bing (2022) Human adenovirus (HAdV) infection in children with acute respiratory tract infections in Guangzhou, China, 2010–2021: a molecular epidemiology study. En: World Journal of Pediatrics. Vol. 18; No. 8; pp. 545 - 552; Zhejiang University School of Medicine Children's Hospital; Disponible en: https://link.springer.com/article/10.1007/s12519-022-00590-w. Disponible en: 10.1007/s12519-022-00590-w. Kendall Scott, Magdalena; Chommanard, Christina; Lu, Xiaoyan; Appelgate, Dianna; Grenz, Ladonna; Schneider, Eileen; Gerber, Susan I.; Erdman, Dean D.; Thomas, Ann (2016) Human adenovirus associated with severe respiratory infection, Oregon, USA, 2013-2014. En: Emerging Infectious Diseases. Vol. 22; No. 6; pp. 1044 - 1051; Centers for Disease Control and Prevention (CDC); Disponible en: https://stacks.cdc.gov/view/cdc/39693. Disponible en: 10.3201/eid2206.151898. Shieh, Wun Ju (2022) Human adenovirus infections in pediatric population. En: Biomedical Journal. Vol. 45; No. 1; pp. 38 - 49; Chang Gung University; Disponible en: https://www.sciencedirect.com/science/article/pii/S2319417021001098?via%3Dihub. Disponible en: 10.1016/j.bj.2021.08.009. Fu, Yangxi; Tang, Zhengzhen; Ye, Zhixu; Mo, Shi; Tian, Xingui; Ni, Ke; Ren, Luo; Liu, Enmei; Zang, Na (2019) Human adenovirus type 7 infection causes a more severe disease than type 3. En: BMC Infectious Diseases. Vol. 19; No. 1; BioMed Central Ltd.; Disponible en: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-018-3651-2#:~:text=Human%20adenovirus%20type%203%20(HAdV,7%20rather%20than%20HAdV%2D3. Disponible en: 10.1186/s12879-018-3651-2. Huang, Yiman; Wang, Chao; Ma, Fenlian; Guo, Qiong; Yao, Lihong; Chen, Aijun; Luo, Xiaoyi; Zheng, Lishu (2021) Human adenoviruses in paediatric patients with respiratory tract infections in Beijing, China. En: Virology Journal. Vol. 18; No. 1; BioMed Central Ltd; Disponible en: https://virologyj.biomedcentral.com/articles/10.1186/s12985-021-01661-6. Disponible en: 10.1186/s12985-021-01661-6. Rima, Bert; Collins, Peter; Easton, Andrew; Fouchier, Ron; Kurath, Gael; Lamb, Robert A.; Lee, Benhur; Maisner, Andrea; Rota, Paul; Wang, Linfa (2017) ICTV virus taxonomy profile: Pneumoviridae. En: Journal of General Virology. Vol. 98; No. 12; pp. 2912 - 2913; Microbiology Society; Disponible en: https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000959#tab2. Disponible en: 10.1099/jgv.0.000959. Carolina, Diana; Sánchez, Malo; Lucero, Sandra; Molano, Bonilla (2019) INFECCIÓN RESPIRATORIA AGUDA. pp. 1 - 22; Disponible en: https://www.ins.gov.co/buscador-eventos/Informesdeevento/INFECCI%C3%93N%20RESPIRATORIA%20AGUDA_2019.pdf. Carolina, Diana; Sánchez, Malo; Milena, Sandra; Fuentes, Aparicio (2020) INFECCIÓN RESPIRATORIA AGUDA. pp. 1 - 28; Disponible en: https://www.ins.gov.co/buscador-eventos/Informesdeevento/INFECCI%C3%93N%20RESPIRATORIA%20AGUDA_2020.pdf. Malo, Diana; Pulido, Paola; Inmunoprevenibles, Equipo; Grupo Enfermedades Transmisibles; Subdirección de Prevención Vigilancia y Control en Salud Pública; Dirección de Vigilancia y Análisis del Riesgo en Salud Pública (2017) Infección Respiratoria Aguda, Colombia 2017. En: Instituto Nacional de Salud. pp. 1 - 31; 1001.732.375; Disponible en: https://www.ins.gov.co/buscador-eventos/Informesdeevento/Informe IRA Final 2017.pdf. Hobby, J; Bryson, G L. ; W; Bact, J; Bartz, Q R; Controulis, J; Crooks, H M; Rebstock, M C; Frost, D; Grassle, . M; Hawkins, . E; Kuna, J E; Mushett, S; Silver, C W; Solotorovsky, R H; Feldman, M; Karlson, W I<; Hin-Shau, A G; Pansy,; Jambor, F E; Donovick, W P; Ibid. ; C, R P; Bohnhoff, M ; R F; Foster, J W (1952) Isolation of a Cytopathogenic Agent from Human Adenoids LTndergoing Spontaneous Degeneration in Tissue Culture. (20714). En: World Health Organization Monograph Series. Vol. 64; No. 5; pp. 84 - 84; Disponible en: https://europepmc.org/article/MED/13134217. Zuleta M Yuri; Martínez B Pamela; Patarroyo G María Cristina; Concha V Marcela; Monreal E Víctor (2020) Lethal Infection For Adenovirus. Case Report. En: Sociedad Chilena de Neumologia pediatrica. pp. 52 - 54; Disponible en: https://www.neumologia-pediatrica.cl/index.php/NP/article/view/80. United Nations Inter-agency Group for Child Mortality Estimation (UN; IGME) (2021) Levels and trends in child mortality: report 2021. pp. 1 - 70; 9789280653212; Disponible en: https://www.who.int/publications/m/item/levels-and-trends-in-child-mortality-report-2021. Edmond, Karen; Scott, Susana; Korczak, Viola; Ward, Catherine; Sanderson, Colin; Theodoratou, Evropi; Clark, Andrew; Griffiths, Ulla; Rudan, Igor; Campbell, Harry (2012) Long term sequelae from childhood pneumonia; systematic review and meta-analysis. En: PLoS ONE. Vol. 7; No. 2; Disponible en: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031239. Disponible en: 10.1371/journal.pone.0031239. Landry, Jennifer S; Chan, Tiffany; Lands, Larry; Menzies, Dick (2011) Long-term impact of bronchopulmonary dysplasia on pulmonary function. En: Can Respir J. Vol. 18; No. 5; pp. 514 - 843; Landry, Jennifer S; Chan, Tiffany; Lands, Larry; Menzies, Dick (2011) Long-term impact of bronchopulmonary dysplasia on pulmonary function. En: Can Respir J. Vol. 18; No. 5; pp. 514 - 843; Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267603/pdf/crj18265.pdf. De Oliveira, Felipe Rezende Caino; Macias, Krisna De Medeiros; Rolli, Patricia Andrea; Colleti, José; De Carvalho, Werther Brunow (2020) Management of acute respiratory distress syndrome in a child with adenovirus pneumonia: Case report and literature review. En: Revista Paulista de Pediatria. Vol. 38; Sao Paulo Pediatric Society; Disponible en: https://www.scielo.br/j/rpp/a/TtDW75qqt6YpcrMTsbJNQyN/?lang=en. Disponible en: 10.1590/1984-0462/2020/38/2018280. Kajon, Adriana E; Suarez, Manuela Vicente (1990) Molecular Epidemiology of Adenoviruses Isolated From Hospitalized Children With Severe Lower Acute Respiratory Infection in Santiago, Chile. En: Journal of Medical Virology. Vol. 30; pp. 294 - 297; Disponible en: https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.1890300412?sid=nlm%3Apubmed. Zadheidar, Sevrin; Yavarian, Jila; Heydarifard, Zahra; Nejati, Ahmad; Sadeghi, Kaveh; Ghavami, Nastaran; Abbasi, Simin; Shatizadeh Malekshahi, Somayeh; Mokhtari-Azad, Talat; Shafiei-Jandaghi, Nazanin Zahra (2022) Molecular epidemiology of human adenoviruses in children with and without respiratory symptoms: Preliminary findings from a case-control study. En: BMC Pediatrics. Vol. 22; No. 1; BioMed Central Ltd; Disponible en: https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-022-03625-3. Disponible en: 10.1186/s12887-022-03625-3. Lu, X.; Erdman, D. D. (2006) Molecular typing of human adenoviruses by PCR and sequencing of a partial region of the hexon gene. En: Archives of Virology. Vol. 151; No. 8; pp. 1587 - 1602; Disponible en: https://link.springer.com/article/10.1007/s00705-005-0722-7. Disponible en: 10.1007/s00705-005-0722-7. Aoyama, Brianna C.; Rice, Jessica L.; McGrath-Morrow, Sharon A.; Collaco, Joseph M. (2022) Mortality in Outpatients with Bronchopulmonary Dysplasia. En: Journal of Pediatrics. Vol. 241; pp. 48 - 53.e1; Elsevier Inc.; Disponible en: https://www.jpeds.com/article/S0022-3476(21)00958-6/fulltext. Disponible en: 10.1016/j.jpeds.2021.09.055. Schlapbach, Luregn J.; Straney, Lahn; Alexander, Janet; MacLaren, Graeme; Festa, Marino; Schibler, Andreas; Slater, Anthony (2015) Mortality related to invasive infections, sepsis, and septic shock in critically ill children in Australia and New Zealand, 2002-13: a multicentre retrospective cohort study. En: The Lancet. Infectious diseases. Vol. 