Molecular mimicry and autoimmunity

Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents may induce autoimmunity. It occurs when similarities between foreign and self-peptides favor an activation of autoreactive T or B cells by a foreign-derived antigen in a susceptible individual. However, molecul...

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Autores:
Tipo de recurso:
Fecha de publicación:
2018
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/22261
Acceso en línea:
https://doi.org/10.1016/j.jaut.2018.10.012
https://repository.urosario.edu.co/handle/10336/22261
Palabra clave:
Vaccine
Autoantibody
Autoantigen
Bacterial antigen
Lymphocyte antigen receptor
Virus antigen
Autoimmune disease
Autoimmune hepatitis
Autoimmune liver disease
Autoimmune thyroiditis
Autoimmunity
Cross reaction
Guillain barre syndrome
Human
Insulin dependent diabetes mellitus
Molecular mimicry
Multiple sclerosis
Nonhuman
Primary biliary cirrhosis
Priority journal
Review
Rheumatoid arthritis
Sjoegren syndrome
Systemic lupus erythematosus
Systemic sclerosis
Animal
Autoimmune disease
B lymphocyte
Biosynthesis
Gene expression
Genetics
Immunology
Microbiology
Molecular mimicry
Mouse
T lymphocyte
Virology
Animals
Autoantibodies
Autoantigens
Autoimmune diseases
Autoimmunity
B-lymphocytes
Cross reactions
Gene expression
Humans
Mice
Molecular mimicry
T-lymphocytes
Autoimmune diseases
Autoimmunity
Cross reactions
Cross-reactivity
Molecular mimicry
viral
bacterial
antigen
t-cell
Antigens
Antigens
Receptors
Rights
License
Abierto (Texto Completo)
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network_acronym_str EDOCUR2
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repository_id_str
dc.title.spa.fl_str_mv Molecular mimicry and autoimmunity
title Molecular mimicry and autoimmunity
spellingShingle Molecular mimicry and autoimmunity
Vaccine
Autoantibody
Autoantigen
Bacterial antigen
Lymphocyte antigen receptor
Virus antigen
Autoimmune disease
Autoimmune hepatitis
Autoimmune liver disease
Autoimmune thyroiditis
Autoimmunity
Cross reaction
Guillain barre syndrome
Human
Insulin dependent diabetes mellitus
Molecular mimicry
Multiple sclerosis
Nonhuman
Primary biliary cirrhosis
Priority journal
Review
Rheumatoid arthritis
Sjoegren syndrome
Systemic lupus erythematosus
Systemic sclerosis
Animal
Autoimmune disease
B lymphocyte
Biosynthesis
Gene expression
Genetics
Immunology
Microbiology
Molecular mimicry
Mouse
T lymphocyte
Virology
Animals
Autoantibodies
Autoantigens
Autoimmune diseases
Autoimmunity
B-lymphocytes
Cross reactions
Gene expression
Humans
Mice
Molecular mimicry
T-lymphocytes
Autoimmune diseases
Autoimmunity
Cross reactions
Cross-reactivity
Molecular mimicry
viral
bacterial
antigen
t-cell
Antigens
Antigens
Receptors
title_short Molecular mimicry and autoimmunity
title_full Molecular mimicry and autoimmunity
title_fullStr Molecular mimicry and autoimmunity
title_full_unstemmed Molecular mimicry and autoimmunity
title_sort Molecular mimicry and autoimmunity
dc.subject.keyword.spa.fl_str_mv Vaccine
Autoantibody
Autoantigen
Bacterial antigen
Lymphocyte antigen receptor
Virus antigen
Autoimmune disease
Autoimmune hepatitis
Autoimmune liver disease
Autoimmune thyroiditis
Autoimmunity
Cross reaction
Guillain barre syndrome
Human
Insulin dependent diabetes mellitus
Molecular mimicry
Multiple sclerosis
Nonhuman
Primary biliary cirrhosis
Priority journal
Review
Rheumatoid arthritis
Sjoegren syndrome
Systemic lupus erythematosus
Systemic sclerosis
Animal
Autoimmune disease
B lymphocyte
Biosynthesis
Gene expression
Genetics
Immunology
Microbiology
Molecular mimicry
Mouse
T lymphocyte
Virology
Animals
Autoantibodies
Autoantigens
Autoimmune diseases
Autoimmunity
B-lymphocytes
Cross reactions
Gene expression
Humans
Mice
Molecular mimicry
T-lymphocytes
Autoimmune diseases
Autoimmunity
Cross reactions
Cross-reactivity
Molecular mimicry
topic Vaccine
Autoantibody
Autoantigen
Bacterial antigen
Lymphocyte antigen receptor
Virus antigen
Autoimmune disease
Autoimmune hepatitis
Autoimmune liver disease
Autoimmune thyroiditis
