Cerebrovascular autoregulation in preterm fetal growth restricted neonates
Objective To investigate the effect of fetal growth restriction (FGR) on cerebrovascular autoregulation in preterm neonates during the first 3 days of life. Design Case-control study. Setting Neonatal intensive care unit of the Wilhelmina Children's Hospital, The Netherlands. Patients 57 FGR (b...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2019
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/22755
- Acceso en línea:
- https://doi.org/10.1136/archdischild-2017-313712
https://repository.urosario.edu.co/handle/10336/22755
- Palabra clave:
- Article
Autoregulation
Birth weight
Blood pressure
Blood pressure variability
Brain blood vessel
Case control study
Controlled study
Female
Gestational age
Human
Intrauterine growth retardation
Major clinical study
Male
Mean arterial pressure
Neonatal intensive care unit
Netherlands
Newborn
Oximetry
Oxygen saturation
Patient selection
Premature labor
Prematurity
Priority journal
Retrospective study
Blood pressure measurement
Brain circulation
Devices
Homeostasis
Intrauterine growth retardation
Near infrared spectroscopy
Oxygen consumption
Pathophysiology
Physiologic monitoring
Physiology
Procedures
Prognosis
Statistics and numerical data
Birth Weight
Blood Pressure Determination
Cerebrovascular Circulation
Female
Fetal Growth Retardation
Gestational Age
Homeostasis
Humans
Male
Netherlands
Oxygen Consumption
Prognosis
Cerebrovascular autoregulation
Fetal growth restriction (FGR)
Intrauterine growth restriction (IUGR)
Near-infrared spectroscopy (NIRS)
Prematurity
Premature
Near-Infrared
Neonatal
Newborn
Physiologic
Infant
Infant
Intensive Care Units
Monitoring
Spectroscopy
- Rights
- License
- Abierto (Texto Completo)
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ad24328a-8fc9-493b-9ee6-e58e2e0832ad1659cd2e-ad05-4ffd-a1bd-11801c7c8cf91413951260038de6b05-427b-4843-8821-5161b28c732448245199-eedd-47d1-934a-81d609208e4335510ab8-1d2a-45af-95d9-973c786a681a2020-05-25T23:57:51Z2020-05-25T23:57:51Z2019Objective To investigate the effect of fetal growth restriction (FGR) on cerebrovascular autoregulation in preterm neonates during the first 3 days of life. Design Case-control study. Setting Neonatal intensive care unit of the Wilhelmina Children's Hospital, The Netherlands. Patients 57 FGR (birth weight less than 10th percentile) and 57 appropriate for gestational age (AGA) (birth weight 20th-80th percentiles) preterm neonates, matched for gender, gestational age, respiratory and blood pressure support. Methods The correlation between continuously measured mean arterial blood pressure and regional cerebral oxygen saturation was calculated to generate the cerebral oximetry index (COx). Mean COx was calculated for each patient for each postnatal day. The percentage of time with impaired autoregulation (COx>0.5) was also calculated. Results FGR neonates had higher mean COx values than their AGA peers on day 2 (0.15 (95% CI 0.11 to 0.18) vs 0.09 (95% CI 0.06 to 0.13), p=0.029) and day 3 (0.17 (95% CI 0.13 to 0.20) vs 0.09 (95% CI 0.06 to 0.12), p=0.003) of life. FGR neonates spent more time with impaired autoregulation (COx value >0.5) than controls on postnatal day 2 (19% (95% CI 16% to 22%) vs 14% (95% CI 12% to 17%), p=0.035) and day 3 (20% (95% CI 17% to 24%) vs 15% (95% CI 12% to 18%), p=0.016). Conclusion FGR preterm neonates more frequently display impaired cerebrovascular autoregulation compared with AGA peers on days 2 and 3 of life which may predispose them to brain injury. Further studies are required to investigate whether this impairment persists beyond the first few days of life and whether this impairment is linked to poor neurodevelopmental outcome. © Author(s) (or their employer(s)) 2019.application/pdfhttps://doi.org/10.1136/archdischild-2017-31371213592998https://repository.urosario.edu.co/handle/10336/22755engBMJ Publishing GroupF472No. 5F467Archives of Disease in Childhood: Fetal and Neonatal EditionVol. 