15; No. 1; pp. 46 - 54; Lancet Infect Dis; Disponible en: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(14)71003-5/fulltext. Disponible en: 10.1016/S1473-3099(14)71003-5. Everard, Mark L. (2016) Paediatric respiratory infections. En: European Respiratory Review. Vol. 25; No. 139; pp. 36 - 40; Disponible en: https://err.ersjournals.com/content/25/139/36.long. Disponible en: 10.1183/16000617.0084-2015. Odetola, Folafoluwa O.; Gebremariam, Achamyeleh; Freed, Gary L. (2007) Patient and hospital correlates of clinical outcomes and resource utilization in severe pediatric sepsis. En: Pediatrics. Vol. 119; No. 3; pp. 487 - 494; Pediatrics; Disponible en: https://publications.aap.org/pediatrics/article-abstract/119/3/487/70427/Patient-and-Hospital-Correlates-of-Clinical?redirectedFrom=fulltext. Disponible en: 10.1542/PEDS.2006-2353. Balamuth, Fran; Weiss, Scott L.; Neuman, Mark I.; Scott, Halden; Brady, Patrick W.; Paul, Raina; Farris, Reid W.D.; McClead, Richard; Hayes, Katie; Gaieski, David; Hall, Matt; Shah, Samir S.; Alpern, Elizabeth R. (2014) Pediatric severe sepsis in U.S. children's hospitals. En: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. Vol. 15; No. 9; pp. 798 - 805; Pediatr Crit Care Med; Disponible en: https://journals.lww.com/pccmjournal/Abstract/2014/11000/Pediatric_Severe_Sepsis_in_U_S__Children_s.2.aspx. Disponible en: 10.1097/PCC.0000000000000225. Ruth, Amanda; McCracken, Courtney E.; Fortenberry, James D.; Hall, Matthew; Simon, Harold K.; Hebbar, Kiran B. (2014) Pediatric severe sepsis: current trends and outcomes from the Pediatric Health Information Systems database. En: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. Vol. 15; No. 9; pp. 828 - 838; Pediatr Crit Care Med; Disponible en: https://journals.lww.com/pccmjournal/Abstract/2014/11000/Pediatric_Severe_Sepsis__Current_Trends_and.6.aspx. Disponible en: 10.1097/PCC.0000000000000254. Cardozo Paez Leider (2013) Prevalencia de virus sincitial respiratorio y. pp. 45 - 45; Disponible en: http://repositorio.uchile.cl/bitstream/handle/2250/130118/Memoria.pdf. Instituto Nacional de Salud (2022) Protocolo de Vigilancia de Infección Respiratoria Aguda (IRA). pp. 1 - 32; Disponible en: http://www.ins.gov.co/buscador-eventos/SitePages/Evento.aspx?Event=10. Mazur, Natalie I.; Terstappen, Jonne; Baral, Ranju; Bardají, Azucena; Beutels, Philippe; Buchholz, Ursula J.; Cohen, Cheryl; Crowe, James E.; Cutland, Clare L.; Eckert, Linda; Feikin, Daniel; Fitzpatrick, Tiffany; Fong, Youyi; Graham, Barney S.; Heikkinen, Terho; Higgins, Deborah; Hirve, Siddhivinayak; Klugman, Keith P.; Kragten-Tabatabaie, Leyla; Lemey, Philippe; Libster, Romina; Löwensteyn, Yvette; Mejias, Asuncion; Munoz, Flor M.; Munywoki, Patrick K.; Mwananyanda, Lawrence; Nair, Harish; Nunes, Marta C.; Ramilo, Octavio; Richmond, Peter; Ruckwardt, Tracy J.; Sande, Charles; Srikantiah, Padmini; Thacker, Naveen; Waldstein, Kody A.; Weinberger, Dan; Wildenbeest, Joanne; Wiseman, Dexter; Zar, Heather J.; Zambon, Maria; Bont, Louis (2023) Respiratory syncytial virus prevention within reach: the vaccine and monoclonal antibody landscape. En: The Lancet Infectious Diseases. Vol. 23; No. 1; pp. e2 - e21; Elsevier Ltd; Disponible en: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00291-2/fulltext. Disponible en: 10.1016/S1473-3099(22)00291-2. Rodríguez-Martínez, Carlos E.; Rodríguez, Diego Andrés; Nino, Gustavo (2015) Respiratory syncytial virus, adenoviruses, and mixed acute lower respiratory infections in children in a developing country. En: Journal of Medical Virology. Vol. 87; No. 5; pp. 774 - 781; John Wiley and Sons Inc.; Disponible en: https://onlinelibrary.wiley.com/doi/10.1002/jmv.24139. Disponible en: 10.1002/jmv.24139. Barr, Rachael; Green, Christopher A.; Sande, Charles J.; Drysdale, Simon B. (2019) Respiratory syncytial virus: diagnosis, prevention and management. En: Therapeutic Advances in Infectious Disease. Vol. 6; pp. 1 - 9; SAGE Publications Ltd; Disponible en: https://journals.sagepub.com/doi/full/10.1177/2049936119865798?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org. Disponible en: 10.1177/2049936119865798. Shang, Zifang; Tan, Shuguang; Ma, Dongli (2021) Respiratory syncytial virus: From pathogenesis to potential therapeutic strategies. En: International Journal of Biological Sciences. Vol. 17; No. 14; pp. 4073 - 4091; Ivyspring International Publisher; Disponible en: https://www.ijbs.com/v17p4073.htm. Disponible en: 10.7150/ijbs.64762. Mir, Fatima; Ariff, Shabina; Bhura, Maria; Chanar, Suhail; Nathwani, Apsara Ali; Jawwad, Muhammad; Hussain, Amjad; Rizvi, Arjumand; Umer, Muhammad; Memon, Zahid; Habib, Atif; Soofi, Sajid Bashir; Bhutta, Zulfiqar A. (2022) Risk Factors for Acute Respiratory Infections in Children Between 0 and 23 Months of Age in a Peri-Urban District in Pakistan: A Matched Case–Control Study. En: Frontiers in Pediatrics. Vol. 9; No. January; pp. 1 - 7; Disponible en: https://www.frontiersin.org/articles/10.3389/fped.2021.704545/full. Disponible en: 10.3389/fped.2021.704545. Tazinya, Alexis A.; Halle-Ekane, Gregory E.; Mbuagbaw, Lawrence T.; Abanda, Martin; Atashili, Julius; Obama, Marie Therese (2018) Risk factors for acute respiratory infections in children under five years attending the Bamenda Regional Hospital in Cameroon. En: BMC Pulmonary Medicine. Vol. 18; No. 1; pp. 1 - 8; BMC Pulmonary Medicine; Disponible en: https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-018-0579-7. Disponible en: 10.1186/s12890-018-0579-7. Randolph, Adrienne G.; Meert, Kathleen L.; O'Neil, Mary E.; Hanson, James H.; Luckett, Peter M.; Arnold, John H.; Gedeit, Rainer G.; Cox, Peter N.; Roberts, Joan S.; Venkataraman, Shekhar T.; Forbes, Peter W.; Cheifetz, Ira M. (2003) The feasibility of conducting clinical trials in infants and children with acute respiratory failure. En: American Journal of Respiratory and Critical Care Medicine. Vol. 167; No. 10; pp. 1334 - 1340; Disponible en: https://www.atsjournals.org/doi/10.1164/rccm.200210-1175OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed. Disponible en: 10.1164/rccm.200210-1175OC. Groves, Helen E; Piché-Renaud, Pierre-Philippe; Peci, Adriana; Farrar, Daniel S; Buckrell, Steven; Bancej, Christina; Sevenhuysen, Claire; Campigotto, Aaron; Gubbay, Jonathan B; Morris, Shaun K; Groves, He; Piché-Renaud, P-p; Peci, A (2021) The impact of the COVID-19 pandemic on influenza, respiratory syncytial virus, and other seasonal respiratory virus circulation in Canada: A population-based study-NC-ND. En: The Lancet Regional Health-Americas. Vol. 1; pp. 15 - 15; Disponible en: https://www.sciencedirect.com/science/article/pii/S2667193X21000077?via%3Dihub. Disponible en: 10.1016/j.lana.2021.10. Pollack, Murray M.; Holubkov, Richard; Funai, Tomohiko; Dean, J. Michael; Berger, John T.; Wessel, David L.; Meert, Kathleen; Berg, Robert A.; Newth, Christopher J.L.; Harrison, Rick E.; Carcillo, Joseph; Dalton, Heidi; Shanley, Thomas; Jenkins, Tammara L.; Tamburro, Robert; Nicholson, Carol (2016) The Pediatric Risk of Mortality Score: Update 2015. En: Pediatric Critical Care Medicine. Vol. 17; No. 1; pp. 2 - 9; Lippincott Williams and Wilkins; Disponible en: https://journals.lww.com/pccmjournal/Abstract/2016/01000/The_Pediatric_Risk_of_Mortality_Score__Update.2.aspx. Disponible en: 10.1097/PCC.0000000000000558. Informe Anual (2018) Unicef. 