Functional hubs in mild cognitive impairment

We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to invest...

Full description

Autores:
Tipo de recurso:
Fecha de publicación:
2015
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/24334
Acceso en línea:
https://doi.org/10.1142/S0218127415500340
https://repository.urosario.edu.co/handle/10336/24334
Palabra clave:
Brain mapping
Electric network topology
Magnetoencephalography
Alzheimer's disease
Brain networks
Centrality
Mild cognitive impairments
Mild cognitive impairments (MCI)
Random structures
Short-term memory tasks
Synchronization likelihoods
Neurodegenerative diseases
Centrality
Functional brain networks
Hub characterization
Mild cognitive impairment
Synchronization likelihood
Rights
License
Abierto (Texto Completo)
id EDOCUR2_71daadcfdb72fcea893cd8c50dca0142
oai_identifier_str oai:repository.urosario.edu.co:10336/24334
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 69832189-c196-4454-a3fb-46375fe89987-1fdf305ff-e061-4a49-a568-1d5d255b0301-13864d03b-25ef-4fd4-85a3-4e0d941eb3ce-1987a687a-7ebe-4e96-b06b-7b97a5db9678-1caeab88b-393b-4959-add0-be02f3049bb4-12c308d1b-a4de-43a4-8dc1-de12d4ee5c44-1b694ae7e-282d-4700-8629-9ce9ab41a15b-1402af96f-2f4d-4abd-ac87-f07ce3475704-13667faa1-c1da-43b5-936d-35de48f8690e-14624b110-73fd-463c-ae0f-8db17e554410-12020-05-26T00:11:48Z2020-05-26T00:11:48Z2015We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to investigate the functional brain networks of a group of patients suffering from MCI and a control group of healthy subjects, during the execution of a short-term memory task. Couplings between brain sites were evaluated using synchronization likelihood, from which a network of functional interdependencies was constructed and the centrality, i.e. importance, of their nodes was quantified. The results showed that, with respect to healthy controls, MCI patients were associated with decreases and increases in hub centrality respectively in occipital and central scalp regions, supporting the hypothesis that MCI modifies functional brain network topology, leading to more random structures. © 2015 World Scientific Publishing Company.application/pdfhttps://doi.org/10.1142/S0218127415500340https://repository.urosario.edu.co/handle/10336/24334engWorld Scientific Publishing Co. Pte LtdNo. 3International Journal of Bifurcation and ChaosVol. 25International Journal of Bifurcation and Chaos, Vol.25, No.3 (2015)https://www.scopus.com/inward/record.uri?eid=2-s2.0-84928537119&doi=10.1142%2fS0218127415500340&partnerID=40&md5=08d165cfa85de2bfd833ec700526989dAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURBrain mappingElectric network topologyMagnetoencephalographyAlzheimer's diseaseBrain networksCentralityMild cognitive impairmentsMild cognitive impairments (MCI)Random structuresShort-term memory tasksSynchronization likelihoodsNeurodegenerative diseasesCentralityFunctional brain networksHub characterizationMild cognitive impairmentSynchronization likelihoodFunctional hubs in mild cognitive impairmentarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Navas, AdriánPapo, DavidBoccaletti, StefanoDel-Pozo, F.Bajo, RicardoMaestú, FernandoMartínez, J. H.Gil, PabloSendiña-Nadal, IreneBuldú, Javier M.10336/24334oai:repository.urosario.edu.co:10336/243342022-05-02 07:37:14.95468https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Functional hubs in mild cognitive impairment
title Functional hubs in mild cognitive impairment
spellingShingle Functional hubs in mild cognitive impairment
Brain mapping
Electric network topology
Magnetoencephalography
Alzheimer's disease
Brain networks
Centrality
Mild cognitive impairments
Mild cognitive impairments (MCI)
Random structures
Short-term memory tasks
Synchronization likelihoods
Neurodegenerative diseases
Centrality
Functional brain networks
Hub characterization
Mild cognitive impairment
Synchronization likelihood
title_short Functional hubs in mild cognitive impairment
title_full Functional hubs in mild cognitive impairment
title_fullStr Functional hubs in mild cognitive impairment
title_full_unstemmed Functional hubs in mild cognitive impairment
title_sort Functional hubs in mild cognitive impairment
dc.subject.keyword.spa.fl_str_mv Brain mapping
Electric network topology
Magnetoencephalography
Alzheimer's disease
Brain networks
Centrality
Mild cognitive impairments
Mild cognitive impairments (MCI)
Random structures
Short-term memory tasks
Synchronization likelihoods
Neurodegenerative diseases
Centrality
Functional brain networks
Hub characterization
Mild cognitive impairment
Synchronization likelihood
topic Brain mapping
Electric network topology
Magnetoencephalography
Alzheimer's disease
Brain networks
Centrality
Mild cognitive impairments
Mild cognitive impairments (MCI)
Random structures
Short-term memory tasks
Synchronization likelihoods
Neurodegenerative diseases
Centrality
Functional brain networks
Hub characterization
Mild cognitive impairment
Synchronization likelihood
description We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to investigate the functional brain networks of a group of patients suffering from MCI and a control group of healthy subjects, during the execution of a short-term memory task. Couplings between brain sites were evaluated using synchronization likelihood, from which a network of functional interdependencies was constructed and the centrality, i.e. importance, of their nodes was quantified. The results showed that, with respect to healthy controls, MCI patients were associated with decreases and increases in hub centrality respectively in occipital and central scalp regions, supporting the hypothesis that MCI modifies functional brain network topology, leading to more random structures. © 2015 World Scientific Publishing Company.
publishDate 2015
dc.date.created.spa.fl_str_mv 2015
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:11:48Z
dc.date.available.none.fl_str_mv 2020-05-26T00:11:48Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1142/S0218127415500340
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/24334
url https://doi.org/10.1142/S0218127415500340
https://repository.urosario.edu.co/handle/10336/24334
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationIssue.none.fl_str_mv No. 3
dc.relation.citationTitle.none.fl_str_mv International Journal of Bifurcation and Chaos
dc.relation.citationVolume.none.fl_str_mv Vol. 25
dc.relation.ispartof.spa.fl_str_mv International Journal of Bifurcation and Chaos, Vol.25, No.3 (2015)
dc.relation.uri.spa.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-84928537119&doi=10.1142%2fS0218127415500340&partnerID=40&md5=08d165cfa85de2bfd833ec700526989d
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv World Scientific Publishing Co. Pte Ltd
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
_version_ 1814167560975810560