Physiological and pathological implications of laminins: From the gene to the protein

The extracellular matrix plays an important role in modulating the behavior of cells with which it interacts. There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). LM are the major component of the basal lamina (BL). Here, we revi...

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Autores:
Tipo de recurso:
Fecha de publicación:
2007
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23411
Acceso en línea:
https://doi.org/10.1080/08916930600911519
https://repository.urosario.edu.co/handle/10336/23411
Palabra clave:
Integrin
Laminin
Laminin
Article
Autoimmune disease
Central nervous system
Embryo development
Extracellular matrix
Gene structure
Genetic polymorphism
Genetic regulation
Hemidesmosome
Human
Kidney
Neuromuscular system
Nidation
Nonhuman
Placenta development
Preimplantation embryo
Promoter region
Protein analysis
Protein domain
Protein structure
Sjoegren syndrome
Skin
Systemic lupus erythematosus
Tissue distribution
Antibody specificity
Autoimmune disease
Basement membrane
Chemistry
Genetics
Metabolism
Physiology
Protein conformation
Protein tertiary structure
Review
Sjoegren larsson syndrome
Autoimmune diseases
Basement membrane
Humans
Laminin
Organ specificity
Protein conformation
Sjogren-larsson syndrome
Basal lamina
Extracellular matrix
Laminin
Sjögren’s syndrome
Systemic lupus erythematosus
tertiary
genetic
systemic
Lupus erythematosus
Polymorphism
Protein structure
Rights
License
Abierto (Texto Completo)
Description
Summary:The extracellular matrix plays an important role in modulating the behavior of cells with which it interacts. There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). LM are the major component of the basal lamina (BL). Here, we review the current knowledge on their structure, self-assembly, binding mechanisms, diverse tissue-expression patterns and its impact on pathology. Studies and hypothesis exploring the role of LM and their polymorphic genes on autoimmune diseases (AIDs) such as systemic lupus erythematosus and Sjögren’s syndrome (SS) are also discussed. © 2018, Taylor and Francis Ltd. All rights reserved.