9789280650341; Disponible en: https://www.unicef.org/sites/default/files/2019-07/UNICEF-informe-anual-2018.pdf. Jung, Jae Hwa; Sol, In Suk; Kim, Min Jung; Kim, Yoon Hee; Kim, Kyung Won; Sohn, Myung Hyun (2018) Validation of pediatric index of mortality 3 for predicting mortality among patients admitted to a pediatric intensive care unit. En: Acute and Critical Care. Vol. 33; No. 3; pp. 170 - 177; Korean Society of Critical Care Medicine; Disponible en: https://brieflands.com/articles/apid-104428.html. Disponible en: 10.4266/acc.2018.00150. Popli, Vineet; Kumar, Anjani (2018) Validation of PRISM III (Pediatric Risk of Mortality) Scoring System in Predicting Risk of Mortality in a Pediatric Intensive Care Unit. En: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN. Vol. 17; pp. 81 - 87; Disponible en: www.iosrjournals.orgwww.iosrjournals.org. Disponible en: 10.9790/0853-1703198187. Nye, Steven; Whitley, Richard J.; Kong, Michele (2016) Viral Infection in the Development and Progression of Pediatric Acute Respiratory Distress Syndrome. En: Frontiers in Pediatrics. Vol. 4; No. NOV; pp. 1 - 1; Frontiers Media SA; Disponible en: https://www.frontiersin.org/articles/10.3389/fped.2016.00128/full. Disponible en: 10.3389/FPED.2016.00128. Newth, Christopher J.L.; Venkataraman, Shekhar; Willson, Douglas F.; Meert, Kathleen L.; Harrison, Rick; Dean, J. Michael; Pollack, Murray; Zimmerman, Jerry; Anand, Kanwaljeet J.S.; Carcillo, Joseph A.; Nicholson, Carol E. (2009) Weaning and extubation readiness in pediatric patients. En: Pediatric Critical Care Medicine. Vol. 10; No. 1; pp. 1 - 11; Disponible en: https://journals.lww.com/pccmjournal/Abstract/2009/01000/Weaning_and_extubation_readiness_in_pediatric.1.aspx. Disponible en: 10.1097/PCC.0b013e318193724d. Nations, United; Affairs, Social; Division, Population (2019) World Population Prospects. Disponible en: https://population.un.org/wpp/publications/files/wpp2019_highlights.pdf. United Nations (2019) World Population Prospects 2019. 9789211483161; Disponible en: https://population.un.org/wpp/publications/files/wpp2019_highlights.pdf. |
dc.source.instname.none.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.none.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
bitstream.url.fl_str_mv |
https://repository.urosario.edu.co/bitstreams/5c21de3b-93e2-4144-b774-8a2e63282632/download https://repository.urosario.edu.co/bitstreams/9ec2cbb5-8817-4957-a08f-e343c5a70c98/download https://repository.urosario.edu.co/bitstreams/3679ce4a-68bf-4492-9dc2-23c7209bd37a/download https://repository.urosario.edu.co/bitstreams/0384a169-b8cf-4248-b88f-8aad7508a740/download https://repository.urosario.edu.co/bitstreams/71bdb089-1ac7-41d8-92af-3b7f2d80f291/download https://repository.urosario.edu.co/bitstreams/f2727335-3589-4fb5-8bad-31feb336d843/download https://repository.urosario.edu.co/bitstreams/153c59ac-6f46-4b17-b25f-b513a2a997ad/download https://repository.urosario.edu.co/bitstreams/20f5312e-e9e6-435e-a120-20dff1716caf/download |
bitstream.checksum.fl_str_mv |
bbbf79eded4269115080cc9c485184a8 ce82cb0b3634e9b9b21b92d20894aeb4 b2825df9f458e9d5d96ee8b7cd74fde6 adb7af3ef071a784ffe1b544b9a344ab 45583c6461cc5f50d068b0fe0b6bbe24 45583c6461cc5f50d068b0fe0b6bbe24 c819a14418344d7652669f8ba0988af5 c819a14418344d7652669f8ba0988af5 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167723447418880 |
spelling |
Vasquez Hoyos, Pablo782cf527-e2c5-4841-92b7-f2403109da1a-1Barajas Romero, Juan SebastianMagíster en EpidemiologíaMaestríaFull time36dd6dff-a667-44f3-8b04-07694c26f140-12023-07-17T16:09:13Z2023-07-17T16:09:13Z2023-07-07info:eu-repo/date/embargoEnd/2025-07-19Introducción y objetivos: Las infecciones virales son la causa más frecuente de fallo respiratorio agudo (FRA) y la primera causa de ingreso a cuidados intensivos pediátricos (UCIp) en niños. El tipo de agente viral identificado influye en el curso de la enfermedad. La infección por adenovirus es una de las infecciones más agresivas, aunque no es la más prevalente. Este estudio tiene como objetivo comparar el curso clínico de la infección por adenovirus en relación con la infección por virus sincitial respiratorio (VSR), que es el agente más frecuente implicado en el fallo respiratorio en niños. Métodos: Se llevó a cabo un análisis secundario del registro concurrente de fallo respiratorio agudo de LARed en pacientes pediátricos ingresados en UCIP por FRA secundario a infección respiratoria por adenovirus o VSR entre abril de 2017 y diciembre de 2022. El desenlace primario de gravedad se definió como la estancia hospitalaria, mientras que los desenlaces secundarios incluyeron mortalidad y nueva morbilidad. Se compararon los grupos virales y la estancia mediante análisis de supervivencia ajustada por mortalidad y factores de confusión mediante un modelo de riesgos competitivos. Para los desenlaces secundarios de mortalidad y nueva morbilidad se evaluó como un desenlace compuesto mediante regresión logística multivariada. Resultados: En total, se incluyeron 3,014 pacientes en el estudio, de los cuales 182 presentaban infección por AdV y 2,832 por VSR. La mediana de edad fue de 3.9 meses [RIC 1.8-86], el 62% eran hombres y el 38% mujeres. Previa al ingreso hospitalario, el 32% de los pacientes presentaba comorbilidades, siendo la prematuridad la más frecuente. En comparación con el grupo de pacientes con VSR, los pacientes con infección por AdV presentaron con mayor frecuencia ingreso por neumonía (29% Vs 17%, p<0.01), mayor mediana de edad (8,2 meses Vs 3,7 meses, p<0,01) y mayor frecuencia de comorbilidades (42,7% Vs 32,2, p<0,01). La infección por AdV se asoció con un aumento en la estancia hospitalaria (HR 0,74, IC 95% 0,61-0,89), y mortalidad y morbilidad (ORa 6,15, IC 95% 2,78-13,57). Otros factores que se asociaron con mayor gravedad de la infección fueron: edad, antecedente displasia broncopulmonar, antecedente de daño pulmonar crónico y diagnóstico de neumonía.Introduction and Objectives: Viral infections are the most common cause of acute respiratory failure (ARF) and the leading cause of admission to pediatric intensive care units (PICUs) in children. The type of viral agent identified influences the course of the disease. Adenovirus infection is one of the most aggressive infections, although it is not the most prevalent. This study aims to compare the clinical course of adenovirus infection in relation to respiratory syncytial virus (RSV) infection, which is the most frequent agent involved in respiratory failure in children. Methods: A secondary analysis of the concurrent registry of acute respiratory failure by LARed was conducted in pediatric patients admitted to the PICU due to ARF secondary to adenovirus or RSV respiratory infection between April 2017 and December 2022. The primary outcome of severity was defined as hospital stay, while secondary outcomes included mortality and new morbidity. Viral groups and hospital stay were compared using survival analysis adjusted for mortality and confounding factors through a competing risks model. For the secondary outcomes of mortality and new morbidity, a multivariate logistic regression was used to evaluate them as a composite outcome. Results: A total of 3,014 patients were included in the study, of whom 182 had AdV infection and 2,832 had RSV infection. The median age was 3.9 months [IQR 1.8-86], 62% were male, and 38% were female. Prior to hospital admission, 32% of patients had comorbidities, with prematurity being the most frequent. Compared to the VSR group, patients with AdV infection more frequently presented with pneumonia upon admission (29% vs. 17%, p < 0.01), had a higher median age (8.2 months vs. 3.7 months, p < 0.01), and had a higher frequency of comorbidities (42.7% vs. 32.2%, p < 0.01). AdV infection was associated with an increase in hospital stay (HR 0.74, 95% CI 0.61-0.89), as well as mortality and morbidity (aOR 6.15, 95% CI 2.78-13.57). Other factors associated with increased severity of infection were age, history of bronchopulmonary dysplasia, history of chronic lung injury, and pneumonia diagnosis. Conclusion: Adenovirus infection in pediatric patients with ARF was associated with longer hospital stays and increased risk of mortality and morbidity compared to those infected with RSV.59application/pdfhttps://doi.org/10.48713/10336_40178 https://repository.urosario.edu.co/handle/10336/40178spaUniversidad del RosarioEscuela de Medicina y Ciencias de la SaludMaestría en EpidemiologíaAttribution-ShareAlike 4.0 InternationalRestringido (Temporalmente bloqueado)EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.http://creativecommons.org/licenses/by-sa/4.0/http://purl.org/coar/access_right/c_f1cfWu, Zhan; Zhang, Rong; Liu, Dongdong; Liu, Xuesong; Zhang, Jierong; Zhang, Zhihui; Chen, Sibei; He, Weiqun; Li, Yimin; Xu, Yonghao; Liu, Xiaoqing (2022) Acute Respiratory Distress Syndrome Caused by Human Adenovirus in Adults: A Prospective Observational Study in Guangdong, China. En: Frontiers in Medicine. Vol. 8; Frontiers Media S.A.; Disponible en: https://www.frontiersin.org/articles/10.3389/fmed.2021.791163/full. Disponible en: 10.3389/fmed.2021.791163.Hammer, J; Numa, A; Newth, C J L (1997) Acute Respiratory Distress Syndrome Caused by Respiratory Syncytial Virus. En: Pediatr. Pulmonol. Vol. 23; pp. 176 - 183; Disponible en: https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291099-0496%28199703%2923%3A3%3C176%3A%3AAID-PPUL2%3E3.0.CO%3B2-M?sid=nlm%3Apubmed.Schneider, James; Sweberg, Todd (2013) Acute Respiratory Failure. En: Critical Care Clinics. Vol. 29; No. 2; pp. 167 - 183; Disponible en: https://journals.lww.com/ccnq/Abstract/2022/07000/Acute_Respiratory_Failure.5.aspx. Disponible en: 10.1016/j.ccc.2012.12.004.Friedman, Matthew L.; Nitu, Mara E. (2018) Acute respiratory failure in children. En: Pediatric Annals. Vol. 47; No. 7; pp. e268 - e273; Disponible en: 10.3928/19382359-20180625-01.Trollfors, B. (1994) Acute respiratory infections in children. En: Current Opinion in Infectious Diseases. Vol. 7; No. 2; pp. 157 - 161; Disponible en: 10.1097/00001432-199404000-00002. Disponible en: 10.1097/00001432-199404000-00002.Ghazaly, Marwa M H; Faddan, Nagla H Abu; Raafat, Duaa M; Mohammed, Nagwa A; Nadel, Simon (2021) Acute viral bronchiolitis as a cause of pediatric acute respiratory distress syndrome. En: European Journal of Pediatrics. Vol. 180; pp. 1229 - 1234; Disponible en: https://doi.org/10.1007/s00431-020-; https://link.springer.com/article/10.1007/s00431-020-03852-9. Disponible en: 10.1007/s00431-020.Koirala, Bibek; Wang, Jennifer P. (2013) Adenovirus. En: Viruses and the Lung: Infections and Non-Infectious Viral-Linked Lung Disorders. pp. 35 - 41; 9783642406058; Disponible en: https://link.springer.com/chapter/10.1007/978-3-642-40605-8_4. Disponible en: 10.1007/978-3-642-40605-8_4.Qi, Lifeng; Wang, Yajuan; Wang, Heping; Deng, Jikui (2020) Adenovirus 7 Induces Interlukin-6 Expression in Human Airway Epithelial Cells via p38/NF-κB Signaling Pathway. En: Frontiers in Immunology. Vol. 11; Frontiers Media S.A.; Disponible en: https://www.frontiersin.org/articles/10.3389/fimmu.2020.551413/full. Disponible en: 10.3389/fimmu.2020.551413.Greber, Urs F; Flatt, Justin W (2019) Adenovirus Entry : From Infection to Immunity. pp. 177 - 200; Disponible en: https://www.annualreviews.org/doi/10.1146/annurev-virology-092818-015550?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed.Zou, Lirong; Yi, Lina; Yu, Jianxiang; Song, Yinchao; Liang, Lijun; Guo, Qianfang; Zhuang, Xue; Zhang, Yunqiang; Kang, Min; Wu, Jie (2021) Adenovirus infection in children hospitalized with pneumonia in Guangzhou, China. En: Influenza and other Respiratory Viruses. Vol. 15; No. 1; pp. 27 - 33; Disponible en: https://onlinelibrary.wiley.com/doi/10.1111/irv.12782. Disponible en: 10.1111/irv.12782.Liu, Chunyan; Xiao, Yan; Zhang, Jing; Ren, Lili; Li, Jianguo; Xie, Zhengde; Xu, Baoping; Yang, Yan; Qian, Suyun; Wang, Jianwei; Shen, Kunling (2015) Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China, 2007 to 2012. En: BMC Infectious Diseases. Vol. 15; No. 1; BioMed Central Ltd.; Disponible en: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-015-1126-2. Disponible en: 10.1186/s12879-015-1126-2.Zhang, Yuanming; Bergelson, Jeffrey M (2005) Adenovirus Receptors. Vol. 79; No. 19; pp. 12125 - 12131; Disponible en: https://journals.asm.org/journal/jvi. Disponible en: 10.1128/JVI.79.19.12125.Gutierrez-Tobar, Ivan F.; Beltran-Arroyave, Claudia; Díaz, Alejandro; Londoño, Juan P.; Jimenez, Karen L.; Zamora, Carmen G.; Camacho-Moreno, German; Alvarez-Olmos, Martha I.; Beltran-Higuera, Sandra J.; Alvarez-Moreno, Carlos A. (2023) Adenovirus Respiratory Infections Post Pandemic in Colombia: An Old Enemy With Increased Severity in Pediatric Population?. En: Pediatric Infectious Disease Journal. Vol. 42; No. 4; pp. E133 - E134; Lippincott Williams and Wilkins; Disponible en: https://journals.lww.com/pidj/Fulltext/2023/04000/Adenovirus_Respiratory_Infections_Post_Pandemic_in.31.aspx. Disponible en: 10.1097/INF.0000000000003827.Lai, Chen Yin; Lee, Chia Jie; Lu, Chun Yi; Lee, Ping Ing; Shao, Pei Lan; Wu, En Ting; Wang, Ching Chia; Tan, Boon Fatt; Chang, Hsin Yu; Hsia, Shao Hsuan; Lin, Jainn Jim; Chang, Luan Yin; Huang, Yhu Chering; Huang, Li Min (2013) Adenovirus Serotype 3 and 7 Infection with Acute Respiratory Failure in Children in Taiwan, 2010-2011. En: PLoS ONE. Vol. 8; No. 1; Disponible en: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053614. Disponible en: 10.1371/journal.pone.0053614.Lynch, Joseph P.; Kajon, Adriana E. (2016) Adenovirus: Epidemiology, Global Spread of Novel Serotypes, and Advances in Treatment and Prevention. En: Seminars in Respiratory and Critical Care Medicine. Vol. 37; No. 4; pp. 586 - 602; Disponible en: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0036-1584923. Disponible en: 10.1055/s-0036-1584923.Costa, Graziela de Araujo; Delgado, Artur F.; Ferraro, Alexandre; Okay, Thelma Suely (2010) Application of the pediatric risk of mortality score (PRISM) score and determination of mortality risk factors in a tertiary pediatric intensive care unit. En: Clinics. Vol. 65; No. 11; pp. 1087 - 1092; Universidade de Sao Paulo; Disponible en: https://www.sciencedirect.com/science/article/pii/S1807593222028897?via%3Dihub. Disponible en: 10.1590/S1807-59322010001100005.Bartholomeusz, A; Locarnini, S (2006) Associated With Antiviral Therapy. En: Antiviral Therapy. Vol. 55; No. November 2005; pp. 52 - 55; Disponible en: 10.1002/jmv.Coutts, Jonathan; Fullarton, John; Morris, Carole; Grubb, Eliza Beth; Buchan, Scot; Rodgers-Gray, Barry; Thwaites, Richard (2020) Association between respiratory syncytial virus hospitalization in infancy and childhood asthma. En: Pediatric Pulmonology. Vol. 55; No. 5; pp. 1104 - 1110; John Wiley and Sons Inc.; Disponible en: https://onlinelibrary.wiley.com/doi/10.1002/ppul.24676. Disponible en: 10.1002/ppul.24676.Insitutio Nacional de Salud (2022) Boletin epidemiologico Colombia. Disponible en: https://www.ins.gov.co/buscador-eventos/Paginas/Vista-Boletin-Epidemilogico.aspx.Davidson, Lauren M.; Berkelhamer, Sara K. (2017) Bronchopulmonary dysplasia: Chronic lung disease of infancy and long-term pulmonary outcomes. En: Journal of Clinical Medicine. Vol. 6; No. 1; MDPI; Disponible en: https://www.mdpi.com/2077-0383/6/1/4. Disponible en: 10.3390/jcm6010004.Garcia, Constanza Marcela; Suarez, Edgar Prieto (2014) Caracterización epidemiológica de la infección respiratoria aguda grave y