Physiological and pathological implications of laminins: From the gene to the protein

The extracellular matrix plays an important role in modulating the behavior of cells with which it interacts. There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). LM are the major component of the basal lamina (BL). Here, we revi...

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Autores:
Tipo de recurso:
Fecha de publicación:
2007
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23411
Acceso en línea:
https://doi.org/10.1080/08916930600911519
https://repository.urosario.edu.co/handle/10336/23411
Palabra clave:
Integrin
Laminin
Laminin
Article
Autoimmune disease
Central nervous system
Embryo development
Extracellular matrix
Gene structure
Genetic polymorphism
Genetic regulation
Hemidesmosome
Human
Kidney
Neuromuscular system
Nidation
Nonhuman
Placenta development
Preimplantation embryo
Promoter region
Protein analysis
Protein domain
Protein structure
Sjoegren syndrome
Skin
Systemic lupus erythematosus
Tissue distribution
Antibody specificity
Autoimmune disease
Basement membrane
Chemistry
Genetics
Metabolism
Physiology
Protein conformation
Protein tertiary structure
Review
Sjoegren larsson syndrome
Autoimmune diseases
Basement membrane
Humans
Laminin
Organ specificity
Protein conformation
Sjogren-larsson syndrome
Basal lamina
Extracellular matrix
Laminin
Sjögren’s syndrome
Systemic lupus erythematosus
tertiary
genetic
systemic
Lupus erythematosus
Polymorphism
Protein structure
Rights
License
Abierto (Texto Completo)
id EDOCUR2_7ad5b3c02faff41a62cf8843231ac1d9
oai_identifier_str oai:repository.urosario.edu.co:10336/23411
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 8febe101-f27d-4a2e-99ba-7d3c3609084cc2d7a56e-c335-4781-bf79-6376d119216a1194287e-d121-4119-96bf-cc3bf656baa46b286b69-16c0-4eae-a12c-57f7a4b4c759194747786002020-05-26T00:01:49Z2020-05-26T00:01:49Z2007The extracellular matrix plays an important role in modulating the behavior of cells with which it interacts. There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). LM are the major component of the basal lamina (BL). Here, we review the current knowledge on their structure, self-assembly, binding mechanisms, diverse tissue-expression patterns and its impact on pathology. Studies and hypothesis exploring the role of LM and their polymorphic genes on autoimmune diseases (AIDs) such as systemic lupus erythematosus and Sjögren’s syndrome (SS) are also discussed. © 2018, Taylor and Francis Ltd. All rights reserved.application/pdfhttps://doi.org/10.1080/089169306009115198916934https://repository.urosario.edu.co/handle/10336/23411engTaylor and Francis Ltd94No. 283AutoimmunityVol. 40Autoimmunity, ISSN:8916934, Vol.40, No.2 (2007); pp. 83-94https://www.scopus.com/inward/record.uri?eid=2-s2.0-34250327154&doi=10.1080%2f08916930600911519&partnerID=40&md5=928e702e3ce0ddfb47455eefa3c68287Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURIntegrinLamininLamininArticleAutoimmune diseaseCentral nervous systemEmbryo developmentExtracellular matrixGene structureGenetic polymorphismGenetic regulationHemidesmosomeHumanKidneyNeuromuscular systemNidationNonhumanPlacenta developmentPreimplantation embryoPromoter regionProtein analysisProtein domainProtein structureSjoegren syndromeSkinSystemic lupus erythematosusTissue distributionAntibody specificityAutoimmune diseaseBasement membraneChemistryGeneticsMetabolismPhysiologyProtein conformationProtein tertiary structureReviewSjoegren larsson syndromeAutoimmune diseasesBasement membraneHumansLamininOrgan specificityProtein conformationSjogren-larsson syndromeBasal laminaExtracellular matrixLamininSjögren’s syndromeSystemic lupus erythematosustertiarygeneticsystemicLupus erythematosusPolymorphismProtein structurePhysiological and pathological implications of laminins: From the gene to the proteinarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Páez M.-C.González M.-J.Serrano N.C.Shoenfeld Y.Anaya, Juan-Manuel10336/23411oai:repository.urosario.edu.co:10336/234112022-05-02 07:37:13.261069https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Physiological and pathological implications of laminins: From the gene to the protein
title Physiological and pathological implications of laminins: From the gene to the protein
spellingShingle Physiological and pathological implications of laminins: From the gene to the protein
Integrin
Laminin
Laminin
Article
Autoimmune disease
Central nervous system
Embryo development
Extracellular matrix
Gene structure
Genetic polymorphism
Genetic regulation
Hemidesmosome
Human
Kidney
Neuromuscular system
Nidation
Nonhuman
Placenta development
Preimplantation embryo
Promoter region
Protein analysis
Protein domain
