Molecular mimicry and autoimmunity

Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents may induce autoimmunity. It occurs when similarities between foreign and self-peptides favor an activation of autoreactive T or B cells by a foreign-derived antigen in a susceptible individual. However, molecul...

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Autores:
Tipo de recurso:
Fecha de publicación:
2018
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/28418
Acceso en línea:
https://doi.org/10.1016/j.jaut.2018.10.012
https://repository.urosario.edu.co/handle/10336/28418
Palabra clave:
Autoimmune diseases
Autoimmunity
Molecular mimicry
Cross-reactivity
Cross reactions
Rights
License
Abierto (Texto Completo)
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network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 1947477860035198483600531672886001a7e928c-665d-44c9-9159-06b61ac7b1d71110541485600524835266002020-08-28T15:48:09Z2020-08-28T15:48:09Z2018Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents may induce autoimmunity. It occurs when similarities between foreign and self-peptides favor an activation of autoreactive T or B cells by a foreign-derived antigen in a susceptible individual. However, molecular mimicry is unlikely to be the only underlying mechanism for autoimmune responses; other factors such as breach in central tolerance, non-specific bystander activation, or persistent antigenic stimuli (amongst others) may also contribute to the development of autoimmune diseases. Host genetics, exposure to microbiota and environmental chemicals are additional links to our understanding of molecular mimicry. Our current knowledge of the detailed mechanisms of molecular mimicry is limited by the issues of prolonged periods of latency before the appearance of disease, the lack of enough statistical power in epidemiological studies, the limitations of the potential role of genetics in human studies, the relevance of inbred murine models to the diverse human population and especially the limited technology to systematically dissect the human T-cell repertoire and B-cell responses. Nevertheless, studies on the role of autoreactive T-cells that are generated secondary to molecular mimicry, the diversity of the T-cell receptor repertoires of auto-reactive T-cells, the role of exposure to cryptic antigens, the generation of autoimmune B-cell responses, the interaction of microbiota and chemical adjuvants with the host immune systems all provide clues in advancing our understanding of the molecular mechanisms involved in the evolving concept of molecular mimicry and also may potentially aid in the prevention and treatment of autoimmune diseases.application/pdfhttps://doi.org/10.1016/j.jaut.2018.10.012ISSN:0896-8411EISSN: 1095-9157https://repository.urosario.edu.co/handle/10336/28418engElsevier123100Journal of AutoimmunityVol. 95Journal of Autoimmunity, ISSN:0896-8411; EISSN: 1095-9157,Vol. 95 (December 2018); pp. 100-123https://www.sciencedirect.com/science/article/pii/S0896841118305365Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Journal of Autoimmunityinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURAutoimmune diseasesAutoimmunityMolecular mimicryCross-reactivityCross reactionsMolecular mimicry and autoimmunityMimetismo molecular y autoinmunidadarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Anaya, Juan-ManuelPacheco Nieva, YovanaMonsalve Carmona, Diana MarcelaRestrepo Jimenez, PaulaRojas Quintana, Manuel EduardoRamírez Santana, Heily Carolina10336/28418oai:repository.urosario.edu.co:10336/284182021-10-06 16:47:32.587https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Molecular mimicry and autoimmunity
dc.title.TranslatedTitle.spa.fl_str_mv Mimetismo molecular y autoinmunidad
title Molecular mimicry and autoimmunity
spellingShingle Molecular mimicry and autoimmunity
Autoimmune diseases
Autoimmunity
Molecular mimicry
Cross-reactivity
Cross reactions
title_short Molecular mimicry and autoimmunity
title_full Molecular mimicry and autoimmunity
title_fullStr Molecular mimicry and autoimmunity
title_full_unstemmed Molecular mimicry and autoimmunity
title_sort Molecular mimicry and autoimmunity
dc.subject.keyword.spa.fl_str_mv Autoimmune diseases
Autoimmunity
Molecular mimicry
Cross-reactivity
Cross reactions
topic Autoimmune diseases
Autoimmunity
Molecular mimicry
Cross-reactivity
Cross reactions
description Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents may induce autoimmunity. It occurs when similarities between foreign and self-peptides favor an activation of autoreactive T or B cells by a foreign-derived antigen in a susceptible individual. However, molecular mimicry is unlikely to be the only underlying mechanism for autoimmune responses; other factors such as breach in central tolerance, non-specific bystander activation, or persistent antigenic stimuli (amongst others) may also contribute to the development of autoimmune diseases. Host genetics, exposure to microbiota and environmental chemicals are additional links to our understanding of molecular mimicry. Our current knowledge of the detailed mechanisms of molecular mimicry is limited by the issues of prolonged periods of latency before the appearance of disease, the lack of enough statistical power in epidemiological studies, the limitations of the potential role of genetics in human studies, the relevance of inbred murine models to the diverse human population and especially the limited technology to systematically dissect the human T-cell repertoire and B-cell responses. Nevertheless, studies on the role of autoreactive T-cells that are generated secondary to molecular mimicry, the diversity of the T-cell receptor repertoires of auto-reactive T-cells, the role of exposure to cryptic antigens, the generation of autoimmune B-cell responses, the interaction of microbiota and chemical adjuvants with the host immune systems all provide clues in advancing our understanding of the molecular mechanisms involved in the evolving concept of molecular mimicry and also may potentially aid in the prevention and treatment of autoimmune diseases.
publishDate 2018
dc.date.created.spa.fl_str_mv 2018
dc.date.accessioned.none.fl_str_mv 2020-08-28T15:48:09Z
dc.date.available.none.fl_str_mv 2020-08-28T15:48:09Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.jaut.2018.10.012
dc.identifier.issn.none.fl_str_mv ISSN:0896-8411
EISSN: 1095-9157
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/28418
url https://doi.org/10.1016/j.jaut.2018.10.012
https://repository.urosario.edu.co/handle/10336/28418
identifier_str_mv ISSN:0896-8411
EISSN: 1095-9157
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 123
dc.relation.citationStartPage.none.fl_str_mv 100
dc.relation.citationTitle.none.fl_str_mv Journal of Autoimmunity
dc.relation.citationVolume.none.fl_str_mv Vol. 95
dc.relation.ispartof.spa.fl_str_mv Journal of Autoimmunity, ISSN:0896-8411; EISSN: 1095-9157,Vol. 95 (December 2018); pp. 100-123
dc.relation.uri.spa.fl_str_mv https://www.sciencedirect.com/science/article/pii/S0896841118305365
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Elsevier
dc.source.spa.fl_str_mv Journal of Autoimmunity
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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