Cerebrovascular autoregulation in preterm fetal growth restricted neonates

Objective To investigate the effect of fetal growth restriction (FGR) on cerebrovascular autoregulation in preterm neonates during the first 3 days of life. Design Case-control study. Setting Neonatal intensive care unit of the Wilhelmina Children's Hospital, The Netherlands. Patients 57 FGR (b...

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Autores:
Tipo de recurso:
Fecha de publicación:
2019
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/22755
Acceso en línea:
https://doi.org/10.1136/archdischild-2017-313712
https://repository.urosario.edu.co/handle/10336/22755
Palabra clave:
Article
Autoregulation
Birth weight
Blood pressure
Blood pressure variability
Brain blood vessel
Case control study
Controlled study
Female
Gestational age
Human
Intrauterine growth retardation
Major clinical study
Male
Mean arterial pressure
Neonatal intensive care unit
Netherlands
Newborn
Oximetry
Oxygen saturation
Patient selection
Premature labor
Prematurity
Priority journal
Retrospective study
Blood pressure measurement
Brain circulation
Devices
Homeostasis
Intrauterine growth retardation
Near infrared spectroscopy
Oxygen consumption
Pathophysiology
Physiologic monitoring
Physiology
Procedures
Prognosis
Statistics and numerical data
Birth Weight
Blood Pressure Determination
Cerebrovascular Circulation
Female
Fetal Growth Retardation
Gestational Age
Homeostasis
Humans
Male
Netherlands
Oxygen Consumption
Prognosis
Cerebrovascular autoregulation
Fetal growth restriction (FGR)
Intrauterine growth restriction (IUGR)
Near-infrared spectroscopy (NIRS)
Prematurity
Premature
Near-Infrared
Neonatal
Newborn
Physiologic
Infant
Infant
Intensive Care Units
Monitoring
Spectroscopy
Rights
License
Abierto (Texto Completo)
id EDOCUR2_74c42d73ad36ab75e1bee12231cc92e5
oai_identifier_str oai:repository.urosario.edu.co:10336/22755
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling ad24328a-8fc9-493b-9ee6-e58e2e0832ad1659cd2e-ad05-4ffd-a1bd-11801c7c8cf91413951260038de6b05-427b-4843-8821-5161b28c732448245199-eedd-47d1-934a-81d609208e4335510ab8-1d2a-45af-95d9-973c786a681a2020-05-25T23:57:51Z2020-05-25T23:57:51Z2019Objective To investigate the effect of fetal growth restriction (FGR) on cerebrovascular autoregulation in preterm neonates during the first 3 days of life. Design Case-control study. Setting Neonatal intensive care unit of the Wilhelmina Children's Hospital, The Netherlands. Patients 57 FGR (birth weight less than 10th percentile) and 57 appropriate for gestational age (AGA) (birth weight 20th-80th percentiles) preterm neonates, matched for gender, gestational age, respiratory and blood pressure support. Methods The correlation between continuously measured mean arterial blood pressure and regional cerebral oxygen saturation was calculated to generate the cerebral oximetry index (COx). Mean COx was calculated for each patient for each postnatal day. The percentage of time with impaired autoregulation (COx>0.5) was also calculated. Results FGR neonates had higher mean COx values than their AGA peers on day 2 (0.15 (95% CI 0.11 to 0.18) vs 0.09 (95% CI 0.06 to 0.13), p=0.029) and day 3 (0.17 (95% CI 0.13 to 0.20) vs 0.09 (95% CI 0.06 to 0.12), p=0.003) of life. FGR neonates spent more time with impaired autoregulation (COx value >0.5) than controls on postnatal day 2 (19% (95% CI 16% to 22%) vs 14% (95% CI 12% to 17%), p=0.035) and day 3 (20% (95% CI 17% to 24%) vs 15% (95% CI 12% to 18%), p=0.016). Conclusion FGR preterm neonates more frequently display impaired cerebrovascular autoregulation compared with AGA peers on days 2 and 3 of life which may predispose them to brain injury. Further studies are required to investigate whether this impairment persists beyond the first few days of life and whether this impairment is linked to poor neurodevelopmental outcome. © Author(s) (or their employer(s)) 2019.application/pdfhttps://doi.org/10.1136/archdischild-2017-31371213592998https://repository.urosario.edu.co/handle/10336/22755engBMJ Publishing GroupF472No. 5F467Archives of Disease in Childhood: Fetal and Neonatal EditionVol. 