circulación viral en Boyacá, Julio de 2012 a Julio de 2013. pp. 85 - 85; Disponible en: https://repositorio.unal.edu.co/handle/unal/49646.Xu, Lili; Liu, Jun; Liu, Chunyan; Duan, Yali; Zhu, Yun; Xu, Baoping; Xie, Zhengde (2018) Case-control study of the epidemiological and clinical features of human adenovirus 55 and human adenovirus 7 infection in children with acute lower respiratory tract infections in Beijing, China, 2008-2013. En: BMC Infectious Diseases. Vol. 18; No. 1; BioMed Central Ltd; Disponible en: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-018-3520-z. Disponible en: 10.1186/s12879-018-3520-z.Bakir, Julia; Juárez, Mariá Del V.; Lución, Mariá F.; Areso, Mariá S.; Viegas, Mariana; Mistchenko, Alicia S.; Gentile, Ángela (2020) Clinical and epidemiological study of acute lower respiratory tract infections caused by adenovirus in hospitalized children. Nineteen years of active epidemiological surveillance. En: Archivos Argentinos de Pediatria. Vol. 118; No. 3; pp. 193 - 201; Sociedad Argentina de Pediatria; Disponible en: https://www.sap.org.ar/docs/publicaciones/archivosarg/2020/v118n3a03e.pdf. Disponible en: 10.5546/aap.2020.eng.193.Muthupandi, V; Dianagrace, R; Narayanan, E; Sathya, J (2022) Comparison of PRISM III and PIM II Score in Predicting Mortality in Paediatric Intensive Care Unit: An Observational Study. En: JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH.: JCDR Research and Publications; Disponible en: https://www.jcdr.net/articles/PDF/15971/51410_CE[Ra1]_F(KR)_PF1(TW_SS)_PFA(TW_KM)_PN(KM).pdf. Disponible en: 10.7860/jcdr/2022/51410.15971.Bratton, Susan L.; Newth, Christopher J.L.; Zuppa, Athena F.; Moler, Frank W.; Meert, Kathleen L.; Berg, Robert A.; Berger, John; Wessel, David; Pollack, Murray; Harrison, Rick; Carcillo, Joseph A.; Shanley, Thomas P.; Liu, Teresa; Holubkov, Richard; Dean, J. Michael; Nicholson, Carol E. (2012) Critical care for pediatric asthma: wide care variability and challenges for study. En: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. Vol. 13; No. 4; pp. 407 - 414; Pediatr Crit Care Med; Disponible en: https://journals.lww.com/pccmjournal/Abstract/2012/07000/Critical_care_for_pediatric_asthma__Wide_care.6.aspx. Disponible en: 10.1097/PCC.0B013E318238B428.Chatterjee, Archana; Mavunda, Kunjana; Krilov, Leonard R. (2021) Current State of Respiratory Syncytial Virus Disease and Management. En: Infectious Diseases and Therapy. Vol. 10; pp. 5 - 16; Adis; Disponible en: https://link.springer.com/article/10.1007/s40121-020-00387-2. Disponible en: 10.1007/s40121-020-00387-2.Mao, Nai Ying; Zhu, Zhen; Zhang, Yan; Xu, Wen Bo (2022) Current status of human adenovirus infection in China. En: World Journal of Pediatrics. Vol. 18; No. 8; pp. 533 - 537; Springer Nature Singapore; 1251902200; Disponible en: https://link.springer.com/article/10.1007/s12519-022-00568-8. Disponible en: 10.1007/s12519-022-00568-8.Jeon, Ga Won; Oh, Minkyung; Chang, Yun Sil (2021) Definitions of bronchopulmonary dysplasia and long-term outcomes of extremely preterm infants in Korean Neonatal Network. En: Scientific Reports. Vol. 11; No. 1; Nature Research; Disponible en: https://www.nature.com/articles/s41598-021-03644-7. Disponible en: 10.1038/s41598-021-03644-7.Driscoll, Amanda J.; Arshad, S. Hasan; Bont, Louis; Brunwasser, Steven M.; Cherian, Thomas; Englund, Janet A.; Fell, Deshayne B.; Hammitt, Laura L.; Hartert, Tina V.; Innis, Bruce L.; Karron, Ruth A.; Langley, Gayle E.; Mulholland, E. Kim; Munywoki, Patrick K.; Nair, Harish; Ortiz, Justin R.; Savitz, David A.; Scheltema, Nienke M.; Simões, Eric A.F.; Smith, Peter G.; Were, Fred; Zar, Heather J.; Feikin, Daniel R. (2020) Does respiratory syncytial virus lower respiratory illness in early life cause recurrent wheeze of early childhood and asthma? Critical review of the evidence and guidance for future studies from a World Health Organization-sponsored meeting. En: Vaccine. Vol. 38; No. 11; pp. 2435 - 2448; Elsevier Ltd; Disponible en: https://www.sciencedirect.com/science/article/pii/S0264410X20300359?via%3Dihub. Disponible en: 10.1016/j.vaccine.2020.01.020.Azzari, Chiara; Baraldi, Eugenio; Bonanni, Paolo; Bozzola, Elena; Coscia, Alessandra; Lanari, Marcello; Manzoni, Paolo; Mazzone, Teresa; Sandri, Fabrizio; Checcucci Lisi, Giovanni; Parisi, Salvatore; Piacentini, Giorgio; Mosca, Fabio (2021) Epidemiology and prevention of respiratory syncytial virus infections in children in Italy. En: Italian Journal of Pediatrics. Vol. 47; No. 1; BioMed Central Ltd; Disponible en: https://ijponline.biomedcentral.com/articles/10.1186/s13052-021-01148-8. Disponible en: 10.1186/s13052-021-01148-8.Nolan, Vikki G.; Arnold, Sandra R.; Bramley, Anna M.; Ampofo, Krow; Williams, Derek J.; Grijalva, Carlos G.; Self, Wesley H.; Anderson, Evan J.; Wunderink, Richard G.; Edwards, Kathryn M.; Pavia, Andrew T.; Jain, Seema; McCullers, Jonathan A. (2018) Etiology and impact of coinfections in children hospitalized with community-acquired pneumonia. En: Journal of Infectious Diseases. Vol. 218; No. 2; pp. 179 - 188; Oxford University Press; Disponible en: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-017-2891-x. Disponible en: 10.1093/infdis/jix641.Fathmawati, Fathmawati; Rauf, Saidah; Indraswari, Braghmandita Widya (2021) Factors related with the incidence of acute respiratory infections in toddlers in Sleman, Yogyakarta, Indonesia: Evidence from the Sleman Health and Demographic Surveillance System. En: PLoS ONE. Vol. 16; No. 9 September; pp. 1 - 13; 1111111111; Disponible en: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0257881. Disponible en: 10.1371/journal.pone.0257881.Henquell, Cécile; Bœuf, Benoît; Mirand, Audrey; Bacher, Catherine; Traore, Ousmane; Déchelotte, Pierre; Labbé, André; Bailly, Jean Luc; Peigue-Lafeuille, Hélène (2009) Fatal adenovirus infection in a neonate and transmission to health-care workers. En: Journal of Clinical Virology. Vol. 45; No. 4; pp. 345 - 348; Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1386653209001826?via%3Dihub. Disponible en: 10.1016/j.jcv.2009.04.019.Pollack, Murray M.; Holubkov, Richard; Glass, Penny; Dean, J. Michael; Meert, Kathleen L.; Zimmerman, Jerry; Anand, Kanwaljeet J.S.; Carcillo, Joseph; Newth, Christopher J.L.; Harrison, Rick; Willson, Douglas F.; Nicholson, Carol; Heidemann, Sabrina; Frey, Maureen; Bell, Michael; Reardon, Jean; Prodhan, Parthak; Hefley, Glenda; Brogan, Thomas; Barker, Ruth; Venkataraman, Shekhar T.; Abraham, Alan; Fajardo, J. Francisco; Donaldson, Amy; Burr, Jeri; Singh, Devinder; Enriquez, Rene; Jenkins, Tammara; Cobb, Linda Ewing; Gilles, Elizabeth; Sholas, Maurice; Matthews, Dennis (2009) Functional status scale: New pediatric outcome measure. En: Pediatrics. Vol. 124; No. 1; Disponible en: https://publications.aap.org/pediatrics/article-abstract/124/1/e18/71666/Functional-Status-Scale-New-Pediatric-Outcome?redirectedFrom=fulltext. Disponible en: 10.1542/peds.2008-1987.Weiss, Scott L.; Fitzgerald, Julie C.; Pappachan, John; Wheeler, Derek; Jaramillo-Bustamante, Juan C.; Salloo, Asma; Singhi, Sunit C.; Erickson, Simon; Roy, Jason A.; Bush, Jenny L.; Nadkarni, Vinay M.; Thomas, Neal J. (2015) Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study. En: American journal of respiratory and critical care medicine. Vol. 191; No. 10; pp. 1147 - 1157; Am J Respir Crit Care Med; Disponible en: https://www.atsjournals.org/doi/10.1164/rccm.201412-2323OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed. Disponible en: 10.1164/RCCM.201412-2323OC.Shi, Ting; McAllister, David A.; O'Brien, Katherine L.; Simoes, Eric A.F.; Madhi, Shabir A.; Gessner, Bradford