Functional hubs in mild cognitive impairment
We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to invest...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2015
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/24334
- Acceso en línea:
- https://doi.org/10.1142/S0218127415500340
https://repository.urosario.edu.co/handle/10336/24334
- Palabra clave:
- Brain mapping
Electric network topology
Magnetoencephalography
Alzheimer's disease
Brain networks
Centrality
Mild cognitive impairments
Mild cognitive impairments (MCI)
Random structures
Short-term memory tasks
Synchronization likelihoods
Neurodegenerative diseases
Centrality
Functional brain networks
Hub characterization
Mild cognitive impairment
Synchronization likelihood
- Rights
- License
- Abierto (Texto Completo)
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Repositorio EdocUR - U. Rosario |
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69832189-c196-4454-a3fb-46375fe89987-1fdf305ff-e061-4a49-a568-1d5d255b0301-13864d03b-25ef-4fd4-85a3-4e0d941eb3ce-1987a687a-7ebe-4e96-b06b-7b97a5db9678-1caeab88b-393b-4959-add0-be02f3049bb4-12c308d1b-a4de-43a4-8dc1-de12d4ee5c44-1b694ae7e-282d-4700-8629-9ce9ab41a15b-1402af96f-2f4d-4abd-ac87-f07ce3475704-13667faa1-c1da-43b5-936d-35de48f8690e-14624b110-73fd-463c-ae0f-8db17e554410-12020-05-26T00:11:48Z2020-05-26T00:11:48Z2015We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to investigate the functional brain networks of a group of patients suffering from MCI and a control group of healthy subjects, during the execution of a short-term memory task. Couplings between brain sites were evaluated using synchronization likelihood, from which a network of functional interdependencies was constructed and the centrality, i.e. importance, of their nodes was quantified. The results showed that, with respect to healthy controls, MCI patients were associated with decreases and increases in hub centrality respectively in occipital and central scalp regions, supporting the hypothesis that MCI modifies functional brain network topology, leading to more random structures. © 2015 World Scientific Publishing Company.application/pdfhttps://doi.org/10.1142/S0218127415500340https://repository.urosario.edu.co/handle/10336/24334engWorld Scientific Publishing Co. Pte LtdNo. 3International Journal of Bifurcation and ChaosVol. 25International Journal of Bifurcation and Chaos, Vol.25, No.3 (2015)https://www.scopus.com/inward/record.uri?eid=2-s2.0-84928537119&doi=10.1142%2fS0218127415500340&partnerID=40&md5=08d165cfa85de2bfd833ec700526989dAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURBrain mappingElectric network topologyMagnetoencephalographyAlzheimer's diseaseBrain networksCentralityMild cognitive impairmentsMild cognitive impairments (MCI)Random structuresShort-term memory tasksSynchronization likelihoodsNeurodegenerative diseasesCentralityFunctional brain networksHub characterizationMild cognitive impairmentSynchronization likelihoodFunctional hubs in mild cognitive impairmentarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Navas, AdriánPapo, DavidBoccaletti, StefanoDel-Pozo, F.Bajo, RicardoMaestú, FernandoMartínez, J. H.Gil, PabloSendiña-Nadal, IreneBuldú, Javier M.10336/24334oai:repository.urosario.edu.co:10336/243342022-05-02 07:37:14.95468https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Functional hubs in mild cognitive impairment |
title |
Functional hubs in mild cognitive impairment |
spellingShingle |
Functional hubs in mild cognitive impairment Brain mapping Electric network topology Magnetoencephalography Alzheimer's disease Brain networks Centrality Mild cognitive impairments Mild cognitive impairments (MCI) Random structures Short-term memory tasks Synchronization likelihoods Neurodegenerative diseases Centrality Functional brain networks Hub characterization Mild cognitive impairment Synchronization likelihood |
title_short |
Functional hubs in mild cognitive impairment |
title_full |
Functional hubs in mild cognitive impairment |
title_fullStr |
Functional hubs in mild cognitive impairment |
title_full_unstemmed |
Functional hubs in mild cognitive impairment |
title_sort |
Functional hubs in mild cognitive impairment |
dc.subject.keyword.spa.fl_str_mv |
Brain mapping Electric network topology Magnetoencephalography Alzheimer's disease Brain networks Centrality Mild cognitive impairments Mild cognitive impairments (MCI) Random structures Short-term memory tasks Synchronization likelihoods Neurodegenerative diseases Centrality Functional brain networks Hub characterization Mild cognitive impairment Synchronization likelihood |
topic |
Brain mapping Electric network topology Magnetoencephalography Alzheimer's disease Brain networks Centrality Mild cognitive impairments Mild cognitive impairments (MCI) Random structures Short-term memory tasks Synchronization likelihoods Neurodegenerative diseases Centrality Functional brain networks Hub characterization Mild cognitive impairment Synchronization likelihood |
description |
We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to investigate the functional brain networks of a group of patients suffering from MCI and a control group of healthy subjects, during the execution of a short-term memory task. Couplings between brain sites were evaluated using synchronization likelihood, from which a network of functional interdependencies was constructed and the centrality, i.e. importance, of their nodes was quantified. The results showed that, with respect to healthy controls, MCI patients were associated with decreases and increases in hub centrality respectively in occipital and central scalp regions, supporting the hypothesis that MCI modifies functional brain network topology, leading to more random structures. © 2015 World Scientific Publishing Company. |
publishDate |
2015 |
dc.date.created.spa.fl_str_mv |
2015 |
dc.date.accessioned.none.fl_str_mv |
2020-05-26T00:11:48Z |
dc.date.available.none.fl_str_mv |
2020-05-26T00:11:48Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1142/S0218127415500340 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/24334 |
url |
https://doi.org/10.1142/S0218127415500340 https://repository.urosario.edu.co/handle/10336/24334 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationIssue.none.fl_str_mv |
No. 3 |
dc.relation.citationTitle.none.fl_str_mv |
International Journal of Bifurcation and Chaos |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 25 |
dc.relation.ispartof.spa.fl_str_mv |
International Journal of Bifurcation and Chaos, Vol.25, No.3 (2015) |
dc.relation.uri.spa.fl_str_mv |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84928537119&doi=10.1142%2fS0218127415500340&partnerID=40&md5=08d165cfa85de2bfd833ec700526989d |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
World Scientific Publishing Co. Pte Ltd |
institution |
Universidad del Rosario |
dc.source.instname.spa.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167560975810560 |