104Archives of Disease in Childhood: Fetal and Neonatal Edition, ISSN:13592998, Vol.104, No.5 (2019); pp. F467-F472https://www.scopus.com/inward/record.uri?eid=2-s2.0-85055502414&doi=10.1136%2farchdischild-2017-313712&partnerID=40&md5=36e1b4d7f69f02dec28f137c59620387Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURArticleAutoregulationBirth weightBlood pressureBlood pressure variabilityBrain blood vesselCase control studyControlled studyFemaleGestational ageHumanIntrauterine growth retardationMajor clinical studyMaleMean arterial pressureNeonatal intensive care unitNetherlandsNewbornOximetryOxygen saturationPatient selectionPremature laborPrematurityPriority journalRetrospective studyBlood pressure measurementBrain circulationDevicesHomeostasisIntrauterine growth retardationNear infrared spectroscopyOxygen consumptionPathophysiologyPhysiologic monitoringPhysiologyProceduresPrognosisStatistics and numerical dataBirth WeightBlood Pressure DeterminationCerebrovascular CirculationFemaleFetal Growth RetardationGestational AgeHomeostasisHumansMaleNetherlandsOxygen ConsumptionPrognosisCerebrovascular autoregulationFetal growth restriction (FGR)Intrauterine growth restriction (IUGR)Near-infrared spectroscopy (NIRS)PrematurityPrematureNear-InfraredNeonatalNewbornPhysiologicInfantInfantIntensive Care UnitsMonitoringSpectroscopyCerebrovascular autoregulation in preterm fetal growth restricted neonatesarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Cohen E.Baerts W.Caicedo Dorado, AlexanderNaulaers G.Van Bel F.Lemmers P.M.A.10336/22755oai:repository.urosario.edu.co:10336/227552022-05-02 07:37:17.732821https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Cerebrovascular autoregulation in preterm fetal growth restricted neonates
title Cerebrovascular autoregulation in preterm fetal growth restricted neonates
spellingShingle Cerebrovascular autoregulation in preterm fetal growth restricted neonates
Article
Autoregulation
Birth weight
Blood pressure
Blood pressure variability
Brain blood vessel
Case control study
Controlled study
Female
Gestational age
Human
Intrauterine growth retardation
Major clinical study
Male
Mean arterial pressure
Neonatal intensive care unit
Netherlands
Newborn
Oximetry
Oxygen saturation
Patient selection
Premature labor
Prematurity
Priority journal
Retrospective study
Blood pressure measurement
Brain circulation
Devices
Homeostasis
Intrauterine growth retardation
Near infrared spectroscopy
Oxygen consumption
Pathophysiology
Physiologic monitoring
Physiology
Procedures
Prognosis
Statistics and numerical data
Birth Weight
Blood Pressure Determination
Cerebrovascular Circulation
Female
Fetal Growth Retardation
Gestational Age
Homeostasis
Humans
Male
Netherlands
Oxygen Consumption
Prognosis
Cerebrovascular autoregulation
Fetal growth restriction (FGR)
Intrauterine growth restriction (IUGR)
Near-infrared spectroscopy (NIRS)
Prematurity
Premature
Near-Infrared
Neonatal
Newborn
Physiologic
Infant
Infant
Intensive Care Units
Monitoring
Spectroscopy
title_short Cerebrovascular autoregulation in preterm fetal growth restricted neonates
title_full Cerebrovascular autoregulation in preterm fetal growth restricted neonates
title_fullStr Cerebrovascular autoregulation in preterm fetal growth restricted neonates
title_full_unstemmed Cerebrovascular autoregulation in preterm fetal growth restricted neonates
title_sort Cerebrovascular autoregulation in preterm fetal growth restricted neonates
dc.subject.keyword.spa.fl_str_mv Article
Autoregulation
Birth weight
Blood pressure
Blood pressure variability
Brain blood vessel
Case control study
Controlled study
Female
Gestational age
Human
Intrauterine growth retardation
Major clinical study
Male
Mean arterial pressure
Neonatal intensive care unit
Netherlands
Newborn
Oximetry
Oxygen saturation
Patient selection
Premature labor
Prematurity
Priority journal
Retrospective study
Blood pressure measurement
Brain circulation
Devices
Homeostasis
Intrauterine growth retardation
Near infrared spectroscopy
Oxygen consumption
Pathophysiology
Physiologic monitoring
Physiology
Procedures
Prognosis
Statistics and numerical data
Birth Weight
Blood Pressure Determination
Cerebrovascular Circulation
Female
Fetal Growth Retardation
Gestational Age
Homeostasis
Humans
Male
Netherlands
Oxygen Consumption
Prognosis
Cerebrovascular autoregulation
Fetal growth restriction (FGR)
Intrauterine growth restriction (IUGR)
Near-infrared spectroscopy (NIRS)