D.; Polack, Fernando P.; Balsells, Evelyn; Acacio, Sozinho; Aguayo, Claudia; Alassani, Issifou; Ali, Asad; Antonio, Martin; Awasthi, Shally; Awori, Juliet O.; Azziz-Baumgartner, Eduardo; Baggett, Henry C.; Baillie, Vicky L.; Balmaseda, Angel; Barahona, Alfredo; Basnet, Sudha; Bassat, Quique; Basualdo, Wilma; Bigogo, Godfrey; Bont, Louis; Breiman, Robert F.; Brooks, W. Abdullah; Broor, Shobha; Bruce, Nigel; Bruden, Dana; Buchy, Philippe; Campbell, Stuart; Carosone-Link, Phyllis; Chadha, Mandeep; Chipeta, James; Chou, Monidarin; Clara, Wilfrido; Cohen, Cheryl; de Cuellar, Elizabeth; Dang, Duc Anh; Dash-yandag, Budragchaagiin; Deloria-Knoll, Maria; Dherani, Mukesh; Eap, Tekchheng; Ebruke, Bernard E.; Echavarria, Marcela; de Freitas Lázaro Emediato, Carla Cecília; Fasce, Rodrigo A.; Feikin, Daniel R.; Feng, Luzhao; Gentile, Angela; Gordon, Aubree; Goswami, Doli; Goyet, Sophie; Groome, Michelle; Halasa, Natasha; Hirve, Siddhivinayak; Homaira, Nusrat; Howie, Stephen R.C.; Jara, Jorge; Jroundi, Imane; Kartasasmita, Cissy B.; Khuri-Bulos, Najwa; Kotloff, Karen L.; Krishnan, Anand; Libster, Romina; Lopez, Olga; Lucero, Marilla G.; Lucion, Florencia; Lupisan, Socorro P.; Marcone, Debora N.; McCracken, John P.; Mejia, Mario; Moisi, Jennifer C.; Montgomery, Joel M.; Moore, David P.; Moraleda, Cinta; Moyes, Jocelyn; Munywoki, Patrick; Mutyara, Kuswandewi; Nicol, Mark P.; Nokes, D. James; Nymadawa, Pagbajabyn; da Costa Oliveira, Maria Tereza; Oshitani, Histoshi; Pandey, Nitin; Paranhos-Baccalà, Gláucia; Phillips, Lia N.; Picot, Valentina Sanchez; Rahman, Mustafizur; Rakoto-Andrianarivelo, Mala; Rasmussen, Zeba A.; Rath, Barbara A.; Robinson, Annick; Romero, Candice; Russomando, Graciela; Salimi, Vahid; Sawatwong, Pongpun; Scheltema, Nienke; Schweiger, Brunhilde; Scott, J. Anthony G.; Seidenberg, Phil; Shen, Kunling; Singleton, Rosalyn; Sotomayor, Viviana; Strand, Tor A.; Sutanto, Agustinus; Sylla, Mariam; Tapia, Milagritos D.; Thamthitiwat, Somsak; Thomas, Elizabeth D.; Tokarz, Rafal; Turner, Claudia; Venter, Marietjie; Waicharoen, Sunthareeya; Wang, Jianwei; Watthanaworawit, Wanitda; Yoshida, Lay Myint; Yu, Hongjie; Zar, Heather J.; Campbell, Harry; Nair, Harish (2017) Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study. En: The Lancet. Vol. 390; No. 10098; pp. 946 - 958; Lancet Publishing Group; Disponible en: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)30938-8/fulltext. Disponible en: 10.1016/S0140-6736(17)30938-8.Chen, Yi; Lin, Tao; Wang, Chang Bing; Liang, Wan Li; Lian, Guang Wan; Zanin, Mark; Wong, Sook San; Tian, Xin Gui; Zhong, Jia Yu; Zhang, Ying Ying; Xie, Jia Hui; Zheng, Ling Ling; Chen, Fei Yan; Dang, Run; Zhao, Ming Qi; Yang, Yi Yu; Zhou, Rong; Zhu, Bing (2022) Human adenovirus (HAdV) infection in children with acute respiratory tract infections in Guangzhou, China, 2010–2021: a molecular epidemiology study. En: World Journal of Pediatrics. Vol. 18; No. 8; pp. 545 - 552; Zhejiang University School of Medicine Children's Hospital; Disponible en: https://link.springer.com/article/10.1007/s12519-022-00590-w. Disponible en: 10.1007/s12519-022-00590-w.Kendall Scott, Magdalena; Chommanard, Christina; Lu, Xiaoyan; Appelgate, Dianna; Grenz, Ladonna; Schneider, Eileen; Gerber, Susan I.; Erdman, Dean D.; Thomas, Ann (2016) Human adenovirus associated with severe respiratory infection, Oregon, USA, 2013-2014. En: Emerging Infectious Diseases. Vol. 22; No. 6; pp. 1044 - 1051; Centers for Disease Control and Prevention (CDC); Disponible en: https://stacks.cdc.gov/view/cdc/39693. Disponible en: 10.3201/eid2206.151898.Shieh, Wun Ju (2022) Human adenovirus infections in pediatric population. En: Biomedical Journal. Vol. 45; No. 1; pp. 38 - 49; Chang Gung University; Disponible en: https://www.sciencedirect.com/science/article/pii/S2319417021001098?via%3Dihub. Disponible en: 10.1016/j.bj.2021.08.009.Fu, Yangxi; Tang, Zhengzhen; Ye, Zhixu; Mo, Shi; Tian, Xingui; Ni, Ke; Ren, Luo; Liu, Enmei; Zang, Na (2019) Human adenovirus type 7 infection causes a more severe disease than type 3. En: BMC Infectious Diseases. Vol. 19; No. 1; BioMed Central Ltd.; Disponible en: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-018-3651-2#:~:text=Human%20adenovirus%20type%203%20(HAdV,7%20rather%20than%20HAdV%2D3. Disponible en: 10.1186/s12879-018-3651-2.Huang, Yiman; Wang, Chao; Ma, Fenlian; Guo, Qiong; Yao, Lihong; Chen, Aijun; Luo, Xiaoyi; Zheng, Lishu (2021) Human adenoviruses in paediatric patients with respiratory tract infections in Beijing, China. En: Virology Journal. Vol. 18; No. 1; BioMed Central Ltd; Disponible en: https://virologyj.biomedcentral.com/articles/10.1186/s12985-021-01661-6. Disponible en: 10.1186/s12985-021-01661-6.Rima, Bert; Collins, Peter; Easton, Andrew; Fouchier, Ron; Kurath, Gael; Lamb, Robert A.; Lee, Benhur; Maisner, Andrea; Rota, Paul; Wang, Linfa (2017) ICTV virus taxonomy profile: Pneumoviridae. En: Journal of General Virology. Vol. 98; No. 12; pp. 2912 - 2913; Microbiology Society; Disponible en: https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000959#tab2. Disponible en: 10.1099/jgv.0.000959.Carolina, Diana; Sánchez, Malo; Lucero, Sandra; Molano, Bonilla (2019) INFECCIÓN RESPIRATORIA AGUDA. pp. 1 - 22; Disponible en: https://www.ins.gov.co/buscador-eventos/Informesdeevento/INFECCI%C3%93N%20RESPIRATORIA%20AGUDA_2019.pdf.Carolina, Diana; Sánchez, Malo; Milena, Sandra; Fuentes, Aparicio (2020) INFECCIÓN RESPIRATORIA AGUDA. pp. 1 - 28; Disponible en: https://www.ins.gov.co/buscador-eventos/Informesdeevento/INFECCI%C3%93N%20RESPIRATORIA%20AGUDA_2020.pdf.Malo, Diana; Pulido, Paola; Inmunoprevenibles, Equipo; Grupo Enfermedades Transmisibles; Subdirección de Prevención Vigilancia y Control en Salud Pública; Dirección de Vigilancia y Análisis del Riesgo en Salud Pública (2017) Infección Respiratoria Aguda, Colombia 2017. En: Instituto Nacional de Salud. pp. 1 - 31; 1001.732.375; Disponible en: https://www.ins.gov.co/buscador-eventos/Informesdeevento/Informe IRA Final 2017.pdf.Hobby, J; Bryson, G L. ; W; Bact, J; Bartz, Q R; Controulis, J; Crooks, H M; Rebstock, M C; Frost, D; Grassle, . M; Hawkins, . E; Kuna, J E; Mushett, S; Silver, C W; Solotorovsky, R H; Feldman, M; Karlson, W I<; Hin-Shau, A G; Pansy,; Jambor, F E; Donovick, W P; Ibid. ; C, R P; Bohnhoff, M ; R F; Foster, J W (1952) Isolation of a Cytopathogenic Agent from Human Adenoids LTndergoing Spontaneous Degeneration in Tissue Culture. (20714). En: World Health Organization Monograph Series. Vol. 64; No. 5; pp. 84 - 84; Disponible en: https://europepmc.org/article/MED/13134217.Zuleta M Yuri; Martínez B Pamela; Patarroyo G María Cristina; Concha V Marcela; Monreal E Víctor (2020) Lethal Infection For Adenovirus. Case Report. En: Sociedad Chilena de Neumologia pediatrica. pp. 52 - 54; Disponible en: https://www.neumologia-pediatrica.cl/index.php/NP/article/view/80.United Nations Inter-agency Group for Child Mortality Estimation (UN; IGME) (2021) Levels and trends in child mortality: report 2021. pp. 1 - 70; 9789280653212; Disponible en: https://www.who.int/publications/m/item/levels-and-trends-in-child-mortality-report-2021.Edmond, Karen; Scott, Susana; Korczak, Viola; Ward, Catherine; Sanderson, Colin; Theodoratou, Evropi; Clark, Andrew; Griffiths, Ulla; Rudan, Igor; Campbell, Harry (2012) Long term sequelae from childhood pneumonia; systematic review and meta-analysis. En: PLoS ONE. Vol. 7; No. 2; Disponible en: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031239. Disponible en: 10.1371/journal.pone.0031239.Landry, Jennifer S; Chan, Tiffany; Lands, Larry; Menzies, Dick (2011) Long-term impact of bronchopulmonary