Protein structure
Sjoegren syndrome
Skin
Systemic lupus erythematosus
Tissue distribution
Antibody specificity
Autoimmune disease
Basement membrane
Chemistry
Genetics
Metabolism
Physiology
Protein conformation
Protein tertiary structure
Review
Sjoegren larsson syndrome
Autoimmune diseases
Basement membrane
Humans
Laminin
Organ specificity
Protein conformation
Sjogren-larsson syndrome
Basal lamina
Extracellular matrix
Laminin
Sjögren’s syndrome
Systemic lupus erythematosus
tertiary
genetic
systemic
Lupus erythematosus
Polymorphism
Protein structure
title_short Physiological and pathological implications of laminins: From the gene to the protein
title_full Physiological and pathological implications of laminins: From the gene to the protein
title_fullStr Physiological and pathological implications of laminins: From the gene to the protein
title_full_unstemmed Physiological and pathological implications of laminins: From the gene to the protein
title_sort Physiological and pathological implications of laminins: From the gene to the protein
dc.subject.keyword.spa.fl_str_mv Integrin
Laminin
Laminin
Article
Autoimmune disease
Central nervous system
Embryo development
Extracellular matrix
Gene structure
Genetic polymorphism
Genetic regulation
Hemidesmosome
Human
Kidney
Neuromuscular system
Nidation
Nonhuman
Placenta development
Preimplantation embryo
Promoter region
Protein analysis
Protein domain
Protein structure
Sjoegren syndrome
Skin
Systemic lupus erythematosus
Tissue distribution
Antibody specificity
Autoimmune disease
Basement membrane
Chemistry
Genetics
Metabolism
Physiology
Protein conformation
Protein tertiary structure
Review
Sjoegren larsson syndrome
Autoimmune diseases
Basement membrane
Humans
Laminin
Organ specificity
Protein conformation
Sjogren-larsson syndrome
Basal lamina
Extracellular matrix
Laminin
Sjögren’s syndrome
Systemic lupus erythematosus
topic Integrin
Laminin
Laminin
Article
Autoimmune disease
Central nervous system
Embryo development
Extracellular matrix
Gene structure
Genetic polymorphism
Genetic regulation
Hemidesmosome
Human
Kidney
Neuromuscular system
Nidation
Nonhuman
Placenta development
Preimplantation embryo
Promoter region
Protein analysis
Protein domain
Protein structure
Sjoegren syndrome
Skin
Systemic lupus erythematosus
Tissue distribution
Antibody specificity
Autoimmune disease
Basement membrane
Chemistry
Genetics
Metabolism
Physiology
Protein conformation
Protein tertiary structure
Review
Sjoegren larsson syndrome
Autoimmune diseases
Basement membrane
Humans
Laminin
Organ specificity
Protein conformation
Sjogren-larsson syndrome
Basal lamina
Extracellular matrix
Laminin
Sjögren’s syndrome
Systemic lupus erythematosus
tertiary
genetic
systemic
Lupus erythematosus
Polymorphism
Protein structure
dc.subject.keyword.eng.fl_str_mv tertiary
genetic
systemic
Lupus erythematosus
Polymorphism
Protein structure
description The extracellular matrix plays an important role in modulating the behavior of cells with which it interacts. There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). LM are the major component of the basal lamina (BL). Here, we review the current knowledge on their structure, self-assembly, binding mechanisms, diverse tissue-expression patterns and its impact on pathology. Studies and hypothesis exploring the role of LM and their polymorphic genes on autoimmune diseases (AIDs) such as systemic lupus erythematosus and Sjögren’s syndrome (SS) are also discussed. © 2018, Taylor and Francis Ltd. All rights reserved.
publishDate 2007
dc.date.created.spa.fl_str_mv 2007
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:01:49Z
dc.date.available.none.fl_str_mv 2020-05-26T00:01:49Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1080/08916930600911519
dc.identifier.issn.none.fl_str_mv 8916934
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/23411
url https://doi.org/10.1080/08916930600911519
https://repository.urosario.edu.co/handle/10336/23411
identifier_str_mv 8916934
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 94
dc.relation.citationIssue.none.fl_str_mv No. 2
dc.relation.citationStartPage.none.fl_str_mv 83
dc.relation.citationTitle.none.fl_str_mv Autoimmunity
dc.relation.citationVolume.none.fl_str_mv Vol. 40
dc.relation.ispartof.spa.fl_str_mv Autoimmunity, ISSN:8916934, Vol.40, No.2 (2007); pp. 83-94
dc.relation.uri.spa.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-34250327154&doi=10.1080%2f08916930600911519&partnerID=40&md5=928e702e3ce0ddfb47455eefa3c68287
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Taylor and Francis Ltd
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
_version_ 1814167723137040384

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