104Archives of Disease in Childhood: Fetal and Neonatal Edition, ISSN:13592998, Vol.104, No.5 (2019); pp. F467-F472https://www.scopus.com/inward/record.uri?eid=2-s2.0-85055502414&doi=10.1136%2farchdischild-2017-313712&partnerID=40&md5=36e1b4d7f69f02dec28f137c59620387Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURArticleAutoregulationBirth weightBlood pressureBlood pressure variabilityBrain blood vesselCase control studyControlled studyFemaleGestational ageHumanIntrauterine growth retardationMajor clinical studyMaleMean arterial pressureNeonatal intensive care unitNetherlandsNewbornOximetryOxygen saturationPatient selectionPremature laborPrematurityPriority journalRetrospective studyBlood pressure measurementBrain circulationDevicesHomeostasisIntrauterine growth retardationNear infrared spectroscopyOxygen consumptionPathophysiologyPhysiologic monitoringPhysiologyProceduresPrognosisStatistics and numerical dataBirth WeightBlood Pressure DeterminationCerebrovascular CirculationFemaleFetal Growth RetardationGestational AgeHomeostasisHumansMaleNetherlandsOxygen ConsumptionPrognosisCerebrovascular autoregulationFetal growth restriction (FGR)Intrauterine growth restriction (IUGR)Near-infrared spectroscopy (NIRS)PrematurityPrematureNear-InfraredNeonatalNewbornPhysiologicInfantInfantIntensive Care UnitsMonitoringSpectroscopyCerebrovascular autoregulation in preterm fetal growth restricted neonatesarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Cohen E.Baerts W.Caicedo Dorado, AlexanderNaulaers G.Van Bel F.Lemmers P.M.A.10336/22755oai:repository.urosario.edu.co:10336/227552022-05-02 07:37:17.732821https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Cerebrovascular autoregulation in preterm fetal growth restricted neonates |
title |
Cerebrovascular autoregulation in preterm fetal growth restricted neonates |
spellingShingle |
Cerebrovascular autoregulation in preterm fetal growth restricted neonates Article Autoregulation Birth weight Blood pressure Blood pressure variability Brain blood vessel Case control study Controlled study Female Gestational age Human Intrauterine growth retardation Major clinical study Male Mean arterial pressure Neonatal intensive care unit Netherlands Newborn Oximetry Oxygen saturation Patient selection Premature labor Prematurity Priority journal Retrospective study Blood pressure measurement Brain circulation Devices Homeostasis Intrauterine growth retardation Near infrared spectroscopy Oxygen consumption Pathophysiology Physiologic monitoring Physiology Procedures Prognosis Statistics and numerical data Birth Weight Blood Pressure Determination Cerebrovascular Circulation Female Fetal Growth Retardation Gestational Age Homeostasis Humans Male Netherlands Oxygen Consumption Prognosis Cerebrovascular autoregulation Fetal growth restriction (FGR) Intrauterine growth restriction (IUGR) Near-infrared spectroscopy (NIRS) Prematurity Premature Near-Infrared Neonatal Newborn Physiologic Infant Infant Intensive Care Units Monitoring Spectroscopy |
title_short |
Cerebrovascular autoregulation in preterm fetal growth restricted neonates |
title_full |
Cerebrovascular autoregulation in preterm fetal growth restricted neonates |
title_fullStr |
Cerebrovascular autoregulation in preterm fetal growth restricted neonates |
title_full_unstemmed |
Cerebrovascular autoregulation in preterm fetal growth restricted neonates |
title_sort |
Cerebrovascular autoregulation in preterm fetal growth restricted neonates |
dc.subject.keyword.spa.fl_str_mv |
Article Autoregulation Birth weight Blood pressure Blood pressure variability Brain blood vessel Case control study Controlled study Female Gestational age Human Intrauterine growth retardation Major clinical study Male Mean arterial pressure Neonatal intensive care unit Netherlands Newborn Oximetry Oxygen saturation Patient selection Premature labor Prematurity Priority journal Retrospective study Blood pressure measurement Brain circulation Devices Homeostasis Intrauterine growth retardation Near infrared spectroscopy Oxygen consumption Pathophysiology Physiologic monitoring Physiology Procedures Prognosis Statistics and numerical data Birth Weight Blood Pressure Determination Cerebrovascular Circulation Female Fetal Growth Retardation Gestational Age Homeostasis Humans Male Netherlands Oxygen Consumption Prognosis Cerebrovascular autoregulation Fetal growth restriction (FGR) Intrauterine growth restriction (IUGR) Near-infrared spectroscopy (NIRS) Prematurity |
topic |
