The T-cell receptor in primates: Identifying and sequencing new owl monkey TRBV gene sub-groups
The New World primate Aotus nancymaae (owl monkey) has been shown to be an excellent experimental model when studying malarial parasites. Characterising the T-cell receptor (TR) ?? repertoire by means of the different variable beta (TRBV) genes displayed contributes to a better understanding of thes...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2005
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/26291
- Acceso en línea:
- https://doi.org/10.1007/s00251-004-0758-y
https://repository.urosario.edu.co/handle/10336/26291
- Palabra clave:
- Aotus
T-cell receptor beta variable
New World monkeys
Animal model
Primates
- Rights
- License
- Restringido (Acceso a grupos específicos)
id |
EDOCUR2_77803476582402695d5f67b740a598d4 |
---|---|
oai_identifier_str |
oai:repository.urosario.edu.co:10336/26291 |
network_acronym_str |
EDOCUR2 |
network_name_str |
Repositorio EdocUR - U. Rosario |
repository_id_str |
|
spelling |
3fc7749f-5240-488a-b741-c7513e874863-1ecc2fd1e-5110-444c-a652-7006ce7b96c9-1ff3eeca1-3629-40c1-bfcf-0ab4ff8aece0-18fae7db6-7b9b-4538-b476-6f5ae5a41e7a-110ecd4f9-843f-4ef2-bec0-7d39d3381a13-179653065-12020-08-06T16:21:13Z2020-08-06T16:21:13Z2005-02-12The New World primate Aotus nancymaae (owl monkey) has been shown to be an excellent experimental model when studying malarial parasites. Characterising the T-cell receptor (TR) ?? repertoire by means of the different variable beta (TRBV) genes displayed contributes to a better understanding of these lymphocytes’ role in the response against several malarial antigens. This study describes identifying and characterising eleven new TRBV gene sub-groups in cDNA from Aotus nancymaae’s peripheral blood lymphocytes; these 11 gene sequences displayed homology to the previously reported human TRBV3, TRBV10, TRBV11, TRBV14, TRBV18, TRBV19, TRBV20, TRBV25, TRBV27, TRBV29 and TRBV30 sub-groups, resulting in 83% overall homology at the amino acid level. An additional Aotus sequence was found having similarity with the human TRBJ-2–7*01 gene. Evolutionary relationships amongst these sequences and the homologous genes from both New and Old World primates have shown that the TRBV repertoire has been maintained in the species being studied, displaying varying association patterns and substitution rates, depending on the sub-group being studied. The degree of identity observed when comparing human and Aotus genes suggests that these species might have a similar TRBV repertoire.application/pdfhttps://doi.org/10.1007/s00251-004-0758-yISSN: 0093-7711EISSN: 1432-1211https://repository.urosario.edu.co/handle/10336/26291engSpringer Nature5242ImmunogeneticsVol. 57Immunogenetics, ISSN:0093-7711;EISSN:1432-1211, Vol.57, (February, 2005); pp.42-52https://link.springer.com/article/10.1007/s00251-004-0758-yRestringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecImmunogeneticsinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURAotusT-cell receptor beta variableNew World monkeysAnimal modelPrimatesThe T-cell receptor in primates: Identifying and sequencing new owl monkey TRBV gene sub-groupsEl receptor de células T en primates: identificación y secuenciación de nuevos subgrupos de genes TRBV de mono búhoarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Moncada, Camilo A.Guerrero, EduarCardenas, PaulaSuarez, Carlos F.Patarroyo, Manuel E.Patarroyo, Manuel A.10336/26291oai:repository.urosario.edu.co:10336/262912022-05-02 07:37:21.816267https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
The T-cell receptor in primates: Identifying and sequencing new owl monkey TRBV gene sub-groups |
dc.title.TranslatedTitle.spa.fl_str_mv |
El receptor de células T en primates: identificación y secuenciación de nuevos subgrupos de genes TRBV de mono búho |
title |
