Far from the madding crowd: The molecular basis for immunological escape of plasmodium falciparum

Like Thomas Hardy’s famous novel Far from the Madding Crowd, Plasmodium falciparum parasites display their most relevant survival structures (proteins) involved in host cell invasion far away from the immune system’s susceptible regions, displaying tremendous genetic variability, to attract the immu...

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Autores:
Tipo de recurso:
Fecha de publicación:
2017
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23813
Acceso en línea:
https://doi.org/10.21775/cimb.022.065
https://repository.urosario.edu.co/handle/10336/23813
Palabra clave:
Immune response
Nonhuman
Plasmodium falciparum
Animal
Host parasite interaction
Immunology
Malaria falciparum
Plasmodium falciparum
Parasite antigen
Animals
Host-parasite interactions
Plasmodium falciparum
protozoan
falciparum
Antigens
Malaria
Rights
License
Abierto (Texto Completo)
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oai_identifier_str oai:repository.urosario.edu.co:10336/23813
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 76e03223-040d-4e46-864f-3bdecc8d2790-1c097ad50-1f6e-4d04-9a55-38876ffe0ea9-1e77c244a-2cd7-4aca-bd38-0a2a5524f917-13ec909b1-d14b-4a5a-bbc4-61bd89d7ff48-1d9612453-6d92-4c77-a1ab-cfb2f68f98d5-19fc64f6d-a903-48f1-ac2e-4e55fd2ed9af-12020-05-26T00:05:39Z2020-05-26T00:05:39Z2017Like Thomas Hardy’s famous novel Far from the Madding Crowd, Plasmodium falciparum parasites display their most relevant survival structures (proteins) involved in host cell invasion far away from the immune system’s susceptible regions, displaying tremendous genetic variability, to attract the immune response and escape immune pressure. The 3D structure localisation of the conserved amino acid sequences of this deadly parasite’s most relevant proteins involved in host cell invasion, as well as the location of the highly polymorphic, highly immunogenic regions, clearly demonstrates that such structures are far apart, sometimes 90° to 180° opposite, thereby rendering the immune response useless. It is also shown here that these conserved, functionally-relevant structures are immunologically silent, since no immune response has been induced. © 2017, Caister Academic Press. All rights reserved.application/pdfhttps://doi.org/10.21775/cimb.022.0651467303714673045https://repository.urosario.edu.co/handle/10336/23813engCaister Academic Press7865Current Issues in Molecular BiologyVol. 22Current Issues in Molecular Biology, ISSN:14673037, 14673045, Vol.22,(2017); pp. 65-78https://www.scopus.com/inward/record.uri?eid=2-s2.0-85010930947&doi=10.21775%2fcimb.022.065&partnerID=40&md5=25b87c7556274d999e66ca1804e6da9bAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURImmune responseNonhumanPlasmodium falciparumAnimalHost parasite interactionImmunologyMalaria falciparumPlasmodium falciparumParasite antigenAnimalsHost-parasite interactionsPlasmodium falciparumprotozoanfalciparumAntigensMalariaFar from the madding crowd: The molecular basis for immunological escape of plasmodium falciparumarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Patarroyo M.E.Aza-Conde J.Moreno-Vranich A.Pabón L.Varela Y.Patarroyo M.A.10336/23813oai:repository.urosario.edu.co:10336/238132022-05-02 07:37:21.219032https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Far from the madding crowd: The molecular basis for immunological escape of plasmodium falciparum
title Far from the madding crowd: The molecular basis for immunological escape of plasmodium falciparum
spellingShingle Far from the madding crowd: The molecular basis for immunological escape of plasmodium falciparum
Immune response
Nonhuman
Plasmodium falciparum
Animal
Host parasite interaction
Immunology
Malaria falciparum
Plasmodium falciparum
Parasite antigen
Animals
Host-parasite interactions
Plasmodium falciparum
protozoan
falciparum
Antigens
Malaria
title_short Far from the madding crowd: The molecular basis for immunological escape of plasmodium falciparum
title_full Far from the madding crowd: The molecular basis for immunological escape of plasmodium falciparum
title_fullStr Far from the madding crowd: The molecular basis for immunological escape of plasmodium falciparum
title_full_unstemmed Far from the madding crowd: The molecular basis for immunological escape of plasmodium falciparum
title_sort Far from the madding crowd: The molecular basis for immunological escape of plasmodium falciparum
dc.subject.keyword.spa.fl_str_mv Immune response
Nonhuman
Plasmodium falciparum
Animal
Host parasite interaction
Immunology
Malaria falciparum
Plasmodium falciparum
Parasite antigen
Animals
Host-parasite interactions
Plasmodium falciparum
topic Immune response
Nonhuman
Plasmodium falciparum
Animal
Host parasite interaction
Immunology
Malaria falciparum
Plasmodium falciparum
Parasite antigen
Animals
Host-parasite interactions
Plasmodium falciparum
protozoan
falciparum
Antigens
Malaria
dc.subject.keyword.eng.fl_str_mv protozoan
falciparum
Antigens
Malaria
description Like Thomas Hardy’s famous novel Far from the Madding Crowd, Plasmodium falciparum parasites display their most relevant survival structures (proteins) involved in host cell invasion far away from the immune system’s susceptible regions, displaying tremendous genetic variability, to attract the immune response and escape immune pressure. The 3D structure localisation of the conserved amino acid sequences of this deadly parasite’s most relevant proteins involved in host cell invasion, as well as the location of the highly polymorphic, highly immunogenic regions, clearly demonstrates that such structures are far apart, sometimes 90° to 180° opposite, thereby rendering the immune response useless. It is also shown here that these conserved, functionally-relevant structures are immunologically silent, since no immune response has been induced. © 2017, Caister Academic Press. All rights reserved.
publishDate 2017
dc.date.created.spa.fl_str_mv 2017
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:05:39Z
dc.date.available.none.fl_str_mv 2020-05-26T00:05:39Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.21775/cimb.022.065
dc.identifier.issn.none.fl_str_mv 14673037
14673045
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/23813
url https://doi.org/10.21775/cimb.022.065
https://repository.urosario.edu.co/handle/10336/23813
identifier_str_mv 14673037
14673045
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 78
dc.relation.citationStartPage.none.fl_str_mv 65
dc.relation.citationTitle.none.fl_str_mv Current Issues in Molecular Biology
dc.relation.citationVolume.none.fl_str_mv Vol. 22
dc.relation.ispartof.spa.fl_str_mv Current Issues in Molecular Biology, ISSN:14673037, 14673045, Vol.22,(2017); pp. 65-78
dc.relation.uri.spa.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-85010930947&doi=10.21775%2fcimb.022.065&partnerID=40&md5=25b87c7556274d999e66ca1804e6da9b
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Caister Academic Press
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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