Article Autoregulation Birth weight Blood pressure Blood pressure variability Brain blood vessel Case control study Controlled study Female Gestational age Human Intrauterine growth retardation Major clinical study Male Mean arterial pressure Neonatal intensive care unit Netherlands Newborn Oximetry Oxygen saturation Patient selection Premature labor Prematurity Priority journal Retrospective study Blood pressure measurement Brain circulation Devices Homeostasis Intrauterine growth retardation Near infrared spectroscopy Oxygen consumption Pathophysiology Physiologic monitoring Physiology Procedures Prognosis Statistics and numerical data Birth Weight Blood Pressure Determination Cerebrovascular Circulation Female Fetal Growth Retardation Gestational Age Homeostasis Humans Male Netherlands Oxygen Consumption Prognosis Cerebrovascular autoregulation Fetal growth restriction (FGR) Intrauterine growth restriction (IUGR) Near-infrared spectroscopy (NIRS) Prematurity Premature Near-Infrared Neonatal Newborn Physiologic Infant Infant Intensive Care Units Monitoring Spectroscopy |
dc.subject.keyword.eng.fl_str_mv |
Premature Near-Infrared Neonatal Newborn Physiologic Infant Infant Intensive Care Units Monitoring Spectroscopy |
description |
Objective To investigate the effect of fetal growth restriction (FGR) on cerebrovascular autoregulation in preterm neonates during the first 3 days of life. Design Case-control study. Setting Neonatal intensive care unit of the Wilhelmina Children's Hospital, The Netherlands. Patients 57 FGR (birth weight less than 10th percentile) and 57 appropriate for gestational age (AGA) (birth weight 20th-80th percentiles) preterm neonates, matched for gender, gestational age, respiratory and blood pressure support. Methods The correlation between continuously measured mean arterial blood pressure and regional cerebral oxygen saturation was calculated to generate the cerebral oximetry index (COx). Mean COx was calculated for each patient for each postnatal day. The percentage of time with impaired autoregulation (COx>0.5) was also calculated. Results FGR neonates had higher mean COx values than their AGA peers on day 2 (0.15 (95% CI 0.11 to 0.18) vs 0.09 (95% CI 0.06 to 0.13), p=0.029) and day 3 (0.17 (95% CI 0.13 to 0.20) vs 0.09 (95% CI 0.06 to 0.12), p=0.003) of life. FGR neonates spent more time with impaired autoregulation (COx value >0.5) than controls on postnatal day 2 (19% (95% CI 16% to 22%) vs 14% (95% CI 12% to 17%), p=0.035) and day 3 (20% (95% CI 17% to 24%) vs 15% (95% CI 12% to 18%), p=0.016). Conclusion FGR preterm neonates more frequently display impaired cerebrovascular autoregulation compared with AGA peers on days 2 and 3 of life which may predispose them to brain injury. Further studies are required to investigate whether this impairment persists beyond the first few days of life and whether this impairment is linked to poor neurodevelopmental outcome. © Author(s) (or their employer(s)) 2019. |
publishDate |
2019 |
dc.date.created.spa.fl_str_mv |
2019 |
dc.date.accessioned.none.fl_str_mv |
2020-05-25T23:57:51Z |
dc.date.available.none.fl_str_mv |
2020-05-25T23:57:51Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1136/archdischild-2017-313712 |
dc.identifier.issn.none.fl_str_mv |
13592998 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/22755 |
url |
https://doi.org/10.1136/archdischild-2017-313712 https://repository.urosario.edu.co/handle/10336/22755 |
identifier_str_mv |
13592998 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
F472 |
dc.relation.citationIssue.none.fl_str_mv |
No. 5 |
dc.relation.citationStartPage.none.fl_str_mv |
F467 |
dc.relation.citationTitle.none.fl_str_mv |
Archives of Disease in Childhood: Fetal and Neonatal Edition |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 104 |
dc.relation.ispartof.spa.fl_str_mv |
Archives of Disease in Childhood: Fetal and Neonatal Edition, ISSN:13592998, Vol.104, No.5 (2019); pp. F467-F472 |
dc.relation.uri.spa.fl_str_mv |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85055502414&doi=10.1136%2farchdischild-2017-313712&partnerID=40&md5=36e1b4d7f69f02dec28f137c59620387 |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
BMJ Publishing Group |
institution |
Universidad del Rosario |
dc.source.instname.spa.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167602113544192 |