Autoimmunity
Cross reaction
Guillain barre syndrome
Human
Insulin dependent diabetes mellitus
Molecular mimicry
Multiple sclerosis
Nonhuman
Primary biliary cirrhosis
Priority journal
Review
Rheumatoid arthritis
Sjoegren syndrome
Systemic lupus erythematosus
Systemic sclerosis
Animal
Autoimmune disease
B lymphocyte
Biosynthesis
Gene expression
Genetics
Immunology
Microbiology
Molecular mimicry
Mouse
T lymphocyte
Virology
Animals
Autoantibodies
Autoantigens
Autoimmune diseases
Autoimmunity
B-lymphocytes
Cross reactions
Gene expression
Humans
Mice
Molecular mimicry
T-lymphocytes
Autoimmune diseases
Autoimmunity
Cross reactions
Cross-reactivity
Molecular mimicry
viral
bacterial
antigen
t-cell
Antigens
Antigens
Receptors
dc.subject.keyword.eng.fl_str_mv viral
bacterial
antigen
t-cell
Antigens
Antigens
Receptors
description Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents may induce autoimmunity. It occurs when similarities between foreign and self-peptides favor an activation of autoreactive T or B cells by a foreign-derived antigen in a susceptible individual. However, molecular mimicry is unlikely to be the only underlying mechanism for autoimmune responses; other factors such as breach in central tolerance, non-specific bystander activation, or persistent antigenic stimuli (amongst others) may also contribute to the development of autoimmune diseases. Host genetics, exposure to microbiota and environmental chemicals are additional links to our understanding of molecular mimicry. Our current knowledge of the detailed mechanisms of molecular mimicry is limited by the issues of prolonged periods of latency before the appearance of disease, the lack of enough statistical power in epidemiological studies, the limitations of the potential role of genetics in human studies, the relevance of inbred murine models to the diverse human population and especially the limited technology to systematically dissect the human T-cell repertoire and B-cell responses. Nevertheless, studies on the role of autoreactive T-cells that are generated secondary to molecular mimicry, the diversity of the T-cell receptor repertoires of auto-reactive T-cells, the role of exposure to cryptic antigens, the generation of autoimmune B-cell responses, the interaction of microbiota and chemical adjuvants with the host immune systems all provide clues in advancing our understanding of the molecular mechanisms involved in the evolving concept of molecular mimicry and also may potentially aid in the prevention and treatment of autoimmune diseases. © 2018 The Authors
publishDate 2018
dc.date.created.spa.fl_str_mv 2018
dc.date.accessioned.none.fl_str_mv 2020-05-25T23:55:55Z
dc.date.available.none.fl_str_mv 2020-05-25T23:55:55Z
dc.type.eng.fl_str_mv article
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dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.jaut.2018.10.012
dc.identifier.issn.none.fl_str_mv 10959157
08968411
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/22261
url https://doi.org/10.1016/j.jaut.2018.10.012
https://repository.urosario.edu.co/handle/10336/22261
identifier_str_mv 10959157
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dc.relation.citationEndPage.none.fl_str_mv 123
dc.relation.citationStartPage.none.fl_str_mv 100
dc.relation.citationTitle.none.fl_str_mv Journal of Autoimmunity
dc.relation.citationVolume.none.fl_str_mv Vol. 95
dc.relation.ispartof.spa.fl_str_mv Journal of Autoimmunity, ISSN:10959157, 08968411, Vol.95,(2018); pp. 100-123
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dc.publisher.spa.fl_str_mv Academic Press
