Physiological and pathological implications of laminins: From the gene to the protein

The extracellular matrix plays an important role in modulating the behavior of cells with which it interacts. There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). LM are the major component of the basal lamina (BL). Here, we review the current knowledge on their structure, self-assembly, binding mechanisms, diverse tissue-expression patterns and its impact on pathology. Studies and hypothesis exploring the role of LM and their polymorphic genes on autoimmune diseases (AIDs) such as systemic lupus erythematosus and Sjögren’s syndrome (SS) are also discussed. © 2018, Taylor and Francis Ltd. All rights reserved.

• Fecha de publicación: 2007
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/23411
• Acceso en línea: https://doi.org/10.1080/08916930600911519; https://repository.urosario.edu.co/handle/10336/23411
• Palabra clave: Integrin; Laminin; Laminin; Article; Autoimmune disease; Central nervous system; Embryo development; Extracellular matrix; Gene structure; Genetic polymorphism; Genetic regulation; Hemidesmosome; Human; Kidney; Neuromuscular system; Nidation; Nonhuman; Placenta development; Preimplantation embryo; Promoter region; Protein analysis; Protein domain; Protein structure; Sjoegren syndrome; Skin; Systemic lupus erythematosus; Tissue distribution; Antibody specificity; Autoimmune disease; Basement membrane; Chemistry; Genetics; Metabolism; Physiology; Protein conformation; Protein tertiary structure; Review; Sjoegren larsson syndrome; Autoimmune diseases; Basement membrane; Humans; Laminin; Organ specificity; Protein conformation; Sjogren-larsson syndrome; Basal lamina; Extracellular matrix; Laminin; Sjögren’s syndrome; Systemic lupus erythematosus; tertiary; genetic; systemic; Lupus erythematosus; Polymorphism; Protein structure
• License: Abierto (Texto Completo)