The T-cell receptor in primates: Identifying and sequencing new owl monkey TRBV gene sub-groups

The New World primate Aotus nancymaae (owl monkey) has been shown to be an excellent experimental model when studying malarial parasites. Characterising the T-cell receptor (TR) ?? repertoire by means of the different variable beta (TRBV) genes displayed contributes to a better understanding of thes...

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Tipo de recurso:
Fecha de publicación:
2005
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/26291
Acceso en línea:
https://doi.org/10.1007/s00251-004-0758-y
https://repository.urosario.edu.co/handle/10336/26291
Palabra clave:
Aotus
T-cell receptor beta variable
New World monkeys
Animal model
Primates
Rights
License
Restringido (Acceso a grupos específicos)
id EDOCUR2_77803476582402695d5f67b740a598d4
oai_identifier_str oai:repository.urosario.edu.co:10336/26291
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 3fc7749f-5240-488a-b741-c7513e874863-1ecc2fd1e-5110-444c-a652-7006ce7b96c9-1ff3eeca1-3629-40c1-bfcf-0ab4ff8aece0-18fae7db6-7b9b-4538-b476-6f5ae5a41e7a-110ecd4f9-843f-4ef2-bec0-7d39d3381a13-179653065-12020-08-06T16:21:13Z2020-08-06T16:21:13Z2005-02-12The New World primate Aotus nancymaae (owl monkey) has been shown to be an excellent experimental model when studying malarial parasites. Characterising the T-cell receptor (TR) ?? repertoire by means of the different variable beta (TRBV) genes displayed contributes to a better understanding of these lymphocytes’ role in the response against several malarial antigens. This study describes identifying and characterising eleven new TRBV gene sub-groups in cDNA from Aotus nancymaae’s peripheral blood lymphocytes; these 11 gene sequences displayed homology to the previously reported human TRBV3, TRBV10, TRBV11, TRBV14, TRBV18, TRBV19, TRBV20, TRBV25, TRBV27, TRBV29 and TRBV30 sub-groups, resulting in 83% overall homology at the amino acid level. An additional Aotus sequence was found having similarity with the human TRBJ-2–7*01 gene. Evolutionary relationships amongst these sequences and the homologous genes from both New and Old World primates have shown that the TRBV repertoire has been maintained in the species being studied, displaying varying association patterns and substitution rates, depending on the sub-group being studied. The degree of identity observed when comparing human and Aotus genes suggests that these species might have a similar TRBV repertoire.application/pdfhttps://doi.org/10.1007/s00251-004-0758-yISSN: 0093-7711EISSN: 1432-1211https://repository.urosario.edu.co/handle/10336/26291engSpringer Nature5242ImmunogeneticsVol. 57Immunogenetics, ISSN:0093-7711;EISSN:1432-1211, Vol.57, (February, 2005); pp.42-52https://link.springer.com/article/10.1007/s00251-004-0758-yRestringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecImmunogeneticsinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURAotusT-cell receptor beta variableNew World monkeysAnimal modelPrimatesThe T-cell receptor in primates: Identifying and sequencing new owl monkey TRBV gene sub-groupsEl receptor de células T en primates: identificación y secuenciación de nuevos subgrupos de genes TRBV de mono búhoarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Moncada, Camilo A.Guerrero, EduarCardenas, PaulaSuarez, Carlos F.Patarroyo, Manuel E.Patarroyo, Manuel A.10336/26291oai:repository.urosario.edu.co:10336/262912022-05-02 07:37:21.816267https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv The T-cell receptor in primates: Identifying and sequencing new owl monkey TRBV gene sub-groups
dc.title.TranslatedTitle.spa.fl_str_mv El receptor de células T en primates: identificación y secuenciación de nuevos subgrupos de genes TRBV de mono búho
title The T-cell receptor in primates: Identifying and sequencing new owl monkey TRBV gene sub-groups
spellingShingle The T-cell receptor in primates: Identifying and sequencing new owl monkey TRBV gene sub-groups
Aotus
T-cell receptor beta variable
New World monkeys
Animal model
Primates
title_short The T-cell receptor in primates: Identifying and sequencing new owl monkey TRBV gene sub-groups
title_full The T-cell receptor in primates: Identifying and sequencing new owl monkey TRBV gene sub-groups
title_fullStr The T-cell receptor in primates: Identifying and sequencing new owl monkey TRBV gene sub-groups
title_full_unstemmed The T-cell receptor in primates: Identifying and sequencing new owl monkey TRBV gene sub-groups
title_sort The T-cell receptor in primates: Identifying and sequencing new owl monkey TRBV gene sub-groups
dc.subject.keyword.spa.fl_str_mv Aotus
T-cell receptor beta variable
New World monkeys
Animal model
Primates
topic Aotus
T-cell receptor beta variable
New World monkeys
Animal model
Primates
description The New World primate Aotus nancymaae (owl monkey) has been shown to be an excellent experimental model when studying malarial parasites. Characterising the T-cell receptor (TR) ?? repertoire by means of the different variable beta (TRBV) genes displayed contributes to a better understanding of these lymphocytes’ role in the response against several malarial antigens. This study describes identifying and characterising eleven new TRBV gene sub-groups in cDNA from Aotus nancymaae’s peripheral blood lymphocytes; these 11 gene sequences displayed homology to the previously reported human TRBV3, TRBV10, TRBV11, TRBV14, TRBV18, TRBV19, TRBV20, TRBV25, TRBV27, TRBV29 and TRBV30 sub-groups, resulting in 83% overall homology at the amino acid level. An additional Aotus sequence was found having similarity with the human TRBJ-2–7*01 gene. Evolutionary relationships amongst these sequences and the homologous genes from both New and Old World primates have shown that the TRBV repertoire has been maintained in the species being studied, displaying varying association patterns and substitution rates, depending on the sub-group being studied. The degree of identity observed when comparing human and Aotus genes suggests that these species might have a similar TRBV repertoire.
publishDate 2005
dc.date.created.spa.fl_str_mv 2005-02-12
dc.date.accessioned.none.fl_str_mv 2020-08-06T16:21:13Z
dc.date.available.none.fl_str_mv 2020-08-06T16:21:13Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1007/s00251-004-0758-y
dc.identifier.issn.none.fl_str_mv ISSN: 0093-7711
EISSN: 1432-1211
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/26291
url https://doi.org/10.1007/s00251-004-0758-y
https://repository.urosario.edu.co/handle/10336/26291
identifier_str_mv ISSN: 0093-7711
EISSN: 1432-1211
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 52
dc.relation.citationStartPage.none.fl_str_mv 42
dc.relation.citationTitle.none.fl_str_mv Immunogenetics
dc.relation.citationVolume.none.fl_str_mv Vol. 57
dc.relation.ispartof.spa.fl_str_mv Immunogenetics, ISSN:0093-7711;EISSN:1432-1211, Vol.57, (February, 2005); pp.42-52
dc.relation.uri.spa.fl_str_mv https://link.springer.com/article/10.1007/s00251-004-0758-y
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_16ec
dc.rights.acceso.spa.fl_str_mv Restringido (Acceso a grupos específicos)
rights_invalid_str_mv Restringido (Acceso a grupos específicos)
http://purl.org/coar/access_right/c_16ec
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Springer Nature
dc.source.spa.fl_str_mv Immunogenetics
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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