Prematurity
topic Article
Autoregulation
Birth weight
Blood pressure
Blood pressure variability
Brain blood vessel
Case control study
Controlled study
Female
Gestational age
Human
Intrauterine growth retardation
Major clinical study
Male
Mean arterial pressure
Neonatal intensive care unit
Netherlands
Newborn
Oximetry
Oxygen saturation
Patient selection
Premature labor
Prematurity
Priority journal
Retrospective study
Blood pressure measurement
Brain circulation
Devices
Homeostasis
Intrauterine growth retardation
Near infrared spectroscopy
Oxygen consumption
Pathophysiology
Physiologic monitoring
Physiology
Procedures
Prognosis
Statistics and numerical data
Birth Weight
Blood Pressure Determination
Cerebrovascular Circulation
Female
Fetal Growth Retardation
Gestational Age
Homeostasis
Humans
Male
Netherlands
Oxygen Consumption
Prognosis
Cerebrovascular autoregulation
Fetal growth restriction (FGR)
Intrauterine growth restriction (IUGR)
Near-infrared spectroscopy (NIRS)
Prematurity
Premature
Near-Infrared
Neonatal
Newborn
Physiologic
Infant
Infant
Intensive Care Units
Monitoring
Spectroscopy
dc.subject.keyword.eng.fl_str_mv Premature
Near-Infrared
Neonatal
Newborn
Physiologic
Infant
Infant
Intensive Care Units
Monitoring
Spectroscopy
description Objective To investigate the effect of fetal growth restriction (FGR) on cerebrovascular autoregulation in preterm neonates during the first 3 days of life. Design Case-control study. Setting Neonatal intensive care unit of the Wilhelmina Children's Hospital, The Netherlands. Patients 57 FGR (birth weight less than 10th percentile) and 57 appropriate for gestational age (AGA) (birth weight 20th-80th percentiles) preterm neonates, matched for gender, gestational age, respiratory and blood pressure support. Methods The correlation between continuously measured mean arterial blood pressure and regional cerebral oxygen saturation was calculated to generate the cerebral oximetry index (COx). Mean COx was calculated for each patient for each postnatal day. The percentage of time with impaired autoregulation (COx>0.5) was also calculated. Results FGR neonates had higher mean COx values than their AGA peers on day 2 (0.15 (95% CI 0.11 to 0.18) vs 0.09 (95% CI 0.06 to 0.13), p=0.029) and day 3 (0.17 (95% CI 0.13 to 0.20) vs 0.09 (95% CI 0.06 to 0.12), p=0.003) of life. FGR neonates spent more time with impaired autoregulation (COx value >0.5) than controls on postnatal day 2 (19% (95% CI 16% to 22%) vs 14% (95% CI 12% to 17%), p=0.035) and day 3 (20% (95% CI 17% to 24%) vs 15% (95% CI 12% to 18%), p=0.016). Conclusion FGR preterm neonates more frequently display impaired cerebrovascular autoregulation compared with AGA peers on days 2 and 3 of life which may predispose them to brain injury. Further studies are required to investigate whether this impairment persists beyond the first few days of life and whether this impairment is linked to poor neurodevelopmental outcome. © Author(s) (or their employer(s)) 2019.
publishDate 2019
dc.date.created.spa.fl_str_mv 2019
dc.date.accessioned.none.fl_str_mv 2020-05-25T23:57:51Z
dc.date.available.none.fl_str_mv 2020-05-25T23:57:51Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1136/archdischild-2017-313712
dc.identifier.issn.none.fl_str_mv 13592998
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/22755
url https://doi.org/10.1136/archdischild-2017-313712
https://repository.urosario.edu.co/handle/10336/22755
identifier_str_mv 13592998
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv F472
dc.relation.citationIssue.none.fl_str_mv No. 5
dc.relation.citationStartPage.none.fl_str_mv F467
dc.relation.citationTitle.none.fl_str_mv Archives of Disease in Childhood: Fetal and Neonatal Edition
dc.relation.citationVolume.none.fl_str_mv Vol. 104
dc.relation.ispartof.spa.fl_str_mv Archives of Disease in Childhood: Fetal and Neonatal Edition, ISSN:13592998, Vol.104, No.5 (2019); pp. F467-F472
dc.relation.uri.spa.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-85055502414&doi=10.1136%2farchdischild-2017-313712&partnerID=40&md5=36e1b4d7f69f02dec28f137c59620387
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv BMJ Publishing Group
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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