dysplasia on pulmonary function. En: Can Respir J. Vol. 18; No. 5; pp. 514 - 843;Landry, Jennifer S; Chan, Tiffany; Lands, Larry; Menzies, Dick (2011) Long-term impact of bronchopulmonary dysplasia on pulmonary function. En: Can Respir J. Vol. 18; No. 5; pp. 514 - 843; Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267603/pdf/crj18265.pdf.De Oliveira, Felipe Rezende Caino; Macias, Krisna De Medeiros; Rolli, Patricia Andrea; Colleti, José; De Carvalho, Werther Brunow (2020) Management of acute respiratory distress syndrome in a child with adenovirus pneumonia: Case report and literature review. En: Revista Paulista de Pediatria. Vol. 38; Sao Paulo Pediatric Society; Disponible en: https://www.scielo.br/j/rpp/a/TtDW75qqt6YpcrMTsbJNQyN/?lang=en. Disponible en: 10.1590/1984-0462/2020/38/2018280.Kajon, Adriana E; Suarez, Manuela Vicente (1990) Molecular Epidemiology of Adenoviruses Isolated From Hospitalized Children With Severe Lower Acute Respiratory Infection in Santiago, Chile. En: Journal of Medical Virology. Vol. 30; pp. 294 - 297; Disponible en: https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.1890300412?sid=nlm%3Apubmed.Zadheidar, Sevrin; Yavarian, Jila; Heydarifard, Zahra; Nejati, Ahmad; Sadeghi, Kaveh; Ghavami, Nastaran; Abbasi, Simin; Shatizadeh Malekshahi, Somayeh; Mokhtari-Azad, Talat; Shafiei-Jandaghi, Nazanin Zahra (2022) Molecular epidemiology of human adenoviruses in children with and without respiratory symptoms: Preliminary findings from a case-control study. En: BMC Pediatrics. Vol. 22; No. 1; BioMed Central Ltd; Disponible en: https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-022-03625-3. Disponible en: 10.1186/s12887-022-03625-3.Lu, X.; Erdman, D. D. (2006) Molecular typing of human adenoviruses by PCR and sequencing of a partial region of the hexon gene. En: Archives of Virology. Vol. 151; No. 8; pp. 1587 - 1602; Disponible en: https://link.springer.com/article/10.1007/s00705-005-0722-7. Disponible en: 10.1007/s00705-005-0722-7.Aoyama, Brianna C.; Rice, Jessica L.; McGrath-Morrow, Sharon A.; Collaco, Joseph M. (2022) Mortality in Outpatients with Bronchopulmonary Dysplasia. En: Journal of Pediatrics. Vol. 241; pp. 48 - 53.e1; Elsevier Inc.; Disponible en: https://www.jpeds.com/article/S0022-3476(21)00958-6/fulltext. Disponible en: 10.1016/j.jpeds.2021.09.055.Schlapbach, Luregn J.; Straney, Lahn; Alexander, Janet; MacLaren, Graeme; Festa, Marino; Schibler, Andreas; Slater, Anthony (2015) Mortality related to invasive infections, sepsis, and septic shock in critically ill children in Australia and New Zealand, 2002-13: a multicentre retrospective cohort study. En: The Lancet. Infectious diseases. Vol. 15; No. 1; pp. 46 - 54; Lancet Infect Dis; Disponible en: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(14)71003-5/fulltext. Disponible en: 10.1016/S1473-3099(14)71003-5.Everard, Mark L. (2016) Paediatric respiratory infections. En: European Respiratory Review. Vol. 25; No. 139; pp. 36 - 40; Disponible en: https://err.ersjournals.com/content/25/139/36.long. Disponible en: 10.1183/16000617.0084-2015.Odetola, Folafoluwa O.; Gebremariam, Achamyeleh; Freed, Gary L. (2007) Patient and hospital correlates of clinical outcomes and resource utilization in severe pediatric sepsis. En: Pediatrics. Vol. 119; No. 3; pp. 487 - 494; Pediatrics; Disponible en: https://publications.aap.org/pediatrics/article-abstract/119/3/487/70427/Patient-and-Hospital-Correlates-of-Clinical?redirectedFrom=fulltext. Disponible en: 10.1542/PEDS.2006-2353.Balamuth, Fran; Weiss, Scott L.; Neuman, Mark I.; Scott, Halden; Brady, Patrick W.; Paul, Raina; Farris, Reid W.D.; McClead, Richard; Hayes, Katie; Gaieski, David; Hall, Matt; Shah, Samir S.; Alpern, Elizabeth R. (2014) Pediatric severe sepsis in U.S. children's hospitals. En: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. Vol. 15; No. 9; pp. 798 - 805; Pediatr Crit Care Med; Disponible en: https://journals.lww.com/pccmjournal/Abstract/2014/11000/Pediatric_Severe_Sepsis_in_U_S__Children_s.2.aspx. Disponible en: 10.1097/PCC.0000000000000225.Ruth, Amanda; McCracken, Courtney E.; Fortenberry, James D.; Hall, Matthew; Simon, Harold K.; Hebbar, Kiran B. (2014) Pediatric severe sepsis: current trends and outcomes from the Pediatric Health Information Systems database. En: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. Vol. 15; No. 9; pp. 828 - 838; Pediatr Crit Care Med; Disponible en: https://journals.lww.com/pccmjournal/Abstract/2014/11000/Pediatric_Severe_Sepsis__Current_Trends_and.6.aspx. Disponible en: 10.1097/PCC.0000000000000254.Cardozo Paez Leider (2013) Prevalencia de virus sincitial respiratorio y. pp. 45 - 45; Disponible en: http://repositorio.uchile.cl/bitstream/handle/2250/130118/Memoria.pdf.Instituto Nacional de Salud (2022) Protocolo de Vigilancia de Infección Respiratoria Aguda (IRA). pp. 1 - 32; Disponible en: http://www.ins.gov.co/buscador-eventos/SitePages/Evento.aspx?Event=10.Mazur, Natalie I.; Terstappen, Jonne; Baral, Ranju; Bardají, Azucena; Beutels, Philippe; Buchholz, Ursula J.; Cohen, Cheryl; Crowe, James E.; Cutland, Clare L.; Eckert, Linda; Feikin, Daniel; Fitzpatrick, Tiffany; Fong, Youyi; Graham, Barney S.; Heikkinen, Terho; Higgins, Deborah; Hirve, Siddhivinayak; Klugman, Keith P.; Kragten-Tabatabaie, Leyla; Lemey, Philippe; Libster, Romina; Löwensteyn, Yvette; Mejias, Asuncion; Munoz, Flor M.; Munywoki, Patrick K.; Mwananyanda, Lawrence; Nair, Harish; Nunes, Marta C.; Ramilo, Octavio; Richmond, Peter; Ruckwardt, Tracy J.; Sande, Charles; Srikantiah, Padmini; Thacker, Naveen; Waldstein, Kody A.; Weinberger, Dan; Wildenbeest, Joanne; Wiseman, Dexter; Zar, Heather J.; Zambon, Maria; Bont, Louis (2023) Respiratory syncytial virus prevention within reach: the vaccine and monoclonal antibody landscape. En: The Lancet Infectious Diseases. Vol. 23; No. 1; pp. e2 - e21; Elsevier Ltd; Disponible en: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00291-2/fulltext. Disponible en: 10.1016/S1473-3099(22)00291-2.Rodríguez-Martínez, Carlos E.; Rodríguez, Diego Andrés; Nino, Gustavo (2015) Respiratory syncytial virus, adenoviruses, and mixed acute lower respiratory infections in children in a developing country. En: Journal of Medical Virology. Vol. 87; No. 5; pp. 774 - 781; John Wiley and Sons Inc.; Disponible en: https://onlinelibrary.wiley.com/doi/10.1002/jmv.24139. Disponible en: 10.1002/jmv.24139.Barr, Rachael; Green, Christopher A.; Sande, Charles J.; Drysdale, Simon B. (2019) Respiratory syncytial virus: diagnosis, prevention and management. En: Therapeutic Advances in Infectious Disease. Vol. 6; pp. 1 - 9; SAGE Publications Ltd; Disponible en: https://journals.sagepub.com/doi/full/10.1177/2049936119865798?