The T-cell receptor in primates: Identifying and sequencing new owl monkey TRBV gene sub-groups |
spellingShingle |
The T-cell receptor in primates: Identifying and sequencing new owl monkey TRBV gene sub-groups Aotus T-cell receptor beta variable New World monkeys Animal model Primates |
title_short |
The T-cell receptor in primates: Identifying and sequencing new owl monkey TRBV gene sub-groups |
title_full |
The T-cell receptor in primates: Identifying and sequencing new owl monkey TRBV gene sub-groups |
title_fullStr |
The T-cell receptor in primates: Identifying and sequencing new owl monkey TRBV gene sub-groups |
title_full_unstemmed |
The T-cell receptor in primates: Identifying and sequencing new owl monkey TRBV gene sub-groups |
title_sort |
The T-cell receptor in primates: Identifying and sequencing new owl monkey TRBV gene sub-groups |
dc.subject.keyword.spa.fl_str_mv |
Aotus T-cell receptor beta variable New World monkeys Animal model Primates |
topic |
Aotus T-cell receptor beta variable New World monkeys Animal model Primates |
description |
The New World primate Aotus nancymaae (owl monkey) has been shown to be an excellent experimental model when studying malarial parasites. Characterising the T-cell receptor (TR) ?? repertoire by means of the different variable beta (TRBV) genes displayed contributes to a better understanding of these lymphocytes’ role in the response against several malarial antigens. This study describes identifying and characterising eleven new TRBV gene sub-groups in cDNA from Aotus nancymaae’s peripheral blood lymphocytes; these 11 gene sequences displayed homology to the previously reported human TRBV3, TRBV10, TRBV11, TRBV14, TRBV18, TRBV19, TRBV20, TRBV25, TRBV27, TRBV29 and TRBV30 sub-groups, resulting in 83% overall homology at the amino acid level. An additional Aotus sequence was found having similarity with the human TRBJ-2–7*01 gene. Evolutionary relationships amongst these sequences and the homologous genes from both New and Old World primates have shown that the TRBV repertoire has been maintained in the species being studied, displaying varying association patterns and substitution rates, depending on the sub-group being studied. The degree of identity observed when comparing human and Aotus genes suggests that these species might have a similar TRBV repertoire. |
publishDate |
2005 |
dc.date.created.spa.fl_str_mv |
2005-02-12 |
dc.date.accessioned.none.fl_str_mv |
2020-08-06T16:21:13Z |
dc.date.available.none.fl_str_mv |
2020-08-06T16:21:13Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1007/s00251-004-0758-y |
dc.identifier.issn.none.fl_str_mv |
ISSN: 0093-7711 EISSN: 1432-1211 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/26291 |
url |
https://doi.org/10.1007/s00251-004-0758-y https://repository.urosario.edu.co/handle/10336/26291 |
identifier_str_mv |
ISSN: 0093-7711 EISSN: 1432-1211 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
52 |
dc.relation.citationStartPage.none.fl_str_mv |
42 |
dc.relation.citationTitle.none.fl_str_mv |
Immunogenetics |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 57 |
dc.relation.ispartof.spa.fl_str_mv |
Immunogenetics, ISSN:0093-7711;EISSN:1432-1211, Vol.57, (February, 2005); pp.42-52 |
dc.relation.uri.spa.fl_str_mv |
https://link.springer.com/article/10.1007/s00251-004-0758-y |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_16ec |
dc.rights.acceso.spa.fl_str_mv |
Restringido (Acceso a grupos específicos) |
rights_invalid_str_mv |
Restringido (Acceso a grupos específicos) http://purl.org/coar/access_right/c_16ec |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Springer Nature |
dc.source.spa.fl_str_mv |
Immunogenetics |
institution |
Universidad del Rosario |
dc.source.instname.none.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.none.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167644994011136 |