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spelling 11105414856008931e5b7-37b5-450e-b9d1-165c2a550b505316728860038361933600524835266003e5fce36-4cb7-4f3d-802e-33ad3ba5bf7bedd94305-d53c-4840-83f6-ba65ce0528da1327ecd3-59bb-4cf6-adf3-b209067af16219474778600351984836002020-05-25T23:55:55Z2020-05-25T23:55:55Z2018Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents may induce autoimmunity. It occurs when similarities between foreign and self-peptides favor an activation of autoreactive T or B cells by a foreign-derived antigen in a susceptible individual. However, molecular mimicry is unlikely to be the only underlying mechanism for autoimmune responses; other factors such as breach in central tolerance, non-specific bystander activation, or persistent antigenic stimuli (amongst others) may also contribute to the development of autoimmune diseases. Host genetics, exposure to microbiota and environmental chemicals are additional links to our understanding of molecular mimicry. Our current knowledge of the detailed mechanisms of molecular mimicry is limited by the issues of prolonged periods of latency before the appearance of disease, the lack of enough statistical power in epidemiological studies, the limitations of the potential role of genetics in human studies, the relevance of inbred murine models to the diverse human population and especially the limited technology to systematically dissect the human T-cell repertoire and B-cell responses. Nevertheless, studies on the role of autoreactive T-cells that are generated secondary to molecular mimicry, the diversity of the T-cell receptor repertoires of auto-reactive T-cells, the role of exposure to cryptic antigens, the generation of autoimmune B-cell responses, the interaction of microbiota and chemical adjuvants with the host immune systems all provide clues in advancing our understanding of the molecular mechanisms involved in the evolving concept of molecular mimicry and also may potentially aid in the prevention and treatment of autoimmune diseases. © 2018 The Authorsapplication/pdfhttps://doi.org/10.1016/j.jaut.2018.10.0121095915708968411https://repository.urosario.edu.co/handle/10336/22261engAcademic Press123100Journal of AutoimmunityVol. 95Journal of Autoimmunity, ISSN:10959157, 08968411, Vol.95,(2018); pp. 100-123https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059332875&doi=10.1016%2fj.jaut.2018.10.012&partnerID=40&md5=e8d56134df82078aa74f1a54eb59dbeaAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURVaccineAutoantibodyAutoantigenBacterial antigenLymphocyte antigen receptorVirus antigenAutoimmune diseaseAutoimmune hepatitisAutoimmune liver diseaseAutoimmune thyroiditisAutoimmunityCross reactionGuillain barre syndromeHumanInsulin dependent diabetes mellitusMolecular mimicryMultiple sclerosisNonhumanPrimary biliary cirrhosisPriority journalReviewRheumatoid arthritisSjoegren syndromeSystemic lupus erythematosusSystemic sclerosisAnimalAutoimmune diseaseB lymphocyteBiosynthesisGene expressionGeneticsImmunologyMicrobiologyMolecular mimicryMouseT lymphocyteVirologyAnimalsAutoantibodiesAutoantigensAutoimmune diseasesAutoimmunityB-lymphocytesCross reactionsGene expressionHumansMiceMolecular mimicryT-lymphocytesAutoimmune diseasesAutoimmunityCross reactionsCross-reactivityMolecular mimicryviralbacterialantigent-cellAntigensAntigensReceptorsMolecular mimicry and autoimmunityarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Rojas Quintana, Manuel EduardoRestrepo-Jiménez, PaulaMonsalve Carmona, Diana MarcelaAcosta Ampudia, Yeny YasbleidyRamírez Santana, Heily CarolinaLeung, Patrick S.C.Ansari, Aftab A.Gershwin, M. EricAnaya, Juan-ManuelPacheco Nieva, YovanaORIGINAL1-s2-0-S0896841118305365-main.pdfapplication/pdf2232339https://repository.urosario.edu.co/bitstreams/7079b676-2c2f-4c3f-8400-a40d2721deff/download95ce37b219cf16ccf9a17ca27d917c90MD51TEXT1-s2-0-S0896841118305365-main.pdf.txt1-s2-0-S0896841118305365-main.pdf.txtExtracted texttext/plain207526https://repository.urosario.edu.co/bitstreams/7895852c-3669-4d92-8d9c-0a5e31e07dfa/download7f5dbfe8cfd89889041202d00e96ee1dMD52THUMBNAIL1-s2-0-S0896841118305365-main.pdf.jpg1-s2-0-S0896841118305365-main.pdf.jpgGenerated Thumbnailimage/jpeg4464https://repository.urosario.edu.co/bitstreams/52f894fb-38cb-4b9e-8d92-60a6edab9be3/downloadc7d32de6b5d4e2eac787a0af220c8816MD5310336/22261oai:repository.urosario.edu.co:10336/222612022-05-02 07:37:16.644265https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co