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org. Disponible en: 10.1177/2049936119865798.Shang, Zifang; Tan, Shuguang; Ma, Dongli (2021) Respiratory syncytial virus: From pathogenesis to potential therapeutic strategies. En: International Journal of Biological Sciences. Vol. 17; No. 14; pp. 4073 - 4091; Ivyspring International Publisher; Disponible en: https://www.ijbs.com/v17p4073.htm. Disponible en: 10.7150/ijbs.64762.Mir, Fatima; Ariff, Shabina; Bhura, Maria; Chanar, Suhail; Nathwani, Apsara Ali; Jawwad, Muhammad; Hussain, Amjad; Rizvi, Arjumand; Umer, Muhammad; Memon, Zahid; Habib, Atif; Soofi, Sajid Bashir; Bhutta, Zulfiqar A. (2022) Risk Factors for Acute Respiratory Infections in Children Between 0 and 23 Months of Age in a Peri-Urban District in Pakistan: A Matched Case–Control Study. En: Frontiers in Pediatrics. Vol. 9; No. January; pp. 1 - 7; Disponible en: https://www.frontiersin.org/articles/10.3389/fped.2021.704545/full. Disponible en: 10.3389/fped.2021.704545.Tazinya, Alexis A.; Halle-Ekane, Gregory E.; Mbuagbaw, Lawrence T.; Abanda, Martin; Atashili, Julius; Obama, Marie Therese (2018) Risk factors for acute respiratory infections in children under five years attending the Bamenda Regional Hospital in Cameroon. En: BMC Pulmonary Medicine. Vol. 18; No. 1; pp. 1 - 8; BMC Pulmonary Medicine; Disponible en: https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-018-0579-7. Disponible en: 10.1186/s12890-018-0579-7.Randolph, Adrienne G.; Meert, Kathleen L.; O'Neil, Mary E.; Hanson, James H.; Luckett, Peter M.; Arnold, John H.; Gedeit, Rainer G.; Cox, Peter N.; Roberts, Joan S.; Venkataraman, Shekhar T.; Forbes, Peter W.; Cheifetz, Ira M. (2003) The feasibility of conducting clinical trials in infants and children with acute respiratory failure. En: American Journal of Respiratory and Critical Care Medicine. Vol. 167; No. 10; pp. 1334 - 1340; Disponible en: https://www.atsjournals.org/doi/10.1164/rccm.200210-1175OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed. Disponible en: 10.1164/rccm.200210-1175OC.Groves, Helen E; Piché-Renaud, Pierre-Philippe; Peci, Adriana; Farrar, Daniel S; Buckrell, Steven; Bancej, Christina; Sevenhuysen, Claire; Campigotto, Aaron; Gubbay, Jonathan B; Morris, Shaun K; Groves, He; Piché-Renaud, P-p; Peci, A (2021) The impact of the COVID-19 pandemic on influenza, respiratory syncytial virus, and other seasonal respiratory virus circulation in Canada: A population-based study-NC-ND. En: The Lancet Regional Health-Americas. Vol. 1; pp. 15 - 15; Disponible en: https://www.sciencedirect.com/science/article/pii/S2667193X21000077?via%3Dihub. Disponible en: 10.1016/j.lana.2021.10.Pollack, Murray M.; Holubkov, Richard; Funai, Tomohiko; Dean, J. Michael; Berger, John T.; Wessel, David L.; Meert, Kathleen; Berg, Robert A.; Newth, Christopher J.L.; Harrison, Rick E.; Carcillo, Joseph; Dalton, Heidi; Shanley, Thomas; Jenkins, Tammara L.; Tamburro, Robert; Nicholson, Carol (2016) The Pediatric Risk of Mortality Score: Update 2015. En: Pediatric Critical Care Medicine. Vol. 17; No. 1; pp. 2 - 9; Lippincott Williams and Wilkins; Disponible en: https://journals.lww.com/pccmjournal/Abstract/2016/01000/The_Pediatric_Risk_of_Mortality_Score__Update.2.aspx. Disponible en: 10.1097/PCC.0000000000000558.Informe Anual (2018) Unicef. 9789280650341; Disponible en: https://www.unicef.org/sites/default/files/2019-07/UNICEF-informe-anual-2018.pdf.Jung, Jae Hwa; Sol, In Suk; Kim, Min Jung; Kim, Yoon Hee; Kim, Kyung Won; Sohn, Myung Hyun (2018) Validation of pediatric index of mortality 3 for predicting mortality among patients admitted to a pediatric intensive care unit. En: Acute and Critical Care. Vol. 33; No. 3; pp. 170 - 177; Korean Society of Critical Care Medicine; Disponible en: https://brieflands.com/articles/apid-104428.html. Disponible en: 10.4266/acc.2018.00150.Popli, Vineet; Kumar, Anjani (2018) Validation of PRISM III (Pediatric Risk of Mortality) Scoring System in Predicting Risk of Mortality in a Pediatric Intensive Care Unit. En: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN. Vol. 17; pp. 81 - 87; Disponible en: www.iosrjournals.orgwww.iosrjournals.org. Disponible en: 10.9790/0853-1703198187.Nye, Steven; Whitley, Richard J.; Kong, Michele (2016) Viral Infection in the Development and Progression of Pediatric Acute Respiratory Distress Syndrome. En: Frontiers in Pediatrics. Vol. 4; No. NOV; pp. 1 - 1; Frontiers Media SA; Disponible en: https://www.frontiersin.org/articles/10.3389/fped.2016.00128/full. Disponible en: 10.3389/FPED.2016.00128.Newth, Christopher J.L.; Venkataraman, Shekhar; Willson, Douglas F.; Meert, Kathleen L.; Harrison, Rick; Dean, J. Michael; Pollack, Murray; Zimmerman, Jerry; Anand, Kanwaljeet J.S.; Carcillo, Joseph A.; Nicholson, Carol E. (2009) Weaning and extubation readiness in pediatric patients. En: Pediatric Critical Care Medicine. Vol. 10; No. 1; pp. 1 - 11; Disponible en: https://journals.lww.com/pccmjournal/Abstract/2009/01000/Weaning_and_extubation_readiness_in_pediatric.1.aspx. Disponible en: 10.1097/PCC.0b013e318193724d.Nations, United; Affairs, Social; Division, Population (2019) World Population Prospects. Disponible en: https://population.un.org/wpp/publications/files/wpp2019_highlights.pdf.United Nations (2019) World Population Prospects 2019. 9789211483161; Disponible en: https://population.un.org/wpp/publications/files/wpp2019_highlights.pdf.instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURNiñoFalla respiratoria agudaAdenovirusVirus sincitial respiratorioChildAcute respiratory failureAdenovirusRespiratory syncytial virusComparación de la gravedad de la infección por adenovirus y virus sincitial respiratorio en niños con insuficiencia respiratoria aguda en cuidados intensivos: un estudio multicéntrico de LARed en América Latina entre 2017 y 2022.Comparison of the severity of adenovirus and respiratory syncytial virus infections in children with acute respiratory failure in intensive care: a multicenter study by LARed in Latin America between 2017 and 2022.bachelorThesisTrabajo de gradoTrabajo de gradohttp://purl.org/coar/resource_type/c_7a1fEscuela de Medicina y Ciencias de la SaludORIGINALexport (1).risexport (1).risapplication/x-research-info-systems167022https://repository.urosario.edu.co/bitstreams/5c21de3b-93e2-4144-b774-8a2e63282632/downloadbbbf79eded4269115080cc9c485184a8MD54Comparacion-de -la-gravedad-de-la-infeccion-por-AdV-y-VSR-en-ninos.pdfComparacion-de -la-gravedad-de-la-infeccion-por-AdV-y-VSR-en-ninos.pdfapplication/pdf2418900https://repository.urosario.edu.co/bitstreams/9ec2cbb5-8817-4957-a08f-e343c5a70c98/downloadce82cb0b3634e9b9b21b92d20894aeb4MD56LICENSElicense.txtlicense.txttext/plain1483https://repository.urosario.edu.co/bitstreams/3679ce4a-68bf-4492-9dc2-23c7209bd37a/downloadb2825df9f458e9d5d96ee8b7cd74fde6MD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81154https://repository.urosario.edu.co/bitstreams/0384a169-b8cf-4248-b88f-8aad7508a740/downloadadb7af3ef071a784ffe1b544b9a344abMD55TEXTComparación-de -la-gravedad-de-la-infeccion-por-AdV-y-VSR-en-niños.pdf.txtComparación-de -la-gravedad-de-la-infeccion-por-AdV-y-VSR-en-niños.pdf.txtExtracted texttext/plain101401https://repository.urosario.edu.co/bitstreams/71bdb089-1ac7-41d8-92af-3b7f2d80f291/download45583c6461cc5f50d068b0fe0b6bbe24MD57Comparacion-de -la-gravedad-de-la-infeccion-por-AdV-y-VSR-en-ninos.pdf.txtComparacion-de -la-gravedad-de-la-infeccion-por-AdV-y-VSR-en-ninos.pdf.txtExtracted texttext/plain101401https://repository.urosario.edu.co/bitstreams/f2727335-3589-4fb5-8bad-31feb336d843/download45583c6461cc5f50d068b0fe0b6bbe24MD59THUMBNAILComparación-de -la-gravedad-de-la-infeccion-por-AdV-y-VSR-en-niños.pdf.jpgComparación-de -la-gravedad-de-la-infeccion-por-AdV-y-VSR-en-niños.pdf.jpgGenerated Thumbnailimage/jpeg2897https://repository.urosario.edu.co/bitstreams/153c59ac-6f46-4b17-b25f-b513a2a997ad/downloadc819a14418344d7652669f8ba0988af5MD58Comparacion-de -la-gravedad-de-la-infeccion-por-AdV-y-VSR-en-ninos.pdf.jpgComparacion-de -la-gravedad-de-la-infeccion-por-AdV-y-VSR-en-ninos.pdf.jpgGenerated Thumbnailimage/jpeg2897https://repository.urosario.edu.co/bitstreams/20f5312e-e9e6-435e-a120-20dff1716caf/downloadc819a14418344d7652669f8ba0988af5MD51010336/40178oai:repository.urosario.edu.co:10336/401782023-07-19 03:03:28.122http://creativecommons.org/licenses/by-sa/4.0/Attribution-ShareAlike 4.0 Internationalhttps://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.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 |